About LA-3 by Live Cell Research

LA-3 by Live Cell Research is a nutritional supplement that promises to boost your AMPK levels, resulting in increased energy, clearer thinking, decreased abdominal fat, and a “stronger, healthier body.” For these reasons, Live Cell Research calls LA-3 a “longevity activator.”

How? According to the company, LA-3 contains three different ingredients that have never been combined before, which can provide maximum benefits after just a few months of continuous use:

  • Days 1-7: You may begin experiencing increased energy and reduced appetite and cravings.
  • Days 7-30: Because you’re eating less, you might notice your abdominal fat melting away, further increasing your energy.
  • 1 Month+: After this time, we’re told your AMPK levels should be elevated sufficiently so that your thoughts become clearer and your mind less forgetful. You might also notice that your body is becoming stronger and healthier, along with a continued change in your shape.

To achieve these benefits, Live Cell Research states you'll just need to take two capsules of LA-3 with water per day, with or without food. They also promise that LA-3 can work for anyone, is safe to use with no known side effects, and is third-party tested for safety, purity, and potency.

If you didn’t know better, Live Cell Research’s LA-3 supplement might sound like some fountain of youth and an incredible weight loss program rolled into one.

But what does science have to say about many of the company's claims? Will this supplement work? Is it worth the money? Keep reading to find out what we uncovered during our research.

What is AMPK? How Does It Work?

5' AMP-activated protein kinase (or AMPK for short) is “an enzyme that plays a role in cellular energy homeostasis,” and is concentrated in a number of areas throughout the human body, including the brain, liver, and skeletal muscle. AMPK itself is made up of three proteins: STE-related adaptor (STRAD), mouse protein 25 (MO25), and LKB1.

Live Cell Research calls AMPK a “master switch” because this enzyme regulates several key systems within the body, such as increasing cellular energy, stimulating the oxidation of fatty acids and glucose transport, and more.

While the exact details are far outside the scope of this review (and they might make you go cross-eyed), the thing about AMPK is that some fairly specific conditions need to be present for the enzyme to be activated—the primary method of which is muscle contraction (i.e. working out).

Once AMPK is activated, there is some clinical evidence showing it may increase blood supply to muscles, help transport glucose (simple sugars), boost fatty acid metabolism (thereby creating more energy for the cell), and more.

What if you don't want to hit the gym to boost your AMPK levels? Can you accomplish the same thing by popping a couple of LA-3 pills?

Will LA-3’s Ingredients Boost Your AMPK Levels?

According to their supplement label, LA-3 contains the following ingredients:

Of these, WebMD indicates that 30mg daily of gynostemma may be effective for reducing cholesterol. So, at 450mg per dose, LA-3 delivers significantly more than this, although there doesn’t seem to be any clinical evidence indicating that increased gynostemma consumption results in more obvious benefits.

Is ActivAMP a Clinically Proven Ingredient?

Important note: The gynostemma pentaphyllum found in LA-3 is part of a proprietary ingredient named ActivAMP, which is manufactured by a company named Gencor Pacific.

According to their website, in a 12-week randomized clinical trial, ActivAMP was shown to decrease body fat mass and body fat percentage, reduce body weight and BMI, and shrink the total abdominal area.

To see the results for ourselves, we reached out to Gencor Pacific and obtained some of their clinical evidence for ActivAMP, which consists of seven different trials. Here is just a handful:

  • A 2013, 23-week randomized, double-blind, placebo-controlled clinical trial that concluded ActivAMP might be useful for treating obese individuals.
  • A 2012, 8-week study that showed mice “decreased body weight gain, liver weight, and blood cholesterol levels with AMPK activation in the soleus muscle.”
  • A 2011 study showing the ingredient may be effective for improving glucose and lipid metabolism.
  • A 2008 study showing that ginsenosides may have an anti-obesity effective. All results were obtained via cells in a controlled laboratory setting.

Now, we’re not medical experts (which is why we rely on authoritative sites to determine whether or not an ingredient is classified as “effective”), so we have no reason to doubt the findings in Gencor Pacific’s research.

Just keep in mind that results obtained through experiments conducted on mice and cells don’t necessarily mean you, as a human, will experience the same thing.

And even if these studies were conducted on humans, it would require dozens (or perhaps even hundreds) of reproducible, double-blind, placebo controlled, peer reviewed studies before if could be considered “proven” to work as advertised.

For more about this topic, be sure to read Think That Clinical Study Is Legit?

LA-3’s Other Ingredients

Moving on, WebMD also tells us that 1,000mg daily of quercetin (commonly known as jiaogulan) might help alleviate prostate pain and inflammation. But at just 100mg per dose, there doesn’t appear to be enough in LA-3 to provide these benefits.

