About LA-3 by Live Cell Research

By HighYa Research Team
Updated on: Nov 14, 2016

LA-3 by Live Cell Research is a nutritional supplement that promises to boost your AMPK levels, resulting in increased energy, clearer thinking, decreased abdominal fat, and a “stronger, healthier body.” For these reasons, Live Cell Research calls LA-3 a “longevity activator.”

How? According to the company, LA-3 contains three different ingredients that have never been combined before, which can provide maximum benefits after just a few months of continuous use:

  • Days 1-7: You may begin experiencing increased energy and reduced appetite and cravings.
  • Days 7-30: Because you’re eating less, you might notice your abdominal fat melting away, further increasing your energy.
  • 1 Month+: After this time, we’re told your AMPK levels should be elevated sufficiently so that your thoughts become clearer and your mind less forgetful. You might also notice that your body is becoming stronger and healthier, along with a continued change in your shape.

To achieve these benefits, Live Cell Research states you'll just need to take two capsules of LA-3 with water per day, with or without food. They also promise that LA-3 can work for anyone, is safe to use with no known side effects, and is third-party tested for safety, purity, and potency.

If you didn’t know better, Live Cell Research’s LA-3 supplement might sound like some fountain of youth and an incredible weight loss program rolled into one.

But what does science have to say about many of the company's claims? Will this supplement work? Is it worth the money? Keep reading to find out what we uncovered during our research.

How Does AMPK Work?

5' AMP-activated protein kinase (or AMPK for short) is “an enzyme that plays a role in cellular energy homeostasis,” and is concentrated in a number of areas throughout the human body, including the brain, liver, and skeletal muscle. AMPK itself is made up of three proteins: STE-related adaptor (STRAD), mouse protein 25 (MO25), and LKB1.

Live Cell Research calls AMPK a “master switch” because this enzyme regulates several key systems within the body, such as increasing cellular energy, stimulating the oxidation of fatty acids and glucose transport, and more.

While the exact details are far outside the scope of this review (and they might make you go cross-eyed), the thing about AMPK is that some fairly specific conditions need to be present for the enzyme to be activated—the primary method of which is muscle contraction (i.e. working out).

Once AMPK is activated, there is some clinical evidence showing it may increase blood supply to muscles, help transport glucose (simple sugars), boost fatty acid metabolism (thereby creating more energy for the cell), and more.

What if you don't want to hit the gym to boost your AMPK levels? Can you accomplish the same thing by popping a couple of LA-3 pills?

Will LA-3’s Ingredients Boost Your AMPK Levels?

According to their supplement label, LA-3 contains the following ingredients:

Of these, WebMD indicates that 30mg daily of gynostemma may be effective for reducing cholesterol. So, at 450mg per dose, LA-3 delivers significantly more than this, although there doesn’t seem to be any clinical evidence indicating that increased gynostemma consumption results in more obvious benefits.

Is ActivAMP a Clinically Proven Ingredient?

Important note: The gynostemma pentaphyllum found in LA-3 is part of a proprietary ingredient named ActivAMP, which is manufactured by a company named Gencor Pacific.

According to their website, in a 12-week randomized clinical trial, ActivAMP was shown to decrease body fat mass and body fat percentage, reduce body weight and BMI, and shrink the total abdominal area.

To see the results for ourselves, we reached out to Gencor Pacific and obtained some of their clinical evidence for ActivAMP, which consists of seven different trials. Here is just a handful:

  • A 2013, 23-week randomized, double-blind, placebo-controlled clinical trial that concluded ActivAMP might be useful for treating obese individuals.
  • A 2012, 8-week study that showed mice “decreased body weight gain, liver weight, and blood cholesterol levels with AMPK activation in the soleus muscle.”
  • A 2011 study showing the ingredient may be effective for improving glucose and lipid metabolism.
  • A 2008 study showing that ginsenosides may have an anti-obesity effective. All results were obtained via cells in a controlled laboratory setting.

Just keep in mind that results obtained through experiments conducted on mice and cells don’t necessarily mean you, as a human, will experience the same thing.

And even if these studies were conducted on humans, it would require dozens (or perhaps even hundreds) of reproducible, double-blind, placebo controlled, peer reviewed studies before if could be considered “proven” to work as advertised.

For more about this topic, be sure to read Think That Clinical Study Is Legit?

LA-3’s Other Ingredients

Moving on, WebMD also tells us that 1,000mg daily of quercetin (commonly known as jiaogulan) might help alleviate prostate pain and inflammation. But at just 100mg per dose, there doesn’t appear to be enough in LA-3 to provide these benefits.

Finally, WebMD indicates that berberine might also be effective at reducing cholesterol, as well as blood sugar levels in diabetes patients.

Bringing It All Together Regarding LA-3’s Ingredients: What Can You Realistically Expect?

As we can see, there are clearly some clinically validated benefits for the ingredients found in LA-3.

