What is Active Stem from LCR Health?

By HighYa Research Team
Published on: Jan 4, 2017

Using only five high-quality, science-backed ingredients, LCR Health Active Stem is a new berry flavored supplement formula that promises to boost adult stem cell proliferation, leading to better mental and physical health.

This includes improved cognitive function, enhanced joint and muscle strength, increased longevity, and improved energy levels, as well as anti-aging benefits.

LCR Health submits all batches of Active Stem to third-party testing for purity and potency, and the supplement is manufactured without synthetic additives, magnesium stearate, dairy, or caffeine.

You’re passionate about your health, which is why you want to learn more about Active Stem before handing over your money. Is it a unique product? Will it work as advertised? Are its ingredients really backed by science?

Let’s start answering your questions by taking a look at Active Stem’s price.

How Much Does Active Stem Cost?

  • 1 Bottle (approximately 30 scoops): $46.99 plus $3.95 standard shipping
  • 3 Bottles: $117
  • 6 Bottles: $214.27

All orders $50 and over come with free shipping. Regardless of the amount you purchase, Active Stem comes with a 90-day money back guarantee, less S&H, even if you’ve used the entire bottle.

To request a refund, LCR Health’s customer support department can be reached at 800-384-8308 or support@lcrhealth.com.

What kind of results might you realistically expect for your money?

Are Active Stem’s Ingredients Backed by Science?

One scoop of Active Stem contains the following ingredients:

Are there clinically proven health benefits associated with many of these ingredients? Certainly. For example:

Vitamin D3

Vitamin D3 (and vitamin D in general) plays an important role in calcium and phosphorus regulation inside the body, as well as in maintaining bone structure.

As such, according to authoritative websites like WebMD, vitamin D supplementation may help address softening of the bones, bone loss, and osteoporosis—all conditions commonly associated with aging.

However, these websites indicate that vitamin D supplementation may not be useful for those who aren’t deficient or who are otherwise healthy.


Leucine belongs to a class of essential nutrients known as branched-chain amino acids (BCAAs) that play an important role in muscle health.

Again, though, we're told that there isn't sufficient clinical evidence that l-leucine supplementation can provide any health benefits in humans, or play a role in boosting adult stem cell proliferation.

Blueberry Powder

Blueberry naturally contains high levels of vitamin C and other antioxidants that may help fight free radical damage, and its high fiber content can also boost digestion.

Green Tea

Green tea contains caffeine, which can temporarily boost alertness, while its polyphenol content may help prevent inflammation and swelling and improve joint health.

Like blueberry, green tea is also naturally high in antioxidants that may assist with heart and blood vessel health.


Carnosine is an amino acid (specifically, it’s a combination of the amino acids beta-alanine and histidine) that helps the muscles, heart, liver, kidneys, and brain function and grow properly.

Despite the potential benefits of each of these ingredients, though, authoritative websites indicate there isn’t enough evidence that their supplementation can provide any stem cell-related benefits in humans.

What About the Clinical Evidence Listed on Active Stem’s Website?

On Active Stem’s Research page, LCR Health referenced three studies to support their claims:

A 2010 study conducted by the International Biotechnological Center of MV Lomonosov at Moscow State University, which found “carnosine can be recommended for patients under oxidative stress as a natural remedy having high efficiency and no side effects.”

Unfortunately, nothing else is referenced (such as actual clinical work) to support this conclusion, so we’re not sure how much credence this adds to Active Stem’s claims.

A 1999 study completed by the Department of Biology of Physical Activity at the University of Jyväskylä, Finland, which found that the consumption of BCAAs (30-35% leucine) may play a role in reduced protein degradation and depletion of muscle glycogen stores.

However, they conclude by stating, “Caution must be paid when interpreting the limited number of studies [emphasis ours] in this area since, in many studies, leucine has been supplemented as part of a mixture of BCAA. Consequently, further research into the effects of leucine supplementation alone is needed.”

Finally, the company references another 1999 study on carnosine that found the amino acid may affect fibroblast (a cell in connective tissue that produces collagen and other fibers) rejuvenation.

