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Profemin

Overall Rating

2.5

17 Customer Reviews

Summary

Profemin is a dietary supplement that blends 3 natural ingredients that allegedly helps relieve premenopausal and menopausal symptoms without the use of hormones. Although safe, long term benefits may not be sustainable.

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Profemin Reviews - Does It Provide Menopause Symptom Relief?

By Anthony Dugarte, M.D., C.S.C.S

Updated on: Mar 26, 2020

What Is Profemin?

Profemin is a dietary supplement intended to offer relief for your menopausal symptoms with 3 natural ingredients.

Menopause is a process that is associated with the end of menstrual periods and the depletion of ovarian follicles. Symptoms are wide-ranging and may negatively affect your quality of life.

While most are familiar with “hot flashes”, other common menopausal symptoms can include restless sleep, night sweats, mood disturbances, changes in urinary frequency, pain during sex, and even a rapid heart rate.

As these symptoms are thought to be related to the rapid decline of estrogen, medical management often includes hormone replacement.

According to Profemin, you can find relief without the use of hormones. But is their blend of ingredients actually proven to alleviate your menopausal symptoms?

In this article, we’ll review the science behind each ingredient, if any, to help you make a more informed decision about using Profemin to manage your symptoms.

Profemin’s Ingredients: Does Science Back Them?

According to the product page, simply taking 1 Profemin capsule twice daily will relieve many of the common symptoms that can be associated with menopause.

Each capsule contains a 257mg blend of the following:

Angelica gigas Nakai extract

Angelica gigas Nakai (AGN) is an herb cultivated mainly in Korea and China that has been a common ingredient in folk medicine for centuries. AGN is often included in dietary supplements as it is proposed to improve blood flow, pain, cognitive function, and much more.

According to Profemin, AGN is included in their blend to support gynecological health. The evidence for this in human subjects is lacking, however.

Rats that consumed 500 mg/kg body weight of AGN over 8-weeks improved estrogen and bone density measures when compared to placebo.

Interestingly, researchers also found that rats treated with ultrafine AGN had better effects than those who received coarsely ground AGN. Thus, the processing of the AGN offered in Profemin may affect its ability to deliver results.

A laboratory study tested the active compounds found in AGN and concluded that these ingredients would be challenging to formulate into an oral supplement. Another laboratory study found that these same compounds inhibited the growth of human breast cancer cells by targeting estrogen receptors.

While there is some evidence that AGN and its active compounds do have estrogen-related actions, most of the support is in animal and laboratory studies. Much more work is needed to determine the long-term effects regarding use in women’s sexual health.

Cynanchum wilfordii extract

Cynanchum includes about 300 species that are found all over the world, including both tropic and subtropic regions of Africa, Europe, and Asia. Like AGN, it has been included in various natural medicine formulations for centuries.

Cynanchum wilfordii’s (CW) support for its proposed ability to manage menopausal symptoms is mainly in animal and laboratory models.

Menopausal rats treated with 200mg/kg bodyweight of CW over 7-days had reduced hot flash symptoms, though treatment did not boost estrogen levels.

Additional support for the sole use of CW to improve symptoms related to menopause is lacking. Again, more studies are needed with human subjects to determine the lasting effects.

Phlomis Umbrosa extract

Another common folk medicine ingredient, Phlomis Umbrosa (PU), may offer anti-inflammatory and pain relief capabilities.

However, studies investigating the sole use of PU in managing symptoms related to menopause are lacking.

Studies Examining the Combination of Profemin’s 3 Ingredients

While Profemin’s herbal ingredients have not been extensively studied individually regarding their abilities to manage menopausal symptoms, their combined actions have been investigated in perimenopausal women.

According to Profemin’s website, their supplement was studied on a clinical trial. Profemin claims that nearly 97% of the women randomized to treatment experienced an improvement in 4 or more menopausal symptoms.

This study has yet to be published in a medical journal, however. Results must be interpreted with caution as the study has not undergone a rigorous peer-review process to determine if the scientific methods were sound.

Two other studies investigating these ingredients do offer published results, however.

In a 2005 study, 48 perimenopausal women were randomized to herbal treatment or placebo. The herbal treatment was a 315mg blend of AGN, CW, PU, and about 10 other extracts taken twice daily.

At 3-months of herbal treatment, women experienced improvements in hot flashes and joint pain. At 1-year, bone density was improved when compared to placebo.

More recently, 64 pre-, peri-, and postmenopausal women were randomized to treatment with an herbal blend or placebo. The herbal blend was a 514mg blend of AGN, CW, and PU.

Women treated with the herbal supplement over 3-months experienced improvements in hot flashes, poor sleep, nervousness, mood, vertigo, fatigue, vaginal dryness, and joint pain when compared to placebo

The Takeaway Message:

The evidence supporting the sole use of the Profemin ingredients in treating menopausal symptoms is lacking. The fact that similar blends were tested in human trials adds merit to Profemin’s claims, however.

