About LA-3 by Live Cell Research

LA-3 by Live Cell Research is a nutritional supplement that promises to boost your AMPK levels, resulting in increased energy, clearer thinking, decreased abdominal fat, and a “stronger, healthier body.” For these reasons, Live Cell Research calls LA-3 a “longevity activator.”

How? According to the company, LA-3 contains three different ingredients that have never been combined before, which can provide maximum benefits after just a few months of continuous use:

  • Days 1-7: You may begin experiencing increased energy and reduced appetite and cravings.
  • Days 7-30: Because you’re eating less, you might notice your abdominal fat melting away, further increasing your energy.
  • 1 Month+: After this time, we’re told your AMPK levels should be elevated sufficiently so that your thoughts become clearer and your mind less forgetful. You might also notice that your body is becoming stronger and healthier, along with a continued change in your shape.

To achieve these benefits, Live Cell Research states you'll just need to take two capsules of LA-3 with water per day, with or without food. They also promise that LA-3 can work for anyone, is safe to use with no known side effects, and is third-party tested for safety, purity, and potency.

If you didn’t know better, Live Cell Research’s LA-3 supplement might sound like some fountain of youth and an incredible weight loss program rolled into one.

But what does science have to say about many of the company's claims? Will this supplement work? Is it worth the money? Keep reading to find out what we uncovered during our research.

What is AMPK? How Does It Work?

5' AMP-activated protein kinase (or AMPK for short) is “an enzyme that plays a role in cellular energy homeostasis,” and is concentrated in a number of areas throughout the human body, including the brain, liver, and skeletal muscle. AMPK itself is made up of three proteins: STE-related adaptor (STRAD), mouse protein 25 (MO25), and LKB1.

Live Cell Research calls AMPK a “master switch” because this enzyme regulates several key systems within the body, such as increasing cellular energy, stimulating the oxidation of fatty acids and glucose transport, and more.

While the exact details are far outside the scope of this review (and they might make you go cross-eyed), the thing about AMPK is that some fairly specific conditions need to be present for the enzyme to be activated—the primary method of which is muscle contraction (i.e. working out).

Once AMPK is activated, there is some clinical evidence showing it may increase blood supply to muscles, help transport glucose (simple sugars), boost fatty acid metabolism (thereby creating more energy for the cell), and more.

What if you don't want to hit the gym to boost your AMPK levels? Can you accomplish the same thing by popping a couple of LA-3 pills?

Will LA-3’s Ingredients Boost Your AMPK Levels?

According to their supplement label, LA-3 contains the following ingredients:

Of these, WebMD indicates that 30mg daily of gynostemma may be effective for reducing cholesterol. So, at 450mg per dose, LA-3 delivers significantly more than this, although there doesn’t seem to be any clinical evidence indicating that increased gynostemma consumption results in more obvious benefits.

Is ActivAMP a Clinically Proven Ingredient?

Important note: The gynostemma pentaphyllum found in LA-3 is part of a proprietary ingredient named ActivAMP, which is manufactured by a company named Gencor Pacific.

According to their website, in a 12-week randomized clinical trial, ActivAMP was shown to decrease body fat mass and body fat percentage, reduce body weight and BMI, and shrink the total abdominal area.

To see the results for ourselves, we reached out to Gencor Pacific and obtained some of their clinical evidence for ActivAMP, which consists of seven different trials. Here is just a handful:

  • A 2013, 23-week randomized, double-blind, placebo-controlled clinical trial that concluded ActivAMP might be useful for treating obese individuals.
  • A 2012, 8-week study that showed mice “decreased body weight gain, liver weight, and blood cholesterol levels with AMPK activation in the soleus muscle.”
  • A 2011 study showing the ingredient may be effective for improving glucose and lipid metabolism.
  • A 2008 study showing that ginsenosides may have an anti-obesity effective. All results were obtained via cells in a controlled laboratory setting.

Now, we’re not medical experts (which is why we rely on authoritative sites to determine whether or not an ingredient is classified as “effective”), so we have no reason to doubt the findings in Gencor Pacific’s research.

