What Is Probiogen?

By Derek Lakin
HighYa Staff
Published on: Jul 20, 2017

Using their SmartSpore technology, Probiogen’s lineup of seven probiotics-based supplements promises to help support the growth of good bacteria, boost digestive health and regularity, reduce gas and bloating, promote a healthy immune system, and support mood and energy.

Compared to other probiotics, the company claims their bacteria strains boast 100 times better survival—they’re even clinically proven to outlive the leading probiotics and yogurt. According to the company, these supplements are also effective when used in conjunction with antibiotics treatments, making them effective condition-specific formulas for the entire family.

In addition, using DNA verification techniques, Probiogen guarantees the potency of their supplements, and that they contain the level of probiotic bacteria advertised on their label. No refrigeration needed.

What’s the bottom line about Probiogen’s probiotics? Will they provide a meaningful difference in your health? Even then, will they deliver a better value than the competition?

Let’s start with the basics.

What Are Probiotics & What Benefits Do They Provide?

We’ll be brief: Probiotics are beneficial bacteria that primarily live in our digestive tract (informally known as the gut) and contribute to a wide range of benefits, including digestion and immune function.

Sometimes however, whether due to a recent illness (and a subsequent round of antibiotics), eating a poor diet, or excessive stress levels, these beneficial bacteria can become outnumbered by bad bacteria. This can then lead to a host of side effects like gas and bloating, weight gain, increased illness, and reduced energy.

But by purposely replacing these lost beneficial bacteria strains through probiotic supplements, many have been clinically proven over the course of decades to potentially help balance gut flora.

In the instance of Probiogen's formulas, the company claims their Smart Spore strains are unique in that they already exist in the gut (and in a higher concentration), can survive the harsh environment found in the digestive tract, and that are stable in both the gut and the environment.

What other ingredients are found in their supplements?

Which Ingredients Will You Find in Probiogen’s Probiotics Lineup?

Each product description on the Probiogen website was very similar (some might say essentially identical), so the only meaningful differences we found between each formula were listed on their product labels—specifically, the ingredients they contained. Let’s take a closer look at each one:

Daily Digestive Balance

A once-daily formula designed around dairy-free spores, with eight billion CFU of the probiotic strains Saccharomyces boulardii, Bacillus clausii, Bacillus subtilis HU58, and Bacillus coagulans HC.

According to their summarizations of the available clinical evidence, websites like the Natural Medicines Database, WebMD, and the National Institutes of Health’s PubMed indicate that Saccharomyces boulardii may help some types of diarrhea (associated with antibiotics and feeding tubes, caused by Clostridium difficile, related to HIV, and traveler’s).

It may also help improve the appearance of acne and reduce ulcers caused by Helicobacter pylori.

PubMed hosted nearly 100 clinical studies and papers related to Bacillus clausii at the time of our research, although it wasn’t listed as effective or possibly effective for any specific conditions when taken as a supplement.

While B. subtilis is often used in laboratory environments to produce enzymes and hyaluronic acid, we didn’t encounter any reported clinical evidence for its benefits in humans. This same lack of reported benefits also held true for Bacillus coagulans HC.

Women’s Vitality Probiotic

A Probiogen supplement that’s focused on women’s urinary health and balanced vaginal flora. Contains nine billion CFU of Bacillus clausii, Bacillus subtilis HU58, Lactobacillus acidophilus DDS-1, Bacillus coagulans HC, along with 600mg of cranberry whole fruit concentrate.

In addition to what we’ve already discussed, Lactobacillus acidophilus is one of the most common species found in probiotic supplements today, since it's reported to potentially help address rotaviral, chemotherapy-induced, and antibiotic-associated diarrhea; hayfever, eczema, bacterial vaginosis, high cholesterol, rheumatoid arthritis, and irritable bowel syndrome (IBS).

Specifically, according to the evidence posted on the creator’s website, the DDS-1 sub-strain promises to be more lactose tolerant than standard Lactobacillus acidophilus.

