What Is uBiome?

By Derek Lakin
HighYa Staff Published on: Jul 18, 2017

As a genetics company, uBiome offers two sequencing-based microbiome screening tests that promise to provide customers with actionable insight they can use to understand and improve their gut health.

Specifically, the website tells us that you’ll be able to discover the bacteria that live in and on your body (collectively referred to as the ‘microbiome’), and whether these microorganisms are beneficial or pathogenic—such as those associated with Inflammatory Bowel Disease (IBD) and irritable bowel syndrome (IBS).

From there, you’ll learn how diet and lifestyle factors can affect these microorganisms and potentially help you feel better.

Together, uBiome’s claim that they’re “pioneering a new era of microbiome-based precision medicine" seems warranted. But does this necessarily mean the price you pay will deliver the value you expect? Stick with us, and we'll help you explore important factors like these.

What Importance Does Your Microbiome Play?

The microbiome is defined as “the microorganisms in a particular environment (the body as a whole or a part of the body),” including their combined genetic material.

According to University of Utah’s Genetic Science Learning Center, like any other community on earth, these microorganisms respond to their surroundings and continuously shift throughout our lifetime. But if these populations shift too far in one direction, leading to an excessive number of “bad” microorganisms, they report it can result in a whole host of conditions; from acne and asthma to eczema and obesity.

From a gut health perspective, this is the basic approach behind probiotics. These supplements contain specific bacteria strains, which are typically chosen based on their ability to repopulate the gut with beneficial bacteria and potentially address digestion-related issues.

Now, how does uBiome fit into this picture?

SmartGut vs. Explorer: How Do the uBiome Tests Work?

uBiome currently offers two different consumer-level screening services:

What Are the Details Behind uBiome’s SmartGut Test?

Available only in the U.S., SmartGut is designed for patients experiencing chronic gut conditions or those who are working with their physician to optimize their gut microbiome.

Speaking of which, the test must be ordered by your doctor, and involves an easy-to-use collection kit that requires just enough fecal matter to tint a cotton swab. Then, this is cleanly returned in a pre-paid mailer.

uBiome SmartGut Sample Collection KitAccording to their website, uBiome’s SmartGut Collection Kit includes everything you’ll need to obtain a sample, which will be sent back to the company using a pre-paid label. Image credit: uBiome, Inc.

Once received by the company’s CLIA-certified and CAP-accredited lab, they’ll use their high-throughput DNA sequencing technology to measure your bacterial diversity and identify specific pathogens that could be making you feel less-than-optimal. This includes microorganisms associated with conditions like IBS, gas, bloating, diarrhea, and even sore throat.

Their Microbiome Diversity Score will also let you know “how your microbiome compares to healthy participants from the world’s largest microbiome research dataset,” as well as how your lifestyle and diet impact these microorganisms.

With these details in mind, it’s important to point out the uBiome site emphasizes that SmartGut does not represent “a diagnosis without the evaluation of your symptoms by a medical professional” and that it’s “not intended to diagnose, treat, cure or prevent any disease.”

What About the uBiome Explorer Test?

Comparatively, Explorer is available to residents of 202 countries and was designed “for citizen scientists and academic researchers to conduct experiments relating to the microbiome.”

Customers have the opportunity to take samples from up to five different sites, including the nose, skin, mouth, genitalia (both male and female), as well as the gut. Just swab across the corresponding site, send the kit back to uBiome, and you’ll receive results within 4-6 weeks.

Instead of a detailed report like with the SmartGut screen, Explorer will provide access to online interactive tools (e.g. graphs and charts) that can help you understand how your bacteria compare to others, as well as the ability to track your bacteria over time (should you decide to order more than one test):

  • Gut Explorer – A one-time test for curious beginners.
  • Time Lapse Explorer – A three-time sequence that could be handy for tracking levels before, during, and after a diet or other lifestyle change.
  • Five Site Explorer – Provides access to five sample sites, including gut, mouth, nose, genitals, and skin.

Regardless of which screen you choose, uBiome indicates your data is protected by “multiple layers of encryption and the highest levels of computer security. You control your data, and can choose whether or not you consent to having your data be anonymized and aggregated into our research studies.”

How Much Does a uBiome Screen Cost?

According to the FAQ on uBiome’s website, their SmartGut test is currently only available to residents of the U.S. through their Pilot program. While this means you must have health insurance in order to participate, they note that “any costs not covered by your insurance company will be covered by uBiome.” In other words, it’s free while this program is operational.

