Using a patented, eight-in-one formulation, Proflexoral is a double action dietary supplement that promises to relieve joint stiffness and pain, soothe inflammation, increase mobility, and rebuild your cartilage and joint material destroyed by the aging process—without the potentially dangerous side effects associated with pain relievers.
In fact, the website tells us the supplement has even been shown to outperform popular OTC medications and prescription drugs by easing pain in as little as 15 minutes, while steadily improving mobility and stiffness over the course of 24 hours. When used on a regular basis, they claim some patients have reported a reduction of 87 percent in their pain management costs.
All of this sounds great in principle, but will you find that Proflexoral delivers on its marketing promises once you have the supplement in your home? Does it actually represent a beginning to your pain-free life?
Let’s start by taking a look at some of the most common underlying causes of joint pain.
Joint Pain Basics: Common Causes & Treatments
Like pain in any other part of the body, joint pain can be caused by an innumerable number of injuries, infections, and diseases, as well as inflammation. Although, because joints are designed to provide support and help you move, pain in these areas can often be especially impactful in your day-to-day life.
With this in mind, WebMD reports that some of the most common causes of joint pain—which is thought to affect one-third of American adults—include “osteoarthritis, rheumatoid arthritis, bursitis, gout, strains, sprains, and other injuries.” Knee pain seems to be most common, with shoulder and hip pain following close behind.
After speaking with your doctor and undergoing the appropriate tests (if necessary), the treatment they prescribe will largely depend on where your joint pain is occurring, what’s causing it, and how severe it is.
Common options include “over-the-counter or prescription nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), or naproxen sodium (Aleve),” along with heat and ice therapy. If severe enough, your doctor might recommend more intensive options like muscle relaxants or antidepressants, fluid removal from the joint, injecting hyaluronan (synthetic joint fluid), or physical therapy.
Comparatively, what does the scientific community have to say about the ingredients contained in Proflexoral? Will it provide a similar level of pain relief as any of these options, but without the potential side effects?
Taking a Closer Look at Proflexoral’s Ingredients
The exact ingredients contained in Proflexarol’s formula seemed to depend on where we looked at the time of our research. For example, taking a look at Healthy Living Association’s main URL, the following ingredients were listed:
Pea Protein, Spirulina, Chlorella, Barley and Wheat Grass, Probiotics, CoQ10, Organic Vegetables, Organic Fruits, Cinnamon, Turmeric (150 mg), Acerola Cherry, Flax Seeds, Chia Seeds, Cocoa Powder, Kelp, Milk Thistle, Dandelion Root, Digestive Enzymes, Ginseng, Ginger, Aloe Vera
On the other hand, their Order page added the following ingredients:
Boswellia Serrata Resin Extract (200 mg), Glucosamine, Chondroitin, Quercetin, L-Methionine, MSM, Bromelain, Potassium
We emailed the company for clarification, including a copy of the supplement facts label and dosage details, but hadn't received a response as of publishing.
With this in mind, the HighYa team relies on the summaries of the available clinical evidence, as provided by sites like WebMD, Examine.com, and the Natural Medicines Database, to determine whether or not an ingredient is classified as ‘effective’ for a given claim.
And according to them, there’s insufficient clinical evidence that most of the ingredients found in Proflexoral’s formula will address joint pain in any way. However, there are several they indicate could show promise:
Turmeric & Osteoarthritis
According to these sites, there is some research showing that taking 500 mg of turmeric, anywhere between two and four times daily and for a period of one to three months, can reduce pain and improve function in individuals with osteoarthritis. In some instances, it worked about as well as OTC and prescription medications, while in others it did not.
Ginger & Osteoarthritis
Along these same lines, there’s some evidence that taking between 170 mg and 500 mg of ginger, two to four times daily and over the course of one to three months, could provide a variety of benefits, including:
- Reduced arthritis-related pain in the hip and knee
- Reduces pain upon standing, pain after walking, and stiffness
- Short-term relief from knee stiffness and pain
Sometimes, patients reported relief about as well as ibuprofen; sometimes not.
Glucosamine & Osteoarthritis
Taking between 500 mg and 1,500 mg of glucosamine one to three times daily, alone or in combination with chondroitin (more next) and for between six weeks and three years, has been shown to reduce osteoarthritis-related knee pain about as well as some OTC pain relievers.
However, these sites point out that, whether contained in a standalone supplement or a multi-ingredient formula like Proflexoral, glucosamine doesn’t seem to work for everyone. Specifically, it seems that the longer your symptoms have been present and the more severe they are, the less likely it is that glucosamine might provide some measure of relief.
Chondroitin & Osteoarthritis
These sites indicate the clinical research on chondroitin’s effectiveness is “inconsistent,” although some studies report that taking between 800 mg and 2,000 mg, one to three times daily and over a period of three to six months, could help relieve osteoarthritis-related knee or hand pain. However, they emphasize the “pain relief is likely to be small at best.”
Often times, chondroitin is combined with glucosamine sulfate or glucosamine hydrochloride, which some studies have shown might reduce pain and improve joint function in those with osteoarthritis of the knee.
What About the BSE Frequently Mentioned on the Proflexoral Website?
Since the ingredient is referenced so often in the marketing material, we thought it would be a good idea to quickly discuss the available clinical evidence surrounding it.
BSE is short for Boswellia Serrata Extract, a gum-like resin procured from the Boswellia carteri tree, perhaps more commonly known as frankincense. While the Proflexoral website is correct when mentioning that this has been used for centuries, the above sites report there remains insufficient evidence that ingesting it orally can have any beneficial effects in humans, whether related to joint pain or otherwise.
