About Nucific BIO X4

Billed as a 4-in-1 weight management probiotic, Nucific BIO X4 claims to be a “revolutionary new compound” containing 4 proven nutrients that provide digestive support, suppress appetite, and support weight loss management. This includes:

  • 39 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins,
  • Green tea to boost your metabolism, and
  • Caralluma Fimbriata to suppress cravings.

Despite these benefits, Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regular and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1-2 months.

Whether you’re just starting with a weight loss regimen or have been at it for years, can Nucific BIO X4 provide the digestion support you need to break through your barriers? Consider the following:

Is BIO X4’s Ingredients Effective for Weight Loss?

According to BIO X4’s product label, the supplement contains:

  • Probiotic Blend: 4 billion CFU per capsule – Lactobacillus acidophilus, L. rhamnosus, L. plantarum, Bifidobacterium lactis, B. animalis.
  • Digestive Enzyme Blend: 88mg – Amylase (from Aspergilus Oryzae), Bromelain, Lipase (from Rhizopus Oryzae).
  • Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)
  • Craving Control Blend: 166mg – Caralluma Fimbriata Extract

As we detailed in our Probiotics Buyer’s Guide, probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data proving them to be effective.

Note: Although BIO X4’s website claims that it contains 39 billion CFUs, each capsule only contains 13 billion. In other words, by taking 3 capsules per day, you’ll cumulatively be ingesting 39 billion CFUs. This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

Amylase is “an enzyme that catalyses the hydrolysis of starch into sugars,” and bromelain “is an enzyme found in pineapple juice and in the pineapple stem” that’s used for “reducing swelling (inflammation), especially of the nose and sinuses, after surgery or injury,” and more. Finally, lipase “is an enzyme that catalyzes the hydrolysis of fats (lipids).”

While there are multiple studies related to the oral administration of amylase, clinical support for many of BIO X4’s claims appears to be on the slim side. Likewise, except for treating osteoarthritis and preventing muscle soreness after exercise, there isn’t enough clinical evidence showing that bromelain can provide other benefits.

And other than treating digestive problems related to pancreatic disorders, there is insufficient clinical evidence showing that lipase can provide any other benefits. Similarly, there isn’t enough clinical evidence showing that caralluma can provide any benefits, either.

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits, although there is insufficient evidence supporting any of them.

BIO X4 Side Effects

As with most nutritional supplements, even though many of BIO X4’s ingredients may not provide the benefits claimed by the manufacturer, they should be well tolerated by most individuals.

However, the probiotics in BIO X4 may cause a temporary increase in bloating or gassiness, although this side effect should resolve itself over the course of a couple days. Caralluma might also lead to gas, constipation, or stomach pain, which should subside after a week of use.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants. Additionally, 5-HTP has been known to cause heartburn, drowsiness, and sexual and muscle problems.

Nucific’s Arbitration Agreement

Finally, it’s important to note that by placing your order for BIO X4, you’ll automatically be bound by an arbitration agreement.

Although this is a fairly common practice among companies who sell most of their products online, if you experienced any damages from using BIO X4, this means that your legal recourse against Nucific would be extremely limited, including becoming part of a trial by jury or joining a class action lawsuit.

What’s the Customer Buzz about Nucific BIO X4?

BIO X4 was a very new product at the time of our research (Nucific’s URL was registered in April 2015 and the company’s trademark was filed in June of 2015), so there weren’t any online reviews available.

Since Nucific is such a new company, they also weren’t listed with the Better Business Bureau.

Nucific BIO X4 Pricing & Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle (30-day supply): $49
  • 3 Bottles: $129
  • 6 Bottles: $240

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. Although no further details were provided, you’ll need to contact Nucific’s customer service department at 888-679-5520 or support@nucific.com in order to request a refund.

Can Nucific BIO X4 Support Digestion & Weight Management?

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor. On top of this, all of the supplement’s other ingredients have insufficient evidence to back up Nucific’s claims.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

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420 Customer Reviews for Nucific BIO X4

Average Customer Rating: 4.3
Rating Snapshot:
5 stars: 276 4 stars: 83 3 stars: 10 2 stars: 17 1 stars: 34
Bottom Line: 87% would recommend it to a friend
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  • 1 out 1 people found this review helpful

    New customer

    I really liked the BIO X4 product. I can feel that I am starting to lose a little weight and that makes me feel good.

    Thanks for creating this product. I will be a loyal customer as long as you keep creating good healthy products. Thanks!

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    As a user of the BIO X4 product, I attest

    My experience with the intake of BIO X4 from Nucific has been a wonderfully positive one. While in use, I experienced reduced abdominal bloating (that was not only uncomfortable but also clothing fitting distortion), increased bowel motility, decreased bouts of constipation, loss of seven (7lbs) in three weeks (by the fecal matter output via increased bowel evacuation, I presume), increased energy (since as I have said to friends "with using my BIO X4, I'm no longer full of crap), increased alertness (likely due to better nutrient absorption from my diet), and increased positive mood (since I have a greater and increased feeling of general well-being). If I'm allowed the time to fully boast of all the positive effects, which I without doubt credit to the intake of BIO X4, I would go on and on.

