About LA-3 by Live Cell Research

By HighYa Research Team
Updated on: Nov 14, 2016

LA-3 by Live Cell Research is a nutritional supplement that promises to boost your AMPK levels, resulting in increased energy, clearer thinking, decreased abdominal fat, and a “stronger, healthier body.” For these reasons, Live Cell Research calls LA-3 a “longevity activator.”

How? According to the company, LA-3 contains three different ingredients that have never been combined before, which can provide maximum benefits after just a few months of continuous use:

  • Days 1-7: You may begin experiencing increased energy and reduced appetite and cravings.
  • Days 7-30: Because you’re eating less, you might notice your abdominal fat melting away, further increasing your energy.
  • 1 Month+: After this time, we’re told your AMPK levels should be elevated sufficiently so that your thoughts become clearer and your mind less forgetful. You might also notice that your body is becoming stronger and healthier, along with a continued change in your shape.

To achieve these benefits, Live Cell Research states you'll just need to take two capsules of LA-3 with water per day, with or without food. They also promise that LA-3 can work for anyone, is safe to use with no known side effects, and is third-party tested for safety, purity, and potency.

If you didn’t know better, Live Cell Research’s LA-3 supplement might sound like some fountain of youth and an incredible weight loss program rolled into one.

But what does science have to say about many of the company's claims? Will this supplement work? Is it worth the money? Keep reading to find out what we uncovered during our research.

How Does AMPK Work?

5' AMP-activated protein kinase (or AMPK for short) is “an enzyme that plays a role in cellular energy homeostasis,” and is concentrated in a number of areas throughout the human body, including the brain, liver, and skeletal muscle. AMPK itself is made up of three proteins: STE-related adaptor (STRAD), mouse protein 25 (MO25), and LKB1.

Live Cell Research calls AMPK a “master switch” because this enzyme regulates several key systems within the body, such as increasing cellular energy, stimulating the oxidation of fatty acids and glucose transport, and more.

While the exact details are far outside the scope of this review (and they might make you go cross-eyed), the thing about AMPK is that some fairly specific conditions need to be present for the enzyme to be activated—the primary method of which is muscle contraction (i.e. working out).

Once AMPK is activated, there is some clinical evidence showing it may increase blood supply to muscles, help transport glucose (simple sugars), boost fatty acid metabolism (thereby creating more energy for the cell), and more.

What if you don't want to hit the gym to boost your AMPK levels? Can you accomplish the same thing by popping a couple of LA-3 pills?

Will LA-3’s Ingredients Boost Your AMPK Levels?

According to their supplement label, LA-3 contains the following ingredients:

Of these, WebMD indicates that 30mg daily of gynostemma may be effective for reducing cholesterol. So, at 450mg per dose, LA-3 delivers significantly more than this, although there doesn’t seem to be any clinical evidence indicating that increased gynostemma consumption results in more obvious benefits.

Is ActivAMP a Clinically Proven Ingredient?

Important note: The gynostemma pentaphyllum found in LA-3 is part of a proprietary ingredient named ActivAMP, which is manufactured by a company named Gencor Pacific.

According to their website, in a 12-week randomized clinical trial, ActivAMP was shown to decrease body fat mass and body fat percentage, reduce body weight and BMI, and shrink the total abdominal area.

To see the results for ourselves, we reached out to Gencor Pacific and obtained some of their clinical evidence for ActivAMP, which consists of seven different trials. Here is just a handful:

  • A 2013, 23-week randomized, double-blind, placebo-controlled clinical trial that concluded ActivAMP might be useful for treating obese individuals.
  • A 2012, 8-week study that showed mice “decreased body weight gain, liver weight, and blood cholesterol levels with AMPK activation in the soleus muscle.”
  • A 2011 study showing the ingredient may be effective for improving glucose and lipid metabolism.
  • A 2008 study showing that ginsenosides may have an anti-obesity effective. All results were obtained via cells in a controlled laboratory setting.

Now, we’re not medical experts (which is why we rely on authoritative sites to determine whether or not an ingredient is classified as “effective”), so we have no reason to doubt the findings in Gencor Pacific’s research.

Just keep in mind that results obtained through experiments conducted on mice and cells don’t necessarily mean you, as a human, will experience the same thing.

And even if these studies were conducted on humans, it would require dozens (or perhaps even hundreds) of reproducible, double-blind, placebo controlled, peer reviewed studies before if could be considered “proven” to work as advertised.

For more about this topic, be sure to read Think That Clinical Study Is Legit?

LA-3’s Other Ingredients

Moving on, WebMD also tells us that 1,000mg daily of quercetin (commonly known as jiaogulan) might help alleviate prostate pain and inflammation. But at just 100mg per dose, there doesn’t appear to be enough in LA-3 to provide these benefits.