So far, it seems as though short-term relief of menopausal symptoms is possible at doses of AGN, CW, and PU comparable to what is offered in Profemin. Safety has also been demonstrated in the long-term, though only improvements in bone density were noted at 1-year.

Are There Any Profemin Side Effects?

The ability of Profemin’s ingredients to individually address menopausal symptoms was studied mainly in laboratory and animal studies. While these types of investigations can highlight a potential role in treatment, they do not guarantee safety and efficacy in humans.

The combination of the 3 ingredients was studied in 2 published clinical trials at dosing comparable to what is available in Profemin, however. Both studies did not report any serious adverse effects, even with use of the herbal blend up to 1-year.

As most herbal blends have a favorable safety profile, the presence of published research further strengthens the claim that Profemin is safe. Nonetheless, there is currently no data for the use of Profemin beyond a 1-year duration.

While this blend of ingredients has not been demonstrated to alter hormone levels in human trials, it is still best to speak with your doctor before use.

Even if you can avoid medical management of your menopausal symptoms, your doctor can answer any questions regarding dietary supplements and ensure they are safe for you to use.

The Cost and Where to Buy It

Profemin is available directly from their website. They offer several purchasing options.

For $9.95, you can “try it before you buy it.” They’ll ship a 2-month supply, though if you don’t call to cancel within 30-days, you’ll be charged $39.95 for subsequent monthly deliveries.

Ordering a 2-month supply otherwise costs $69.90 + $9.95 shipping. Again, if you don’t cancel, you’ll be charged $79.90 + $9.95 shipping for subsequent 60-day supplies.

Lastly, single orders are also available. You’ll pay $59.95 per 30-day supply + $9.95 shipping.

A 30-day guarantee backs all orders. Call support at 800-221-0905 to cancel the order and return your unused portion for a full refund.

Amazon carries a 30-day supply a bit cheaper at $57.95. Purchasing here also allows for a 30-day return.

What Are the Alternatives to Profemin?

Profemin isn’t the only supplement that claims to offer relief for menopausal symptoms without the use of hormones.

In fact, you find the same blend for much cheaper.

Herbal Pause from Now Foods offers the same dosage of all 3 ingredients in a patented blend called EstroG-100. This is the same blend tested in the 2012 trial reviewed above. They offer a 30-day supply for just $15.11.

Though you should still speak with your physician before use, Herbal Pause may be a better option as their specific blend was researched and you can get a 4-month supply for the cost of 30-day’s worth of Profemin.

The Bottom Line

The ability of Profemin’s 3 ingredients to manage menopausal symptoms has not been well studied individually.

The combination of these ingredients was proven safe and effective in managing menopausal symptoms in 2 clinical trials, however. Still, more work is needed to identify the long-term benefit of Profemin.

At Amazon, Profemin garners a 3.7-star rating on 187 reviews. Though half are 5-star, many users are unsatisfied due to a lack of results, continued menopausal symptoms, and side effects like headaches.

While it may be advantageous to avoid some of the side effects that can be associated with the medical management of menopausal symptoms, I would still recommend speaking to your primary care physician before using Profemin or similar products.

Even if you wish to avoid medical treatment, a visit with your doctor may help clarify some of your questions, determine the safety, and identify a plan of action if a dietary supplement does not offer the relief you need.

Customer Reviews

2.5 Stars out of 17 Reviews
5 Star:17% 4 Star:11% 3 Star:5% 2 Star:29% 1 Star:35%
35% Recommend This Company
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Posted on Jul 13, 2015

I'd recommend Profemin.

By Pamela Switzer , Cleveland, OH

I've been taking Profemin for three weeks now. The first thing I recognize was my irritability and moodiness less severe. I could go from 1 to 100 in a minute and the stress of it. Now my moods are calmer and I can think clearer. I sleep better, can lay down and fall asleep. No more vaginal dryness and best of all I am not fatigued when I wake. I'm also ok with the pricing because I chose the vitamin d blend, so roughly I'm paying $50 a month. So it's $100 bi-monthly. I'm okay with it because I truly wanted to feel better and I truly do. It felt good to be calm when I was challenged by my everyday life and not to respond the way I was accustomed to. I'd recommend Profemin and hope it gives you the same effect. It's been roughly three weeks, I'm hoping this does it.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 35 People Have Voted

Posted on Apr 23, 2016

Nurse

By Lynn Walker, Omaha, Nebraska, Verified Reviewer

I love Profemin. I've been taking it for 2 weeks now, and I fell so good. I used to have hot flashes every 45 minutes, I was so embarrassed when I was in public, my face dripping sweat and my makeup would be smeared. Thank God for Profemin. And it's natural.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 35 People Have Voted

Posted on Aug 26, 2016

Love it!

By Renita, California, Verified Reviewer

I've been using Profemin for about a month now. Literally after the first use I haven't had any hot flashes and have been sleeping like a baby.

I ordered through Amazon as I wanted to try first and I must admit that it is working great for me.

