About Gundry MD Glucose Defense

Called the “most advanced natural blood sugar support supplement ever developed,” Gundry MD Glucose Defense claims to use five potent, all-natural compounds to help support insulin sensitivity and healthy blood sugar levels.

Once your blood sugar is optimized using Glucose Defense, Gundry MD tells us that you could experience higher energy levels, boosted concentration and focus, and even improved weight loss. Worried about cholesterol levels and/or high blood pressure? Glucose Defense promises to help there, too.

To accomplish this, Gundry MD claims you should take two capsules of Glucose Defense once in the morning and again in the evening, preferably with meals. Despite its efficacy, the company claims Glucose Defense is side effect-free.

Given the fact that about 1 out of every 3 Americans has prediabetes, you’re certainly taking a step in the right direction by trying to take control of your blood sugar. But when the rubber meets the road, is Glucose Defense an effective, valuable tool for achieving this?

That’s exactly what we’ll help you decide in this review.

What Is Blood Sugar? How Does It Relate to Insulin Sensitivity?

We’re not going to bore you with a bunch of science-y information here, but it’s important that we have a solid foundation before moving on to Glucose Defense’s claims.

When we eat food, our body digests it and breaks it down into smaller components, allowing the nutrients it contains to be utilized by our body. Different nutrients perform different “tasks” and have different effects on our physiology.

For example, foods like bread and pasta, in addition to many types of fruit, contain high levels of glucose (a type of sugar, along with fructose and sucrose), which is an important source of energy for every cell in your body.

Despite this importance, the problem is that glucose can’t pass through cell walls without the help of a hormone called insulin. A good way to think of insulin is that it’s a “key” that allows a “door” to open in a cell wall, giving the opportunity for glucose to pass through, which can then be turned into usable energy.

Prediabetes & Diabetes

When your body is consistently flooded with excess glucose (by eating a lot of refined grains, for example) over a long period of time, your cells can actually become resistant to insulin. This, along with other important factors like genetics, causes glucose levels to rise in your bloodstream; a condition known as prediabetes.

The good news is that prediabetes—or type 2 diabetes—can often be reversed (with the help of your doctor, of course) by carefully monitoring your blood sugar levels, watching what you eat, and exercising regularly. But if you don’t address your diabetes in a timely manner, it can morph into full-blown type 1 diabetes, which is where you’ll need to inject insulin directly into your bloodstream to avoid a condition known as hypoglycemia.

Now, with this foundation to work with, let’s take a closer look at how Gundry MD claims their Glucose Defense supplement addresses these concerns.

What Does Gundry MD Glucose Defense Claim to Do?

You’re right; we already talked about what Glucose Defense is supposed to do in the introduction. In this section though, we’re going to take a closer look at what—exactly—this means for you. Here’s what Gundry MD claims:

“This formula is designed to help support healthy blood sugar levels in people whose blood sugar is already within normal range.”

We’re also told the supplement will assists in “achieving higher energy levels,” increasing concentration and focus, supporting weight loss, and maintaining healthy cholesterol levels and blood pressure.

In other words, Glucose Defense isn’t intended to help reduce your blood sugar or address prediabetes or diabetes in any way. It’s simply supposed to help keep your healthy blood sugar levels as they are.

But we have to ask: If your blood sugar levels are already healthy (i.e. you’re obviously doing something right), why would you need a supplement like Glucose Defense in the first place? In this instance, wouldn’t your current diet and exercise habits be much more impactful on maintaining healthy blood sugar levels than a supplement?

Given this, based on Gundry MD’s claims, it seems like they’re saying that Glucose Defense will optimize your existing insulin sensitivity. This way, it will be able to help your cells better utilize glucose, which can then boost energy, help you lose weight, and so forth.

Let’s keep this at the front of our mind as we move to the next section and discuss Glucose Defense’s ingredients.

Will Glucose Defense’s Ingredients Deliver Real World Results?

According to the supplement facts label listed on the Gundry MD website, Glucose Defense contains the following ingredients:

Manufactured by InterHealth USA, Zychrome is a proprietary “high-grade chromium complex” of chromium, niacin, and l-cysteine that’s promoted as a healthy way of supporting “healthy insulin levels.” The only clinical evidence provided to support these claims is a 2010 study on rats.

According to WebMD:

“Some evidence shows that taking chromium picolinate (a chemical compound that contains chromium) by mouth, either alone or along with biotin, can lower fasting blood sugar, lower insulin levels, and help insulin work in people with type 2 diabetes. Also, chromium picolinate might decrease weight gain and fat accumulation in people with type 2 diabetes who are taking a class of antidiabetes medications called sulfonylureas.”

However, keep in mind that the recommended dose of chromium to achieve this is 200-1,000 mcg daily, although we’re not told how much is found in Zychrome.

Niacin is listed as “likely effective” for addressing high cholesterol, but only in very high doses (1,200-3,000mg per day). To this extent, again, we’re not told how much niacin Zychrome contains, although WebMD notes that, “Since very high doses of niacin are required for high cholesterol, dietary supplement niacin usually isn’t appropriate.”