Finally, WebMD indicates that berberine might also be effective at reducing cholesterol, as well as blood sugar levels in diabetes patients.

Bringing It All Together Regarding LA-3’s Ingredients: What Can You Realistically Expect?

As we can see, there are clearly some clinically validated benefits for the ingredients found in LA-3.

However, according to authoritative websites like WebMD, there doesn’t appear to be enough clinical evidence showing that these ingredients—whether on their own or in combination—can elevate AMPK levels.

Granted, there is some promising research related to AMPK, although most clinical studies have been conducted on mice (including one of the studies for ActivAMP).

So, based on what we learned after reaching out to Live Cell Research, there seems to be little clinical proof that these same protocols will work in humans.

Are There Any Potential Side Effects from LA-3?

Despite the limited evidence showing that these ingredients can boost AMPK levels, the good news is that they’re generally considered safe.

However, WebMD notes that gynostemma pentaphyllum “can cause some side effects such as severe nausea and increased bowel movements.” Also, it’s unknown if taking quercetin for more than 12 weeks is considered safe.

How much will you pay for LA-3’s three-ingredient formulation?

How Much Does LA-3 Longevity Activator Cost?

Live Cell Research’s LA-3 supplement is available in the following quantities:

  • 1 Bottle: $46.99
  • 3 Bottles: $117
  • 6 Bottles: $216

Like all Live Cell Research products, LA-3 comes with a 90-day refund policy, less S&H charges. To request one, you'll need to contact customer service at (844) 650-5933 or support@LiveCellResearch.com.

What Can We Learn from LA-3 Customer Reviews?

Since conducting our original research, 19 LA-3 customers have written about their experience on HighYa, giving the supplement an average rating of 3.8 stars.

Here, most compliments seem to reference effective results, including reduced belly fat, increased energy, improved weight loss, and decreased appetite and cravings.

On the other hand, as is the case with many other nutritional supplements, the most common customer complaint about LA-3 seems related to ineffective (or non-existent) results. In fact, even among those who experienced positive results, several noted that it took several weeks to achieve any effects and that they were fairly mild.

Granted, all of this relates to LA-3 as a product. What about the company who manufactures it?

About Live Cell Research

Live Cell Research is based out of Southern California, where they manufacture a line of popular supplements, including Niagen, Midogen, Vital Stem, and more.

Overall, the company’s supplements seem to come with mostly positive online customer reviews, with common compliments citing effective results. On the flip side, common complaints reference failure to work/achieve results and difficult customer service experiences.

Unfortunately, the company wasn’t listed with the Better Business Bureau at the time of our research.

Is LA-3 the Right Nutritional Supplement for You?

On the one hand, with many of the Live Cell Research products we’ve written about in the past, authoritative websites like WebMD note that the clinical evidence supporting many of the company’s claims is lacking.

On the other hand, many customers claim to have experienced positive results with the company’s supplements—LA-3 included—clinical evidence notwithstanding.

Does this mean you should hand over your hard-earned money for Live Cell Research’s LA-3 supplement? Like any other nutritional supplement, what works fantastically for you might be a total flop for someone else and vice versa.

The seemingly good news is that Live Cell Research offers a 90-day refund window on all of their products, which you can take advantage of if you’re not fully satisfied. Just keep in mind that you'll be out a few dollars for return shipping and handling.

Finally, if you type the phrase “AMPK supplement” or “AMPK activator” into your favorite search engine, you’ll be met with dozens of supplements making many of the same claims as LA-3.

Sure, they might not be formulated exactly like LA-3, but their claims (and general lack of clinical support) are much the same.

Read 301 LA-3 by Live Cell Research Customer Reviews and Complaints

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Average Customer Rating: 4.1
Rating Snapshot:
5 star: 145 4 star: 94 3 star: 23 2 star: 12 1 star:  27
Bottom Line: 84% would recommend it to a friend
Showing 1-11 of 301
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  • 17 out 18 people found this review helpful

    So far so good

    • Palm Springs, CA,
    • Aug 22, 2016
    • Verified Reviewer

    I just finished the first of a three months supply. Overall I feel better and lost 3 pounds with little effort. There seem to be no side effects or tummy upsets while talking the capsules. In fact I think my digestive system is running smoother and my energy level has improved.

    I think I will have a better idea after I complete all the months but so far so good!

    Bottom Line: Yes, I would recommend this to a friend

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  • 5 out 7 people found this review helpful

    It does what you said it would do!

    I now have great energy and weight loss and I'm less hungry!

    Thanks a million!

