About BioCell Collagen

You may have seen supplements that proudly proclaim to include BioCell Collagen. The product can’t be bought by itself. Instead, BioCell Collagen is a proprietary blend of ingredients that can be found in many third-party supplements.

But, what is BioCell Collagen and what does it do?

The manufacturers of BioCell Collagen, Biocell Technology, LLC, claim that it can help ease the effects of aging on your skin and mobility—including dryness, wrinkles, and stiff joints. More than other collagen blends, Biocell Technology claims that theirs stands above the supplement crowd as “the brand that really works.”

We’ll take a look at BioCell Collagen’s claims, clinical trials, and reputation to learn if their patented composition can really help you look and feel years younger.

How BioCell Collagen Claims To Be Better

According to BioCell Collagen’s official website, their product is both more effective and better tested than other supplements containing collagen and hyaluronic acid.

What makes BioCell Collagen more effective? Promoted as “not just a blend,” the manufacturers claim that their patented composition achieves unique synergy using the following ingredients:

  • 10% Hyaluronic Acid (50 mg)
  • 70% Type-II Hydrolyzed Collagen (300 mg)
  • 20% Chondroitin Sulfate (100 mg)

BioCell Says That Smaller Is Better

According to the manufacturer, regular (unhydrolyzed) collagen exists as macromolecules with a molecular weight that ranges from 200-300 kDa. This results in poor solubility and bioavailability—the proportion of a nutrient that’s absorbed and put to use after digestion.

Using hydrolysis, a process that involves breaking down molecular bonds using water, the size of collagen molecules can be reduced. Supplements containing BioCell Collagen feature this hydrolyzed collagen, and the company claims that these smaller molecules result in better absorption and higher bioavailability.

And That Their Ingredients Work Together

BioCell Collagen claims that their formula is more effective, not only due to smaller collagen molecules, but because their patented blend offers unique “synergistic benefits.”

By synergistic, they’re implying that hydrolyzed collagen type-2, hyaluronic acid, and chondroitin sulfate offer multi-dimensional nutritional support for skin, joints, tendons, and ligaments, resulting in easy absorption, fast action, and effective results.

BioCell Collagen Provides Clinical Studies

The official website provides data from several clinical trials performed over a decade, reporting results they claim demonstrate both the safety and effectiveness of BioCell Collagen. These include:

Joint Health: 89 Subjects who were experiencing joint discomfort were given 2 grams of BioCell Collagen per day, for 45 days. According to the website, 80 participants (89%) reported improved joint comfort and no adverse reactions were reported.

Another randomized, double-blind, and placebo-controlled study gave 16 individuals 2 grams of BioCell Collagen per day, for eight weeks. When compared to the placebo, BioCell Collagen reports those who took supplements containing their ingredient experienced a 40% reduction in joint discomfort.

A final study confirming similar results was published in a 2012 edition of the Journal of Agricultural and Food Chemistry.

Skin Health: The first study enrolled 26 subjects who were undergoing both natural (chronological) and sun damage-related aging process in their face. Tools were used to measure both the quantitative (how many) and qualitative (how severe) wrinkles and fine lines shown on each participant. They were then given 1 gram of BioCell Collagen per day for 12 weeks.

The reported results include improving both natural and sun-related signs of aging, including a reduction of fine lines and wrinkles (13.2%), dryness (76%), and an increase in measurable collagen content present in each participant’s skin. Additionally, no adverse reactions were reported.

The outcome of this study was published in a 2012 edition of The Clinical Interventions in Aging.

BioCell Collagen Pricing & Refund Policy

Again, BioCell Collagen can’t be purchased as a standalone supplement. Instead, those interested in testing out its potential benefits should look for third-party supplements that display the BioCell Collagen logo on their label.

A list of brands that include BioCell Collagen in their supplements can be found on their Where To Buy page. Please note that each of the third-party retailers listed offers varying prices, shipping costs, and return policies. Additionally, the manufacturers of BioCell Collagen supplements don’t accept responsibility for the products or services sold by any of their third-party retailers.

Are Collagen Supplements Good For Your Joints & Skin?

BioCell Collagen might claim to deliver better results, but what’s up with the popularity of collagen in the first place?

Collagen is a major component of the connective tissues in your body. So much so that it’s actually a quarter of our body mass! Collagen is found in our skin, muscles, tendons, and cartilage—that last one being where BioCell Collagen is derived. (From the sternal cartilage of chickens, not humans, to be precise.)

Having too little collagen can create big trouble for your body. Lobstein syndrome (osteogenesis imperfecta), a congenital disease that results in the failure to produce type-1 collagen, results in exceptionally brittle bones.

A lack of collagen also affects your body’s ability to synthesize vitamin C, resulting in scurvy—otherwise known as the least awesome aspect of being a pirate or 16th-century sailor.

While it’s unlikely that you’re interested in BioCell Collagen to cure Lobstein syndrome or prepare for a lengthy sea voyage, we mention those two diseases because while they’re both caused by a lack of collagen—neither can be cured by swallowing collagen supplements.

