About Niagen

Why are some people calling Niagen the “fountain of youth?” Because, according to research, the nicotinamide riboside inside Niagen may help improve communication within your cells and reduce their age by up to 66%. As a result, you can experience a variety of anti-aging benefits, including improved brain and cardiovascular health, increased muscle endurance, in addition to a boosted metabolism.

As it turns out though, the reality about Niagen may be a lot less revolutionary than the manufacturer makes it appear. But why?

Stick with us and we promise 3 things by the time you’re finished reading: 1) You’ll have a much better understanding of what Niagen is, 2) you’ll learn about the different kinds of research behind it, and 3) whether or not you should give Niagen a try.

First Things First: Who Makes Niagen?

Niagen is a proprietary ingredient manufactured by ChromaDex, which they claim is the “first and only commercially available form of nicotinamide riboside” (more about this next). After it’s been manufactured, ChromaDex then licenses Niagen to third-party companies—such as Live Cell Research—who encapsulate the supplement and sell it as they wish.

Because of this, a quick online search for Niagen will reveal dozens of results, none of which appear to be any different that the Niagen offered through other companies.

What is Nicotinamide Riboside?

The truth: Answering some of your basic questions about Niagen requires some fairly in-depth explanation. So let’s begin from square one, shall we?

Here’s the whittled-down series of events that occur after you take a capsule of Niagen:

  1. The nicotinamide riboside contained in Niagen is transformed by your body into Nicotinamide Adenine Dinucleotide (NAD), which is why it’s known as a precursor (e.g. a substance from which another is formed).
  2. Within the human body, NAD’s primary function is to transfer electrons from one molecule to another, which is a basic part of energy production (also known as “energy sparks”), and is almost wholly achieved by the mitochondria within each of your cells. Think of mitochondria as little engines that power your body.
  3. NAD also acts as a precursor to the messenger molecule cyclic ADP-ribose, which can help improve the transmission of information, both inside and outside cells.

As we age though, the communication between the nucleus (the “brain” of a cell) and its mitochondria becomes interrupted, which can lead to common signs of aging, such as certain types of dementia (e.g. Alzheimer’s), wrinkles, the weakening of bones and muscles, and more.

What Happens When You Take Niagen?

Each capsule of Niagen is claimed to include only one ingredient; a 250mg dose of nicotinamide riboside, which is a NAD precursor (don’t worry, we’ll talk more about this in a moment) that improves communication between the mitochondria and the nucleus inside your cells. As a result, Niagen is claimed to provide the following benefits:

  • Prevents cellular damage caused by free radicals from occurring, instead of addressing the damage only after it’s occurred (like most mainstream antioxidants do).
  • Supports healthy cholesterol levels.
  • Supports cellular metabolism and enhances the amount of energy your body naturally burns, without requiring you to restrict your diet or increase your exercise habits.
  • May help prevent age-related brain degeneration (e.g. Alzheimer’s) by preventing the degeneration of axons and neurons (nerve cells responsible for the transmission of information; think of them almost like “information highways”).

According to the company, each capsule of Live Cell Research Niagen is claimed to be manufactured in Southern California without the use of stimulants, allergens, or toxins, and to be tested by the company for quality and purity, as well as by an independent third-party lab.

The manufacturer claims you should take one capsule of Niagen each morning upon waking, on an empty stomach, and with a glass of water. There are no known side effects from the use of Niagen (more about this later).

But does supplementing NAD actually translate into real-world benefits? Let’s see what the available evidence says.

What Clinical Trials Have Been Conducted Using NAD?

According to the Niagen website, nicotinamide riboside (remember, this is the chemical that turns into NAD) was only recently discovered to have anti-aging properties in late 2013 by Harvard Medical School’s Dr. David Sinclair, during his clinical research performed on mice. After the study was complete, the researchers examined “muscle from two-year-old mice that had been given the NAD-producing compound for just one week, [and] looked for indicators of insulin resistance, inflammation and muscle wasting. In all three instances, tissue from the mice resembled that of six-month-old mice. In human years, this would be like a 60-year-old converting to a 20-year-old in these specific areas.”

However, keep in mind that just because these benefits were shown to have occurred at a cellular level in mice, this doesn’t necessarily translate into any real-world benefits—whether for mice or for humans. In fact, of those NAD studies conducted on humans (such as for Parkinson’s disease), the benefits are murky, and even completely non-existent in some instances.

On top of this, in the 2013 Harvard study noted above, mice were injected with 400mg of nicotinamide riboside, versus the 250mg found in each dose of Live Cell Research’s Niagen. In other words, these mice—which weigh much less than humans—were given a higher dose than what you’ll receive in this supplement.

Niagen’s Limited Online Reputation with Consumers

Although Niagen is offered through several different resellers, the most popular option appears to be offered through Live Cell Research, a relatively new supplements manufacturer based out of Culver City, CA. Although the company isn’t listed with the Better Business Bureau, they do have a 3.5-star rating here on HighYa (as of 1/20/15), with the most common compliment citing products that work as advertised. On the other hand, the most common complaint appears to reference products that are priced much higher than the benefits they provide.