Finally, these sites report that 30-300 ml of cranberry juice may help prevent urinary tract infections when taken daily for six months.

Men’s Vitality Probiotic

According to the Probiogen website, this contains prostate health-focused nutrients like 150mg of saw palmetto and 150mg of boswellia extract, along with four billion CFU of Bacillus coagulans, Bacillus clausii, and Bacillus subtilis HU58.

We’ve already discussed the formula’s other bacteria strains, with the exception of Bacillus coagulans. This is another exceptionally popular option included in probiotic supplements, although WebMD, MedlinePlus.gov, and the Natural Medicines Database indicate there’s insufficient clinical evidence it can provide benefits in humans when taken as a supplement.

Adult 55+ Probiotic Multi

In addition to three billion CFU of Bacillus coagulans HC and Bacillus subtilis HU58, this powdered Probiogen supplement features multivitamins and minerals that promise to meet the specific nutrient needs of seniors:

  • Vitamin A 900mcg
  • Vitamin C 400mg
  • Vitamin D3 30mcg
  • Vitamin E 300mg
  • Vitamin K 180mcg (Vitamin K1 90mcg, Vitamin K2 90mcg)
  • Thiamin 1.2mg
  • Riboflavin 1.3mg
  • Niacin 15mg
  • Vitamin B6 1.7mg
  • Folic Acid 400mcg
  • Vitamin B12 250mcg
  • Pantothenic Acid 5mg
  • Calcium 1,200mg
  • Iron 6mg
  • Magnesium 350mg
  • Zinc 12mg
  • Selenium 70mcg
  • Copper 1.5mg
  • Chromium 50mcg

While all of these vitamins and minerals can play key roles in our health, many respected organizations like the American Cancer Association, the American Heart Association, and the American Academy of Family Physicians (to name just a handful), report that their supplementation is unnecessary for otherwise healthy individuals.

In other words, unless you’re deficient in one of these substances, they report that you might not experience meaningful benefits. If you believe you're deficient, be sure to speak with your doctor before taking any supplement, whether from Probiogen or otherwise.

Allergy Defense Probiotic

This supplement is focused on supporting a healthy immune system for allergy relief using 250mg of vitamin C, 25mg of magnesium, and a 550mg proprietary Allergy Defense Herbal Blend with Stinging Nettles, Bromelain, Quercetin Dihydrate, and N-Acetyl-L-Cysteine.

The probiotic blend includes Bacillus clausii and Bacillus subtilis HU58.

None of the sites mentioned above listed any of these ingredients as having sufficient clinical evidence showing they’re effective for addressing allergy symptoms. However, magnesium is reported to possibly help ease indigestion, which could potentially be caused by excessive drainage related to allergies.

Weight Management Probiotic

Uses a 525mg blend of nutrients focused on weight management, including naringin bioflavonoid, bitter orange extract, hesperidin bioflavonoid, and acetyl-l-carnitine. You’ll also find two billion CFU of the spore strain Bacillus subtilis HU58.

Acetyl-L-Carnitine seems to have many potential brain-related benefits, although neither it, nor any of this formula’s other ingredients, were reported as having sufficient clinical evidence that they’re effective for weight management.

Stress and Mood Balance Probiotic

Contains 100mg of magnesium, combined with an 800mg blend of ashwagandha, lemon balm, sage, l-theanine, and holy basil. It also contains two billion CFU of Bacillus coagulans HC and Bacillus subtilis HU58, all intended to help manage stress, improve focus, and promote relaxation.

The Natural Medicines Database lists two studies indicating that lemon balm may help reduce anxiety, although no dosages are referenced, and one of these studies involved a formula of 13 total ingredients. The NMD also indicates that theanine may help boost cognitive performance, but not that it—or any other ingredients—have sufficient evidence that they can affect stress or mood.

Are There Any Potential Side Effects Related to Probiogen’s Ingredients?