However, according to authoritative websites like WebMD, there doesn’t appear to be enough clinical evidence showing that these ingredients—whether on their own or in combination—can elevate AMPK levels.

Granted, there is some promising research related to AMPK, although most clinical studies have been conducted on mice (including one of the studies for ActivAMP).

So, based on what we learned after reaching out to Live Cell Research, there seems to be little clinical proof that these same protocols will work in humans.

Are There Any Potential Side Effects from LA-3?

Despite the limited evidence showing that these ingredients can boost AMPK levels, the good news is that they’re generally considered safe.

However, WebMD notes that gynostemma pentaphyllum “can cause some side effects such as severe nausea and increased bowel movements.” Also, it’s unknown if taking quercetin for more than 12 weeks is considered safe.

How much will you pay for LA-3’s three-ingredient formulation?

How Much Does LA-3 Longevity Activator Cost?

Live Cell Research’s LA-3 supplement is available in the following quantities:

  • 1 Bottle: $46.99
  • 3 Bottles: $117
  • 6 Bottles: $216

Like all Live Cell Research products, LA-3 comes with a 90-day refund policy, less S&H charges. To request one, you'll need to contact customer service at (844) 650-5933 or support@LiveCellResearch.com.

What Can We Learn from LA-3 Customer Reviews?

Since conducting our original research, 19 LA-3 customers have written about their experience on HighYa, giving the supplement an average rating of 3.8 stars.

Here, most compliments seem to reference effective results, including reduced belly fat, increased energy, improved weight loss, and decreased appetite and cravings.

On the other hand, as is the case with many other nutritional supplements, the most common customer complaint about LA-3 seems related to ineffective (or non-existent) results. In fact, even among those who experienced positive results, several noted that it took several weeks to achieve any effects and that they were fairly mild.

Granted, all of this relates to LA-3 as a product. What about the company who manufactures it?

About Live Cell Research

Live Cell Research is based out of Southern California, where they manufacture a line of popular supplements, including Niagen, Midogen, and more.

Overall, the company’s supplements seem to come with mostly positive online customer reviews, with common compliments citing effective results. On the flip side, common complaints reference failure to work/achieve results and difficult customer service experiences.

Unfortunately, the company wasn’t listed with the Better Business Bureau at the time of our research.

Is LA-3 the Right Nutritional Supplement for You?

On the one hand, with many of the Live Cell Research products we’ve written about in the past, authoritative websites like WebMD note that the clinical evidence supporting many of the company’s claims is lacking.

On the other hand, many customers claim to have experienced positive results with the company’s supplements—LA-3 included—clinical evidence notwithstanding.

Does this mean you should hand over your hard-earned money for Live Cell Research’s LA-3 supplement? Like any other nutritional supplement, what works fantastically for you might be a total flop for someone else and vice versa.

The seemingly good news is that Live Cell Research offers a 90-day refund window on all of their products, which you can take advantage of if you’re not fully satisfied. Just keep in mind that you'll be out a few dollars for return shipping and handling.

Finally, if you type the phrase “AMPK supplement” or “AMPK activator” into your favorite search engine, you’ll be met with dozens of supplements making many of the same claims as LA-3.

Sure, they might not be formulated exactly like LA-3, but their claims (and general lack of clinical support) are much the same.

Read 301 LA-3 by Live Cell Research Customer Reviews and Complaints

Write a Review
Average Customer Rating: 4.1
Rating Snapshot:
5 star: 145 4 star: 94 3 star: 23 2 star: 12 1 star:  27
Bottom Line: 84% would recommend it to a friend
Showing 1-11 of 301
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  • Great product

    • By J J.,
    • South Dakota,
    • Nov 4, 2018
    • Verified Reviewer

    I'm a 44-year-old married guy that had a dad bod! I recently went in for a physical, and I had to get on the scale and I weight 210 lbs. I have never weighed that in my life. I started taking LA-3 two months ago. I am down to 180. I hate exercising, but what little I get in during my job and a daily portion of food has really helped. I feel better with more energy and my clothes fit looser. If you are skeptical about trying, you got nothing to lose but inches and pounds.

    Bottom Line: Yes, I would recommend this to a friend

  • We are all different. This has worked for my brain fog!

    • By Windy L.,
    • Myrtle Beach, SC,
    • Sep 5, 2018
    • Verified Reviewer

    I am going to sound like an infomercial but people in the brain fog world, it works. My stress levels were so high. My legs began to shut down and I would wake up in the morning with such a fog in my head, I felt hungover every day. I understand it takes time to get in your system but I had been trying other supplements for my cognition, and when I took this three days later, I felt the fog lift. AMAZING. We are all wired different but for me, it's better than many other products I have tried. This works.

    Bottom Line: Yes, I would recommend this to a friend

  • Lost four dress sizes

    I took LA-3 for ten months. It gave me mega energy for about the first six months. A representative told me to double the dose, but I decided not to. I lost about 16 pounds and went down from a size 2 to a size 14.