    Bottom Line: Yes, I would recommend this to a friend

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  • 9 out 10 people found this review helpful


    • Maine,
    • Sep 26, 2016
    • Verified Reviewer

    I am a post menopausal woman who has been carrying a stubborn 15lbs of belly fat around for 6 years. I am active, eat well, but just cannot rid myself of this weight.

    I have taken this product for 2.5 months now and have changed nothing in my daily routine. About 2 weeks ago, I stepped on the scale, ( I usually avoid this because it depresses me), and I saw that I had lost 7lbs. Coincidence?

    Bottom Line: Yes, I would recommend this to a friend

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  • 18 out 21 people found this review helpful

    Good Product

    • Lynchburg, TN,
    • Sep 30, 2016
    • Verified Reviewer

    I'm starting my 3rd week of LA-3 and so far I have noticed that my sweet craving is much better than it was last week. I have Type 2 diabetes and was mainly taking it for that reason. I haven't really been checking my blood sugar, but just the thought that I have less of a sweet crave is a good thing. I take two pills 1st thing in the morning on an empty stomach. I notice that I really don't want much to eat until after lunch. I give this product 5 thumbs up!

    Bottom Line: Yes, I would recommend this to a friend

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  • 25 out 31 people found this review helpful


    • Grand Islsnd, NE,
    • Oct 25, 2016
    • Verified Reviewer

    I love how this product makes me feel: rested, energetic and full. My hunger is incredibly less as I use this product. I will be recommending it to friends. May I have more at a special rate?

    Bottom Line: Yes, I would recommend this to a friend

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  • 43 out 49 people found this review helpful


    • California,
    • Nov 7, 2016
    • Verified Reviewer

    Put simply, all my Actinic Keratoses, about 15 or so, have resolved completely. A number of them had morphed to precancerous lesions. Poof, gone!

    Bottom Line: Yes, I would recommend this to a friend

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  • 50 out 52 people found this review helpful

    Lose Belly Fat Almost Immediately

    • New York, NY,
    • Nov 21, 2016
    • Verified Reviewer

    I've noticed that since I have been using LA-3 I have lost inches around my waist due to the decreasing amount of belly fat. I've noticed this the first week of taking LA-3.

    Finally, a supplement that does for the body exactly what it promises. I have also lost weight over my entire body that has also been very noticeable. I have one suggestion, and that would be to make a powdered form of this supplement for even better results.

    Powdered form supplements tend to work more efficiently, and faster because it is absorbed by the body instantly. If the LA 3 supplement works wonders in pill form, just imagine how effectively it will work in powdered form? I am sure it will get great results!

    Bottom Line: Yes, I would recommend this to a friend

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  • 34 out 39 people found this review helpful

    I think it is working, not sure.

    • Atlanta, GA,
    • Dec 7, 2016
    • Verified Reviewer

    I have lost about 20 pounds since I started this supplement about one month or so ago. I find that I am eating less than before. Therefore, I feel this is more of an appetite suppressant that a belly fat remover.

    I have not experienced any side effects that appetite suppressants usually bring about like jitteriness. This is a good thing and I can only hope there are no long-term effects.

    In the past, I have seriously considered Bariatric surgery and thanks to my wife I canceled that notion since so many are having serious health problems if they don't keep up with the supplements. I say this because I think, at this time, I feel this is a good alternative.I rated this 5 stars because this is what it is doing for me now.

    I would not recommend it to a friend until I am convinced it is a safe product since I feel I'm taking a risk by going this route with such a new product.

    My only problem is how to reorder. Does anyone know how to do this?

    Bottom Line: No, I would not recommend this to a friend

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  • 22 out 26 people found this review helpful

    Pants falling down

    Great to have purchased LA-3. Following directions 2 a day. Longevity Activator was working for me. Lost 3 inches of belly fat and 15 pounds, no real changes in old habits. Thanks, Live Cell Research.

    Bottom Line: Yes, I would recommend this to a friend

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  • 19 out 20 people found this review helpful


    • San Francisco, CA,
    • Dec 26, 2016
    • Verified Reviewer

    It works great! I am more conscious of what I eat. I have also lost 10 pounds. I was diagnosed with fatty liver. I cannot wait to keep losing and get rechecked.

    Bottom Line: Yes, I would recommend this to a friend

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  • 12 out 12 people found this review helpful

    It worked for me!

    • New Jersey,
    • Jan 3, 2017
    • Verified Reviewer

    It hasn't even been 30 days, and my gut is down by inches. People have been telling me that I look good, and asking if I've lost weight. I cannot be happier telling everyone, and my daughter is now getting results too.

    Bottom Line: Yes, I would recommend this to a friend

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