What Is DermaSet?

By HighYa Research Team
Updated on: Sep 6, 2017

Advertised as equally effective for men and women of all skin types, DermaSet Skincare is an all-in-one anti-aging formula that promises to deliver a blend of 10 clinically researched botanicals and natural elements that can increase skin elasticity, firmness, and moisture retention.

The website tells us that the luxurious, nutrient-rich cream should be applied once in the morning and again in the evening, in place of your daily skin care moisturizer or other facial product. After 30 days, we’re told you’ll notice a reduction in age spots, crow’s feet, and wrinkle depth.

In addition, the company claims DermaSet will provide more even tone and texture, your skin will be soft and ultra-hydrated, you’ll boast an “overall younger looking air brushed appearance,” and the serum’s antioxidants will help counter the aging effects of stress. And with time, this stem cell renewal treatment will only penetrate your skin more deeply, thereby boosting its impact on both the face and the neck.

Just because DermaSet’s cream is clinically tested, dermatologist tested, and hypoallergenic, does this mean it will necessarily make a valuable addition to your skincare regimen?

Even then, will it help you reclaim your youth, as claimed on the website? Does it actually represent a time machine in a tube? Is it the most powerful option around? You're here for some answers, so let's dive right into the topic of stem cells.

What Role Do Stem Cells Play In the Aging Process?

In a nutshell, there are basically two types of stem cells: Adult stem cells have the ability to transform only into the same type of tissue (e.g., muscle, skin, etc.), while embryonic stem cells are pluripotent; that is, they have the ability to become any type of cell in the body. In either instance, the body uses stem cells to help maintain and repair tissue.

And while the aging process is extraordinarily complex and isn’t fully understood by the medical community, according to the Harvard Stem Cell Institute, “new evidence indicates that a progressive decline in stem cell frequency and function may significantly contribute to the conditions related to aging, but it is not known why this is.”

Consequently, it might make sense that boosting stem cell count on the skin could help alleviate some of the side effects of aging. But exactly how does DermaSet claim to do this, and what kinds of results might you realistically expect?

Taking a Closer Look at DermaSet Skincare’s Ingredients

While no formal label was listed on the website, we’re told DermaSet contains the following 10 clinically proven ingredients:

  • Apple Stem Cells
  • Edelweiss Stem Cells
  • Sea Fennel Stem Cells
  • BV-OSC
  • Argireline Extract
  • Chromabright
  • Dermaxyl
  • Matrixyl
  • Hyaluronic Acid
  • Phytoceramides

DermaSet’s Stem Cells

Like the human versions, plant stem cells are undifferentiated and can become any other cell in the organism. And according to Truth In Aging, there is some clinical evidence that edelweiss, mushroom, and apple stem cells may impact different aspects of external aging.

However, interviewed for a 2015 USA Today article, Margaret Foster Riley, a law professor and expert on food and drug law at the University of Virginia, noted:

“Stem cells that are in contact with skin are not really alive anymore, so I don’t really see how a stem cell product is working on the skin. I suppose some of them may actually work in a way that cosmetics work otherwise, because of moisturizing capability. But it’s not stem cell capability that’s working there to the degree we know how stem cells work.”

DermaSet’s Proprietary Ingredients

BVC-OSC is a proprietary form of vitamin C. In general, the Micronutrient Information Center at Oregon State University indicates this ingredient has been shown to provide antioxidant benefits for skin and prevent ultraviolet damage.

Argireline (formally known as acetyl hexapeptide) is another proprietary ingredient, although it works by inhibiting muscle contraction and reducing the appearance of related wrinkles.

Manufactured by Lipotec, Chromabright promises to inhibit tyrosinase, an enzyme that plays a key role in skin color. As a result, it’s said to help lighten areas where it’s applied.

Dermaxyl is claimed to stimulate cell communication and repair age-related skin damage, while Matrixyl (palmitoyl-pentapeptide 3) is said to stimulate collagen synthesis and skin repair.

Outside of Matrixyl, however, we didn’t encounter any double blind, placebo controlled clinical studies supporting these claims during our research.

What About the Remaining Ingredients?

Hyaluronic acid is a molecule that can hold many times its weight in water, which can help maintain moisture on the skin. Although phytoceramides (plant-derived ceramides) are lipids, they can also help keep skin hydrated and plump.

Is DermaSet Clinically Proven?