Just keep in mind that results obtained through experiments conducted on mice and cells don’t necessarily mean you, as a human, will experience the same thing.

And even if these studies were conducted on humans, it would require dozens (or perhaps even hundreds) of reproducible, double-blind, placebo controlled, peer reviewed studies before if could be considered “proven” to work as advertised.

For more about this topic, be sure to read Think That Clinical Study Is Legit?

LA-3’s Other Ingredients

Moving on, WebMD also tells us that 1,000mg daily of quercetin (commonly known as jiaogulan) might help alleviate prostate pain and inflammation. But at just 100mg per dose, there doesn’t appear to be enough in LA-3 to provide these benefits.

Finally, WebMD indicates that berberine might also be effective at reducing cholesterol, as well as blood sugar levels in diabetes patients.

Bringing It All Together Regarding LA-3’s Ingredients: What Can You Realistically Expect?

As we can see, there are clearly some clinically validated benefits for the ingredients found in LA-3.

However, according to authoritative websites like WebMD, there doesn’t appear to be enough clinical evidence showing that these ingredients—whether on their own or in combination—can elevate AMPK levels.

Granted, there is some promising research related to AMPK, although most clinical studies have been conducted on mice (including one of the studies for ActivAMP).

So, based on what we learned after reaching out to Live Cell Research, there seems to be little clinical proof that these same protocols will work in humans.

Are There Any Potential Side Effects From LA-3?

Despite the limited evidence showing that these ingredients can boost AMPK levels, the good news is that they’re generally considered safe.

However, WebMD notes that gynostemma pentaphyllum “can cause some side effects such as severe nausea and increased bowel movements.” Also, it’s unknown if taking quercetin for more than 12 weeks is considered safe.

How much will you pay for LA-3’s three-ingredient formulation?

How Much Does LA-3 Longevity Activator Cost?

Live Cell Research’s LA-3 supplement is available in the following quantities:

  • 1 Bottle: $46.99
  • 3 Bottles: $117
  • 6 Bottles: $216

Like all Live Cell Research products, LA-3 comes with a 90-day refund policy, less S&H charges. To request one, you'll need to contact customer service at (844) 650-5933 or support@LiveCellResearch.com.

Based on these prices, are LA-3’s customers generally satisfied with what they get for their money?

What Can We Learn From LA-3 Customer Reviews?

Since conducting our original research, 19 LA-3 customers have written about their experience on HighYa, giving the supplement an average rating of 3.8 stars.

Here, most compliments seem to reference effective results, including reduced belly fat, increased energy, improved weight loss, and decreased appetite and cravings.

On the other hand, as is the case with many other nutritional supplements, the most common customer complaint about LA-3 seems related to ineffective (or non-existent) results. In fact, even among those who experienced positive results, several noted that it took several weeks to achieve any effects and that they were fairly mild.

Granted, all of this relates to LA-3 as a product. What about the company who manufactures it?

Who is Live Cell Research? Are They Reputable?

Live Cell Research is based out of Southern California, where they manufacture a line of popular supplements, including Niagen, Cerastim, Midogen, Vital Stem, and more.

Overall, the company’s supplements seem to come with mostly positive online customer reviews, with common compliments citing effective results. On the flip side, common complaints reference failure to work/achieve results and difficult customer service experiences.

Unfortunately, the company wasn’t listed with the Better Business Bureau at the time of our research. Let’s bring it all together, shall we?

Is LA-3 the Right Nutritional Supplement for You?

On the one hand, with many of the Live Cell Research products we’ve written about in the past, authoritative websites like WebMD note that the clinical evidence supporting many of the company’s claims is lacking.

On the other hand, many customers claim to have experienced positive results with the company’s supplements—LA-3 included—clinical evidence notwithstanding.

Does this mean you should hand over your hard-earned money for Live Cell Research’s LA-3 supplement? Like any other nutritional supplement, what works fantastically for you might be a total flop for someone else, and vice versa.

The seemingly good news is that Live Cell Research offers a 90-day refund window on all of their products, which you can take advantage of if you’re not fully satisfied. Just keep in mind that you'll be out a few dollars for return shipping and handling.