Some specific selenium supplements (not Glucose Defense) have been shown to modestly reduce cholesterol in patients with abnormal cholesterol levels. However, it’s noted that many of these individuals already had low selenium levels, so it’s unclear if this same benefit would manifest in those with normal selenium levels.

Similarly, taking 500 mg of berberine 2-3 times daily might also help slightly reduce cholesterol and maintain healthy cholesterol levels. It appears Glucose Defense contains about half this amount.

Turmeric has also been shown to help reduce cholesterol and triglycerides, although much of the clinical evidence only relates to overweight individuals. To achieve this, 1.4g daily is recommended (Glucose Defense only contains 100mg).

Finally, black pepper extract is claimed to help other ingredients absorb better into the body, but doesn’t provide any related benefits itself.

Will You Experience Any Side Effects From Glucose Defense’s Ingredients?

Before diving in, we think it’s important to address Gundry MD’s claim that “There is nothing artificial or synthetic or man-made [in Glucose Defense], so there's no risk of side effects.”

The HighYa team has reviewed hundreds of nutritional supplements over the years, and we often see these “it’s-safe-because-it’s-natural” claims. Although this is surprising coming from a physician (more soon), remember that many ingredients that are natural aren’t necessarily safe for human consumption—think cyanide.

With this said, most of Glucose Defense’s ingredients likely won’t cause any side effects worse than mild digestive upset, if anything at all.

However, niacin is known to cause flushing, especially in higher doses (remember, we’re not told how much Glucose Defense contains). In rare instances, WebMD claims that l-cysteine can cause “rashes, fever, headache, drowsiness, low blood pressure, and liver problems.”

How Much Does Glucose Defense Cost?

Gundry MD prices Glucose Defense as follows:

  • 1 Bottle (120 capsules): $49
  • 3 Bottles: $127
  • 6 Bottles: $235

The manufacturer provides free shipping on all US orders.

Regardless of where you’re ordering from, all Gundry MD products come with a 90-day customer satisfaction guarantee, less S&H, which you can request by calling (800) 852-0477.

How does this price compare to the competition?

What’s Everyone Saying In Their Glucose Defense Reviews?

Type the phrase “blood sugar supplement” into your favorite search engine, and you’ll quickly learn that there are literally thousands of products claiming to offer something very similar to Glucose Defense. In fact, we’re reviewed several of these popular options, including Diabazole, Diabacor, SugarDown, Insul-3X, and many others.

In a lot of cases, you’ll find these supplements contain many of the same ingredients found in Glucose Defense, and many are even priced in the same range.

One of the biggest differences, however, is that many of these other supplements have been available for some time, whereas Glucose Defense was a brand new product at the time of our research, without any customer feedback. The good news is that we’ve also written in-depth reviews about several other Gundry MD products, including Vital Reds, Correct + Calm Redness Relief Cream, Dark Spot Diminisher, and Primal Plants.

Here on HighYa, most of these products seem to come with positive customer feedback, including real-world results and great taste/quality products.

Will you experience the same with Glucose Defense? We’ll be sure to answer this as we wrap things up.

Is Glucose Defense the “Most Advanced Natural Blood Sugar Support Supplement Ever Developed”?

Dr. Steven Gundry is a board certified thoracic cardiovascular surgeon with more than two decades of experience, and is also the founder of the Center for Restorative Medicine in Palm Springs and Santa Barbara, CA. He’s even developed several innovative medical technologies, and is the author of Dr. Gundry’s Diet Revolution.

Given this, Dr. Gundry certainly has a lot of medical experience under his belt. But does this necessarily mean that Glucose Defense will deliver on its promises? To help you answer this, we think it’s important to reiterate what we learned above:

  • First, five of Glucose Defense’s seven ingredients (more than 70%) are clinically shown to address some aspects of cholesterol—not blood sugar.
  • Second, among the proprietary blend that is intended to address blood sugar (Zychrome), some of its ingredients may have clinical support. However, we’re not told how much of these ingredients are found in the blend, or if there’s enough to provide any real-world benefits.
  • Speaking of which, even among Glucose Defense’s cholesterol-fighting ingredients (again, based on the available clinical evidence), it doesn’t appear the supplement contains enough to deliver results.

Where does this leave you? If you think you might have prediabetes or diabetes, the first person you should speak with is your doctor. Then, they’ll be able to formulate an effective treatment plan based on your diagnosis. At that same time you can speak with them about Glucose Defense, and whether or not it’s worth the money.

On the other hand, do you already have healthy blood sugar levels? Even though you’re Glucose Defense’s target audience, you’re clearly doing something right, so we’re not quite sure how the supplement will help. And if you’re looking for something to address cholesterol, there are hundreds of standalone supplements (such as selenium, zinc, and berberine) that might be offered in the appropriate doses, while costing meaningfully less than Glucose Defense.

Taken together, we’re not quite sure Glucose Defense has earned a distinction as an “advanced” supplement for addressing blood sugar or cholesterol.

Did you place an order for Glucose Defense? Did its ingredients provide you with any benefits? Would you say it delivered a solid value? Be sure to tell us in your review below!

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