About LA-3 by Live Cell Research

By HighYa Research Team
Updated on: Nov 14, 2016

LA-3 by Live Cell Research is a nutritional supplement that promises to boost your AMPK levels, resulting in increased energy, clearer thinking, decreased abdominal fat, and a “stronger, healthier body.” For these reasons, Live Cell Research calls LA-3 a “longevity activator.”

How? According to the company, LA-3 contains three different ingredients that have never been combined before, which can provide maximum benefits after just a few months of continuous use:

  • Days 1-7: You may begin experiencing increased energy and reduced appetite and cravings.
  • Days 7-30: Because you’re eating less, you might notice your abdominal fat melting away, further increasing your energy.
  • 1 Month+: After this time, we’re told your AMPK levels should be elevated sufficiently so that your thoughts become clearer and your mind less forgetful. You might also notice that your body is becoming stronger and healthier, along with a continued change in your shape.

To achieve these benefits, Live Cell Research states you'll just need to take two capsules of LA-3 with water per day, with or without food. They also promise that LA-3 can work for anyone, is safe to use with no known side effects, and is third-party tested for safety, purity, and potency.

If you didn’t know better, Live Cell Research’s LA-3 supplement might sound like some fountain of youth and an incredible weight loss program rolled into one.

But what does science have to say about many of the company's claims? Will this supplement work? Is it worth the money? Keep reading to find out what we uncovered during our research.

How Does AMPK Work?

5' AMP-activated protein kinase (or AMPK for short) is “an enzyme that plays a role in cellular energy homeostasis,” and is concentrated in a number of areas throughout the human body, including the brain, liver, and skeletal muscle. AMPK itself is made up of three proteins: STE-related adaptor (STRAD), mouse protein 25 (MO25), and LKB1.

Live Cell Research calls AMPK a “master switch” because this enzyme regulates several key systems within the body, such as increasing cellular energy, stimulating the oxidation of fatty acids and glucose transport, and more.

While the exact details are far outside the scope of this review (and they might make you go cross-eyed), the thing about AMPK is that some fairly specific conditions need to be present for the enzyme to be activated—the primary method of which is muscle contraction (i.e. working out).

Once AMPK is activated, there is some clinical evidence showing it may increase blood supply to muscles, help transport glucose (simple sugars), boost fatty acid metabolism (thereby creating more energy for the cell), and more.

What if you don't want to hit the gym to boost your AMPK levels? Can you accomplish the same thing by popping a couple of LA-3 pills?

Will LA-3’s Ingredients Boost Your AMPK Levels?

According to their supplement label, LA-3 contains the following ingredients:

Of these, WebMD indicates that 30mg daily of gynostemma may be effective for reducing cholesterol. So, at 450mg per dose, LA-3 delivers significantly more than this, although there doesn’t seem to be any clinical evidence indicating that increased gynostemma consumption results in more obvious benefits.

Is ActivAMP a Clinically Proven Ingredient?

Important note: The gynostemma pentaphyllum found in LA-3 is part of a proprietary ingredient named ActivAMP, which is manufactured by a company named Gencor Pacific.

According to their website, in a 12-week randomized clinical trial, ActivAMP was shown to decrease body fat mass and body fat percentage, reduce body weight and BMI, and shrink the total abdominal area.

To see the results for ourselves, we reached out to Gencor Pacific and obtained some of their clinical evidence for ActivAMP, which consists of seven different trials. Here is just a handful:

  • A 2013, 23-week randomized, double-blind, placebo-controlled clinical trial that concluded ActivAMP might be useful for treating obese individuals.
  • A 2012, 8-week study that showed mice “decreased body weight gain, liver weight, and blood cholesterol levels with AMPK activation in the soleus muscle.”
  • A 2011 study showing the ingredient may be effective for improving glucose and lipid metabolism.
  • A 2008 study showing that ginsenosides may have an anti-obesity effective. All results were obtained via cells in a controlled laboratory setting.

Now, we’re not medical experts (which is why we rely on authoritative sites to determine whether or not an ingredient is classified as “effective”), so we have no reason to doubt the findings in Gencor Pacific’s research.

Just keep in mind that results obtained through experiments conducted on mice and cells don’t necessarily mean you, as a human, will experience the same thing.

And even if these studies were conducted on humans, it would require dozens (or perhaps even hundreds) of reproducible, double-blind, placebo controlled, peer reviewed studies before if could be considered “proven” to work as advertised.

For more about this topic, be sure to read Think That Clinical Study Is Legit?

LA-3’s Other Ingredients

Moving on, WebMD also tells us that 1,000mg daily of quercetin (commonly known as jiaogulan) might help alleviate prostate pain and inflammation. But at just 100mg per dose, there doesn’t appear to be enough in LA-3 to provide these benefits.

Finally, WebMD indicates that berberine might also be effective at reducing cholesterol, as well as blood sugar levels in diabetes patients.

Bringing It All Together Regarding LA-3’s Ingredients: What Can You Realistically Expect?

As we can see, there are clearly some clinically validated benefits for the ingredients found in LA-3.

