Profollica is a hair recovery system for men that promises to work from the inside out to lower dihydrotestosterone (DHT) levels and slow, stop, and even reverse hair loss.
Specifically, the website reports this natural, non-prescription, doctor-endorsed anti-hair loss system was designed to help stop the conversion of 5-alpha-reductase to DHT, and thereby reduce hair loss and increase growth. The process is said to work over the following two steps:
- Profollica’s Daily Supplement delivers a potent blend of herbal extracts, amino acids, proteins, nutrients, and enzymes that help control DHT production from the inside.
- The Activator Gel w/Trichogen is gently massaged throughout hair and down to the scalp, and then left in (don’t wash it out). In 90 percent of users, the site claims, this has been “clinically proven to visibly improve hair growth, promote a healthier growth phase, [and] actively block the formulation of DHT.”
Continuing this for 60 days, Profollica’s manufacturer indicates you could experience a slew of potential benefits, including improved blood circulation and nutrient availability to follicles, decreased scalp oiliness, increased hair elasticity, quality, and texture; relief from itchy scalp, and protection against sun damage, to name just a few. And all of this without a prescription.
The bottom line is that hair loss stinks. It can make you look older than you really are, feel self-conscious about your looks, and even hurt your chances with love interests. But is all of this a thing of the past with Profollica’s two-step system?
In this article, we investigate the company’s claims so you can make a more informed purchase as a consumer.
What Role Does DHT Play In Hair Loss?
In men, testosterone is a key hormone responsible for characteristics like penis and testes size, muscle growth (both size and strength), a deep voice, and the growth of body hair. Clearly, it plays a large role in transforming a boy into a man.
However, the American Hair Loss Association tells us that once testosterone is exposed to the enzyme type II 5-alpha-reductase, it's converted into a different—but similar-sounding—hormone called dihydrotestosterone. Then, this chemical is ‘stored’ in the glands of hair follicles, where it slowly shrinks the hairs produced, until the follicles stop producing hair altogether.
Whether in men or women, the process is much the same and is referenced by the medical term androgenetic alopecia (commonly called male or female pattern baldness).
But have more than 90 million people finally found a solution to their hair loss with the ingredients found in Profollica’s system?
Taking a Closer Look at Profollica’s Products & Ingredients
There weren’t any labels provided on the Profollica website at the time of our research, but according to the ingredients lists provided, their products contain:
The Daily Supplement
Niacin 40 mg, Pantothenic Acid 92 mg, Iodine 100 mcg, Manganese Gluconate 10 mg, Folic Acid 400 mcg, Biotin 600 mcg, Chlorophyll 30 mg, Zinc Oxide 20 mg, PABA 30 mg, L-Cysteine 40 mg, L-Isoleucine 4 mg, L-Histidine 4 mg, L-Arginine 4 mg, L-Leucine 4 mg, L-Methionine 4 mg, L-Phenylalanine 4 mg, L-Threonine 4 mg, L-Tryptophan 4 mg, L-Valine 4 mg, L-Aspartic Acid 4 mg, L-Serine 4 mg, L-Glutamic Acid 4 mg, L-Proline 4 mg, L-Glycine 4 mg, L-Alanine 4 mg, L-Tyrosine 4 mg
According to sites like the Natural Medicines Database, WebMD, and Examine.com, many of these ingredients are beneficial for human health. To name just a few, niacin may help reduce cholesterol, iodine can address hyperthyroidism, manganese is possibly effective for improving osteoporosis symptoms, and folic acid could help improve serious kidney disease.
Furthermore, branched-chain amino acids (BCAAs) like l-cysteine could help address chest pain and kidney problems; isoleucine may reduce muscle breakdown during exercise, and l-arginine might improve conditions like erectile dysfunction and high blood pressure.
However, these sources indicated there’s insufficient clinical evidence that any of these ingredients can reduce hair loss or increase hair growth, as claimed on the Profollica website.
Water, Panax Ginseng Root Extract, Arginine, Acetyl Tyrosine, Arctium Majus Root Extract, Hydrolyzed Soy Protein, Polyquaternium-11, PEG-12 Dimethicone, Calcium Pantothenate, Zinc Gluconate, Niacinamide, Ornithine HCl, Citrulline, Glucosamine HCl, Biotin, Propylene Glycol, Kigelia Africana Fruit Extract, Gingko Biloba Leaf Extract, Salvia Sclarea (Clary) Extract, Cinnamomum Zeylanicum Bark Extract, Germall Plus
As with the Daily Supplement, WebMD, the Natural Medicines Database, and Examine.com cumulatively report there’s insufficient clinical evidence that any of these topical ingredients can achieve reduced hair loss or increased hair growth.
Hair Loss Wash
Although Profollica’s Hair Loss Wash wasn’t advertised on any of the company’s websites we encountered during our research, we found it for sale on their Amazon marketplace. As such, we think it’s important to list here.
But, while this Wash featured an extensive list of ingredients, according to Paula Begoun, author of Beautypedia.com, “Only the first five or six ingredients impact the formula’s effectiveness.” As such, we only listed the first six here:
Water, Sodium Olefin Sulfonate C14-16 (coconut derived), Cocomidyl Propyl Betaine, Cocamide DEA, DL Panthenol, Acetamide MEA
Using sites like Truth In Aging, Paula’s Choice, and EWG.org as our sources, we learned that most of these work as foaming agents (sodium olefin sulfonate C14-16, cocamide DEA), cleansing agents (cocomidyl propyl betaine), and conditioning agents (DL panthenol, acetamide MEA).