    Bottom Line: Yes, I would recommend this to a friend

  • It is working but just not as good as I thought it would

    I am not sure how well it is supposed to work. I have been taking it every morning before breakfast, and I have had more bowel movements, but my stomach hasn't shrunk any. And that what I thought that this was supposed to shrink; fat cells, and your stomach would shrink. So please tell me what I am doing wrong. Or is it because I haven't been on it long enough? I would like to get some kind of answer, please. You have my email. I really needed to lose the weight because I have severe lower back pain and right knee pain. Thanks for any advice you can give me.

    Bottom Line: Yes, I would recommend this to a friend

  • Recommending it

    • By Kelli DeLallo,
    • Pittsburgh, PA,
    • Feb 20, 2018
    • Verified Reviewer

    I have been taking LA-3 for about three weeks now. I would say that after about two weeks I noticed that my appetite (I am a total sugar junkie) decreased. I, myself, didn't make changes right away, I mean, I love my cookies, but I didn't feel the urgency to eat them all the time like I did before.

    As for energy, I was diagnosed with fibromyalgia about nine years ago and have chronic pain and fatigue. I do not notice any changes in pain or fatigue, but I have to say I didn't really expect them, I was more concerned with my voracious sugar appetite.

    I would recommend this product for someone who was trying to kick a bad eating habit like sugar. I can't say it will work for everyone, I didn't even give it up right away, but it has sure made it much easier.

    Bottom Line: Yes, I would recommend this to a friend

  • Results of taking LA-3

    I noticed a difference in my bowel movement. I don't know if this product is supposed to do that or not.

    As far as weight loss goes, I would say that it helped a little. Also with the little bit of weight loss, of course, you would see a reduction in the stomach area.

    It has been almost a month, and I do like the product so far.

    Bottom Line: Yes, I would recommend this to a friend

  • It works!

    I have been taking the LA-3 for almost a month now, and I am ready to re-order my next bottle. I didn't have much faith in it, but I must say it is working for me. Will it work for you? One bottle will tell you!

    Bottom Line: Yes, I would recommend this to a friend

    • Feb 16, 2018

      Company Response from The Living Cell Research, LLC

      Hi Karen, I'm Aurora from Live Cell Research. Thank you so much for taking the time to leave us a review about your experience with LA-3 so far! I am overjoyed to hear that you are experiencing the many benefits of LA-3! I would love to be updated on your experience as time goes on. Please e-mail me at Aurora@LiveCellResearch.com if you have any questions or concerns along the way. Thank you!

  • Working for me

    The LA-3 combined with my workouts and food intake adjustments I have been making seems to be working for me. I can tell a difference in how my jeans fit, and my mom also told me she can see the difference. I've always had heavy thighs and now I am battling the hormonal weight issues. I am very pleased with the product and how it is working for me. I'm in control once again!

    Bottom Line: Yes, I would recommend this to a friend

  • Too early to judge

    • By Martha Parker,
    • Mill Valley, CA,
    • Feb 6, 2018
    • Verified Reviewer

    I’m 65 years old and use enzymes at times. I have not needed as many enzymes, but the fasting blood glucose continued to run above 110. I had hoped this would help reduce belly fat, which my MD said was why my fasting and a1c was borderline diabetes, even though I had lost 40 pounds.

    Possibly my mental acuity is better, but that is difficult to measure. I am certainly less anxious, but other mood swings continue.

    Overall, I am hoping to see a change as I have a 6-month supply. I’m currently doing a liver cleanse so will let you know if results happen. I have hope as I think the ingredients are all amazing. The product is expensive so I can’t recommend yet.

    Bottom Line: No, I would not recommend this to a friend

  • So far so good.

    • By Debra Mann,
    • Southwest Florida,
    • Jan 30, 2018
    • Verified Reviewer

    I have been taking LA-3 for three weeks now and have found my belly fat disappearing! I am truly stunned that this product seems to be working!

    I also find I have more energy and am not having as much trouble getting to sleep at night.

    I would recommend at least giving it a try and see how it works for you. I am very glad I took a chance and am being pleasantly surprised that it works.

    Bottom Line: Yes, I would recommend this to a friend

  • This is an awesome product

    • By Deborah Davis,
    • Rolling Hills Estates, CA,
    • Jan 25, 2018
    • Verified Reviewer

    I tried a trial bottle of LA-3 and got excellent results. I believe this doctor is onto something with this product. One has to wait until about the third week of product to see results, but I expected that a supplement needs time to build up within one's system. After that time, I saw a big difference. My stomach was flattening out. But you just cannot go out a eat irresponsibly, you have to maintain a healthy diet. Anyone with common sense knows that.

    Bottom Line: Yes, I would recommend this to a friend

Showing 1-11 of 301

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LA-3 by Live Cell Research