About Flexogenix Knee Pain Relief

By HighYa Research Team
Published on: Jan 25, 2017

Flexogenix Knee Pain Relief clinics utilize non-surgical joint pain treatments—such as injection protocols, physical therapy, and regenerative medicine—to help patients reduce chronic pain, regain strength and mobility, and restore normal joint function.

The five nationwide Flexogenix clinics don’t just treat knee-related problems, though. Through a custom program tailored to each patient’s needs, they can also address hip, shoulder, elbow, wrist, and ankle pain, whether caused by injury, osteoarthritis, or the normal aging process.

Flexogenix was founded by board certified radiologists and is staffed by board-certified physicians intent on dramatically reducing pain, helping you live a more active lifestyle, and eliminating the need for surgery—or, at least until it’s determined that surgery remains your last option.

While it certainly seems like Flexogenix’s suite of joint treatments could help reduce your pain and get you back in the game faster, without surgery or potentially dangerous medication, are they your best option? Are there any important considerations to keep in mind?

We’ll address these important questions (and more!) as we discuss what we learned during our research. Stick with us, and we’ll help you make a more informed decision.

Let’s start by taking a brief look at each service offered through Flexogenix.

How Does Flexogenix Help Deliver Knee & Joint Pain Relief?

Unpacking a Couple Key Terms

Before taking a closer look at each of Flexogenix’s treatments and protocols, it’s important to briefly define a few terms used on their website.

Viscosupplementation: According to the American Academy of Orthopaedic Surgeons, viscosupplementation involves injecting hyaluronic acid (HA) into the fluid around joints.

Since individuals with osteoarthritis tend to have lower than optimal HA levels in joints, the additional of this gel-like substance can help provide lubrication and shock absorption, leading to improved movement and reduced pain.

The AAOS goes on to note: “The most recent research, however, has not found viscosupplementation to be effective at significantly reducing pain or improving function. Although some patients report pain relief with the procedure, some people are not helped by the injections.”

Regenerative Medicine: The Mayo Clinic tells us that regenerative medicine involves delivering substances to a diseased area that can help the body heal itself and restore normal function in areas that might otherwise be beyond repair.

Although there are many different regenerative medicine treatments available, some of the most promising (including some at Flexogenix clinics) involve stem cells. These are undifferentiated cells that can become any other cell type in the body (embryonic), or at least tissue of the same origin (adult).

Physical Therapy & Re-Conditioning: If you’ve ever been involved in a serious accident, or experienced a sideline-inducing sports injury, you probably understand what physical therapy is.

Here, the injured area is subject to a variety of treatments, such as heat, cold, ultrasound, electrical stimulation, and manual therapy, to recondition your body and relieve pain.

Biologics: Biologics (or biologic response modifiers) are genetically engineered proteins derived from human genes that, when injected, may help reduce inflammation for rheumatoid arthritis-related pain that's resistant to traditional medication.

Now, how does Flexogenix use these treatments and protocols to address your joint problems?

What Happens During the Consultation & Initial Exam?

During your first visit to a Flexogenix clinic, a board certified physician will provide you with a no-cost (to you) exam, using highly accurate medical imaging equipment, to see how bad the deterioration is and the exact location of the problem.

From there, each AIUM accredited physician will interpret the results, diagnose your condition, and determine if you’re a candidate for treatment. In some cases, surgery may be your only option—and if Flexogenix can’t assist, they’ll help you find someone who can.

If you qualify, Flexogenix will provide you with a detailed diagnosis and treatment plan. In some instances, you could even be treated the very same day.

Which treatments, exactly?


Progeni-Flex is Flexogenix’s regenerative medicine treatment that uses stem cell and platelet-rich plasma (PRP) therapies to promote healing, relieve chronic joint pain, and help rebuild tissue.

Whether you’re a weekend warrior, an elite athlete, suffer from osteoarthritis, or are looking for a preventative approach, Flexogenix claims that Progeni-Flex might be ideal for those with:

  • Rotator cuff injuries
  • Chronic knee, hip, ankle, or other joint pain
  • Tennis and golfers elbow
  • Ligament and meniscus tears
  • Carpal tunnel syndrome


Remember the hyaluronic acid we discussed earlier? Here’s where we come back to it.

With Flexogenix’s VisCare-Flex procedure, a physician will use this same advanced imaging technology to see inside the joint and accurately inject the hyaluronic acid into the appropriate areas.

We’re told that the entire procedure takes less than an hour and that you’ll be out of the clinic the same day. You might even be able to drive yourself home!

By lubricating and nourishing the joint, this hyaluronic acid should continue to improve the joint for 6-8 months afterward.

