About Nucific BIO X4

Billed as a 4-in-1 weight management probiotic, Nucific BIO X4 claims to be a “revolutionary new compound” containing 4 proven nutrients that provide digestive support, suppress appetite, and support weight loss management. This includes:

  • 39 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins,
  • Green tea to boost your metabolism, and
  • Caralluma Fimbriata to suppress cravings.

Despite these benefits, Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regular and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1-2 months.

Whether you’re just starting with a weight loss regimen or have been at it for years, can Nucific BIO X4 provide the digestion support you need to break through your barriers? Consider the following:

Is BIO X4’s Ingredients Effective for Weight Loss?

According to BIO X4’s product label, the supplement contains:

  • Probiotic Blend: 4 billion CFU per capsule – Lactobacillus acidophilus, L. rhamnosus, L. plantarum, Bifidobacterium lactis, B. animalis.
  • Digestive Enzyme Blend: 88mg – Amylase (from Aspergilus Oryzae), Bromelain, Lipase (from Rhizopus Oryzae).
  • Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)
  • Craving Control Blend: 166mg – Caralluma Fimbriata Extract

As we detailed in our Probiotics Buyer’s Guide, probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data proving them to be effective.

Note: Although BIO X4’s website claims that it contains 39 billion CFUs, each capsule only contains 13 billion. In other words, by taking 3 capsules per day, you’ll cumulatively be ingesting 39 billion CFUs. This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

Amylase is “an enzyme that catalyses the hydrolysis of starch into sugars,” and bromelain “is an enzyme found in pineapple juice and in the pineapple stem” that’s used for “reducing swelling (inflammation), especially of the nose and sinuses, after surgery or injury,” and more. Finally, lipase “is an enzyme that catalyzes the hydrolysis of fats (lipids).”

While there are multiple studies related to the oral administration of amylase, clinical support for many of BIO X4’s claims appears to be on the slim side. Likewise, except for treating osteoarthritis and preventing muscle soreness after exercise, there isn’t enough clinical evidence showing that bromelain can provide other benefits.

And other than treating digestive problems related to pancreatic disorders, there is insufficient clinical evidence showing that lipase can provide any other benefits. Similarly, there isn’t enough clinical evidence showing that caralluma can provide any benefits, either.

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits, although there is insufficient evidence supporting any of them.

BIO X4 Side Effects

As with most nutritional supplements, even though many of BIO X4’s ingredients may not provide the benefits claimed by the manufacturer, they should be well tolerated by most individuals.

However, the probiotics in BIO X4 may cause a temporary increase in bloating or gassiness, although this side effect should resolve itself over the course of a couple days. Caralluma might also lead to gas, constipation, or stomach pain, which should subside after a week of use.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants. Additionally, 5-HTP has been known to cause heartburn, drowsiness, and sexual and muscle problems.

Nucific’s Arbitration Agreement

Finally, it’s important to note that by placing your order for BIO X4, you’ll automatically be bound by an arbitration agreement.

Although this is a fairly common practice among companies who sell most of their products online, if you experienced any damages from using BIO X4, this means that your legal recourse against Nucific would be extremely limited, including becoming part of a trial by jury or joining a class action lawsuit.

What’s the Customer Buzz about Nucific BIO X4?

BIO X4 was a very new product at the time of our research (Nucific’s URL was registered in April 2015 and the company’s trademark was filed in June of 2015), so there weren’t any online reviews available.

Since Nucific is such a new company, they also weren’t listed with the Better Business Bureau.

Nucific BIO X4 Pricing & Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle (30-day supply): $49
  • 3 Bottles: $129
  • 6 Bottles: $240

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. Although no further details were provided, you’ll need to contact Nucific’s customer service department at 888-679-5520 or support@nucific.com in order to request a refund.

Can Nucific BIO X4 Support Digestion & Weight Management?

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor. On top of this, all of the supplement’s other ingredients have insufficient evidence to back up Nucific’s claims.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

Tired of Nutritional Supplements Rip-Offs? Want to Learn to Shop Smarter?

Join over 2 million HighYa readers who receive weekly how-to guides, tips & reviews and get a FREE COPY of our 145 Scam Hacks e-book. Enter your email below to get started!

266 Customer Reviews for Nucific BIO X4

Average Customer Rating: 4.2
Rating Snapshot:
5 stars: 165 4 stars: 53 3 stars: 5 2 stars: 16 1 stars: 27
Bottom Line: 84% would recommend it to a friend
Showing 1-11 of 266
Sort reviews by:

  • 14 Years of Chronic Itching until BIO X4

    • Massachusetts,
    • Jan 22, 2017

    I was diagnosed with Auto-Immune Progesterone Dermatitis after suffering from chronic rash and itching for over 13 years since I became pregnant with my daughter. My itching was worse due to hormonal shifts, hence the diagnosis, but I should mention that the condition is extremely rare and not sufficiently studied by scientific research, so there was not much in the way of treatment options. I was forced to take a very, very high dose of antihistamines on a daily basis after trying every other Western and non-Western medical treatment under the sun. At it got worse, so I was taking one Claritin, two Allegra during the day and one Claritin, two Allegra and two Zyrtec at night. And sometimes, when it was really bad, I still had to take some Benedryl!