However, they didn’t report that the topical application of these ingredients has been clinically shown to reduce hair loss or increase hair growth, as claimed by Profollica’s manufacturer.
Could Profollica’s Ingredients Cause Any Side Effects?
While none of these authoritative resources indicated that these ingredients are gender-specific, the Profollica website emphasizes that their products are “specifically formulated to address male pattern baldness. We don't actively recommend it for hair loss in women.”
However, these sites reported that the most common side effect related to niacin is flushing (no specific circumstances noted).
According to WebMD, routine zinc supplementation is not recommended without the advice of a healthcare professional,” although again, no additional details were provided.
They also indicated individuals shouldn’t treat themselves with methionine, since it can “increase blood levels of homocysteine, a chemical that might cause heart disease. Methionine might also promote the growth of some tumors.”
Finally, n-acetyl cysteine is reported to have a major interaction with nitroglycerin medication.
Taken together, this is why it’s always important to speak with your healthcare provider before taking any new dietary supplement, or beginning a hair loss treatment regimen.
How Much Does Profollica Cost?
If ordered through their Profillica.com URL, the two-part hair loss system is available in the following quantities:
- 1-Month Supply: $59.95
- 3-Month Supply: $159.95 ($53.31 per month)
- 6-Month Supply: $299.95 ($49.99 per month)
Shipping options for the one- and three-month supplies are $12.99 (USPS 7-10 day), $14.99 (UPS tracked 3-5 days), $16.99 (UPS 2-3 days), or $36.99 (UPS overnight). 7-10 day shipping for the six-month supply is free.
All direct orders come with a 67-day money back guarantee, less S&H. In order to request one, support can be reached at 866-621-6886 (604-677-5365 outside the U.S.), or via the website’s contact form.
Note: We also found a complete Profollica Hair Loss Kit, which included their Wash outlined earlier, on Amazon via a handful of third-party fulfillers, for between $90 and $130. The Wash was available by itself at a price of $34.95.
What Can We Learn From Profollica Customer Reviews?
The only place we encountered any online customer feedback for Profollica’s products was on Amazon. Between all of their different packages, there were a total of 20 reviews with a combined average rating of about 3.5 stars.
There, most compliments appeared to reference increased hair volume and growth, along with decreased hair loss. Complaints frequently related to no results—one also mentioned that the liquid had a “horrible odor.”
From a company perspective, Profollica is manufactured by Leading Edge Health, based out of Elizabethton, TN. They specialize in a variety of men’s, women’s, and sexual health products, as well as many related to anti-aging and skincare. They weren’t listed with the Better Business Bureau at the time of our research.
Who Is Dr. Dave David & Dr. Karen Vieira?
Dr. Dave E. David is a Boston, MA-based cosmetic surgeon with more than 35 years of experience, who works as the Medical Director of his Medical Face & Body Aesthetics practice. He’s also the mind behind Alluring Skin, a line of anti-aging skincare products.
Dr. Karen Vieira received her Ph.D. in biomedical science from the University of Florida College of Medicine, and has since worked as a research scientist for Kraft Foods and as the owner of The Med Writers.
While both Drs. David and Vieira appear to endorse Profollica, there’s no indication on the system’s sites that they had any role in its formulation.
Profollica vs. Rogaine, Procerin, Provillus, ScalpMed, Minoxidil, & Other Over-the-Counter Hair Loss Treatments
Outside of wigs, hairpieces, and surgery, the Mayo Clinic reports that the only clinically substantiated, FDA approved methods of regrowing hair are:
- Minoxidil – The generic ingredient popularized by products like Rogaine, this liquid or foam is massaged into the scalp and could help slow the rate of hair loss, cause new hair to grow, or both.
- Finasteride – Known as Propecia in its commercial form, this is a prescription medication taken by mouth that could also lead to reduced hair loss and/or increased hair growth.
But, even just a quick online search for variations of terms like “hair regrowth systems,” “DHT blocker,” and “hair loss shampoo conditioner” will reveal that there are perhaps hundreds of products competing in the same space as Profollica. Several popular results at the time of our research included:
- Procerin ($26) – A dietary supplement and foam that claim to block DHT. No supplement ingredients were listed, although the first six contained in the foam isn't reported as effective in addressing androgenetic alopecia.
- Provillus ($50) – A topical solution containing five percent Minoxidil.
- ScalpMed ($50) – Offers a range of products, although their men’s and women’s Med Kits contain two to five percent Minoxidil.
How can you choose the right option for you? Let’s carry this thought over to the final section as we come to a conclusion about Profollica.
Our Final Thoughts About Profollica’s Hair Loss System
In How to Choose a Hair Loss Product, we outline that the right first step is always to speak with your doctor about your hair loss and overall goals, who can then recommend appropriate treatment options based on your diagnosis—whether or not this involves systems like Profollica.
With this said, we learned earlier from the Mayo Clinic that the only OTC ingredients clinically shown to potentially halt hair loss/re-grow hair are Minoxidil and Finasteride. We also learned from sites like WebMD and Examine.com that none of the ingredients in Profollica's lineup has sufficient clinical evidence indicating they can do the same.
If you absolutely can’t wait to order until after you’ve spoken with a healthcare professional, though, Profollica does seem to stand behind their direct-order products and systems with a 67-day refund policy. Just keep in mind that you’ll lose between $12.99 and $36.99 in initial S&H charges, plus whatever it will cost to send back to the company, if you’re dissatisfied with its performance.