However, according to authoritative websites like WebMD, there doesn’t appear to be enough clinical evidence showing that these ingredients—whether on their own or in combination—can elevate AMPK levels.

Granted, there is some promising research related to AMPK, although most clinical studies have been conducted on mice (including one of the studies for ActivAMP).

So, based on what we learned after reaching out to Live Cell Research, there seems to be little clinical proof that these same protocols will work in humans.

Are There Any Potential Side Effects from LA-3?

Despite the limited evidence showing that these ingredients can boost AMPK levels, the good news is that they’re generally considered safe.

However, WebMD notes that gynostemma pentaphyllum “can cause some side effects such as severe nausea and increased bowel movements.” Also, it’s unknown if taking quercetin for more than 12 weeks is considered safe.

How much will you pay for LA-3’s three-ingredient formulation?

How Much Does LA-3 Longevity Activator Cost?

Live Cell Research’s LA-3 supplement is available in the following quantities:

  • 1 Bottle: $46.99
  • 3 Bottles: $117
  • 6 Bottles: $216

Like all Live Cell Research products, LA-3 comes with a 90-day refund policy, less S&H charges. To request one, you'll need to contact customer service at (844) 650-5933 or support@LiveCellResearch.com.

What Can We Learn from LA-3 Customer Reviews?

Since conducting our original research, 19 LA-3 customers have written about their experience on HighYa, giving the supplement an average rating of 3.8 stars.

Here, most compliments seem to reference effective results, including reduced belly fat, increased energy, improved weight loss, and decreased appetite and cravings.

On the other hand, as is the case with many other nutritional supplements, the most common customer complaint about LA-3 seems related to ineffective (or non-existent) results. In fact, even among those who experienced positive results, several noted that it took several weeks to achieve any effects and that they were fairly mild.

Granted, all of this relates to LA-3 as a product. What about the company who manufactures it?

About Live Cell Research

Live Cell Research is based out of Southern California, where they manufacture a line of popular supplements, including Niagen, Cerastim, Midogen, Vital Stem, and more.

Overall, the company’s supplements seem to come with mostly positive online customer reviews, with common compliments citing effective results. On the flip side, common complaints reference failure to work/achieve results and difficult customer service experiences.

Unfortunately, the company wasn’t listed with the Better Business Bureau at the time of our research.

Is LA-3 the Right Nutritional Supplement for You?

On the one hand, with many of the Live Cell Research products we’ve written about in the past, authoritative websites like WebMD note that the clinical evidence supporting many of the company’s claims is lacking.

On the other hand, many customers claim to have experienced positive results with the company’s supplements—LA-3 included—clinical evidence notwithstanding.

Does this mean you should hand over your hard-earned money for Live Cell Research’s LA-3 supplement? Like any other nutritional supplement, what works fantastically for you might be a total flop for someone else and vice versa.

The seemingly good news is that Live Cell Research offers a 90-day refund window on all of their products, which you can take advantage of if you’re not fully satisfied. Just keep in mind that you'll be out a few dollars for return shipping and handling.

Finally, if you type the phrase “AMPK supplement” or “AMPK activator” into your favorite search engine, you’ll be met with dozens of supplements making many of the same claims as LA-3.

Sure, they might not be formulated exactly like LA-3, but their claims (and general lack of clinical support) are much the same.

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Read 301 LA-3 by Live Cell Research Customer Reviews and Complaints

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Average Consumer Rating: 4.1
Rating Snapshot:
5 star: 145 4 star: 94 3 star: 23 2 star: 12 1 star:  27
Bottom Line: 84% would recommend it to a friend
Showing 1-11 of 301
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  • 85 out 87 people found this review helpful

    LA-3 Did Not Work As Advertised

    • Springfield, OH,
    • Jul 9, 2016
    • Verified Reviewer

    I bought a three month supply of LA-3 and took it from April through June. I took it as directed. I didn't notice any kind of side effects while taking it. I didn't noticed any change to my appetite, energy levels and I certainly did not notice any difference in my waist line. I can not recommend this product at what ever cost it is offered. It simply did not do anything for me.

    On top of the product not working I called their customer service to try to get my money back and they said I was past my 90 days from the date of purchase and they refused to give my money back. I was a few days past my 90 days but I thought they would consider shipping time. So that might be something else to keep in mind when trying their products. Contact them within your 90 days of purchase if you plan to get a refund. My conclusion with this company is their products are over priced and are not worth the high cost.

    Bottom Line: No, I would not recommend this to a friend

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  • 50 out 52 people found this review helpful

    Lose Belly Fat Almost Immediately

    • New York, NY,
    • Nov 21, 2016
    • Verified Reviewer

    I've noticed that since I have been using LA-3 I have lost inches around my waist due to the decreasing amount of belly fat. I've noticed this the first week of taking LA-3.

    Finally, a supplement that does for the body exactly what it promises. I have also lost weight over my entire body that has also been very noticeable. I have one suggestion, and that would be to make a powdered form of this supplement for even better results.