First, it’s important to note that this study was conducted in vitro; e.g. in a Petri Dish, and not in humans. Second, fibroblasts aren’t stem cells, so we remain unsure exactly how this study supports LCR Health’s claims.

Granted, this is what we've learned during our research from authoritative websites. But what are Active Stem's real-world customers saying?

Active Stem vs. Other Stem Cell Supplements: What Can We Learn From Reviews?

LCR Health & Live Cell Research

Although we didn’t encounter any legitimate feedback for Active Stem at the time of our research (it was too new), after clicking the LCR Health link at the bottom of Active Stem’s ordering page, we were redirected to Live Cell Research’s home page.

As a company, Live Cell Research (and their DBA LCR Health) is based out of Woodland Hills, CA and manufactures a whole line of popular nutritional supplements, including LA-3 and Niagen.

HighYa readers seemed to give Live Cell Research and their supplements an overall average rating of about 3.5 stars, with most compliments referencing health benefits (e.g. increased energy, improved sleep, boosted concentration) and solid service.

Among complaints, the most popular seemed to be that their supplements didn’t work (in our experience, this is the most common complaint related to all supplements, not just those from LCR Health), in addition to billing problems, less-than-stellar customer service, and even some side effects.

Comparing Active Stem & Vital Stem

Will you experience any of the same with Active Stem? Based on their labels, Active Stem and Vital Stem appear to be identical products—right down to the pricing, formulation, and dosing.

On a positive note, of Live Cell Research’s supplements, Vital Stem is their most highly reviewed here on HighYa, with an average rating of 4.4 stars. Most customers referenced benefits like reduced pain, reduced joint stiffness, better sleep, and increased strength and stamina.

Admittedly, everyone's body is different, so this isn't to say you'll achieve any of these benefits, but customer feedback seems highly positive nonetheless.

Are There Other Stem Cell Supplements?

Type “stem cell supplements” into any search engine and you’ll be met with hundreds of results promising to help you accomplish much of the same as Active Stem (including Live Cell Research’s own Vital Stem).

Some of these contain one or more of the same ingredients found in LCR Health’s Active Stem, while others feature completely different formulations.

The problem? Regardless of the formulation, we didn’t encounter any clinical evidence on authoritative websites during our research that directly linked food or ingredient supplementation with a boost in stem cells—adult or otherwise.

We spoke with Nathan Wei, M.D., a board certified rheumatologist with more than 30 years of clinical research experience, who told us:

“The various concoctions that claim to be able to do this through some type of pill, I believe, are shams. There is no credible scientific proof I’m aware of where these concoctions do anything except lighten a person’s wallet.”

Dr. Angie Sadeghi, a board certified gastroenterologist, expressed a similar sentiment when stating:

“If you have deep pockets, and can afford to take a risk of spending thousands of dollars without any potential clinical benefit from these products, go right ahead. Otherwise, I would say hold your horses, as these promises made by nutraceutical companies are driven by money instead of legitimate scientific research.”

Furthermore, we didn’t come across any evidence that the clinical use of stem cells can provide any of the benefits promoted by Active Stem’s manufacturer.

Let’s carry this thought over to the next section as we wrap things up.

Our Bottom Line About LCR Health’s Active Stem Supplement

Stem cells are unspecialized cells that can divide and renew themselves for long periods of time, and can also become other specialized cells. There are two different types:

  • Derived from embryos, embryonic stem cells are known as pluripotent cells, since they can become all cell types; a heart cell, a brain cell, a skin cell, and so forth.
  • On the other hand, adult stem cells can only differentiate into different cell types of the same tissue origin. So, a muscle cell will remain a muscle cell, a skin cell a skin cell, etc.

Both embryonic and adult stem cells are cultured in laboratory environments under very strict conditions. They’re also very fragile, which is why you often won’t find them contained in supplements or creams.

But while the Active Stem website was correct when noting that our body produces increasingly fewer adult stem cells as we age, we didn’t encounter—and the company didn’t provide—any clinical evidence from authoritative websites drawing a link between Active Stem’s ingredients and increased adult stem cell proliferation.