Finally, if you type the phrase “AMPK supplement” or “AMPK activator” into your favorite search engine, you’ll be met with dozens of supplements making many of the same claims as LA-3, including Life Extension.

Sure, they might not be formulated exactly like LA-3, but their claims (and general lack of clinical support) are much the same.

Were you pleased with LA-3’s performance? Or, do you feel it was a waste of money? Whatever your experience, we want to hear about it—be sure to leave a review below!

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283 Customer Reviews for LA-3 by Live Cell Research

Average Customer Rating: 4.1
Rating Snapshot:
5 star: 137 4 star: 89 3 star: 22 2 star: 10 1 star:  25
Bottom Line: 84% would recommend it to a friend
Showing 1-11 of 283
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  • 1 out 1 people found this review helpful

    Positive results in blood work and physical size

    • Huntersville, NC,
    • Aug 21, 2017
    • Verified Reviewer

    I am a 65-year-old woman who had been diagnosed by my doctor with NASH (non-alcoholic fatty liver). My ALT & AST blood work was above the normal range for several years.

    I started taking LA-3 eleven months ago, every morning on an empty stomach, hoping to reduce the fat around my organs and liver. At my next yearly doctor visit, my blood work was taken. Both my ALT and AST measurements were right in the middle of the normal range! I have also noticed a slow but steady reduction in my waist. Belts that were tight, fit and I am down three notches now. I am active but not any more than before. I also eat the same as I did before starting LA-3. I recommend it.

    Bottom Line: Yes, I would recommend this to a friend

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  • 9 out 9 people found this review helpful

    I'm feeling a difference since starting LA-3

    • Michigan,
    • Aug 7, 2017
    • Verified Reviewer

    Hi.

    I'm a 57 years old, female, fighting the slowdown of menopause along with stubborn upper body fat, mostly belly and upper arms.

    A few weeks in, I started to feel a little more energized. I'm just now finishing my second bottle of 30. I have noticed a decrease in belly fat and a change in my shape, tighter along my waist area. I do exercise and try to eat clean 85% of the time. I've been at this nutrition and exercise faithfully for 2.5 years. I lost 52 lbs after one year. No added diet products. I have been at a plateau for about six months. I recently lost seven pounds during the last 40 days. I still watch what I eat, lift weights and do a cardio minimum of four times a week. I feel like this product is working. I will continue onto my 90 days.

    Thank you.

    Bottom Line: Yes, I would recommend this to a friend

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  • 8 out 9 people found this review helpful

    Happy with weight loss

    • New Jersey,
    • Jul 31, 2017
    • Verified Reviewer

    I am an 87-year-old male and very happy with losing 12 lbs with my first try of LA-3, with no side effects. I feel great. My pot belly is way down, and I'm looking much better. I feel that my routine workout at the gym is much easier and not tiring. Thank you.

    Bottom Line: Yes, I would recommend this to a friend

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  • 5 out 5 people found this review helpful

    Works for me

    • Apex, NC,
    • Jul 31, 2017
    • Verified Reviewer

    I am not sure why this works for some folks and not others (from reading reviews). My sister was always complaining about feeling tired, so I gave her a bottle of LA-3. I am on my third month, and she is on her second. I started feeling more energy after three weeks, then lost a few pounds after four weeks. My sister doesn't think she's lost weight but has noticed an increase in energy and clear thinking. She thinks it is worth taking LA-3.

    I started taking it because I have POTs and EDS. The ingredients seemed to support healing measures for my ailments according to my own study. So far, the loss of eight pounds is a bonus, but the best thing is the increased energy and no foggy brain!

    It works for me! Thank you!

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 4 people found this review helpful

    Totally disappointed with the products and duty charges

    I have been taking these products for the last six or so months and have not noticed any changes in my health and body. Even though I have been taking all the supplements as recommended, I have not lost any weight or gained more energy.

    Moreover, I have ordered 12 products altogether, but because they pack the products separately (9 per pack), I had to pay duty charges for two separate deliveries, each payment of £91.05 (total of £182.10). This is not what I expected in the first place, and secondly, every time I wanted to check the available offer or other offers on your website without confirming that I am purchasing the item I was already charged the payment for every offer I clicked on. Indeed, I was able to withdraw the order but only by calling and explaining the situation.

