Want to maximize your health—using only 100% naturally occurring nutrients?
Formulated by Live Cell Research, Midogen is a nutritional supplement that can increase NAD+ levels in cells and tissues, boost mitochondrial function and performance, and protect against free radicals.
What’s all this mean for you? You’ll be able to reduce your age-related health concerns, which is why Live Cell Research calls Midogen a “breakthrough in the science of aging.”
And perhaps best of all, Midogen is third-party tested, so it’s completely safe with little risk of side effects.
There are certainly a lot of big claims being thrown around, not to mention some words you probably haven’t heard since Biology class. But once you sweep away all of the marketing, does Midogen live up to the hype?
First, let’s dig in to exactly what Midogen claims to do.
What Are Mitochondria? What about NAD+?
Want an easy way to remember what mitochondria do? Just think of them as a cell’s batteries. Here’s a quick rundown of how they work:
In order to generate the energy your cells need to survive and do their jobs, mitochondria “break down carbohydrates and fatty acids” and produce a chemical known as ATP (adenosine triphosphate) through a process called cellular respiration. You can think of ATP as “fuel” for your cells.
ATP is produced over a three-step process, the second of which is something known as glycolosis. Here, two different molecules (NADH and FADH2) “move to the inner mitochondrial membrane,” shed some electrons, and then eventually form ATP.
To this end, the NAD+ contained in Midogen acts as a precursor to NADH, which is thought to boost your mitochondria’s energy production a provide some age-related benefits. But is there any science to support this?
Is Midogen’s Ingredients Effective?
According to their product label, Midogen contains the following ingredients:
- Japanese Knotweed (50% trans-resveratrol) 300mg
- NADH 10mg
- PQQ (Pyrroloquinoline quinone) 5mg
Are these effective for boosting mitochondrial function or providing any of the other benefits claimed by Midogen’s manufacturer? To support their claims, the company references three different documents:
- A 2006 overview for NADH that summarized, “Future studies on NAD+ and NADH may not only elucidate some fundamental mysteries in biology, but also provide novel insights for interfering aging and many disease processes.” Keep in mind this is only an overview, not a formal study in its own right.
- A 2010 study from the University of California, Davis that concluded, “The ability of PQQ to stimulate mitochondrial biogenesis accounts in part for action of this compound and suggests that PQQ may be beneficial in diseases associated with mitochondrial dysfunction.” However, this study was conducted on mouse hepatocytes (i.e. liver cells) in a Petri dish, not on humans.
- A 2002 study from a Portuguese university that concluded, “our results certainly contribute to the understanding of the antioxidant action of resveratrol and consequently provide a new approach for the cardiovascular benefits associated with moderate consumption of red wine.” Again though, this study wasn’t conducted on humans and only referenced reseveratrol’s ability to protect low-density lipoproteins (LDL).
NADH is listed as possibly effective for treating mental decline related to Alzheimer’s, although there’s insufficient evidence showing it or Japanese knotweed (or the resveratrol it contains) can provide any of the benefits claims by Midogen’s manufacturer.
On the other hand, there is some evidence that PQQ may provide a variety of benefits, including reducing areas of damage after a heart attack and protecting memory and cognition. This research though, remains somewhat controversial.
And as always, remember that a small handful doesn’t necessarily mean that something is clinically proven.
What Kind of Side Effects Can You Expect from Midogen?
Despite the limited clinical evidence for Midogen’s ingredients, they’re thought to be generally safe for most individuals, with the most common side effect as digestive upset.
Remember, though, that NADH and PQQ are fairly new ingredients, so dosing and long-term safety is largely unknown.
Will you get a stomachache from Midogen’s price?
How Much Does Midogen Cost?
Midogen is available in the following purchasing options:
- 1 Bottle (30 vegetarian capsules): $46.99 plus $3.95 S&H
- 3 Bottles: $117 plus free shipping
- 6 Bottles: $214.27 plus free shipping
Midogen, like all Live Cell Research products, come with a 90-day refund policy, less S&H charges. In order to request a refund, you’ll need to contact Live Cell Research’s customer service department at 844-650-5933.
