About Nucific BIO X4

Billed as a 4-in-1 weight management probiotic, Nucific BIO X4 claims to be a “revolutionary new compound” containing 4 proven nutrients that provide digestive support, suppress appetite, and support weight loss management. This includes:

  • 39 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins,
  • Green tea to boost your metabolism, and
  • Caralluma Fimbriata to suppress cravings.

Despite these benefits, Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regular and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1-2 months.

Whether you’re just starting with a weight loss regimen or have been at it for years, can Nucific BIO X4 provide the digestion support you need to break through your barriers? Consider the following:

Is BIO X4’s Ingredients Effective for Weight Loss?

According to BIO X4’s product label, the supplement contains:

  • Probiotic Blend: 4 billion CFU per capsule – Lactobacillus acidophilus, L. rhamnosus, L. plantarum, Bifidobacterium lactis, B. animalis.
  • Digestive Enzyme Blend: 88mg – Amylase (from Aspergilus Oryzae), Bromelain, Lipase (from Rhizopus Oryzae).
  • Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)
  • Craving Control Blend: 166mg – Caralluma Fimbriata Extract

As we detailed in our Probiotics Buyer’s Guide, probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data proving them to be effective.

Note: Although BIO X4’s website claims that it contains 39 billion CFUs, each capsule only contains 13 billion. In other words, by taking 3 capsules per day, you’ll cumulatively be ingesting 39 billion CFUs. This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

Amylase is “an enzyme that catalyses the hydrolysis of starch into sugars,” and bromelain “is an enzyme found in pineapple juice and in the pineapple stem” that’s used for “reducing swelling (inflammation), especially of the nose and sinuses, after surgery or injury,” and more. Finally, lipase “is an enzyme that catalyzes the hydrolysis of fats (lipids).”

While there are multiple studies related to the oral administration of amylase, clinical support for many of BIO X4’s claims appears to be on the slim side. Likewise, except for treating osteoarthritis and preventing muscle soreness after exercise, there isn’t enough clinical evidence showing that bromelain can provide other benefits.

And other than treating digestive problems related to pancreatic disorders, there is insufficient clinical evidence showing that lipase can provide any other benefits. Similarly, there isn’t enough clinical evidence showing that caralluma can provide any benefits, either.

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits, although there is insufficient evidence supporting any of them.

BIO X4 Side Effects

As with most nutritional supplements, even though many of BIO X4’s ingredients may not provide the benefits claimed by the manufacturer, they should be well tolerated by most individuals.

However, the probiotics in BIO X4 may cause a temporary increase in bloating or gassiness, although this side effect should resolve itself over the course of a couple days. Caralluma might also lead to gas, constipation, or stomach pain, which should subside after a week of use.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants. Additionally, 5-HTP has been known to cause heartburn, drowsiness, and sexual and muscle problems.

Nucific’s Arbitration Agreement

Finally, it’s important to note that by placing your order for BIO X4, you’ll automatically be bound by an arbitration agreement.

Although this is a fairly common practice among companies who sell most of their products online, if you experienced any damages from using BIO X4, this means that your legal recourse against Nucific would be extremely limited, including becoming part of a trial by jury or joining a class action lawsuit.

What’s the Customer Buzz about Nucific BIO X4?

BIO X4 was a very new product at the time of our research (Nucific’s URL was registered in April 2015 and the company’s trademark was filed in June of 2015), so there weren’t any online reviews available.

Since Nucific is such a new company, they also weren’t listed with the Better Business Bureau.

Nucific BIO X4 Pricing & Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle (30-day supply): $49
  • 3 Bottles: $129
  • 6 Bottles: $240

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. Although no further details were provided, you’ll need to contact Nucific’s customer service department at 888-679-5520 or support@nucific.com in order to request a refund.

Can Nucific BIO X4 Support Digestion & Weight Management?

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor. On top of this, all of the supplement’s other ingredients have insufficient evidence to back up Nucific’s claims.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

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359 Customer Reviews for Nucific BIO X4

Average Customer Rating: 4.2
Rating Snapshot:
5 stars: 231 4 stars: 69 3 stars: 8 2 stars: 17 1 stars: 34
Bottom Line: 86% would recommend it to a friend
Showing 1-11 of 359
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  • It really works

    I have been using BIO X4 for about a month and initially notice my energy levels pick up during my two-mile daily walk. But I really started to see a difference in my belly fat about two weeks in; it's gradual but effective.

    I'm very pleased so far and really hope that my budget allows me to continue. I am very happy with my results.

    Bottom Line: Yes, I would recommend this to a friend

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  • More energy!