According to an article in Science-Based Medicine, “Collagen: An implausible supplement for joint pain,” collagen is a triple-helix, long chain protein that’s produced as the result of elaborate synthesis process that occurs throughout the body:

“When we consume collagen, usually in the form of food, the long chain proteins are broken down during digestion to their original amino acids. Only then can they be absorbed. Once absorbed, these amino acids are available as building blocks to support collagen synthesis throughout the body.”

What does this mean? First, we gather that you can’t just pop a collagen supplement and expect plumper skin. Instead, your body needs to break down the protein before putting those amino acids to work.

However, there’s a more important reason why supplements might come up short.

SBM writer Scott Gavura, (who holds a Bachelor of Science in Pharmacy degree, and a Master of Business Administration degree from the University of Toronto, and has completed an Accredited Canadian Hospital Pharmacy Residency Program) goes on to state:

“From a dietary perspective, your body doesn’t care (and can’t tell) if you ate a collagen supplement, cheese, quinoa, beef, or chick peas—they’re all sources of protein, and indistinguishable by the time they hit the bloodstream. The body doesn’t treat amino acids derived from collagen any differently than any other protein source.”

So what if your body can’t tell the difference between collagen supplements and foods?

Basically, if you’re not experiencing lessened wrinkles and joint pain from a block of cheese, there’s no reason to expect those results from a supplement.

Gavura’s article isn’t about BioCell, but about another collagen supplement that makes similar clinical claims. His bottom line?

Based on what collagen is, how it’s absorbed, and how we know collagen is actually synthesized in the body, Gavura states it’s highly implausible that 1200mg of additional collagen consumed daily will have any meaningful therapeutic effects.

It’s worth noting that Gavura’s article inspired a heated debate in the comments, with one reader linking to research supporting collagen as a treatment for joint disorders. However, the research only examined existing studies and concludes that more research is needed to determine the effectiveness of supplement treatment.

BioCell Technology Warning Letter

The Food and Drug Administration (FDA) doesn’t regulate supplements, providing that manufacturers don’t use wording that oversteps the boundary into what would be considered a “drug”—meaning that a supplement can’t promise to cure, mitigate, treat, or prevent a disease.

In 2005, BioCell Technology received a warning letter from the FDA for doing just that. The warning letter cites several statements still seen on BioCell Collagen’s website, except that the mention of a specific disease has been removed.

For example, the FDA takes issue with the claim that BioCell Collagen “improves the pain, stiffness, and quality of life in persons with osteoarthritis.” At the time of writing, that statement has been amended to state only that the supplement improves the feeling of joint pain and stiffness—notice the difference?

This is important for consumers to note, as we often skim over the small words and phrases that allow brands to limit their liability while still implying that their products are as effective as medicine.

Patents Aren’t Proof

BioCell Technology also adds weight to their claims by stating that both their proprietary blend of ingredients and processing are patented.

However, according to a Quack Watch breakdown of common supplement claims, the U.S. Patent Office does not require proof that a product actually works. Instead, the main requirement is that it be different from previously registered products.

Bottom Line On BioCell Collagen Supplements

As a consumer, the claims made by BioCell Collagen are tempting. Who wouldn’t want to feel and look younger by popping a supplement every day?

However, despite the clinical studies provided on the product’s website, medical experts maintain that there’s no objective proof that collagen supplements are more effective than any source of protein such as meat, cheese, eggs or beans at restoring the collagen in your skin.

Put another way, have you been more collagen-rich foods eased your joint pain? If not, there’s no reason to believe that supplements will do the trick.

Further, medical professionals insist that the best way to get vitamins, minerals, and nutrients is through a balanced diet—and warn that you can’t supplement lacking components with pills.

That’s not to say that BioCell Collagen supplements don’t work—just that, according to sources cited, those looking to boost their collagen should first look to their food choices.

What if you follow certain dietary restrictions that limit the protein-rich foods you can eat?

BioCell Collagen might provide some skin and joint benefits. But, to be on the safe side, we’d recommend discussing the supplements with your doctor before making a purchase.

Whether you’re considering collagen supplements or just boosting how much protein is on your plate, remember that getting good sources of antioxidants from fruits and vegetables is important for collagen production and maintenance:

  • Brightly colored produce such as tomatoes, grapefruit, and watermelon contain the powerful antioxidant lycopene, which helps prevent collagen degeneration
  • Fruits such as oranges, strawberries, and red peppers also contain vitamin C, something that’s key for optimum skin condition
  • Vegetables such as broccoli, leafy greens, and cauliflower provide our skin with glucosinolates, which fight the free radicals that attack our collagen
  • Omega-3 fatty acids have anti-oxidative and anti-inflammatory effects to help protect and heal the skin

Finally, remember that BioCell Collagen isn’t available for purchase directly through the manufacturer, and to evaluate each third-parties claims and costs before purchase.

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