About Nucific BIO X4

Billed as a 4-in-1 weight management probiotic, Nucific BIO X4 claims to be a “revolutionary new compound” containing 4 proven nutrients that provide digestive support, suppress appetite, and support weight loss management. This includes:

  • 39 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins,
  • Green tea to boost your metabolism, and
  • Caralluma Fimbriata to suppress cravings.

Despite these benefits, Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regular and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1-2 months.

Whether you’re just starting with a weight loss regimen or have been at it for years, can Nucific BIO X4 provide the digestion support you need to break through your barriers? Consider the following:

Is BIO X4’s Ingredients Effective for Weight Loss?

According to BIO X4’s product label, the supplement contains:

  • Probiotic Blend: 4 billion CFU per capsule – Lactobacillus acidophilus, L. rhamnosus, L. plantarum, Bifidobacterium lactis, B. animalis.
  • Digestive Enzyme Blend: 88mg – Amylase (from Aspergilus Oryzae), Bromelain, Lipase (from Rhizopus Oryzae).
  • Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)
  • Craving Control Blend: 166mg – Caralluma Fimbriata Extract

As we detailed in our Probiotics Buyer’s Guide, probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data proving them to be effective.

Note: Although BIO X4’s website claims that it contains 39 billion CFUs, each capsule only contains 13 billion. In other words, by taking 3 capsules per day, you’ll cumulatively be ingesting 39 billion CFUs. This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

Amylase is “an enzyme that catalyses the hydrolysis of starch into sugars,” and bromelain “is an enzyme found in pineapple juice and in the pineapple stem” that’s used for “reducing swelling (inflammation), especially of the nose and sinuses, after surgery or injury,” and more. Finally, lipase “is an enzyme that catalyzes the hydrolysis of fats (lipids).”

While there are multiple studies related to the oral administration of amylase, clinical support for many of BIO X4’s claims appears to be on the slim side. Likewise, except for treating osteoarthritis and preventing muscle soreness after exercise, there isn’t enough clinical evidence showing that bromelain can provide other benefits.

And other than treating digestive problems related to pancreatic disorders, there is insufficient clinical evidence showing that lipase can provide any other benefits. Similarly, there isn’t enough clinical evidence showing that caralluma can provide any benefits, either.

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits, although there is insufficient evidence supporting any of them.

BIO X4 Side Effects

As with most nutritional supplements, even though many of BIO X4’s ingredients may not provide the benefits claimed by the manufacturer, they should be well tolerated by most individuals.

However, the probiotics in BIO X4 may cause a temporary increase in bloating or gassiness, although this side effect should resolve itself over the course of a couple days. Caralluma might also lead to gas, constipation, or stomach pain, which should subside after a week of use.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants.

Nucific’s Arbitration Agreement

Finally, it’s important to note that by placing your order for BIO X4, you’ll automatically be bound by an arbitration agreement.

Although this is a fairly common practice among companies who sell most of their products online, if you experienced any damages from using BIO X4, this means that your legal recourse against Nucific would be extremely limited, including becoming part of a trial by jury or joining a class action lawsuit.

What’s the Customer Buzz about Nucific BIO X4?

BIO X4 was a very new product at the time of our research (Nucific’s URL was registered in April 2015 and the company’s trademark was filed in June of 2015), so there weren’t any online reviews available.

Since Nucific is such a new company, they also weren’t listed with the Better Business Bureau.

Nucific BIO X4 Pricing & Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle (30-day supply): $49
  • 3 Bottles: $129
  • 6 Bottles: $240

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. Although no further details were provided, you’ll need to contact Nucific’s customer service department at 888-679-5520 or support@nucific.com in order to request a refund.

Can Nucific BIO X4 Support Digestion & Weight Management?

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor. On top of this, all of the supplement’s other ingredients have insufficient evidence to back up Nucific’s claims.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

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810 Consumer Reviews for Nucific BIO X4

Average Consumer Rating: 4.4
Rating Snapshot:
5 star: 537 4 star: 186 3 star: 21 2 star: 22 1 star:  44
Bottom Line: 91% would recommend it to a friend
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  • Helps prevent bloating when traveling

    I find that BIO X4 improves my digestion and consequently softens my stool, especially when I am eating a high-carbohydrate diet and when I am eating different foods from my normal diet while traveling. Symptoms of gas and bloating are now non-existent, and I feel comfortable after eating regular meals. This makes taking BIO X4 before meals easy and pleasant!

