Endorsed by Phillip Fulmer, national championship winning Hall of Fame coach, Synodrin is a line of natural supplements and gels that promises to relieve arthritic joint pain and inflammation, while improving overall joint health.
At the core of the lineup is Immunodrin, a proprietary blend of cetylated fatty acids and cetyl myristoleate (CMO), which the website indicates has been shown to soothe joints and modulate the immune system. They claim it’s even referred to as the “WD-40 for joints” because of its lubricating qualities.
By using the products in their system regularly, the manufacturer tells us that Synodrin could help you experience better joints, more lubrication, and less inflammation in just one week. However, for best results, they recommend using the products for a minimum of three months.
This certainly sounds like a compelling concept, but are these the types of results you can realistically expect? Does the lineup actually represent complete joint health, as claimed on the company’s website? And just because Synodrin’s products seem popular, does that mean they’ll deliver the most bang for your buck?
Keep reading, and we’ll help you make an informed decision by answering basic questions like these.
What Causes Joint Problems?
The website tells us that Synodrin works to defuse the underlying source of your pain and discomfort, but what causes it in the first place?
The National Library of Medicine’s Medline Plus tells us that joints can sustain damage from many different injuries and diseases, including arthritis (swelling of the joints), bursitis (inflammation of a fluid-filled sac that works to cushion joints), and dislocations (where the bone is forced out of position). Other causes include ligament, cartilage, or bone damage; strains and sprains, and gout.
Among these, arthritis is the most common, affecting about 22.7 percent of the population, or roughly 54.4 million adults. To treat this condition, along with many other types of joint pain, medical professionals often recommend:
- Taking an over the counter pain reliever
- Undergoing acupuncture
- Adding omega-3 fatty acids, along with gamma-linolenic acid, turmeric, glucosamine, and chondroitin sulfate, to your diet
- Using hot and cold therapy on the location of the pain and inflammation
- Wrapping the joint in a compression garment to boost blood flow
- Increasing the amount of exercise you get, which might be especially easy on the joints while in the water
- Losing weight
Of course, they also emphasize that the best treatment will often depend on the diagnosis; i.e., the cause of the problem, which is why you’ll want to speak with your doctor before making any decisions.
What about Synodrin’s products? What do they contain to potentially help address joint pain?
Taking a Closer Look at Synodrin’s Products
There are five different products in the Synodrin lineup:
Joint Pain Relief Topical Gel
A fast acting gel that’s specifically formulated to quickly penetrate the skin, without an overpowering, long-lasting scent or a greasy, sticky feel. Can be applied to skin up to three to four times per day.
Aloe Vera Extract, Carbomer 940, Glycerin, Hyaluronic Acid, Immunodrin® Proprietary Blend (CFAs), Isopropyl Palmitate, L-Arginine, Phenoxyethanol, Purified Water, Triethanolamine, Vitamin E Acetate
Lidocaine Max+ Gel
Like the standard topical gel, this formula promises to deliver fast acting relief by penetrating the skin quickly and not leaving behind greasy or sticky results. However, it also adds lidocaine:
- Active Ingredients: Lidocaine 4%
- Inactive Ingredients: Aloe Vera Extract, Carbomer 940, Glycerin, PEG-100 Distearate, Glyceryl Stearate, Hyaluronic Acid, Immunodrin® Proprietary Blend (CFAs), Isopropyl Palmitate, L-Arginine, Phenoxyethanol, Triethanolamide, Vitamin E Acetate, Purified Water
Advanced Complete Joint Health
According to the Synodrin website, taking just one capsule of this joint action formula per day will help you feel better by easing pain (whether chronic or otherwise), aches and discomfort caused by rigorous activity, exercise, and competition, as well as sustaining joint health and function.
Because of this, they call it the most complete UC-II product on the market.