Finally, WebMD indicates that berberine might also be effective at reducing cholesterol, as well as blood sugar levels in diabetes patients.

Bringing It All Together Regarding LA-3’s Ingredients: What Can You Realistically Expect?

As we can see, there are clearly some clinically validated benefits for the ingredients found in LA-3.

However, according to authoritative websites like WebMD, there doesn’t appear to be enough clinical evidence showing that these ingredients—whether on their own or in combination—can elevate AMPK levels.

Granted, there is some promising research related to AMPK, although most clinical studies have been conducted on mice (including one of the studies for ActivAMP).

So, based on what we learned after reaching out to Live Cell Research, there seems to be little clinical proof that these same protocols will work in humans.

Are There Any Potential Side Effects From LA-3?

Despite the limited evidence showing that these ingredients can boost AMPK levels, the good news is that they’re generally considered safe.

However, WebMD notes that gynostemma pentaphyllum “can cause some side effects such as severe nausea and increased bowel movements.” Also, it’s unknown if taking quercetin for more than 12 weeks is considered safe.

How much will you pay for LA-3’s three-ingredient formulation?

How Much Does LA-3 Longevity Activator Cost?

Live Cell Research’s LA-3 supplement is available in the following quantities:

  • 1 Bottle: $46.99
  • 3 Bottles: $117
  • 6 Bottles: $216

Like all Live Cell Research products, LA-3 comes with a 90-day refund policy, less S&H charges. To request one, you'll need to contact customer service at (844) 650-5933 or support@LiveCellResearch.com.

Based on these prices, are LA-3’s customers generally satisfied with what they get for their money?

What Can We Learn From LA-3 Customer Reviews?

Since conducting our original research, 19 LA-3 customers have written about their experience on HighYa, giving the supplement an average rating of 3.8 stars.

Here, most compliments seem to reference effective results, including reduced belly fat, increased energy, improved weight loss, and decreased appetite and cravings.

On the other hand, as is the case with many other nutritional supplements, the most common customer complaint about LA-3 seems related to ineffective (or non-existent) results. In fact, even among those who experienced positive results, several noted that it took several weeks to achieve any effects and that they were fairly mild.

Granted, all of this relates to LA-3 as a product. What about the company who manufactures it?

Who is Live Cell Research? Are They Reputable?

Live Cell Research is based out of Southern California, where they manufacture a line of popular supplements, including Niagen, Cerastim, Midogen, Vital Stem, and more.

Overall, the company’s supplements seem to come with mostly positive online customer reviews, with common compliments citing effective results. On the flip side, common complaints reference failure to work/achieve results and difficult customer service experiences.

Unfortunately, the company wasn’t listed with the Better Business Bureau at the time of our research. Let’s bring it all together, shall we?

Is LA-3 the Right Nutritional Supplement for You?

On the one hand, with many of the Live Cell Research products we’ve written about in the past, authoritative websites like WebMD note that the clinical evidence supporting many of the company’s claims is lacking.

On the other hand, many customers claim to have experienced positive results with the company’s supplements—LA-3 included—clinical evidence notwithstanding.

Does this mean you should hand over your hard-earned money for Live Cell Research’s LA-3 supplement? Like any other nutritional supplement, what works fantastically for you might be a total flop for someone else, and vice versa.

The seemingly good news is that Live Cell Research offers a 90-day refund window on all of their products, which you can take advantage of if you’re not fully satisfied. Just keep in mind that you'll be out a few dollars for return shipping and handling.

Finally, if you type the phrase “AMPK supplement” or “AMPK activator” into your favorite search engine, you’ll be met with dozens of supplements making many of the same claims as LA-3, including Life Extension.

Sure, they might not be formulated exactly like LA-3, but their claims (and general lack of clinical support) are much the same.

Were you pleased with LA-3’s performance? Or, do you feel it was a waste of money? Whatever your experience, we want to hear about it—be sure to leave a review below!

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263 Customer Reviews for LA-3 by Live Cell Research

Average Customer Rating: 4.1
Rating Snapshot:
5 stars: 131 4 stars: 85 3 stars: 19 2 stars: 8 1 stars: 20
Bottom Line: 87% would recommend it to a friend
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  • 1 out 2 people found this review helpful

    Horrible stuff, does not work

    I have been taking this for about four months, and the only thing I have experienced is a horrible case of exhaustion. We have figured out this is the ONLY thing that has changed, so it has to be this. It is a great medication for a sleep. I tried to get a hold of them for a refund, and you got it, no one would help me out, and now it is too late. Don’t waste your money.