What’s more, there are thousands of different supplements, many of which we’ve reviewed, that contain several of these same ingredients, so they’re certainly not rare.

Based on this alone, we think you might get more value for your money by managing your stress, getting plenty of sleep, taking up an exercise routine (such as walking), and of course, by speaking with your doctor about low energy and any other concerns you may be experiencing.

If you decide to give Active Stem a shot, though, LCR Health stands behind the supplement with a 90-day refund policy, even if the bottle is empty. Just keep in mind that you’ll be out a few bucks in shipping.

Read 17 LCR Health Active Stem Customer Reviews and Complaints

Write a Review
Average Customer Rating: 4.1
Rating Snapshot:
5 star: 12 4 star: 1 3 star: 0 2 star: 1 1 star:  3
Bottom Line: 76% would recommend it to a friend
Showing 1-11 of 17
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  • Absorbent pack in container leaking in the product

    • By Mike T,
    • San Diego, CA,
    • Feb 8, 2018
    • Verified Reviewer

    I started taking Active Stem in the beginning of December 2017 to feel better. I noticed in about half of the Active Stem drinks I had made some little extra pieces at the bottom. Since I always added a 1/2 teaspoon of semi course sugar, I didn't think much of it.

    After this continued, I said this isn't normal. Sure enough, I found a medium size hole in the absorbent bag that sits in the container. To be very honest this did not go over well with me since I was on my second container.

    I called up their customer service number and reported it. The customer service rep offered a replacement bottle and tried to get me to ship it back on my dime. I said no, I want to speak to a supervisor. The supervisor refunded my order and apologized. I was totally shocked that this did not pass quality control and would not recommend this product at all. Very disappointing!

    Bottom Line: No, I would not recommend this to a friend

    • Feb 9, 2018

      Company Response from LCR Health

      Hi Mike, I'm Taylor from LCR Health. I truly appreciate you bringing this to my attention. I am so deeply sorry to hear about the experience that you had. I take these claims seriously and I will make sure that this does not happen again. I am so glad to hear that our customer service department was able to entirely refund your order. Again, I truly apologize for this situation. If you ever have any other concerns or problems, please don't hesitate to reach out to me directly at Taylor@LCRHealth.com, and I will take care of them for you right away.

  • Poor shipping practices

    • By John,
    • California,
    • Apr 23, 2018
    • Verified Reviewer

    I ordered the product on 4/9/18. It's 4/17/18 and it's still not here. "Here" is Fresno, California, just a few hours away from their shipping warehouse. I was supposed to have received a tracking number within 1-3 business days-no number. I just got off the phone with one of their reps who told me that my order was still in their warehouse. What the heck? What kind of business and service is this?

    Bottom Line: No, I would not recommend this to a friend

  • Thinking about it!

    • By Maryluz R.,
    • West Springfield, MA,
    • Nov 28, 2018
    • Verified Reviewer

    I have not tried this product but decided to look into it a little more before trying it. I do wonder if these products are just a temporary fix while you use it only to keep you buying this product. This is a little expensive for a dietary supplement.

    Bottom Line: No, I would not recommend this to a friend

    • Nov 28, 2018

      Company Response from LCR Health

      Hi Maryluz, my name is Taylor with LCR Health. Thank you for taking the time to share your feedback! Our products are extensively researched and contain only the highest quality ingredients. We also offer a risk- free purchase; if you are unsatisfied or unchanged with Active Stem, you are able to return the product within 90 days. If you have any outstanding questions or concerns, please email me at taylor@lcrhealth.com and I will be more than happy to assist you.

  • Two weeks in

    • By Wild J.,
    • Montana,
    • Jul 10, 2018
    • Verified Reviewer

    First thing I noticed is that it does not mix easily in water as stated, so not readily water-soluble. Even after serval hours and sever shaking in a glass bottle, there is a large amount of gritty sediment! The taste, although not pleasant, it is also not repulsive. Now at two weeks no positive effects. But I do seem to have more muscle and joint pain than before? I will continue for a full month before returning.