Regarding Niagen specifically, there weren’t a whole lot of online customer reviews available at the time of our research. However, some forum members on PhoenixRising noted an increase in concentration and energy, although several others complained of failure to provide any noticeable benefits, high price, extreme mood swings, and muscle pain. On Amazon.com, Live Cell Research’s Niagen has a 4-star rating based on just 4 customer reviews, although nearly all were very short and provided very little (or no) information about their experiences.

Finally, there are numerous detailed status reports from customers who tried Niagen on Longecity.org, although many took much higher doses than what you’ll find in a single capsule of the supplement (almost none indicated the company they purchased it from). Overall, it appears that the consensus was evenly split, with some experiencing increased energy and mental clarity, while others experienced no benefits.

Niagen Pricing & Refund Policy

Live Cell Research’s Niagen is available in 3 different purchasing options:

  • 1-Month Supply: $46.99, plus $3.95 S&H
  • 2-Month Supply: $83.64, plus free S&H
  • 3-Month Supply: $117.00, plus free S&H

All Live Cell Research products come with a 90-day refund policy, less S&H charges. In order to initiate the process, you’ll need to contact customer service at 844-650-5933.

Is Niagen the Answer to Reversing Aging?

Chopping to the Point: When it comes down to it, the benefits of nicotinamide riboside supplementation could possibly have a huge impact on how we age. As WebMD notes though, at this point in time there is insufficient clinical evidence showing that NAD can reliably provide any of the anti-aging or health benefits advertised by Chromadex, or by resellers such as Live Cell Research.

With this said, many online customers seem to have experienced positive results from using Niagen, and Live Cell Research seems to stand behind their products with a 90-day no-hassle satisfaction guarantee. So after everything’s said and done, you might only lose S&H charges by giving it a shot (no pun intended).

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87 Customer Reviews for Niagen

Average Customer Rating: 3.2
Rating Snapshot:
5 stars: 33 4 stars: 15 3 stars: 3 2 stars: 7 1 stars: 29
Bottom Line: 60% would recommend it to a friend
Showing 1-11 of 87
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  • 1 out 1 people found this review helpful

    More energy!

    I am experiencing more energy, and I believe it has helped me drop a few pounds in the few weeks I have been taking it.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Great

    I have been taking two pills a day for four months, and now I have so much more energy. One pill a day was not enough, but with two pills I can tell the difference.

    Bottom Line: Yes, I would recommend this to a friend

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  • 5 out 5 people found this review helpful

    Niagen review

    I have had an excellent result with both Niagen and LA-3. They make me feel and look younger.

    Bottom Line: Yes, I would recommend this to a friend

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  • 4 out 4 people found this review helpful

    Great result with Niagen

    I have been using Niagen for over a year. I started out with "trigger finger" (a popping and movement restriction) in the left thumb. Inquires resulted in a surgical process to correct the trigger finger. I did not want to go that route, so I did some research and found Live Cell Research.

    I started taking Niagen daily and noticed that the trigger finger was going away. Thinking what I had changed in my daily routine pointed to me taking the Niagen daily. To test my theory, I stopped taking the Niagen. Sure enough, the trigger finger came back. I started taking the Niagen once again, and low and behold, the trigger finger disappeared again!

    I can't express how much I love the Niagen and count on it to help in my quest to stay healthy, energetic, and pain-free. Live Cell Research is at the top of my list of products that really work, and I love reading the information Bill Sharpe provides.

    I am 61 years old and often get compliments on looking and acting much younger than I am. I believe Niagen plays a significant part in my health. I can't thank Live Cell Research enough for the dedication they show in producing great products and sharing them with us.

    Great job.

    Bottom Line: Yes, I would recommend this to a friend

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  • 6 out 6 people found this review helpful

    Works for my husband

    • San Diego, California,
    • Jan 17, 2017

    My husband has been taking this product on and off for several months. He started off with Elysium 250 mg in the morning and saw immediate results.

    The big issue with my husband has been low energy and mild to moderate depression. Both problems were improved. He wasn't completely convinced that the Niagen was doing anything, so he discontinued it. He is 45 years old.

    He recently started to experience his depression symptoms again and took some leftover Elysium, this time 500 mg. The effect was immediate, like that night. We have now switched to another brand from Amazon that has the best price per mg, NAG+ Ignite Niagen (333 mg per pill), he takes two. It is $67.99 per bottle of 60 pills. So far it's worked great.

    Regarding the cost, people spend more money on coffee or drinks after work or whatever per month than they realize. It's about prioritizing and quality of life. It's not going to work for everyone but make sure you take enough mg per day and give it a chance. I am a much happier wife. Thank you Niagen!

    Bottom Line: Yes, I would recommend this to a friend

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  • 4 out 4 people found this review helpful

    Got my first bottle of Niagen in May 2015, and have taken one capsule daily ever since, to good effect.