    Bottom Line: Yes, I would recommend this to a friend

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  • BIO X4

    I am very happy with BIO X4. I have recommended it to my family and friends. I have seen amazing results from using the BIO X4. I will continue using all of their products, I'm losing weight, and I have more energy. I'm also using the powder every day and the results are amazing as well.

    I'm truly very happy with the product and my sister and my auntie are also using both products and are amazed at the results. We are able to do our daily walks on the boardwalk. With all the extra energy we have, we are even trying to sign up for the gym.

    We sincerely thank you from our hearts. From my family to yours, have a wonderful HOLIDAY.

    Bottom Line: Yes, I would recommend this to a friend

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  • Relief and anticipation for future results

    I am loving this product. Taking consistently now for 3 months. I’ve definitely had positive results including better digestion, much better bathroom habits, loss of inches (8 so far) and no more cravings. Of course, this goes along with eating healthy and working out smartly. This is part of my life now.

    Bottom Line: Yes, I would recommend this to a friend

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  • Good product

    I like the product because it improves my digestion and energy levels. I feel fresher and cleaner on the inside as a result of the probiotics in the product. I will definitely continue to utilize it to continue to maximize the positive effects.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Noticed improvement

    • Ontario, Canada,
    • Nov 21, 2017
    • Verified Reviewer

    I have not completed my supply yet but noticed improvements in the digestion of foods, less bloating of the stomach, reduced frequency of headaches, and combined with drinking more water, my appetite seemed to be reduced.

    Bottom Line: Yes, I would recommend this to a friend

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  • Awesome weight loss product

    I use to be 180 lbs, and I’m now at 150 lbs. I was flabbergasted. That’s why I feel this product is #1. And I’ve tried everything. And nothing worked. I gave BIO X4 a try and the pounds just fell off. I did exercise and change my eating. Thank you for the awesome results.

    Bottom Line: Yes, I would recommend this to a friend

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  • Good so far

    I am losing a little bit, but I am not discouraged yet. My husband is also trying it. We will keep going and hopefully lose what I need to. Thanks so much for a product that seems to be working. I just ordered some more.

    Bottom Line: Yes, I would recommend this to a friend

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  • A godsend!

    • Maumee, OH,
    • Nov 20, 2017
    • Verified Reviewer

    I have been taking BIO X4 since the middle of September and have lost 24 pounds! I have belonged to health clubs for over 30 years and go swimming 3 or 4 times a week, and I could never figure why I never lost weight. This product has been a godsend to me!

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Thank you BIO X4!

    • Folsom, CA,
    • Nov 20, 2017
    • Verified Reviewer

    I have experienced bloating and digestion issues for years. I thought it was allergies, but I could never identify the source. I’ve been taking BIO X4 for 3 months now. My issues are completely gone. I haven’t lost weight, but I have noticed I am not as hungry all the time. Now that I’m feeling better I am looking forward to adding more exercise to my routine.

    Overall a great product. Adding to a reasonable diet and exercise is exactly the routine I need to control my weight and digestive functions.

    Bottom Line: Yes, I would recommend this to a friend

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  • Using Nucific BIO X4

    • Kannapolis, NC,
    • Nov 20, 2017
    • Verified Reviewer

    I've been using Nucific BIO X4 for about 5 weeks. I believe it is a good product but on my last doctor checkup, my thyroid readings for my test were not good so I'm trying to get my medication adjusted. I had to suspend using BIO X4 for now and will begin again after getting thyroid reading more in line.

    Bottom Line: Yes, I would recommend this to a friend

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  • Wonderful find

    After experiencing some overactive probiotic products recommended by doctors, I tried Nucific’s BIO X4 and am very happy with this product. It satisfies the probiotic digestive help without any irritable issues. Highly recommend. I️ already have!

    Bottom Line: Yes, I would recommend this to a friend

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