    Bottom Line: No, I would not recommend this to a friend

    • Jul 10, 2018

      Company Response from LCR Health

      Hi Wild, my name is Taylor with LCR Health. Thank you for taking the time to give us feedback on Active Stem. First, increased muscle and joint pain is not a typical side effect of Active Stem so please consult your physician to ensure that this product is right for you. Once you receive your physician’s approval, I recommend using a shaker bottle or blending Active Stem into your morning smoothie to help the powder mix smoothly. Please feel free to reach out to me at taylor@lcrhealth.com with any updates, questions, or concerns!

  • Still too early to tell much.

    I've been using the product for a few weeks, and feel that it may have some health benefits beyond what I was hoping for. I'd like to give it a full 3-month trial before weighing in officially. Initially, I feel that I may be sleeping better, my skin seems to have improved quite a bit, and just generally feel better.

    Bottom Line: Yes, I would recommend this to a friend

  • Fast, efficient service and excellent supplement!

    • By Barbara Hoffman,
    • Prince George, British Columbia, Canada,
    • Mar 8, 2017
    • Verified Reviewer

    The customer service and speed of delivery were exceptional. I am an Anthropologist and take my health seriously because no one else will. We, as individuals, are responsible for our health and well-being. I researched many supplements, and Active Stem is one of the few that have an iron-clad, 90-day money back guarantee. It can't get any better than that. The product works, hence the confidence of their products!

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 19, 2017

      Company Response from LCR Health

      Hi there, I'm Taylor from LCR Health. We are a reputable company that would absolutely never post fake reviews, or have people post fake reviews. That would be highly unethical. Each honest review is made from a real customer. If you would like, I would be more than happy to send you one free product so you can make a more accurate decision about our company. If you are interested, my email is Taylor@lcrhealth.com. I look forward to hearing from you!

  • Yes, it works!

    • By Sherri,
    • Illinois,
    • Jun 19, 2017
    • Verified Reviewer

    I have been on Active Stem for approximately four months, and it works! I had cancer, and after my surgery and my recovery, which was long and with many setbacks, I got back on my feet. I had no energy, I didn't care about much of anything, couldn't sleep, had aches and pains, so I decided to try this product.

    After the first month, I felt like a human again. I had energy, I wanted to get things done, I worked in my yard, got my house work done, went back to cooking, slept well and just felt wonderful! I felt like me again before I got sick!

    I was off of it for about a month, and holy moly I could tell the differences! So I ordered it again and got to feeling like me again. Now I'm out and having a fit waiting! It's a marvelous thing, and it does work. I WON'T run out again!

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 19, 2017

      Company Response from LCR Health

      Hi Sherri, thank you so much for taking the time to leave us a review. I am so happy to hear that you had more energy, and you were able to be more productive. This is great news! On behalf of everyone at LCR Health, we are so honored to be a part of your journey! If you ever happen to have any questions, please feel free to reach out to me at Taylor@LCRHealth.com.

  • Pleasantly surprised

    After reading about this product online, and also reading a LOT of "warning scam" alerts about this product, I decided to try it anyway. I'm 51, I had recently been diagnosed with Gallstones, I was tired ALL the time, my brain was foggy most days, and overall I just felt run down.

    After 30 days I was still a bit skeptical, hadn't noticed much of a change, but now, after about 90 days, I feel SO MUCH BETTER! I have more energy, I feel sharp, I'm remembering minor details for work, so much so that people are coming to me for clarification. It's awesome! To be fair, it's important to take into consideration that I also changed my diet as part of a major life change to holistically fix the issues I was having. I eliminated most sugar, dairy, coffee, gluten and fatty/processed foods.

    Overall, I feel half my age, and I am confident that the addition of Active Stem played a part in my turn-around.