Flexogenix’s Physical Conditioning Program

Flexogenix’s physical conditioning services are based on their Kineti-Flex approach, which involves one-on-one therapy and evidence-based treatments that can help support, strengthen, realign, improve mobility, and eliminate pain.

At the core of their physical conditioning program is their Zero G-Flex Anti-Gravity Technology. This equipment reduces pressure on weight-bearing joints, giving patients who suffer from chronic pain or osteoarthritis the ability to regain movement and retrain and restore joints, without the pain that can damper resolve and your results.

Each Kineti-Flex session is conducted with the assistance of a fully certified therapist, who can help walk you through exercises that will help you regain and maintain an active lifestyle.

Flexogenix Braces & Support

Flexogenix’s GaitScan technology can scan your foot and map pressure, helping to precisely customize an orthotic that can be inserted into your shoe to alleviate the problem.

Keep in mind that the orthotics from Flexogenix will likely be much more expensive than these OTC options, although tailored to your specific diagnosis (and therefore perhaps more beneficial).

Further, a custom knee brace from Flexogenix can help address asymmetric alignment, reduce joint stress, alleviate inflammation, and help the joint heal.

The Knee-Flex 5-Step Protocol

Flexogenix’s specialized Knee-Flex program brings together many of their standalone treatments under one roof to help you avoid surgery and halt osteoarthritis progression. It works over five steps:

  1. Administer an advanced injection protocol to stop knee joint and cartilage degradation.
  2. Inject hyaluronic acid with “pinpoint precision” to reduce friction and reduce inflammation.
  3. Undergo strength and mobility training using the Zero G-Flex anti-gravity treadmill.
  4. After examining the structure of your knee, a custom brace can help improve range of motion and correct any misalignments.
  5. If you’re experiencing any residual pain, this final step can help control your body’s conditioned response and eliminate it.

Granted, these are the potential benefits. But are there any drawbacks?

Will Flexogenix Treatments Cause Any Side Effects?

Outside of the standard pain and discomfort associated with rehabilitating less-than-optimal joints, WebMD tells us that hyaluronic acid injections may involve temporary redness and minor pain at the site, along with fluid buildup. This should fade over a few days.

Viscosupplementation might also cause mild redness and skin irritation at the injection site.

Stem cell treatments are a relatively new field of medicine, so authoritative websites report that long-term side effects aren’t well understood. However, many short-term side effects are related to other procedures, such as radiation used during a stem cell transplant.

Finally, according to authoritative websites, biologics treatments can sometimes lead to flu-like symptoms (fever, chills, nausea, headache), shortness of breath, and rashes.

Are Flexogenix’s customers reporting any of these side effects?

What Are Customers Saying In Their Reviews? Does Flexogenix Work?

Flexogenix was founded in 2013 and four of their five clinics were Better Business Bureau accredited at the time of our research. Their Los Angeles headquarters had an A+ rating based on one closed complaint (as of 1/23/17), which appeared to reference costs that weren’t covered by insurance.

We found 10 Yelp reviews for this same location, with an average rating of four stars. There, most compliments referenced reduced pain and mobility, improved quality of life, and pleasant staff/atmosphere.

In fact, the only complaints referenced office snafus, such as difficulty contacting someone and problems rescheduling an appointment.

Flexogenix’s Torrance, CA location had a slightly higher average Yelp rating of 4.5 stars, based on just two customer reviews, while their Cary, NC location had four reviews and a 4-star average rating. Most compliments and complaints referenced the same as their LA location.

Now, how much will the Flexogenix programs and treatments cost you? Are there different prices at each location?

How Much Do Flexogenix Knee Pain Relief Treatments Cost?

Your initial consultation at any of Flexogenix’s centers (Downtown LA, South Bay/Torrance, Cary/Raleigh, Charlotte, and Greensboro) is free, although depending on your proximity, don’t forget to factor in travel costs.

While the company doesn’t list prices for any of their treatments or programs, one Yelp reviewer mentioned that each stem cell injection will cost you $500. Flexogenix also claims that Medicare and most major insurance providers cover their Knee-Flex 5-step program.

The Bottom Line: Can Flexogenix Provide Relief?

Just like any other place in your body, pain works to signal that something is wrong—but not specifically what’s wrong.

In other words, there are thousands of different conditions and scenarios in which knee and joint pain can manifest, including trauma, rheumatoid arthritis and osteoarthritis, infection, cancer, and other disease.

Can Flexogenix’s knee and joint pain treatments deliver some measure of relief? As you might expect, this wholly depends on what’s causing your pain, along with your doctor’s specific recommendations for treatment.