With such a broad expanse of ingredients, the authoritative sites above reported a wide variety of potential side effects related to the ingredients found in Probiogen’s formulas. These ranged from mild digestive upset (magnesium and zinc, as but a couple of examples) all the way to severe side effects.

Regarding this last point, WebMD reports that, “bitter orange is possibly unsafe when taken as a supplement for a medical purpose such as weight loss. Bitter orange, particularly when taken with stimulants such as caffeine or caffeine-containing herbs, increases the risk for high blood pressure, fainting, heart attack, stroke, and other severe side effects.”

How Much Do Probiogen’s Supplements Cost?

Probiogen’s formulas are priced as follows:

  • Daily Digestive Balance (30 capsules): $39.95
  • Women’s Vitality Probiotic (60 capsules): $44.95
  • Men’s Vitality Probiotic (30 capsules): $44.95
  • Adult 55+ Probiotic Multi (36 scoops): $44.95
  • Allergy Defense Probiotic (60 capsules): $49.95
  • Weight Management Probiotic (120 capsules): $49.95
  • Stress & Mood Balance Probiotic (120 capsules): $49.95

Through their standalone TV offer, a 30-day supply of Probiogen’s Daily Digestive Balance formula is available at two price points:

  • $29.95 plus $6.95 S&H
  • $29.95 plus free S&H with VIP Membership

If you choose the second option, you’ll continue receiving a fresh supply of Daily Digestive Balance once every 30 days and charged $29.95 each time.

Finally, many of Probiogen’s formulas can be found at online retailers like Biovea, Jet.com, Lucky Vitamin, Amazon, and Walmart, as well as in-store at Bed Bath & Beyond, Meijer, and Walgreens.

Regardless of the formulation, Probiogen’s direct-purchased supplements come with a 30-day refund policy, less S&H. In order to request one, support can be reached at 800-983-2930 or customerservice@probiogen.com.

What Can We Learn From Probiogen Customer Reviews?

On Amazon, Probiogen’s different formulas had anywhere between one and six customer reviews at the time of our research, with an overall rating of about five stars. We also found several reviews across Walmart’s and Biovea’s sites.

There, most compliments appeared to revolve around improved gut health, ease of use, and competitive price. No complaints were cited.

Despite this seeming popularity, the company wasn’t listed with the Better Business Bureau at the time of our research.

How Does Probiogen Compare to Other Probiotic Supplements?

Because of the decades of clinical evidence behind many of these beneficial strains, as well as the mostly positive feedback from customers, thousands of different probiotic supplements have made their way to market over the last several years.

In other words, there’s perhaps been no better time to be in the market for a probiotic supplement. On the flip side of the coin, though, the sheer number of formulations and price points might make your head spin. How to cut through the crowd?

In our probiotics buyer’s guide, we outline that you’ll want to focus on supplements that:

  • Don’t cram a bunch of extra stuff into their capsules,
  • List all of the probiotics strains (including their potency, or colony-forming units) on their label,
  • Isn’t overly expensive compared to the competition, and
  • Comes with mostly positive feedback from consumers (it’s impossible to please everyone).

How does all of this stack up for Probiogen?

Our Final Thoughts About Probiogen’s Probiotic Formulas

Although Probiogen’s formulas contain additional ingredients, their online customer reviews—while limited—seemed to indicate that most customers were pleased with their supplements’ performance, despite the fact that it was priced meaningfully higher than many other probiotic formulas.

And while the Research page on the company’s website indicated that a “Simulated Gastric Survival Study” proves Probiogen’s SmartSpores survive 100X better than other strains, none of this was available for third-party review. We reached out and will be sure to update this article as soon as a response is received.

They also listed each of their strains and their colony-forming unit (CFU) count, and offered a 60-day refund policy on all orders. So, if one of their formulations doesn’t meet your expectations, you might not be out more than a few bucks in shipping charges.

And you might even be able to save on these S&H fees if you find a Probiogen supplement at a local retailer.

See Also: Can Probiotics Help You Lose Weight? How One Study Almost Got Us to Say Yes

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