While this is the reported cumulative evidence, the manufacturer references two studies to support their claims for Proflexoral:
- A 2003 study conducted at the Indira Gandhi Medical College in Nagpur, India, which found that among 30 participants with osteoarthritis of knee, BSE supplementation decreased knee pain, increased knee flexion, and increased walking distance.
- A 2006 study conducted at the Government Medical College in Kansari, India. It found that among those given BSE in combination with two months of physical therapy, it reduced pain, stiffness, and difficulty performing daily activities about as well as the drug valdecoxib. However, it had a slower onset but tended to last longer.
Potential Proflexoral Side Effects
According to the Proflexoral website, “Patient studies have reported no adverse side effects” related to the supplement as a whole.
However, WebMD and the Natural Medicines Database point out that cocoa contains caffeine, which can cause stimulant-related side effects such as nervousness, jitteriness, and insomnia, especially if you’re sensitive.
In some instances (no dosages or other specifics provided), milk thistle can have a laxative effect. And because Panax ginseng “may have some hormone-like effects that could be harmful with prolonged use,” they don’t recommend taking it for more than six months at a time.
Finally, they report that turmeric and ginger can have mild interactions (again, no dosages or specifics provided) with blood clotting medications. Cocoa can also have a slew of potential drug interactions, so be sure to speak with your doctor before taking any new dietary supplement to avoid potential side effects and medication interactions.
How Much Does Proflexoral Cost?
Proflexoral is only available from the manufacturer at the following prices:
- 1 Bottle (90 capsules): $39.99
- 1 Bottle (w/autoship): $29.99
- 4 Bottles: $119.97 ($29.75 per bottle)
- 7 Bottles: $159.96 ($22.85 per bottle)
If you choose the autoship option, you’ll continue receiving a new bottle of Proflexoral once every 30 to, and your card will be charged $29.99 each time until you contact support and cancel your enrollment.
All orders come with a 100 percent satisfaction guarantee, although no time limit or other important details were provided. As mentioned earlier, we sent an email to Chris@HealthyLivingAssociation.com and Barbara@HealthyLivingAssociation.com looking for additional information, and will be sure to update this article as soon as a response is received.
Customer service can also be reached at 970-367-7624. Who, exactly, will you be calling?
What Do We Know About Proflexoral’s Manufacturer?
Proflexoral is brought to you by Healthy Living Association (formerly known as Freedom Writers Publishing) based out of Steamboat Springs, CO. HLA itself is a trademark of Legendary Ventures, who also manufactures other supplements like American Natural SuperFood powder and American Natural SuperReds.
While Healthy Living Association and Legendary Ventures weren’t listed with the Better Business Bureau at the time of our research, Freedom Writers Publishing held an A+ rating, with 21 customer reviews and 11 closed complaints, as of 2/20/18. Most of these referenced ordering/billing concerns, although a representative responded with a solution in each case.
Proflexoral vs. Other Joint Pain Supplements
According to a 2006 report from the Centers for Disease Control, “30% of adults reported experiencing some type of joint pain during the preceding 30 days. Knee pain was reported by 18% of respondents, followed by pain in the shoulder (9%), finger (7%), and hip (7%). Joint pain can be caused by osteoarthritis, injury, prolonged abnormal posture, or repetitive motion.”
With such a widespread issue experienced by so much of the population, it might come as no surprise that a huge market exists for natural joint pain remedies like Proflexoral. In fact, the HighYa team has written about several popular options in the past, including:
|Proflexoral||As low as $22.85 per bottle||Turmeric, ginger, glucosamine, chondroitin|
|Osteo Bi-Flex||About $15, depending on retailer||Glucosamine, chondroitin|
|Omega XL||$150||Omega-3 fatty acids|
|Whole Body Joint Stimuflex||$40||Eggshell membrane, BSE, turmeric, white willow bark|
|Cosamin||$20 - $70, depending on count||Glucosamine, chondroitin|
|Move-Free||$17+, depending on count||Glucosamine, chondroitin|
And of course, these don’t include the hundreds of standalone generic glucosamine, chondroitin, turmeric, omega-3, MSM, and Boswellia supplements available through third-party companies. How to choose?
The bottom line is that the right supplement for you (if any) is going to start with your doctor’s diagnosis regarding the underlying cause of your pain.
But, as we saw earlier, the clinical evidence for Proflexoral’s four potentially effective ingredients revolves almost wholly around osteoarthritis. In fact, based on our years of research writing about hundreds of dietary supplements, it seems like the vast majority of joint options are marketed toward addressing arthritis-related concerns.
As a result, if your pain stems from something else, a dietary supplement might not deliver the benefits you’re looking for. Again, this is where your primary care physician can help you make an informed, science-based decision about whether or not to purchase one.
While you’re waiting for your appointment to roll around, the Arthritis Foundation notes that you might also want to explore additional supplement options for joint pain relief like SAM-e (S-adenosylmethionine), capsaicin (Capsicum frutescens), Avocado-soybean Unsaponifiables (ASU), Cat’s Claw (Uncaria tomentosa), Omega-3 fatty acids, and Gamma Linolenic Acid (GLA), among others—several of which are found in Proflexoral.
Does this mean you should go ahead and place an order?
Our Final Thoughts About Proflexoral
The bottom line is that at least four of Proflexoral’s ingredients are reported by sites like the Natural Medicines Database and WebMD as ‘possibly effective’ for addressing osteoarthritis-related joint pain. However, without a supplement facts label, we can’t be sure if the formula contains the same dosages found in supporting clinical studies.
Again, we reached out to the company for more information about this (as well as the length of their refund policy), so be sure to bookmark this page, and we'll update it as soon as we receive a response.