However, keep in mind that WebMD tells us that there’s not a lot of evidence to support many of the arthritis-related claims for stem cell injections. Further, biologics treatments may help alleviate symptoms and prevent further joint damage related to arthritis, although they do not cure it.

About viscosupplementation, the New England Journal of Medicine writes: “Despite numerous trials and meta-analyses, the efficacy of hyaluronate-related agents in patients with knee osteoarthritis remains debated and uncertain.”

Similarly, WebMD notes that hyaluronic acid injections may work better than painkillers and about as well as corticosteroid knee injections in some, although they “may be less effective in older adults and people with severe osteoarthritis.”

The good news is that you initial Flexogenix Knee Pain Relief consultation might completely free of charge, although you’ll certainly want to contact both the company and your insurance provider to ensure 100 percent certainty before you show up for your appointment.

Finally, it’s important to note that if you’re experiencing chronic knee or joint pain and it’s negatively impacting your quality of life, keep in mind there are many other national businesses that can help provide non-surgical joint treatment” and “stem cell joint injections,” such as Regenexx, along with other services associated with local hospitals and clinics.

Read 3 Flexogenix Knee Pain Relief Customer Reviews and Complaints

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Average Customer Rating: 2.3
Rating Snapshot:
5 star: 1 4 star: 0 3 star: 0 2 star: 0 1 star:  2
Bottom Line: 33% would recommend it to a friend
Showing 1-3 of 3
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  • 0 out 1 people found this review helpful


    • By Aaron B.,
    • North Carolina,
    • Jan 12, 2020
    • Verified Reviewer

    This is a racket!

    I know in all of the reviews here they don't stay anything about how rude Dr. Zeller is. I have gone there for over a year and the two times I saw her she would not listen to me. I was there to do my follow-up today, 1/6/2020, and I ask her about the procedure they had done to my knee and she started with her spill. I ask her was it the PRP that made my knee better or my recumbent bike. She got kind of tense and backed up a bit and said she would get to that and had a very hateful tone. At that point, she told me I came there with an attitude I had not seen here at all. So I let her finish and she was going on about what maybe we could do. I ask her again, she ignored me and I got a bit tiffed that is the first time I have seen her this year and only the second time I have seen her she was not happy when she walked into the room. Then we had a few words and I told her we were finished! She didn’t like it that I was not going to be a repeat patient! I hope and pray that Dr. Zeller has not messed anybody up!

    Bottom Line: No, I would not recommend this to a friend

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  • 1 out 1 people found this review helpful

    Great results

    • By Michael C.,
    • High Point, NC,
    • Nov 22, 2019
    • Verified Reviewer

    I injured my left knee jumping out of helicopters in Vietnam and my advancing age hasn't helped my knee pain. In 2016, I went through a series of injections and it worked for me. A few weeks ago, I started feeling a bit of pain in my left knee. As I've been over 2.5 years pain-free and enjoyed that, I called Flexogenics and scheduled another appointment. After the first injection, my pain level went to zero. I'm about halfway through the series, now, and can state, unequivocally, the treatments have worked for me.

    Bottom Line: Yes, I would recommend this to a friend

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  • 29 out 32 people found this review helpful

    Exactly what the two-star rating says

    • By Douglas B.,
    • Marshville, NC,
    • Mar 21, 2019
    • Verified Reviewer

    I will try to be honest here. This is a genuine review concerning treatments I received from the Charlotte Flexogenix group in 2018. The reason I am writing this review is because I want anyone who attempts to use Flexogenix to carefully listen to what others have to say about it. It might not be for everyone. There were people at the office who provided testimony to me that it worked. It did not for me.

    Here are my impressions of the treatments and why I won't continue them.

    First, the treatments are extremely expensive and not all of it is 100% paid for by insurance. The cost for 7 month period that I had the treatments was about $17,000.

    Secondly, the treatments did not work for me at all. They continued the treatment, and I had hoped for some improvement with my knees, but it did not help at all.

    Thirdly, while I believed that my copay paid for the treatments when I was in their office, they sent me a bill just recently for over a thousand dollars. After calling their office to inquire as to why 7 months after I received my last treatment I was receiving a bill for such an exorbitant amount of money, they informed me that I should have been billed for approximately $100 each time I visited. I told them that it would have been nice if they didn't accumulate the charges and then send them to me as a large sum of money owed.

    Fourth, during the time I visited the clinic, I usually never saw a doctor.

    I don't recommend this service. Perhaps stem cell work would be better and improvements need to be made for this clinic.

    Bottom Line: No, I would not recommend this to a friend

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