    Powdered form supplements tend to work more efficiently, and faster because it is absorbed by the body instantly. If the LA 3 supplement works wonders in pill form, just imagine how effectively it will work in powdered form? I am sure it will get great results!

    Bottom Line: Yes, I would recommend this to a friend

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  • 48 out 50 people found this review helpful

    This will be my last order

    • Bealeton, VA,
    • Jul 22, 2016
    • Verified Reviewer

    Their customer service sucks, their shipping department sucks, the only thing that works smoothly is the money collecting department. And when you call there, you get put on the back order list. With all that said, buy at your own RISK.

    Bottom Line: No, I would not recommend this to a friend

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  • 43 out 45 people found this review helpful

    Almost a month and belly area shrinking.

    I have been taking two capsules daily for almost a month and my spare tire and bulge above my belly button are getting smaller. So far the only problem I have is with the pungent smell and aftertaste. If these could be corrected, I would rate this product as five stars.

    Bottom Line: Yes, I would recommend this to a friend

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  • 43 out 49 people found this review helpful

    LA-3

    • California,
    • Nov 7, 2016
    • Verified Reviewer

    Put simply, all my Actinic Keratoses, about 15 or so, have resolved completely. A number of them had morphed to precancerous lesions. Poof, gone!

    Bottom Line: Yes, I would recommend this to a friend

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  • 42 out 52 people found this review helpful

    LA-3

    • Mcminnville TN,
    • Oct 28, 2016
    • Verified Reviewer

    My energy level may be up some but little. The decrease in belly fat - possibly an inch or two. I have supplies for 11 more months, maybe I will see a increase. At this time, minimal at the best is all I can say. At this time I doubt if I would recommend this product to anyone.

    Bottom Line: No, I would not recommend this to a friend

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  • 34 out 39 people found this review helpful

    I think it is working, not sure.

    • Atlanta, GA,
    • Dec 7, 2016
    • Verified Reviewer

    I have lost about 20 pounds since I started this supplement about one month or so ago. I find that I am eating less than before. Therefore, I feel this is more of an appetite suppressant that a belly fat remover.

    I have not experienced any side effects that appetite suppressants usually bring about like jitteriness. This is a good thing and I can only hope there are no long-term effects.

    In the past, I have seriously considered Bariatric surgery and thanks to my wife I canceled that notion since so many are having serious health problems if they don't keep up with the supplements. I say this because I think, at this time, I feel this is a good alternative.I rated this 5 stars because this is what it is doing for me now.

    I would not recommend it to a friend until I am convinced it is a safe product since I feel I'm taking a risk by going this route with such a new product.

    My only problem is how to reorder. Does anyone know how to do this?

    Bottom Line: No, I would not recommend this to a friend

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  • 33 out 36 people found this review helpful

    Far better than expected

    • Springfield, GA,
    • Oct 27, 2016
    • Verified Reviewer

    I started two days after receiving them and after 4 weeks I have lost 4 pounds without really changing anything I had been doing before. I have noticed that my overall bulk has decreased in areas that have been PROBLEMS over several years.

    Bottom Line: Yes, I would recommend this to a friend

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  • 33 out 46 people found this review helpful

    I appreciate the opportunity to lessen my deep belly fat.

    I have been taking the recommended dosage (two capsules) each day for a little less than a month. For now, I intend to keep using these capsules and look forward to future progress.

    Bottom Line: Yes, I would recommend this to a friend

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  • 29 out 31 people found this review helpful

    I think it is working

    • Byfield, MA,
    • Oct 9, 2016
    • Verified Reviewer

    It is almost a month since I started on the LA-3 and I am noticing a difference in my body shape. I haven't weighed myself yet, so I don't know if I have lost weight. The stubborn belly fat is still there, but it is getting smaller and I don't feel as bloated. The love handle fat is gone and I was even able to wear a belt with my jeans.

    I don't find that I have any more energy through-out the day but I have been able to do my run almost every morning. I am eating less because I get full much easier. Some nights I don't even finish my dinner. Or I eat just a bit at lunch and then have a little snack later. My eating habits have definitely changed.

    I have probably tried every weight loss pill out there. I can't say yet that this is the magic one, but I will stay on it and see what happens. So far so good.

    Bottom Line: Yes, I would recommend this to a friend

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  • 29 out 29 people found this review helpful

    I'm feeling a difference since starting LA-3

    • Michigan,
    • Aug 7, 2017
    • Verified Reviewer

    Hi.

    I'm a 57 years old, female, fighting the slowdown of menopause along with stubborn upper body fat, mostly belly and upper arms.

    A few weeks in, I started to feel a little more energized. I'm just now finishing my second bottle of 30. I have noticed a decrease in belly fat and a change in my shape, tighter along my waist area. I do exercise and try to eat clean 85% of the time. I've been at this nutrition and exercise faithfully for 2.5 years. I lost 52 lbs after one year. No added diet products. I have been at a plateau for about six months. I recently lost seven pounds during the last 40 days. I still watch what I eat, lift weights and do a cardio minimum of four times a week. I feel like this product is working. I will continue onto my 90 days.

    Thank you.

    Bottom Line: Yes, I would recommend this to a friend

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