    Overall, I feel like I have not benefited from taking these products at all and would like to request a refund.

    Bottom Line: No, I would not recommend this to a friend

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  • 7 out 7 people found this review helpful

    Facts - all good

    Beautiful, clean, no side effects, instant activating metabolism. Wow. I have been on these capsules for two weeks taking two a day for ten days, and I lost 1.4 kilos. I am taking four per day now, and it is only the early days for weight loss results, and I'm only targeting belly fat.

    With no hesitations, I bought a one-year supply. My name for LA-3 is "the holy grail" and it should be marketed globally so everyone can try out. I just turned 60, assuming my life was physically over, and thank you to whoever created LA-3, I'm getting a new lease on life.

    Best regards.

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    Can't get anyone to respond.

    I called the 800-number the other day and spoke to a woman, who after some pressure to keep the product finally said she would send me an email for the address to mail the product back, which never came. Please, could I have this info? I have taken the first bottle but feel I have seen no change. I hope to receive the full refund of $117.00. I will wait for a reply.

    Thank you, Sharon.

    Bottom Line: No, I would not recommend this to a friend

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  • 3 out 4 people found this review helpful

    Increase energy only

    I bought this product for the reduced belly fat that they stated highly in their advertisement. I took the product for three months with NO loss of belly fat at all. They claim that this could be achieved without exercise. I did feel that I had an increased energy level and possibly better memory and less brain fog. For the price, I don't feel it was at all worth it. I feel there are probably other products that cost less that could be purchased for the energy and less brain fog.

    Bottom Line: No, I would not recommend this to a friend

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  • 7 out 7 people found this review helpful

    Dissatisfied

    I ordered this product, and all it did was cause diarrhea. I tried to get a refund but wasn't aware that it had to be 90 days from the day you purchased, not when you first started taking it. I tried to get a refund and was told I didn't respond in time even though I have a few days left. It amazes me how they always twist it in their favor.

    So it's not a true 90-day trial, and you have the bottles to send back, which I did not know either. So if you order this product be aware of all the stipulations. I even considered ordering another 90 days to see if it would make a difference, but when the price was another $100 or more, I said no thanks. I can't say whether I would recommend it or not, each person's results are different, but I'm definitely disappointed in the company.

    Bottom Line: No, I would not recommend this to a friend

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  • 16 out 16 people found this review helpful

    Does not work!

    I ordered a six-month supply because I was leaving the country for several months. I have been taking this product as suggested (two a day) for the past two and a half months and I have not noticed any difference. The claims of INCREASED ENERGY, no noticeable difference. DECREASED APPETITE, no noticeable difference. DECREASE IN BELLY FAT, I am actually gaining weight. The only thing I can say about this product is take a placebo; it does the same thing.

    Bottom Line: No, I would not recommend this to a friend

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    Comments (1)
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    • Jul 14, 2017

      Live Cell Research Rep, Customer Relations Manager

      Hi there Patrick, Aurora here with Live Cell Research. I am sorry to hear that you did not see any benefits taking LA-3. While a majority of our customers experience amazing results from LA-3, we realize that it is not for everyone.

      I would like to offer you a full refund for giving our product a fair trial. We never want our customers to be dissatisfied and understand that it is something we cannot control, which is why we offer the 90-day money back guarantee.

      Please send me an email at [email protected] so that I can refund your order as quickly as possible. Thank you Patrick, I look forward to hearing from you.

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  • 7 out 8 people found this review helpful

    Fast shipping

    • Howell, MI,
    • Jun 29, 2017
    • Verified Reviewer

    I've seen many complaints on orders not received. I placed my order for LA-3 on 6/25/17 and received it on 6/28/17! Plus I got the usual email updates for order status and shipping with tracking number. If they had problems in the past, I'd say those problems are fixed. i just took my first dose. I hope the product works as well as the order/delivery process.

    Bottom Line: Yes, I would recommend this to a friend

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