About Niagen

Why are some people calling Niagen the “fountain of youth?” Because, according to research, the nicotinamide riboside inside Niagen may help improve communication within your cells and reduce their age by up to 66%. As a result, you can experience a variety of anti-aging benefits, including improved brain and cardiovascular health, increased muscle endurance, in addition to a boosted metabolism.

As it turns out though, the reality about Niagen may be a lot less revolutionary than the manufacturer makes it appear. But why?

Stick with us and we promise 3 things by the time you’re finished reading: 1) You’ll have a much better understanding of what Niagen is, 2) you’ll learn about the different kinds of research behind it, and 3) whether or not you should give Niagen a try.

First Things First: Who Makes Niagen?

Niagen is a proprietary ingredient manufactured by ChromaDex, which they claim is the “first and only commercially available form of nicotinamide riboside” (more about this next). After it’s been manufactured, ChromaDex then licenses Niagen to third-party companies—such as Live Cell Research—who encapsulate the supplement and sell it as they wish.

Because of this, a quick online search for Niagen will reveal dozens of results, none of which appear to be any different that the Niagen offered through other companies.

What is Nicotinamide Riboside?

The truth: Answering some of your basic questions about Niagen requires some fairly in-depth explanation. So let’s begin from square one, shall we?

Here’s the whittled-down series of events that occur after you take a capsule of Niagen:

  1. The nicotinamide riboside contained in Niagen is transformed by your body into Nicotinamide Adenine Dinucleotide (NAD), which is why it’s known as a precursor (e.g. a substance from which another is formed).
  2. Within the human body, NAD’s primary function is to transfer electrons from one molecule to another, which is a basic part of energy production (also known as “energy sparks”), and is almost wholly achieved by the mitochondria within each of your cells. Think of mitochondria as little engines that power your body.
  3. NAD also acts as a precursor to the messenger molecule cyclic ADP-ribose, which can help improve the transmission of information, both inside and outside cells.

As we age though, the communication between the nucleus (the “brain” of a cell) and its mitochondria becomes interrupted, which can lead to common signs of aging, such as certain types of dementia (e.g. Alzheimer’s), wrinkles, the weakening of bones and muscles, and more.

What Happens When You Take Niagen?

Each capsule of Niagen is claimed to include only one ingredient; a 250mg dose of nicotinamide riboside, which is a NAD precursor (don’t worry, we’ll talk more about this in a moment) that improves communication between the mitochondria and the nucleus inside your cells. As a result, Niagen is claimed to provide the following benefits:

  • Prevents cellular damage caused by free radicals from occurring, instead of addressing the damage only after it’s occurred (like most mainstream antioxidants do).
  • Supports healthy cholesterol levels.
  • Supports cellular metabolism and enhances the amount of energy your body naturally burns, without requiring you to restrict your diet or increase your exercise habits.
  • May help prevent age-related brain degeneration (e.g. Alzheimer’s) by preventing the degeneration of axons and neurons (nerve cells responsible for the transmission of information; think of them almost like “information highways”).

According to the company, each capsule of Live Cell Research Niagen is claimed to be manufactured in Southern California without the use of stimulants, allergens, or toxins, and to be tested by the company for quality and purity, as well as by an independent third-party lab.

The manufacturer claims you should take one capsule of Niagen each morning upon waking, on an empty stomach, and with a glass of water. There are no known side effects from the use of Niagen (more about this later).

But does supplementing NAD actually translate into real-world benefits? Let’s see what the available evidence says.

What Clinical Trials Have Been Conducted Using NAD?

According to the Niagen website, nicotinamide riboside (remember, this is the chemical that turns into NAD) was only recently discovered to have anti-aging properties in late 2013 by Harvard Medical School’s Dr. David Sinclair, during his clinical research performed on mice. After the study was complete, the researchers examined “muscle from two-year-old mice that had been given the NAD-producing compound for just one week, [and] looked for indicators of insulin resistance, inflammation and muscle wasting. In all three instances, tissue from the mice resembled that of six-month-old mice. In human years, this would be like a 60-year-old converting to a 20-year-old in these specific areas.”

