About Nucific BIO X4

Billed as a 4-in-1 weight management probiotic, Nucific BIO X4 claims to be a “revolutionary new compound” containing 4 proven nutrients that provide digestive support, suppress appetite, and support weight loss management. This includes:

  • 39 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins,
  • Green tea to boost your metabolism, and
  • Caralluma Fimbriata to suppress cravings.

Despite these benefits, Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regular and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1-2 months.

Whether you’re just starting with a weight loss regimen or have been at it for years, can Nucific BIO X4 provide the digestion support you need to break through your barriers? Consider the following:

Is BIO X4’s Ingredients Effective for Weight Loss?

According to BIO X4’s product label, the supplement contains:

  • Probiotic Blend: 4 billion CFU per capsule – Lactobacillus acidophilus, L. rhamnosus, L. plantarum, Bifidobacterium lactis, B. animalis.
  • Digestive Enzyme Blend: 88mg – Amylase (from Aspergilus Oryzae), Bromelain, Lipase (from Rhizopus Oryzae).
  • Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)
  • Craving Control Blend: 166mg – Caralluma Fimbriata Extract

As we detailed in our Probiotics Buyer’s Guide, probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data proving them to be effective.

Note: Although BIO X4’s website claims that it contains 39 billion CFUs, each capsule only contains 13 billion. In other words, by taking 3 capsules per day, you’ll cumulatively be ingesting 39 billion CFUs. This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

Amylase is “an enzyme that catalyses the hydrolysis of starch into sugars,” and bromelain “is an enzyme found in pineapple juice and in the pineapple stem” that’s used for “reducing swelling (inflammation), especially of the nose and sinuses, after surgery or injury,” and more. Finally, lipase “is an enzyme that catalyzes the hydrolysis of fats (lipids).”

While there are multiple studies related to the oral administration of amylase, clinical support for many of BIO X4’s claims appears to be on the slim side. Likewise, except for treating osteoarthritis and preventing muscle soreness after exercise, there isn’t enough clinical evidence showing that bromelain can provide other benefits.

And other than treating digestive problems related to pancreatic disorders, there is insufficient clinical evidence showing that lipase can provide any other benefits. Similarly, there isn’t enough clinical evidence showing that caralluma can provide any benefits, either.

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits, although there is insufficient evidence supporting any of them.

BIO X4 Side Effects

As with most nutritional supplements, even though many of BIO X4’s ingredients may not provide the benefits claimed by the manufacturer, they should be well tolerated by most individuals.

However, the probiotics in BIO X4 may cause a temporary increase in bloating or gassiness, although this side effect should resolve itself over the course of a couple days. Caralluma might also lead to gas, constipation, or stomach pain, which should subside after a week of use.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants. Additionally, 5-HTP has been known to cause heartburn, drowsiness, and sexual and muscle problems.

Nucific’s Arbitration Agreement

Finally, it’s important to note that by placing your order for BIO X4, you’ll automatically be bound by an arbitration agreement.

Although this is a fairly common practice among companies who sell most of their products online, if you experienced any damages from using BIO X4, this means that your legal recourse against Nucific would be extremely limited, including becoming part of a trial by jury or joining a class action lawsuit.

What’s the Customer Buzz about Nucific BIO X4?

BIO X4 was a very new product at the time of our research (Nucific’s URL was registered in April 2015 and the company’s trademark was filed in June of 2015), so there weren’t any online reviews available.

Since Nucific is such a new company, they also weren’t listed with the Better Business Bureau.

Nucific BIO X4 Pricing & Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle (30-day supply): $49
  • 3 Bottles: $129
  • 6 Bottles: $240

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. Although no further details were provided, you’ll need to contact Nucific’s customer service department at 888-679-5520 or support@nucific.com in order to request a refund.

Can Nucific BIO X4 Support Digestion & Weight Management?

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor. On top of this, all of the supplement’s other ingredients have insufficient evidence to back up Nucific’s claims.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

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585 Customer Reviews for Nucific BIO X4

Average Customer Rating: 4.4
Rating Snapshot:
5 star: 400 4 star: 113 3 star: 15 2 star: 20 1 star:  37
Bottom Line: 89% would recommend it to a friend
Showing 1-11 of 585
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  • 3 out 4 people found this review helpful

    Weight loss

    • Dallas, TX,
    • Sep 20, 2017
    • Verified Reviewer

    The supplement works as long as you eat healthy foods such as BIO X4 recommends. Exercise is a plus but doesn't need to be overbearing. I'm at the 60-day mark using BIO X4, and I've lost my belly fat around both sides of my stomach, probably lost an inch in my waistline. If I exercised 30 minutes a day, it would be more waistline loss. Definitely a lifestyle change to the diet, but worth the time to consider what you're consuming with your daily diet.

    Taking this supplement makes me conscientious to my food intake, and I'm eating healthier foods. It's actually fun eating out and selecting menu items that maximize the weight loss necessary to compliment the diet. I will continue Dr. Lee's recommendation for another 90 days. I feel healthier and have more energy in my day-to-day routine, plus my clothes fit me better and I'm able to wear clothes that I haven't been able to wear in a while.

    Bottom Line: Yes, I would recommend this to a friend

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  • 4 out 4 people found this review helpful

    It really works!

    I wasn't sure if this product would do what it claimed, but after almost 60 days of taking the product, I must say I feel younger, more energetic and healthier. I would definitely recommend it to anyone who wants to regain their energy and become healthier in the process.

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    A product that actually works!

    I have tried other probiotics and supplements for overall health and weight loss and have been disappointed every time. BIO X4 has helped my digestion, weight loss, and overall well-being. I feel more energetic and have less cravings. I have lost about 13 lbs in the first two months of being on it.