A company representative sent us a copy of a July 2017 clinical study conducted by Abich, Inc., which involved 52 participants. Over the course of six to seven weeks, each participant had a strip containing DermaSet cream adhered to their back for up to 48 hours at a time.

No adverse reactions were noted.

While this is certainly positive, it’s important to point out that the study was only designed to test DermaSet’s irritation and skin sensitization, not its effectiveness at reducing any of the signs of aging or supporting any of the other claims made by the manufacturer.

Are There Potential Side Effects With DermaSet’s Ingredients?

The product’s website indicates that DermaSet is specially formulated and doesn’t contain harsh chemicals or artificial ingredients that might irritate skin.

And according to many of the same sites listed in the ingredients section above, most won’t cause anything worse than mild, temporary redness or irritation at the application site (no specific circumstances were noted), especially for those with sensitive skin.

There have been rumors circulating online that continued Argireline use could lead to skin sagging, although Truth in Aging indicates there’s insufficient clinical evidence to support this.

However, because everyone’s skin is unique, you’ll definitely want to speak with your dermatologist about DermaSet before applying it to your face or neck.

How Much Does DermaSet Skincare Cost?

The only way to purchase DermaSet at the time of our research was through the company’s 30-day trial.

Here, you’ll pay $4.95 initial S&H and will be sent a full 30-day supply of the cream. After this time has passed, you’ll be charged the full price of $179. And from there, you’ll continue receiving a 60-day supply of DermaSet once every two months and charged $139 each time.

All initial orders come with a 60-day refund policy, less S&H, while recurring orders are only covered under a 15-day money back guarantee and must be sent back unopened and in the original packaging.

To request a refund or to cancel your recurring shipments, support can be reached at 855-936-8700 or support@dermasetcream.com.

What Can We Learn From DermaSet Customer Reviews?

As of 8/8/2018, 102 HighYa readers had given DermaSet an average rating of 4.0 stars. Here, most compliments appeared to reference effective results (reduced appearance of wrinkles, improved skin feel, etc.), professional customer service, and good value for the price.

On the other hand, common complaints frequently revolved around no results, unknowingly signing up for the full-price trial and recurring shipping program, and less-than-stellar support experiences. Granted, the bulk of these complaints were nearly two years old, so the company could have addressed many of these concerns since.

On Amazon, we encountered another 175 reviews and a similar 3.5-star customer rating for DermaSet, with many of the same compliments and concerns found on HighYa.

From a company perspective, DermaSet (parent company Hollywood Skincare, Inc.) had 26 reviews, 64 closed complaints, and no rating with the Better Business Bureau as of 9/6/17. There, most of these complaints revolved around being charged the full price after the initial trial.

Given everything we’ve discussed, how can you decide whether or not DermaSet has earned a place in your home?

Our Final Thoughts About DermaSet Skincare

While there are perhaps thousands of different anti-aging creams available in the marketplace, the American Academy of Dermatology recommends that simple sunscreen (SPF 30 or higher) and moisturizer might be the best place to start.

If they don’t work after a few weeks, the AAD recommends focusing on a product that targets your concerns, whether wrinkles, dark spots, or anything else. You’ll also want to buy a product formulated for your skin type, such as oily, sensitive, and so forth, and that’s within your budget.

When browsing products, look for those advertised as hypoallergenic and non-comedogenic or non-acnegenic, as well as those from companies that feature a consumer hotline for questions.

Finally, they emphasize that, “anti-aging skin care products deliver modest results. You cannot get the results of a facelift from a cream.” As a result, keep your expectations realistic.

How does all of this line up for the product in question? On the one hand, DermaSet came with mostly positive online customer feedback, a 60-day refund policy (for initial orders only), a customer service phone number and email address, and several ingredients that had clinical support for their efficacy related to moisturization and the inhibition of muscle contraction.

On the other hand, it was one of the highest priced anti-aging products the HighYa team has reviewed to date, and the only way to purchase it was through a trial that automatically rolls into a recurring shipping program.

Looking for the most value? As consumers ourselves, we think speaking with your doctor about options specifically formulated to address your concerns, your skin type, and your diagnosis is the best way to go.

In the meantime, be sure to read nine home remedies for getting rid of dark circles and how to treat wrinkles, creases, lines, and folds.