    I have learned that most skin problems are caused by intestinal issues, and although I had tried elimination diets, Chinese medicine, acupuncture, chiropractic, NAET, etc. NOTHING worked. The huge amounts of antihistamines I was taking still were not fully doing the job.

    After I saw the video for BIO X4, I decided to give it a try because I had nothing to lose. I was very skeptical, but I figured that at least the product contained some valuable probiotics and, hey, it might help with weight loss.

    I am overjoyed to report that after about two months, I began to notice a difference, both in my itching and my stomach function. I was less bloated and gassy, and my bowel movements were more regular. I also began to see a difference in my ability to maintain my weight.

    However, the most shocking benefit, the one which I was hoping to find, is that since taking BIO X4 for about nine months, I have been able to reduce my antihistamine intake to one Allegra and one Zyrtec per day! I could try to reduce further, but I want to take it really slow. I keep waiting for the itching to come back, thinking it could be somehow a coincidence, but so far my skin has been mostly all better.

    I know that skin problem are not one of the things claimed to be helped by using BIO X4, but I can tell you that for me this has been the ONLY treatment I have ever found, either taken internally or externally, which has given me any relief from this annoying, chronic condition. I will continue taking it as long as I see the amazing results.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (0)
    View all 0 commentsHide comments

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 2 out 2 people found this review helpful

    Awesome weight loss support!

    Nucific BIO X4 has been a great product for me. I have had a lot of energy and have been able to maintain my recent 77-pound weight loss. The probiotics have strengthened my immune system. The digestive enzymes have helped to improve my GERD so that I no longer need to take a pharmaceutical for my heartburn. I am glad I found your products.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (0)
    View all 0 commentsHide comments

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 22 out 24 people found this review helpful

    This product has dramatically improved my digestive system as well as improved my energy and cleared my skin.

    I highly disagree with Highya's assessment of this product.

    Firstly, lack of clinical evidence to support a claim does not mean those ingredients do not work. Before taking this product, my bowel movements were very irregular (too frequent and not normal, and too loose). I am now normal after four days of taking this product. My energy level is substantially better and my skin is clearing up.

    I can now eat really hot yellow chili peppers and never get stomach aches the next day. I cannot believe the latter claim since I love eating chili and almost had to stop eating it. I would HIGHLY comment to anyone with digestive or low energy problems to try using it. If not, your loss.

    I have no financial investment with this Nucific and want the public to get feed back from people who have had amazing results. So try it and you will like it.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (0)
    View all 0 commentsHide comments

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 23 out 25 people found this review helpful

    Caffeine content and reflux

    I've been taking this supplement for one week now to cut back on sugar cravings and lose weight. It's still too early to tell if it will help with that, but I have noticed my reflux is worse. I can't find the actual caffeine content of the 100mg of green tea extract since the caffeine content varies depending on processing. I do know caffeine makes reflux worse.

    I'm giving them three stars only because of lack of information on the stimulants. I'm going to stick with it and stay positive, and will review it again in a month. I can't recommend it to a friend yet.

    Bottom Line: No, I would not recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (1)
    View all 1 commentsHide comments
    • Jan 11, 2017

      Naomi Benson, Customer Care Manager

      Hello Christine, Naomi here with Nucific. Thank you so much for taking the time to leave us a comment.

      I am sorry to hear about your experience. We suggest consulting your physician to see how the ingredients may be effecting you. We understand that certain supplements may not work for everyone, which is why we always offer our 90-day money back guarantee.

      Please email me directly at naomi.benson@nucific.com and I will be happy to assist you with this, thank you.

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 34 out 36 people found this review helpful

    Fantastic weight loss

    I am 5'4" and originally weighed 154 pounds. After using BIO X4, I dropped to 134 pounds, for a total loss of 20 pounds. It did not require any modification of my diet, nor excessive exercising. While watching TV in the evenings I do leg and arm exercises with 5-pound weights for about 60 minutes, five times a week. And I lost four inches off my waist.

    I have tried hundreds of weight loss methods over my 64 years with no really good results until I tried BIO X4. I continue taking BIO X4 to maintain my weight loss.

    I no longer have to take Metformin for diabetes, nor blood pressure meds or water pills. My doctor is amazed at my results. I started my journey on July 9, 2016, and continue through today, December 18, 2016.

    I have no more excess weight to lose and feel absolutely great, thanks to BIO X4. It changed my life. I am 64 years old and don't look my age because of the positive changes, both physically and mentally.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (0)
    View all 0 commentsHide comments

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 52 out 61 people found this review helpful

    Didn't do what they said.

    I'm on my second bottle, almost finished it. I didn't feel anything different in my body. I feel more hungry and want to snack. I do not recommend this product. It's a money making machine.

    Bottom Line: No, I would not recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (1)
    View all 1 commentsHide comments
    • Dec 28, 2016

      Naomi Benson, Customer Care Manager

      Hi Savita,

      I am truly sorry that BIO X4 did not give you the results you were expecting. At Nucific, we understand that certain supplements may not work for everyone. This is why we always offer our 90-day money back guarantee.