However, keep in mind that just because these benefits were shown to have occurred at a cellular level in mice, this doesn’t necessarily translate into any real-world benefits—whether for mice or for humans. In fact, of those NAD studies conducted on humans (such as for Parkinson’s disease), the benefits are murky, and even completely non-existent in some instances.

On top of this, in the 2013 Harvard study noted above, mice were injected with 400mg of nicotinamide riboside, versus the 250mg found in each dose of Live Cell Research’s Niagen. In other words, these mice—which weigh much less than humans—were given a higher dose than what you’ll receive in this supplement.

Niagen’s Limited Online Reputation with Consumers

Although Niagen is offered through several different resellers, the most popular option appears to be offered through Live Cell Research, a relatively new supplements manufacturer based out of Culver City, CA. Although the company isn’t listed with the Better Business Bureau, they do have a 3.5-star rating here on HighYa (as of 1/20/15), with the most common compliment citing products that work as advertised. On the other hand, the most common complaint appears to reference products that are priced much higher than the benefits they provide.

Regarding Niagen specifically, there weren’t a whole lot of online customer reviews available at the time of our research. However, some forum members on PhoenixRising noted an increase in concentration and energy, although several others complained of failure to provide any noticeable benefits, high price, extreme mood swings, and muscle pain. On Amazon.com, Live Cell Research’s Niagen has a 4-star rating based on just 4 customer reviews, although nearly all were very short and provided very little (or no) information about their experiences.

Finally, there are numerous detailed status reports from customers who tried Niagen on Longecity.org, although many took much higher doses than what you’ll find in a single capsule of the supplement (almost none indicated the company they purchased it from). Overall, it appears that the consensus was evenly split, with some experiencing increased energy and mental clarity, while others experienced no benefits.

Niagen Pricing & Refund Policy

Live Cell Research’s Niagen is available in 3 different purchasing options:

  • 1-Month Supply: $46.99, plus $3.95 S&H
  • 2-Month Supply: $83.64, plus free S&H
  • 3-Month Supply: $117.00, plus free S&H

All Live Cell Research products come with a 90-day refund policy, less S&H charges. In order to initiate the process, you’ll need to contact customer service at 844-650-5933.

Is Niagen the Answer to Reversing Aging?

Chopping to the Point: When it comes down to it, the benefits of nicotinamide riboside supplementation could possibly have a huge impact on how we age. As WebMD notes though, at this point in time there is insufficient clinical evidence showing that NAD can reliably provide any of the anti-aging or health benefits advertised by Chromadex, or by resellers such as Live Cell Research.

With this said, many online customers seem to have experienced positive results from using Niagen, and Live Cell Research seems to stand behind their products with a 90-day no-hassle satisfaction guarantee. So after everything’s said and done, you might only lose S&H charges by giving it a shot (no pun intended).

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92 Customer Reviews for Niagen

Average Customer Rating: 3.2
Rating Snapshot:
5 stars: 37 4 stars: 15 3 stars: 3 2 stars: 7 1 stars: 30
Bottom Line: 61% would recommend it to a friend
Showing 1-11 of 92
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  • 1 out 1 people found this review helpful

    Shipping is terrible and customer service is poor

    I would love to do a review, however, I am still waiting for the product to arrive. I ordered it through Live Cell Research. I have emailed them twice and have not reply. I phoned them and they said it was shipped, however, they could not track it. Why give me a tracking number when it does not work?

    Bottom Line: No, I would not recommend this to a friend

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  • 4 out 4 people found this review helpful

    Best supplement

    By far this is the best supplement and lives up to its name. I am 62 years old and am just as strong as if I was 40 or younger.