Just who is Live Cell Research, anyway?
Who is Live Cell Research?
Live Cell Research (aka Living Cell Research) is a nutritional supplements manufacturer based out of Culver City, CA.
Here on HighYa, Live Cell Research had an average rating of 3 stars at the time of our research, based on 27 individual reviews. Many customers claimed that the company’s supplements worked (more about this in a second), although others complained to have experienced nothing but high prices and poor customer service.
Perhaps the company’s most popular supplement is Niagen, which also had a 3-star average rating here on HighYa, based on 53 reader reviews (as of 11/2/15). Again, some claimed to have experienced positive results, while others complained of side effects (at least one requiring hospitalization), that the supplement was overpriced, and of poor service (especially related to overcharged orders).
Midogen seemed to be the company’s newest supplement, which had all 5-star reviews on Live Cell Research’s website (interestingly, we couldn’t find a way to submit reviews or list a star rating). Outside of these, there weren’t any other online customer reviews for Midogen.
Live Cell Research also makes Cerastim, although there weren’t any HighYa reader reviews for this supplement at the time of our research.
Finally, despite being in business for more than a year, Live Cell Research (or Living Cell Research) was not listed with the Better Business Bureau.
Taking all of this important information into consideration, what’s the bottom line about Midogen?
Is Midogen a “Breakthrough in the Science of Aging”?
You’ve learned a lot about Midogen and the ingredients it contains in this review, so here’s what we’re left with:
Yes, there is limited evidence showing that NADH and PQQ supplementation may provide some mental and cardiovascular benefits. However positive this evidence might be, there simply isn’t enough to state conclusively that 1) they can reliably provide these benefits in humans, or 2) that you’ll experience any effects at all from the use of Midogen.
As such, you should speak with your doctor first if you’re seriously considering any nutritional supplement, whether Midogen or something else altogether.
If you feel like giving Midogen a try, it’s positive that the company offers a 90-day refund policy, although you’ll probably be out $10+ by the time you ship your bottle back to the company. Also, based on many HighYa reader reviews, you might experience poor service when requesting your refund.
Did you try Midogen? If so, tell us about your experience by writing a review below!
3 out 4 people found this review helpful
Feeling Great Again
I came across Midogen just searching online. I am 52 years of age. Been taking it for 2 months, my wife and I have both found a boost of energy that I myself had not felt since I was in my 30s. So glad that I came across this, it has made a real difference in me. I used to come home for work and lay down, I was just so tired. After about 3 days of using Midogen I was out working in garden, after 8 and 10 hours of work. Plus now in the second month my doctor actually took me off my blood pressure meds and told me just to keep eye on it. It started actually running low on me, it was 108 over 62. I had to eat salty chips to try to bring it back up. Been off blood pressure meds now for 2 weeks. So far the highest was 131 over 82. Mostly staying around 126 over 72. So far it's working great. As for my wife, she is amazed at how well she is feeling.
Bottom Line: Yes, I would recommend this to a friend
6 out 7 people found this review helpful
Just in Time
I ran across Midogen while looking for wrinkle solutions. I am so glad I found Midogen. It's working great for me. Started taking it about 6 months ago, now my hair is fuller, I can workout and not lose my stamina, I can think better and my skin looks better. I am 58, been working out since the 80's, so I didn't show middle age like my friends. Now I am starting to feel aging like my friends used to talk about in their 40's. For me the improvement was amazing. I look to my 60's with more optimism and enthusiasm. I feel I started taking Midogen at the best time to see quick and amazing results. If you don't workout, maybe Midogen would help in your 40's or even earlier. Just saying.
Bottom Line: Yes, I would recommend this to a friend
14 out 17 people found this review helpful
Trying it now.
I have just started taking Midogen. It's been one week now. All I can say so far is that I'm experiencing a little nausea but that may be just a phase and my body adjusting. I'll give it a couple more weeks and come back for another review.
Bottom Line: No, I would not recommend this to a friend