    Before I started taking BIO X4, I was having a lot of trouble losing weight. Now, after almost two months I've lost 15 pounds. And I have more energy throughout the day, when before I couldn't even take a walk for five minutes without getting tired. BIO X4 has given me hope that I can reach my weight goals.

    Bottom Line: Yes, I would recommend this to a friend

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  • I love BIO X4

    I used a combination of BIO X4 and Gundry Vital Reds because my health was not going in the right direction.

    My doctor let me know I had gained too much weight, my cholesterol was bad, and my blood pressure was dangerously high. He wanted me to take a regiment of medicines to improve my health. I really did not want to be on more medicines, so I asked him to allow me a short time to improve and lower my weight. In was at the time 253 lbs.

    I went home and decided I need to go back to working out. I also started researching online and came across several options, but love the information on BIO X4. I started using the BIO X4 and was following a healthier diet, but also allowed myself a cheat day. I took the BIO X4 before my meals and started seeing my weight go down, but also started feeling more energy.

    Also after the first week, my cravings for food went down. I avoid the foods noted as bad for me on their online video, and I have seen tremendous changes. I feel good about my health, but I am in better shape than when I was in college. I am even doing a Spartan Race this Saturday with a group of co-workers. I look great, but more importantly, I have regained and have control of my health.

    Today at the doctor's office they said my blood pressure is great. Everything is looking good on my weight, blood pressure and overall health.

    I went through a metamorphosis in nine weeks. I lost 48 lbs, and my body feels great, and I have more energy working out and throughout my day!

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Love BIO X4

    I have been taking BIO X4 for about four months now and have had great success. My favorite part is how great my digestive track is working now. I can really tell when I haven't taken it because I feel sluggish.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Great product!

    • Port Coquitlam, British Columbia, Canada,
    • Apr 28, 2017

    I really liked the way this product made me feel. It's long term benefits are great, it curbed my appetite and made me feel like a healthier, happier me! I will definitely be ordering again. Being recently diagnosed with Celiac disease it helps with my fatigue and my gut health, and I would absolutely recommend this product to my friends and family.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Skeptical at first

    After I watched the video, I immediately placed my order. For several days I was thinking how stupid I was to fall for the idea of a supplement to help with weight loss. Of course, diet and exercise are what controls weight loss. That was not working for me, so I gave it a try and have been pleasantly surprised. I feel normal again.

    Before BIO X4 I would constantly crave sweets and never seem to be satisfied after eating. After a couple of months of taking one pill before meals, I feel like I can pass many foods up that I normally would crave and often eat in excess.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Noticed big difference with digestive tract

    The biggest difference I've noticed is the improved digestive process. I'm much more regular than I've ever been, and I feel better because of it. I'm going to continue to use BIO X4 and am anxious to see how it helps with weight loss, as I'm able to be more active in the spring and summer.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Happy with this product

    I started using the product slowly. The first week I was taking one capsule per day, and with the first bottle, I only took it twice a day. I wanted to be sure there would be no side effect. I have not had any problems. Now on the second bottle, I am working on getting up to three pills per day.

    I am noticing that my appetite is more reasonable, and it is easier to keep to my resolutions to eat healthier and avoid snacks. I believe the supplement is helping me also lose weight more consistently, not as a magic bullet, but helping me stick to my plan. I have not had any interactions with the blood pressure medications or antidepressant medication I take. I plan to continue using this product.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Good success

    • Nebraska,
    • Apr 26, 2017

    I have had decent success in weight loss. I have lost 12 lbs. I had a setback getting pneumonia for three weeks and have not exercised very much since that time. I finally feel better and have golfed a few times. I walk the dog when I am not too tired after work. Energy is coming back slowly. Digestion has improved, and I don't have constipation as often. I hope to get going again in the next few days. I do believe this is a good product!

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    I have recommended this product

    I had what I would call severe IBS. Would start out going to church, or maybe shopping with hubby and have to turn around to go home or find a facility quickly. It was awful. I researched and found this product, paid the 'high' price, took it for three months. No IBS. Whatever was out of whack in my body was helped by this product.

    After taking a series of antibiotics I will order this product again. It works for me.

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    Helping my digestive system.

    • Dayton, Ohio,
    • Apr 24, 2017

    I am almost 30+ days in and very pleased with my digestive system results. I am hoping to order more to see if it works long-term for me.

    I do my very best to take it before I eat, although, in some instances, I have taken it after. I am hoping it still works the same.

    Bottom Line: Yes, I would recommend this to a friend

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Showing 1-11 of 359

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