Read 121 DermaSet Skin Care Customer Reviews and Complaints

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Average Customer Rating: 4.2
Rating Snapshot:
5 star: 81 4 star: 17 3 star: 2 2 star: 3 1 star:  18
Bottom Line: 82% would recommend it to a friend
Showing 1-11 of 121
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  • This company is actively collecting reviews from its customers. All reviews submitted are subject to moderation and approval to ensure they meet our Review Guidelines.
  • Excellent product

    • By Fortuna Privis,
    • Fort Lauderdale, Florida,
    • Jun 10, 2015

    After using DermaSet, I noticed a difference in my appearance, my skin looked great, I looked ten years younger. I love this product .I look and feel beautiful. Thank you DermSet, for your outstanding excellent product.

    Bottom Line: Yes, I would recommend this to a friend

  • I'm on my third tube and plan on sticking with.

    • By Joanna Roth,
    • Chicago, IL,
    • Jul 23, 2015

    I have been using DermSet for about five months now and am very satisfied with my results. I'm 47 years young.

    I guess everyone has their own experience and points of view but every time I've called their customer service Paul has always been very helpful and nice.

    Maybe they can train their staff a bit more?

    Bottom Line: Yes, I would recommend this to a friend

  • I higly recommend DermaSet cream

    • By Eleonora,
    • Miami,
    • Jun 10, 2015

    I have used DermaSet since last summer. After my first pregnancy my skin had pigmentation and some hormone stains. I started using DermaSet very intensively and after third use I found that my skin became started to shine more and looked younger. It was just beginning. By now, I don't have any pigmentation or hormones on my face and I find it fabulous. I highly recommend DermaSet​.

    Bottom Line: Yes, I would recommend this to a friend

  • Great

    I love this cream. I have used for years, its done wonders to my skin. This cream is thick and luxurious, and I feel like it really does provide a nice moisture barrier for my skin, which I am in dire need of after such summers. Wish I had found it months ago! So I have combination skin, a bit dry, not really though. Not incredibly oily but I've got my fair share. I have moderate acne. This is my favorite cream. It doesn't feel weird and thick, or have oily residue. It is incredibly moisturizing though.

    Bottom Line: Yes, I would recommend this to a friend

  • Dermasetcream

    • By EJH,
    • Kingsport, TN,
    • Sep 19, 2015

    DermaSet Cream is the best anti aging cream I have ever used. Definitely has improved the texture of my face. I will continue to use it.

    Bottom Line: Yes, I would recommend this to a friend

  • Outstanding Product

    • By Nancy,
    • Illinois,
    • Nov 4, 2016
    • Verified Reviewer

    I am a very skeptical person and think most cosmetic advertising is a scam. However, I did let my guard down and ordered DermaSet! Thank heaven, this product is a miracle for me. I receive positive comments regarding my skin everywhere, even at the leading skin care brands at major department stores I go. I read all the material on this product and was well aware of my responsibility for the free trial. Love it, thanks.

    Bottom Line: Yes, I would recommend this to a friend

  • Wow

    • By Jennifer,
    • Florida,
    • Jan 21, 2017
    • Verified Reviewer

    This product is amazing. It has smoothed out my laugh lines and made my pores much less noticeable. I'll definitely be adding this to my regimen!

    Bottom Line: Yes, I would recommend this to a friend

  • Love it!

    • By Moya,
    • Florida,
    • Jan 21, 2017
    • Verified Reviewer

    I have been using DermaSet for three years now. I take it everywhere I go. It's been a real life saver for all those ugly dark spots I had on my face. Would definitely recommend everyone to try!

    Bottom Line: Yes, I would recommend this to a friend

  • Great product

    • By Fortuna,
    • Fort Lauderdale, FL,
    • Jan 21, 2017
    • Verified Reviewer

    DermaSet offers a free trail for 30 days and thank God that they do.

    I would never know if the product really works if I got the sample instead. I saw excellent results in exactly 30 days. I have been using it for three years and now and my whole family is in love with it too.

    Bottom Line: Yes, I would recommend this to a friend

  • Great stuff

    I love DermaSet. I was initially wary of the price, but the trial allowed me to try it out for just shipping, which was a great deal. Their excellent customer service put me at ease. Now I get regular shipments every couple months now.

    Bottom Line: Yes, I would recommend this to a friend

  • Excellent product

    • By Sophia,
    • San Francisco, CA,
    • Feb 25, 2017
    • Verified Reviewer

    This cream is the best of all, not only for me, but my whole family is using it, and we all agree on the miracles it does with our wrinkles.

    Bottom Line: Yes, I would recommend this to a friend

Showing 1-11 of 121

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