    I have no personal stake or relation/association with Nucific or its reps. I am a consumer willing to pass on a great find in BIO X4 from Nucific. The positive effects mentioned above I continue to experience now. eI took a three weeks break in intake of the product to monitor my well-being and after was without its positive effects.

    Thank you Nucific for your BIO X4 product. I will continue to speak highly of same and also of your excellent business mannerisms. I remain your happy customer and have my second unopened bottle and order notes ready. TRULY, your product increasing my well-being by decreasing my negative digestive symptomology.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Better digestion

    I am experiencing much better digestion. I am hoping to see some weight loss, and I am really working to cut out sugars in my diet. Otherwise, my diet is great. I exercise regularly and have always had high energy.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Excellent product

    I started using this product about two years ago after struggling with persistent yeast overgrowth. I take a capsule with each meal and have found that with eating a healthy diet, I have managed to maintain my weight and have not experienced any other issues with yeast infections. Excellent product that I am confident has the very best ingredients!

    Bottom Line: Yes, I would recommend this to a friend

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  • Great results

    BIO X4 is performing exactly as promised. I am in much better control, and the inches are melting. I have been able to move two notches on my belt. This is a simple product to use and does not require a major lifestyle change.

    Bottom Line: Yes, I would recommend this to a friend

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    • May 23, 2017

      Naomi Benson, Customer Care Manager

      Hi Ron, Nucific here. We're so happy to hear about your great results with BIO X4! We hope your review inspires others to head down the same road to weight loss and optimal health. If you ever have any questions in the future, please do not hesitate to contact me directly at naomi.benson@nucific.com.

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  • 2 out 2 people found this review helpful

    Just what I need!

    I have been taking BIO X4 for two months. Before I started taking it, I had a problem with my daily bowl movements. Now it is a part of my daily routine. I feel so much better. I would recommend it to anyone that has a similar problem. It has no taste, and it also has no other side effects. It does for me exactly what I needed it to.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    BIO X4

    I just finished my second month of using BIO X4 and am very satisfied with the results! While I haven't seen any weight loss, I have more energy and fewer digestive problems. Cravings for snacks are easier to control now, so I'm confident that weight loss will follow.

    Also, the support and follow-up from Nucific have been amazing! I can tell that Nucific wants me to succeed.

    Thank you!

    Kelly D'Alessio.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Probiotic value notable immediately

    I have been taking BIO 4X off and on for about two years. I tested how I felt with it and without it at a very low dose originally. After I used one tablet per day for a couple of weeks, I went off of it to test if I could recognize a difference without it. I am very sensitive to meds and have seen good test results in the past. I was pleased with how effective it was at low dosage to break the cycle of my IBS. The product was able to decrease abdominal pain and gas caused by sluggish bowel and regulate me within just a few days each time I restarted the product. I noted that the appetite suppressant was effective all day with just one tablet, yet I never intended to use it as a weight loss product. My intent was to use natural ingredients to build my immune system and increase the normal flora sensibly.

    I have tried other products proclaimed by MD or western medicine to be effective products in the past and ended up with different side effects or over treated, causing rebound conditions in the past using those products. I have some naturopathic education and know the products in BIO 4X to be safe and effective for me. After doing my self-evaluation, I am currently taking the plunge to take two tablets per meal per day to test the effectiveness of losing weight too. Thank you Nucific and Dr. Amy for this fine product.

    Bottom Line: Yes, I would recommend this to a friend

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  • Excellent

    I started using BIO X4 three months ago after I saw a video online from Nucific. By that time I was having real problems with digesting, and I was bloated all the time after every meal. I was right about to go to a doctor, and then after I saw this video, I immediately bought the product. On my second day, I saw improvements, and I start sharing the video with my friend. Now I feel so light and never bloated, and I feel like my appetite is changing. I never feel hungry or am craving for dessert like I used to do.

    Bottom Line: Yes, I would recommend this to a friend

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    • May 23, 2017

      Naomi Benson, Customer Care Manager

      Hi there Ersida. Thank you for your review on BIO X4. I am so happy to hear that you see some amazing benefits already! If you ever have any questions in the future, please do not hesitate to contact me directly at naomi.benson@nucific.com, thanks again!

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  • 1 out 1 people found this review helpful

    Excellent product

    I have tried this product twice now, and it has really helped my digestive system. I am suffering from bone cancer and have had many chemo treatments which have had an effect on my intestines and stomach. This product has really changed my life and allowed me to start enjoying food again while maintaining a healthy weight. I highly recommend that you try this product, give it some time to correct your digestive system and start living life again.

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    Needed to lose weight

    I saw an ad on the internet of the BIO X4 on losing weight and that they had a special offer on trying it, so I decided to order the BIO X4 on a trial basis, and when I started taking the pills, they started to work after about a week or so.

    I noticed a change in my digestive system and felt more energy, and when I would eat a meal was left feeling more full, and not forcing myself to finish the meal.

    Bottom Line: Yes, I would recommend this to a friend

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