I definitely recommend this product

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 31 People Have Voted

Posted on Oct 22, 2016

It is a good product for Menopause

By Lisiana Carter, United States, Verified Reviewer

I've been using Profemin for about two months. After using it I haven't had any hot flashes and was able to do my daily routine without worrying about it anymore. I was also able to have better sleep in the night.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 31 People Have Voted

Posted on Apr 12, 2019

Menopause vitamins

By Raelynn C., California, Verified Reviewer

Overall I liked Profemin, it worked for me in a lot of areas. Most of all it helped me feel myself instead of feeling confused or who I am. It controlled my mood swings and hot flashes, it helped with sleep. The price was a little high, but worth it for someone who doesn't have menopause that bad this would be good for them. Customer service is good.

Bottom Line: Yes, I would recommend this to a friend

Company Response from Ideal Living Management, LLC

Apr 13, 2019

Hi Raelynn,

Thanks for the review and for sharing your experience with Profemin. :-)

Helpful Review? 3 People Have Voted

Posted on Jun 23, 2015

It helped me

By Norma , Uvalde, Tx

I have been on Profemin for 3 months and it did help me with vaginal dryness and has reduced my night sweats. It does say it reduces menopausal symptoms not a cure. And it does say it may not work the same for everyone. It worked for me. I would rather take herbal natural pills than chemical drugs.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 16 People Have Voted

Posted on Jul 13, 2015

I'm menstruating again.

By Lorna , Poconos, PA

I started taking Profemin two weeks ago and it helped with being hot. But after going six months without menstruating, I was wondering why I am now having a period again? I'm sending them back.

Bottom Line: No, I would not recommend this to a friend

Company Response from Ideal Living Management, LLC

Jan 23, 2018

Hi Lorna. We can certainly understand your concern. Before a woman is completely in menopause, it is common to go many months without a period and then begin menstruating again, followed by other long stretches without menstruating. The onset of natural menopause is confirmed only after 12 consecutive months of being period-free.

Helpful Review? 40 People Have Voted

Posted on Feb 18, 2015

Arbitration Agreement

By Mrs. Pedersen , Alaska

In ordering this product it already has an arbitration agreement that you agree to, prior to purchasing this product. Which means it is more likely not as safe as advertised.

Arbitration agreement: "Finally, keep in mind that you’ll be submitting to an arbitration agreement when placing your Profemin order, which means that you’ll be waiving your right to a jury trial or to become part of a class action lawsuit related to your use of the supplement."

I work in the medical field & this should be "The FIRST CLUE OF JUST HOW SAFE IT IS."

Read the fine print. Dismiss the wonderful glamor it shows or talks about prior to letting you know about the clause you agree too when ordering. Even regular prescriptions do not have you sign a arbitration clause agreement prior to taking their medication (unless you are in a study). I was going to purchase this product until I saw my first warning. I do realize I have not purchased this merchandise and now you know why. I must mark the box that I confirm that I am a real person and this is just the beginning of my experience. I did my research and it always has the clause. Unable to fight for compensation if this medication makes you ill, causes you more harm than good or worse - death. Is this what you want to take? If it is FDA approved then it would be available in stores on the shelves.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 40 People Have Voted

Posted on Jul 15, 2015

Two months and no difference

By Pamela , Utah

I started taking this on December 1st and now into February, I'm still taking Profemin and never missing a dose. I'm not even seeing a small difference in my hot flashes or sleeping. As I'm writing this review, I'm getting hot flashes so in my opinion this product does not work and do what it was supposed to do. Please don't waste your money like I did.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 55 People Have Voted

Posted on Jul 21, 2015

It does help, but what is in there?

By Dorly , Eureka, CA

I bought Profemin through eBay, paying a lot less. I took it for a couple of months and found my hot flashes and night sweats greatly reduced. However, I am rather nervous about the ingredients. I have developed severe headaches over the last few weeks and am wondering if these pills may be the cause. I have stopped taking them. "Proprietary Blend" can mean anything. What is really in there? I am not willing to take that risk.

Bottom Line: No, I would not recommend this to a friend

Company Response from Ideal Living Management, LLC

Jan 23, 2018

Hi Dorly. We're sorry that the ingredients weren't made clear to you. Here's more information on Profemin™, it is a dietary supplement that was formulated to utilize the synergistic benefits of three Asian botanicals that have been used for hundreds of years throughout Asia. Profemin™ is a patented blend of Angelica gigas nakai extract, cynanchum wilfordii extract, and phlomis umbrosa extract. Profemin™ is a safe, natural, state-of-the-art modern health solution for menopausal relief without the use of hormones. In addition, Profemin™ is a gluten-free supplement.

Helpful Review? 72 People Have Voted

Posted on Jul 2, 2015

Causing side effects

By Sandra , California

It is causing me constipation. I never have a problem in that area until I started taking the product and then I began experiencing pains in my stomach. I'm probably going to send back. Everyone's body is different and Profemin is not agreeing with mine

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 17 People Have Voted
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