For maximum results, the company recommends using the supplement along with their topical gel for local application. Ingredients:
- Immunodrin 300mg
- Turmeric 300mg
- Boswellia 100mg
- UC-II 40mg
- Hyaluronic Acid 5mg
- Black Pepper Extract 5mg
Triple Action Complete Joint Health
Similar to the Advanced formula, Synodrin’s Triple Action Complete Joint Health supplement promises to help “ease joint pain, aches, and discomfort caused by rigorous activity, exercise, and competition, as well as aiding those with chronic pain.” In addition, it can be used in conjunction with one of their topical gels.
However, it also adds glucosamine and increases the dosages of Immunodrin, turmeric, and hyaluronic acid:
- Immunodrin 1,200mg
- Glucosamine (vegetable based) 500mg
- Turmeric 400mg
- Boswellia 100mg
- Hyaluronic Acid 30mg
- Black Pepper Extract 5mg
By taking three pills per day, the manufacturer claims this formula has been clinically proven to show improvement in as little as seven days.
Turmeric MAX with Black Pepper Extract
By taking two capsules daily, this supplement is said to promote long-term joint health from the inside out, using just two ingredients:
- Turmeric Extract 1,200mg
- BioPerine Black Pepper Extract 20mg
What Does Science Have to Say About Synodrin’s Ingredients?
No one on the HighYa team is a medical expert or a joint pain specialist. So, in order to gauge the efficacy of Synodrin’s ingredients, we relied on the summarizations of the available clinical evidence reported by the Natural Medicines Database, WebMD, and Examine.com.
They noted that taking 350mg of cetylated fatty acids, along with 50mg of soy lecithin and 75mg of fish oil, six times daily, may help decrease pain and improve function in those with knee osteoarthritis. However, it wasn’t shown to improve morning stiffness.
1,000mg-2,000mg of turmeric daily is listed as possibly effective for reducing pain and improving function in people with osteoarthritis—in some instances, about as well as ibuprofen.
Some research has shown that taking 100mg-333mg of boswellia (whether in Synodrin or on its own) per day might help reduce pain, sometimes as much as 32-65 percent, and improve mobility in people with joint osteoarthritis.
According to ConsumerLab, UC-II collagen “contains a patented form of undenatured type II collagen (i.e., the collagen is not processed by high heat or chemicals) derived from chicken sternum cartilage, along with inactive ingredients,” which “has been evaluated in several clinical studies and appears to provide some improvement in knee stiffness and/or pain.”
Finally,1,500mg of glucosamine sulfate daily is listed as possibly effective for reducing osteoarthritis pain in the knee, hip, and spine; improving joint function, and even slowing the breakdown of joints with long-term use. However, it doesn’t seem to decrease pain or otherwise benefit everyone who takes it.
Lidocaine is an often-used OTC remedy that temporarily numbs tissue in a specific area. Topical aloe vera, glycerin, and hyaluronic acid act as moisturizers, while carbomer 940 is a viscosity enhancer.
Could Synodrin’s Ingredients Cause Side Effects?
According to the company's website, "Synodrin uses only very carefully sourced ingredients of the highest quality to ensure maximum safety and potency." Furthermore, their glucosamine is sourced from vegetables and is safe for those with shellfish allergies.
In their FAQ, they also indicate that after more than 30 years, there are no known side effects or drug interactions to this date. However, they emphasize that you should consult with your doctor before starting any type of supplement.
With this said, these same authoritative sites reported that the most common side effect (if any) experienced with these ingredients is mild, temporary digestive upset. No specific circumstances or dosages were referenced.
They also note that while side effects haven’t been reported with cetyl fatty acids, there isn’t much information available about the safety of long-term use.
How Much Does Synodrin Cost?
By themselves, each of Synodrin’s products is priced as follows, when purchased from the manufacturer:
- Joint Pain Relief Topical Gel (2oz-4oz): $11.95-$17.95
- Advanced Complete Joint Health (30 capsules): $49.95
- Triple Action Complete Joint Health (90 capsules): $39.95
- Turmeric MAX with Black Pepper Extract (60 capsules): $29.95
- Lidocaine Max + Gel (3.4oz): $17.95
There are also a variety of combo packs available, priced between $34.95 and $109.95.