    Bottom Line: No, I would not recommend this to a friend

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  • 6 out 6 people found this review helpful

    Great unexpected result

    The third week into the first month, I noticed that my skin felt firmer and my neck looked better. I did not get the afternoon sweet craving and felt overall lighter in my midsection. My fingernails are so much stronger as well. I ordered my second month and anticipate even more great happenings within my body.

    Bottom Line: Yes, I would recommend this to a friend

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  • 7 out 8 people found this review helpful

    Gained water weight

    Hello,

    I was so excited to use LA-3, and I started right away. I used it for over a month, and I gained 7 lbs. I feel very bloated, so I stopped using LA-3 because I was concerned. It may not be for everyone, and I wish I was one of the above people that it worked for.

    Bottom Line: No, I would not recommend this to a friend

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    Comments (2)
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    • May 15, 2017

      Live Cell Research Rep, Customer Relations Manager

      Hi there Veronica, Aurora here with Live Cell Research. Thank you for taking the time to leave us a review. I am sorry to hear that you did not receive the results you expected while taking LA-3. While most of our customers see quick results, we understand that LA-3 may not be for everyone, which is why we always honor our 90-day money back guarantee. I would be more than happy to refund you for your entire purchase just for giving us a try. Please send me an email at aurora@livecellresearch.com, so I can personally assist you with the refund process. Thank you Veronica, I look forward to hearing from you.

    • May 17, 2017

      Bettie Kessimakis

      Please send me a price list.

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  • 6 out 6 people found this review helpful

    Excellent product

    I am enjoying LA-3. I see results in a reduction of belly fat and the last three weeks I plan to order again, but I also need product to deal with joint pain and muscle pain. I will share this product with friends and family.

    Bottom Line: Yes, I would recommend this to a friend

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    • May 8, 2017

      Live Cell Research Rep, Customer Relations Manager

      Hi there Cheryl, Aurora here with Live Cell Research. I am happy to hear that you see benefits from using LA-3 so far. I would love to hear about any continued result you experience. Please feel free to email me at aurora@livecellresearch.com with any updates you would like to share. Thank you Cheryl.

    • May 10, 2017

      Rick

      I have used LA-3 for over six months. During that period, I have gained an alarming amount of weight. At the end of the third month, I contacted their "support" email as directed and requested a refund. They responded by extending my guarantee period and asked me to use the product until that time, and if I was still dissatisfied, I could contact them for a full refund. I did this.

      Now, they are refusing to respond to my several emailed requests for a full refund. This is a total scam! I must now contact the California Medical Licensing Board and the attorney general to file formal complaints and attempt to get a refund. LA-3 appears to be a total fraud.

    • May 19, 2017

      Maryanne Hippert

      I have been using this product for almost a month. I have increased energy. I changed my eating habits, added walking to my regiment, and have only lost 4.6 pounds. I will give it more time, but I expected more regarding weight loss.

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  • 4 out 6 people found this review helpful

    How LA-3 helped me

    I am 70 years old, and for the past 12 to 18 months, I have had no energy. I haven't been unable to walk to my mailbox and back without having to stop several times and catch my breath.

    I have been taking LA-3 for almost a month, and I can tell I am feeling much better. I can even walk to the mailbox and all the way back to my porch without having to stop for breath. Of course, I am weak from not being able to exercise much. So now I am in the process of building up my strength.

    I plan to join a gym so I can get enough exercise to bring my strength up and keep it up.

    Bottom Line: Yes, I would recommend this to a friend

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    • May 9, 2017

      Mary

      I'm 70, and I was pleased to read this person's review. I recently joined a gym. I workout with a personal trainer three times a week. I was taking two naps per day, with little energy and mental alertness.

      I'm a diabetic, obese, with many other health ailments. I would like more information about the interactions with other supplements and my prescriptions. Thank you.

    • May 10, 2017

      Joyce Clayton

      Mary, I take about 15 prescription pills, plus one 325-milligram aspirin a day. Some days I take two, one time I took three and occasionally only one. I take LA-3 in addition to five more supplements also. I space them out, so it is at least 45 minutes to one hour between taking them. I haven't had any trouble that I noticed while taking these supplements with my prescriptions. If you are worried, just ask your doctor. I have had more energy since I have been taking LA-3. I don't seem to get as confused as I used to either. I hope this helps you.

    • May 11, 2017

      Live Cell Research Rep, Customer Relations Manager

      Hi there Mary, Aurora here with Live Cell Research. Thank you for your interest in taking LA-3. We always recommend speaking with your primary physician prior to introducing any new supplement into your daily health regimen, to ensure it will not have any interaction with anything you are already taking. If you have any other questions, please feel free to email me personally at aurora@livecellresearch.com.