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    Niagen

    My wife and I began feeling so much better once we began taking Niagen. We both feel 20 years younger with much more energy and physical mobility. Lindas' Rheumatoid Arthritis seems to be more under control. We have been taking it for over a year. The expense has been worth it financially. We wish we could afford to take more of it daily, but at least we are able to afford one pill a day for each of us.

    Thank you so very much for helping us to enjoy a more fulfilling lifestyle.

    Bottom Line: Yes, I would recommend this to a friend

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  • It seems to work

    I have been taking four tablets a day for almost a year now. My maths and memory seem much better, and I get less aches and pains as I did last year.

    Bottom Line: Yes, I would recommend this to a friend

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  • Niagen

    • Hopkins, MN,
    • Apr 13, 2017

    Since I am taking Niagen, my health changed for good! I feel stronger, have no pains anymore, am clear thinking, and I feel younger each day.

    I recommend this product to everybody; it is absolutely GREAT!

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    More energy!

    I am experiencing more energy, and I believe it has helped me drop a few pounds in the few weeks I have been taking it.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Great

    I have been taking two pills a day for four months, and now I have so much more energy. One pill a day was not enough, but with two pills I can tell the difference.

    Bottom Line: Yes, I would recommend this to a friend

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  • 5 out 5 people found this review helpful

    Niagen review

    I have had an excellent result with both Niagen and LA-3. They make me feel and look younger.

    Bottom Line: Yes, I would recommend this to a friend

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  • 5 out 5 people found this review helpful

    Great result with Niagen

    I have been using Niagen for over a year. I started out with "trigger finger" (a popping and movement restriction) in the left thumb. Inquires resulted in a surgical process to correct the trigger finger. I did not want to go that route, so I did some research and found Live Cell Research.

    I started taking Niagen daily and noticed that the trigger finger was going away. Thinking what I had changed in my daily routine pointed to me taking the Niagen daily. To test my theory, I stopped taking the Niagen. Sure enough, the trigger finger came back. I started taking the Niagen once again, and low and behold, the trigger finger disappeared again!

    I can't express how much I love the Niagen and count on it to help in my quest to stay healthy, energetic, and pain-free. Live Cell Research is at the top of my list of products that really work, and I love reading the information Bill Sharpe provides.

    I am 61 years old and often get compliments on looking and acting much younger than I am. I believe Niagen plays a significant part in my health. I can't thank Live Cell Research enough for the dedication they show in producing great products and sharing them with us.

    Great job.

    Bottom Line: Yes, I would recommend this to a friend

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  • 7 out 7 people found this review helpful

    Works for my husband

    • San Diego, California,
    • Jan 17, 2017

    My husband has been taking this product on and off for several months. He started off with Elysium 250 mg in the morning and saw immediate results.

    The big issue with my husband has been low energy and mild to moderate depression. Both problems were improved. He wasn't completely convinced that the Niagen was doing anything, so he discontinued it. He is 45 years old.

    He recently started to experience his depression symptoms again and took some leftover Elysium, this time 500 mg. The effect was immediate, like that night. We have now switched to another brand from Amazon that has the best price per mg, NAG+ Ignite Niagen (333 mg per pill), he takes two. It is $67.99 per bottle of 60 pills. So far it's worked great.

    Regarding the cost, people spend more money on coffee or drinks after work or whatever per month than they realize. It's about prioritizing and quality of life. It's not going to work for everyone but make sure you take enough mg per day and give it a chance. I am a much happier wife. Thank you Niagen!

    Bottom Line: Yes, I would recommend this to a friend

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  • 5 out 5 people found this review helpful

    Got my first bottle of Niagen in May 2015, and have taken one capsule daily ever since, to good effect.

    Got my first bottle of Niagen in May 2015, and have taken one capsule daily ever since, to good effect. The science behind this supplement was quite convincing, and it has proved beneficial to my overall health. I'm 78 years old and seem to have more energy than most of my contemporaries. Many have commented that I look pretty good for my age.

    Bottom Line: Yes, I would recommend this to a friend

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