If you choose to save 20 percent with the subscription option, you'll continue receiving the same amount once per month, and your credit card will be charged accordingly each time.
All manufacturer-direct orders some with free shipping within the U.S., along with a 60-day money back guarantee, less S&H charges.
In additional, Synodrin products are sold at several national retailers like Walgreens, Walmart, Amazon, Rite Aid, Albertsons, and Meijer.
To request a refund or change or cancel your subscription program, customer support can be reached at 855-499-6735.
What Can We Learn From Synodrin Customer Reviews?
On Amazon, we encountered 18 customer reviews for Synodrin’s Triple Action Joint formula, which had an average rating of 3.4 stars. There, common compliments referenced effective joint pain reduction and quick results.
On the other hand, common complaints related to no results, high price, and some side effects like stomach upset and weakness.
From a company perspective, Synodrin is manufactured by Natural Solutions For Life, based out of Robinson, IL. Outside of the product line’s website, they didn’t have much of a presence elsewhere online, including with the Better Business Bureau.
Are There Other Joint Gels & Supplements Like Synodrin?
Whether you’re browsing online or the real-world supplements aisle at your local pharmacy, there are perhaps thousands of different joint pain relief products available.
These include everything from standalone glucosamine supplements and proprietary blends like Synodrin, to gels and creams. Per our Google Shopping search, prices ranged between $5 and $50.
Obviously, none of these came with the Immunodrin found in Synodrin. But some, like Instaflex, contained many of the same ingredients, including turmeric, boswellia, UC-II collagen, hyaluronic acid, and Bioperine. Osteo Bi-Flex also contained collagen, hyaluronic acid, and boswellia serrata.
Like Synodrin, many of these options were available locally from national retailers, potentially saving S&H charges and making the refund process as easy as hopping in your car if you’re dissatisfied. Outside of this, though, are there any other considerations to keep in mind when choosing a joint pain relief product?
The Arthritis Foundation notes that, if you’re thinking about purchasing a supplement to help relieve your symptoms, the first thing you should do is speak with your physician. They can help answer your questions and potentially recommend options based on your specific diagnosis.
They also emphasize that the cost of dietary supplements and topical gels can quickly add up, so be sure to watch your budget. Be mindful of the amount you take or apply to your skin, read all the labels correctly before using, and be skeptical of advertising claims you encounter during your research.
Finally, when purchasing online, be mindful of companies that require you to purchase through a “free” trial, or mandate that you enroll in a recurring shipping program soon after purchasing.
Our Final Thoughts About Synodrin
Based on what we learned earlier from Medline Plus, an incredibly large percentage of the population is dealing with one type of joint pain or another at any given time. And like anyone else dealing with discomfort, nearly all of them are looking for some measure of relief.
From this perspective, sites like the Natural Medicines Database, WebMD, and ConsumerLab reported that many of the topical and internal ingredients found in Synodrin’s formulas—specifically, cetylated fatty acids, turmeric, boswellia, UC-II collagen, glucosamine, and lidocaine—have clinical evidence that they could help provide relief from joint pain.
The product lineup also came with a mostly positive—if somewhat limited—online customer reputation and a 60-day refund policy. And if you don’t want to shop online, it was available at several local retailers.
It’s also important to point out that the manufacturer didn’t link to any clinical evidence supporting their claims for Immunodrin, and the term didn’t return any search results through the National Institutes of Health’s PubMed. (Obviously, we’re not saying this evidence doesn’t exist—only that we weren’t able to locate it through typical third-party sites.)
With all of this in mind, you might not have much more to lose than a bit of your time and perhaps return S&H charges if you’re not pleased with one of the products in Synodrin’s lineup. To maximize both your time and your money, though, the smartest option would be to reach out to your doctor first.