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  • 9 out 9 people found this review helpful

    I'm a fan! I believe.

    I've lost 5 lbs in three weeks. I'm sleeping better and have more energy. I'm losing inches too. Today I was able to fit into a jacket I haven't been able to wear for a long time because it was too tight in the arms. I'm also taking Midogen. I have RA and am feeling better as well. My pain is decreasing!

    Bottom Line: Yes, I would recommend this to a friend

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  • 8 out 8 people found this review helpful

    Three weeks

    I am on my third week of taking LA-3, and I am feeling great. I have energy, and I can feel my eating habits changing. I was not one to eat the normal three meals a day (one meal was my usual), but I'm eating three meals and not craving for sweet snacks. I had high anxiety levels, and I can tell that it has greatly dropped. I may have it at moments, but not the constant anxiety.

    I can hardly wait and see what happens next. So far I'm having a good experience with LA-3.

    Bottom Line: Yes, I would recommend this to a friend

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    • May 15, 2017

      Live Cell Research Rep, Customer Relations Manager

      Hi there Stella, Aurora here with Live Cell Research. I am happy to hear that you are loving LA-3 so far and feeling great! We love to hear when customers have great experiences using our products. Please feel free to send me an email at aurora@livecellresearch.com, with any updates you would like to share. Thank you Stella, I look forward to hearing from you.

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  • 8 out 8 people found this review helpful

    First Month

    I'm working on my first bottle and so far my weight has gone from 223 down to 213. I don't do anything but take two capsules as soon as I get out of bed. if it keeps working like this I will order more when the time comes.

    Bottom Line: Yes, I would recommend this to a friend

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  • 5 out 6 people found this review helpful

    The first month

    I ordered this product for my husband and I because I am hoping that it will help reduce abdominal fat. I have been thin all my life and now five years post-menopause I have developed a tummy that won't reduce. I am active, I do Pilates, and my BMI is 23. I am now noticing that my tummy has less fat rolls and my love grips on my waist have reduced a bit in size. I have not lost any weight, but I need to lose ten in order to fit into pants that I wore two years ago.

    My husband has a bigger tummy and has central obesity. He has had type 2 diabetes for thirty years. His BMI is 29.5 and his HgbA1c is 7.2. He hasn't noticed any improvement in his abdominal fat yet, nor a reduction in his blood glucose, which we are hoping for. He just started taking three capsules a day; two in the am and one in the pm.

    Bottom Line: Yes, I would recommend this to a friend

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    • May 9, 2017

      Live Cell Research Rep, Customer Relations Manager

      Hi there Diana, Aurora here with Live Cell Research. I am happy to hear that you are beginning to experience some results in your waist and hips. While many customers see results in the first month, everyone is different, and it may take a bit longer for some. If you are still unsatisfied after three months, please know that we always honor our 90-day money back guarantee and would be more than happy to issue you a full refund. Please email me at aurora@livecellresearch.com, if you would like me to begin processing your refund or if you have any additional questions or comments regarding the product. Thank you Diana, I look forward to hearing from you.

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  • 4 out 4 people found this review helpful

    I like the product, but it is a little pricey

    I don't wake up tired anymore. I feel good, and I do wish it would help me lose some weight. I have more energy than before. I'm thinking about getting more if I can. I want to see how it works in the long run. I will let people know how it is helping me and see if I can't get them started on this product.

    Bottom Line: Yes, I would recommend this to a friend

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    • May 9, 2017

      Live Cell Research Rep, Customer Relations Manager

      Hello Uriah, thank you for leaving us a valuable review on your experience with LA-3. I am so happy to hear that you see results from using the product already. I would love to hear more about your progress as you continue to take the product. Please feel free to email me personally at aurora@livecellresearch.com, with any updates you would like to share. Thank you Uriah, I look forward to hearing from you.

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  • 4 out 4 people found this review helpful

    Too soon to tell

    My husband Bill and I bought three bottles to try. I don't know how this has affected him, but I can share with you about myself. I have only been taking the product for a little over three weeks. The one thing I have noticed is that I have more energy in the afternoons. I used to come home from work around 2 o'clock and would want to take a nap, but not so much anymore. I just had some more surgery so have been a little bit tired, but not as much as I used to be.

    I do like this product, but it is a little on the expensive side for us with us both taking it, but it does work. I would like to rake it for a full three months as I was told it takes that long for your cells to change fully.

    Bottom Line: Yes, I would recommend this to a friend

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