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 19, 2017

      Company Response from LCR Health

      Hi Cherie, I'm Taylor from LCR Health. I am so thrilled to hear that Active Stem has really turned your energy and clarity around! The fact that it is also affecting your productivity in the workplace is amazing too! We are so glad we were able to assist you with this. Thank you so much for letting us know about your major life change! If you ever have any questions along the way, please feel free to email me at Taylor@lcrhealth.com. Take care!

  • Blood work review

    With all blood work as far back as I can remember, it has been known that I had thalassemia minor (size of the blood cells smaller than commonly seen and known predominantly in those of Mediterranean descent). I am second generation American-born 100% Italian, and my family is from Pico, Italy. Prior to starting Active Stem, blood work showed the same. After taking Active Stem for three months, blood work was done and showed the size of my blood cells were larger. My doctor was impressed and said he had never seen a change in size of blood cells before. It also showed improvement in all other readings.

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 19, 2017

      Company Response from LCR Health

      Hi Linda! Wow! What a huge, and positive change! On behalf of everyone at LCR Health, we are so honored to be a part of this journey with you! Thank you so much for telling us your story. If you ever have any questions along the way, please feel free to email me at Taylor@LCRHealth.com. Take care!

  • Great results

    • By Kim Wilson,
    • Coco Beach, FL,
    • Sep 5, 2017
    • Verified Reviewer

    As with any product a person tries, you hope for the best, but part of you doubts you'll see any big changes.

    As a former health food store owner, I'm always interested in new products. My first order was for my son who has many health issues and wanted to try Active Stem. The benefits were amazing. He has connective tissue problems that lead to joint pain and stiffness. Genetic testing showed he, and many of us in the family, had an inability to utilize Vitamin D efficiently. After two weeks of taking Active Stem, he was noticeably more active and complained about his knees, elbows and back far less.

    By the time our second order was placed, I had decided to try it myself. After three days (I know that sounds crazy, but yes, just three days), I was going up the stairs at my mom's house, and she told me to go back down and come up again. I didn't know why she would ask me to do that, but I did. Upon going back up the second time, she asked me if I realized I wasn't using the hand rail and I wasn't saying "ouch my knee" under my breath. I guess I never realized I said that, but on this day I did not say it. I told her about taking Active Stem, and she was shocked that anything could work that quickly.

    As I do with other products, I stop taking them and start back later to see if the difference was in my head or something that I could recreate. I can honestly say at this point, my knees do not hurt when I use the stairs anymore. My son is almost finished with his sixth container, and I have to order more today.

    If I hadn't tried it and seen the amazing results, I wouldn't have believed it. Life is short, and taking a chance on a new product is a small thing to do if there's a chance it can improve your quality of life. I can only hope others have the success we have had with it helping our joint stiffness and pain.

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 19, 2017

      Company Response from LCR Health

      Kim, thank you so much for telling us about your experience with Active Stem, as well as your son's experience. This was so beautiful and touching to read! The fact that our product could help with the issues that you both were having is more than we could ever ask for. On behalf of everyone at LCR Health, thank you for allowing us to be a part of your journey! If you ever have any questions, please feel free to reach out to me at Taylor@LCRHealth.com. Thank you!

  • It really works

    I bought the Active Stem because of what it said on the internet video. Your body will begin to feel good. I am 62 years old, and I don’t exercise the way I should. But the reason was my body was sore and was tired all the time. I have to drink an energy drink just to get the energy to do my everyday things, so exercise was last on my list.

    I got my package pretty quick, so I took my first drink that day and within 30 minutes my body felt different. I was able to stand from sitting without soreness. I said, "Whoa, that is amazing." So I test it again. I ran up the stairs. I have not been able to run upstairs since I turned 59. So I cannot wait until after two weeks of drinking this to see what happens and maybe I will send another review then.

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 19, 2017

      Company Response from LCR Health

      Hi Juanita! Thank you so much for taking the time to leave us a review. I am so thrilled to hear that you have seen such a big difference since you started using Active Stem! This is such amazing news. I would love to hear about your experience after the two-week mark. If you would like, you can email me at Taylor@LCRHealth.com. I would love to hear from you!

Showing 1-11 of 17

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