      Please email me directly at naomi.benson@nucific.com and I will help you with this. Thanks Savita!

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 36 out 42 people found this review helpful

    Works Great

    • Wisconsin,
    • Dec 18, 2016

    I am a 5' 3" 64 year old women who had several hip surgeries and a knee surgery. Because of these issues I have limited physical activity and have gained weight.

    I have taken other probiotics and had no real issues with them but felt that I wanted one that did more. When I started taking BIO X4 6 weeks ago I weighed 176 lbs. and as of today, I have lost 5.5 pounds.

    I no longer feel like I need to take a nap in the afternoon and have much more energy. I did not change my diet very much other than cutting back on sweets but did not cut them out completely. I also love bread and would never give it up.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (0)
    View all 0 commentsHide comments

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 31 out 33 people found this review helpful

    Good product

    I lost 18 pounds in the first month. I have more energy and my appetite is under better control. I feel the product is a valuable part of my nutrition plan.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (0)
    View all 0 commentsHide comments

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 35 out 40 people found this review helpful

    A waste of money

    • Phoenix, AZ,
    • Dec 10, 2016

    This product is a complete waste of money, there were no noticeable effects. My advice is to drink plenty of high-quality water, eat high-quality food, drink a little beer and wine, eat a little cheese, all supply bacteria to your digestive tract, you don't need dried powder supplements that are ineffective.

    Bottom Line: No, I would not recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (1)
    View all 1 commentsHide comments
    • Dec 19, 2016

      Naomi Benson, Customer Care Manager

      Hi Rob,

      My name is Naomi, the Customer Care Manager at Nucific. I am sorry to hear about dissatisfaction with our product. We always recommend keeping a healthy diet and exercise regiment while on BIO X4. Please keep in mind that it is recommended to take the product for 30-60 days to see the best results. If you are still unhappy with your results, I will be happy to offer you a full refund. Please email me at naomi.benson@nucific.com if you have any questions or concerns.

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 20 out 32 people found this review helpful

    Cost

    • Toronto, Ontario,
    • Dec 2, 2016

    I haven't tried my order yet but for other Canadians ordering keep in mind the total cost of 3 bottles of BIO X4 is $200 Canadian dollars with the exchange rate and the 24.39 GST and 9.95 handling costs. Now if it does what it claims I still think it would be worth it I will review after my first month. If it doesn't work for me it wouldn't work for anybody. I workout 2hrs every day, watch what I eat and already drink 60oz of water a day and get almost 8 hours of sleep nightly. I will write a review after my first month and each month that follows till I finish the three bottles

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (5)
    View all 5 commentsHide comments
    • Dec 2, 2016

      Naomi Benson, Customer Care Manager

      Hey Mackinnon, my name is Naomi Benson and I work here at Nucific. We are excited for you to try Bio X4! I would love to hear all about your experience, please keep us updated. Please keep in mind that as with all supplements, everyone's bodies will react differently, regardless of how much you workout or what you eat. Because of this, we always stand by our Full money back guarantee. Please feel free to reach out to me directly, if you have any further questions or concerns. My email is: naomi.benson@nucific.com. Thank you!

    • Dec 14, 2016

      Bonnie Moore

      Just placed first order today, how long does it take to get your order?

    • Dec 14, 2016

      Vickie turner

      I'm almost finished with the first bottle, have not felt good since starting but have continued use hoping it would get better with time - wrong. Still feel bloated, gassy (never was before), no weight loss, body aches, and now my low back pain is so bad can't sleep, sit, or stand. I'm very frustrated.

    • Dec 19, 2016

      Naomi Benson, Customer Care Manager

      Hi Bonnie,

      My name is Naomi, the Customer Care Manager here at Nucific. All orders ship from our climate-controlled facility within 24-48 hours. If you are located in the US, you should receive your order within 5 business days. If you have any other questions or concerns, please reach out to me directly at naomi.benson@nucific.com

    • Dec 19, 2016

      Naomi Benson, Customer Care Manager

      Hi Vickie,

      My name is Naomi, the Customer Care Manager at Nucific. I am sorry to hear about your experience. BIO X4 is not known to cause these side effects, we suggest contacting your doctor to see if you may be allergic to any of the ingredients. Keep in mind, we always stand by our 90 day money back guarantee. Please email me at naomi.benson@nucific.com if you have any questions or concerns.

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


  • 56 out 58 people found this review helpful

    Don't waste your money

    • Des Moines, IA,
    • Nov 25, 2016

    While I have not experienced any side effects I have not seen any benefits either. I do not feel any better (or worse), have not experienced less appetite or lost any weight. I bought a 90 day supply and am on the second bottle.

    Since I spent the money I plan on taking them until they are gone but at this point do not plan on buying more. I think this is just another weight loss scam.

    Bottom Line: No, I would not recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    Comments (0)
    View all 0 commentsHide comments

    Do you have an account? Log In before commenting.

    (If you don’t have an account – don’t worry, you can create it after)


Showing 1-11 of 266

Write a review for Nucific BIO X4!

Share your experience to help others avoid scams & discover great products!

Write a Review