    Got my first bottle of Niagen in May 2015, and have taken one capsule daily ever since, to good effect. The science behind this supplement was quite convincing, and it has proved beneficial to my overall health. I'm 78 years old and seem to have more energy than most of my contemporaries. Many have commented that I look pretty good for my age.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 5 people found this review helpful

    Niagen

    • Pennsylvania,
    • Jan 7, 2017

    While I started taking just one dose a day, after a week I noticed I was oversleeping in the morning. My sleep was very deep and refreshing, though my face and eyes began to look like I was short on sleep.

    Then I noticed lots of hair coming out when I combed or washed my hair. I have great thick curly hair and within another week or so, it was noticeably thinner and definitely falling out.

    After reading other reviews where TSH levels fell, I figure the trial Niagen is affecting my thyroid, which would explain my skin and hair issues. Just be careful and aware of possible adverse effects. It may be a great supplement for some but not for my system.

    Bottom Line: No, I would not recommend this to a friend

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    Comments (1)
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    • Feb 3, 2017

      Live Cell Research Rep, Customer Relations Manager

      Theresa, thank you for your valuable review of Niagen.

      I am sorry to hear that you did not enjoy the product. We always recommend that you speak to your primary physician prior to taking any supplement to ensure that you will not have any adverse reactions to any of the ingredients used. I would be happy to issue you a full refund for at least giving our product a try! Please email me at aurora@livecellresearch.com so that I can go ahead and begin that process for you.

      Thank you.

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  • 6 out 6 people found this review helpful

    This product is a real energy booster

    My mom has dementia and her doctor recommended Niagen. She is more active now and seldom sleeps during the day as before!

    She started out taking 2 on an empty stomach in the morning. The doctor said to add two more on an empty stomach in the afternoon, so we did!

    There are NO side effects! Mom is having more energy so I decided that in order to take care of her, I needed more energy too! I take 2 Niagen pills on an empty stomach in the morning.

    I have energy to spare. I walk 6 miles a day/7 days a week. Try it, You will not be disappointed!

    Bottom Line: Yes, I would recommend this to a friend

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  • 4 out 4 people found this review helpful

    Riboside

    After taking Niagen for five months, I've experienced is increased energy, vitality, and mood. I get more dreams now while I sleep. This helps me get morning erections again.

    I have more muscular strength and it's only increasing. I take a dosage of 500mg per day.

    I'm currently 57 years old and I have taken many supplements in 25 years. This is the best. The benefits continue to remain. If I had to choose any supplement, this would be the one.

    My nails and hair grow faster. Some people thought I was 40 years old.

    Of course I recommend Niagen to everyone, especially to people who are 40 years old.

    Editors Note: This Review was originally submitted in Spanish, Google Translate was used to translate it into the current English version you see above.

    Bottom Line: Yes, I would recommend this to a friend

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  • 9 out 9 people found this review helpful

    Amazing results for me

    I have been taking LCR Niagen for 1 month 1/2 now, and started feeling more energy just one day after starting.

    I am used to taking all sorts of supplements (I have done so for the last 16 years), and apart from CoQ10 which gave me a boost when I started taking it and still helps me some through the day, this is the first time that I have felt that a supplement did help me.

    I am 57, and I suffer from a type of muscular dystrophy that makes me very tired day after day, and which robs me, bit by bit, of my strength. I am also a teacher, so I need a lot of energy to keep on working.

    Not only did I find that Niagen helped from day one as far as energy is concerned, but it also helps my mental clarity, my ability to prepare classes fast and well, and my mood. People at work have noticed that I have a "bounce" that is not there, normally. I sleep better (despite the menopause), and I feel about 20 years younger!

    I got my husband to take it too. He is 60 years old and has a very physically demanding job. He told me yesterday that he does the work of two men.

    And also feels the benefits of greater mental sharpness. So it's not just me!

    Bottom Line: Yes, I would recommend this to a friend

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  • 20 out 22 people found this review helpful

    Already noticed positive results in the 4 days I've taken the pills.

    • Prattville, AL,
    • Jun 24, 2016

    I first heard about Niagen when I read a report from Science Daily a few months ago (https://www.sciencedaily.com/releases/2016/04/160428152124.htm). I viewed many YouTube videos and read testimonials (including the ones here) too. I was going to order them from Amazon but found out that GNC also sold them local. I would have saved around $10 after tax if I ordered them though Amazon, but decided to purchase them local first. I figured that if I like the results after my 60 day supply is up, I'll likely order them though Amazon.

    So far I can tell you that my energy level is noticeably improved and a few of my minor pains (over 50 I am) aren't as noticeable. I notice more effects when I exercise (walk 3 times week) then when I just take them and rest. Regardless, each time I take them, I get a flush feel between my torso and belly (not really bad; pleasant actually) that I even notice a bit several hours later. Not sure what's going on here, I heard that Niacin causes flush like results too and maybe it's due to being a variant of Niacin. All in all, I'm quite happy to have decided to try them. Also glad I did wait though (don't like to buy stuff until I've researched the topic thoroughly).

    Bottom Line: Yes, I would recommend this to a friend

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