    All of that being said, it is not a magic pill, and I use it in conjunction with a healthy diet and regular exercise. It is an important part of my daily lifestyle, and I would notice a difference if I stopped taking it.

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    It works

    I feel energetic and in good health all the time. BIO X4 helps control my hunger, and I am satisfied with healthy moderate meals three times a day and small snacks two times a day. My body rhythms are consistent, I sleep well, and my weight is easy to control.

    We definitely will continue to use BIO X4.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    I tried it for a month and this is what happened

    • Columbus, OH,
    • Sep 19, 2017
    • Verified Reviewer

    I run and strength train four times a week. However, I haven't been losing weight. I have been using BIO X4 for over a month now. This is what happened:

    1) No more bloat or digestive cramps - I feel BETTER! I don't feel weighed down. Clothes even fit looser. I also have regular bowel movements (no surprises on runs) and have no bloating or cramps.

    2) No more cravings - I need carbs to run and even sugar for quick carbs. But my whole life I craved sugar. Candy bars, cakes, etc. It contributed to my 80-pound gain and has been the devil on my back. No more. If I eat sweets, it's because of the taste or texture (like ice cream). Even then, I eat much less than I used to and rarely eat them. If I overeat on them, it throws everything off, and I am back to being bloated, etc. So my desire to binge on sweets is GONE!

    3) More energy - my performance in my physical activities has improved! Green tea does have "caffeine," but I have no jidders, and as long as I don't eat a later dinner, I sleep just fine.

    4) Weight loss - I am finally seeing weight loss, and I have already received comments on my weight loss. I am consistent in my exercise because of the energy it provides and how good I feel. All those things above help you "right" your diet and gives you the energy to start moving.

    Exercise is needed if you want to lose weight and you need to be consistent in taking the pill before meals. I have recommended it to many people and very thankful to finally just feel GOOD!

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    My success

    • West Palm Beach, FL,
    • Sep 19, 2017
    • Verified Reviewer

    I moved to Florida in November of 2016 and began a daily walking regimen. I started using BIO X4 in January of the new year (kind of a New Years gift to myself).

    Since I moved to Florida (at 253 pounds), I have lost 46 pounds and am now hovering at 207. I am very impressed with this product as I have been able to decrease my input (food) significantly while being "pang free." I just take a couple of the capsules a few minutes before I eat and let THEM do the work. I have found eating the last meal earlier in the day and then having a light snack (apple or orange or banana) between then and when I retire for the night has worked for me also (of course, there's a 2-mile walk in there too).

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Weight loss synchrony

    • Los Angeles, CA,
    • Sep 18, 2017
    • Verified Reviewer

    This weight loss product really works in synchronization with the body. I tried it myself immediately had successful results jump starting my weight loss. My friend bought a three-month supply and loved how she felt, losing it slowly but surely. When I saw her, I couldn't believe the results; she looked fabulous.

    This product will actually boost your self-esteem and determination. As you start losing weight setting realistic, healthier, diet goals your body gets into synchrony with this weight loss program and the results are amazing.

    Bottom Line: Yes, I would recommend this to a friend

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  • 4 out 4 people found this review helpful

    This supplement is awesome.

    I started taking this product about five days ago. On the first day, I felt a difference. My stomach girth has gone down an inch, and I eat about a third of what I used to. Actually, I have to make myself eat due to taking this supplement with food. I have more energy and get much more out of my day know. I have tried many products that make claims that just don't happen. This one does exactly what it says it will do. I love it and would recommend it to anyone.

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    Excellent product!

    I have been using BIO X4 for over two months now and have had excellent results. My digestion is improved, and my overall energy level is increased quite a bit. I have more energy at the end of the day, and I no longer feel bloated or have any gas issues.

    Without going too much into detail, I can say that my body is processing food better and by following Amy's suggestions I am eating less but still feel satisfied. I am eating more nutritious foods like fruits, vegetables, and nuts and also using some of Amy's recipes to further my progress.

    I am losing pounds and am now beginning to see even my "Love Handles" starting to disappear.

    Not only is BIO X4 a great product, but of equal or greater value are the follow-up suggestions, tips, recipes, and exercise emails that Amy regularly sends. Talk about customer support! I save all of her messages in a separate folder for later reference and already have quite a collection of helpful insights.

    This product is great, and I feel like I have a personal coach for improving my health and life! I couldn't be happier that I decided to purchase this as all I was expected was a good product, but my expectations were greatly exceeded by Amy's regular follow-up information. Thank you Amy!

    Bottom Line: Yes, I would recommend this to a friend

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  • Unexpected surprise

    Although I did not lose weight, it gave me an even better surprise my psoriasis went away. I thought that it was just a coincidence so I stopped taking it and it came back. Needless to say, I start taking it again and it went away again. I will use it just for that. And it does give you energy.

    Bottom Line: Yes, I would recommend this to a friend

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  • 9 out 10 people found this review helpful

    BIO X4 works

    • Medford, OR,
    • Sep 16, 2017
    • Verified Reviewer

    I have been using BIO X4 for about 60 days. The biggest gain for me has been a reduction of belly size and relief from bloating. I am 63 years old and had been trying to lose weight without success. I started BIO X4 along with a regimen of cottage cheese and banana for breakfast. My belly has been slowly shrinking, the bloating has virtually stopped, and I feel great! I have noticed a reduction in my food intake too, perhaps because of BIO X4, but more likely because of my focus on getting healthier, hard to say.

    The reason I give this product four stars is two-fold. One, it is fairly expensive and two, the purchasing process is VERY annoying with all of the "offers" prior to finalizing the order. Otherwise, this is a truly excellent product!

    Bottom Line: Yes, I would recommend this to a friend

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