However, their Explorer tests are priced as follows:

  • Gut Explorer: One-time purchase $89, $71.20 as monthly subscription
  • Time Lapse Explore: One-time purchase $199
  • Five Site Explorer: One-time purchase $399, $319.20 as monthly subscription

Refunds aren’t available on uBiome’s tests, although customer service can be reached at [email protected] or [email protected]

What Can We Learn From uBiome Reviews?

We found two uBiome customer reviews on Amazon at the time of our research, who had given the genetic screening service an average rating of three stars. The five-star reviewer stated that they were excited to see their lifestyle changes reflected in their screening, while the one-star reviewer wasn’t satisfied with the requirement to share their information, or their overall results.

Back in 2015, Discover Magazine’s Sarah Scoles ordered a uBiome SmartGut screen and concluded:

“I didn’t pay $89 for my sample analysis kit. But if I had, I would have been disappointed. And if I had paid $399 for the five-site kit, I would have been even more so. The amount of readily available information provided little enlightenment about what my internal lurkers meant about me.

While we know the microbiome is important (so important!), we’re just beginning our research into the specifics. And big data — your data — is the way to learn what a high firmicute to bacteriodete ratio means for health. Given that, it would be more appropriate for uBiome to pay you to swab your toilet paper than for you to give them $90 so you can learn what they can’t yet tell you.”

More recently, TechnologyReview.com interviewed Rob Knight, a microbiome researcher, professor at the University of California, San Diego, and co-founder of the American Gut project, who made a similar statement, noting "The enthusiasm of their manufacturers simply goes well beyond where the science is right now."

In other words, while these types of tests might engage us in science and help us learn more about our body, the actionable value they provided seems to currently be limited.

As far as the company, uBiome was founded in October 2012 by Jessica Richman and Zachary Apte, who both worked at the California Institute for Quantitative Biosciences. Then, in 2013, the company went on to raise nearly $363K in a 2013 Indiegogo crowdfunding campaign.

Since that time, uBiome has received a variety of awards, including the Top 10 Most Innovative Companies in Healthcare by Fast Company, as well as CNN 10: Startups To Watch.

Given uBiome’s early success, has this created any competition in the marketplace?

uBiome vs. Other Microbiome Sampling Companies

While there weren’t a whole lot of microbiome screening companies competing with uBiome at the time of our research, there were several other popular options. These included:

Company Price Screening Services / Information Provided
uBiome Free - $399 Gut; Exterior (nose, skin, mouth, genitalia) - Bacterial diversity, microorganisms related to specific conditions
Thryve $99 Gut – Diet and supplement recommendations, learn about probiotic strains, how to improve leaky gut
Map My Gut £250 Gut bacteria classification and what they can mean for health
DexaFit Microbiome Gut Analysis (powered by uBiome) $89 Gut microorganism identification and symptoms they can cause
DayTwo.com $299 Gut - Personalized nutrition and sugar response predictions; app access

How can you choose the right option?

Each of these seemed to come with meaningfully different prices, along with a variety of information contained in their reports. So, if price is your most important factor, a free SmartGut screen through uBiome might be difficult to beat, although you’ll need to have health insurance to qualify.

On the other hand, if you’re diabetic, the DayTwo.com screen might be ideal, while those specifically interested in probiotics or supplement recommendations might be better served by Thryve.

Let’s carry these thoughts over to the final section as we wrap things up.

What’s the Bottom Line About uBiome?

Returning to the TechnologyReview article cited earlier, they emphasize “there’s a lot we don’t know about the microbiome and its connection to our health.”

As a result, American Gut project co-founder Rob Knight acknowledges that "what people can realistically expect to learn from these new commercial tests is more along the lines of a snapshot of how a participant's microbiome compares to others with different diets, ages, and lifestyles, or in different places around the world."

Given these important factors, only you—in conjunction with a healthcare professional, of course—can decide if the “cool” factor behind a gut microbiome screen like uBiome is worth the time and overall expense. But if you’re suffering from a more severe or chronic condition, it just might provide the information you need to find some relief.

See Also: Direct-to-Consumer Genetic Testing Pros & Cons: Is It Right for You?

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12 Consumer Reviews for uBiome

Average Consumer Rating: 1.3
Rating Snapshot:
5 star: 1 4 star: 0 3 star: 0 2 star: 0 1 star:  11
Bottom Line: 8% would recommend it to a friend
Showing 1-11 of 12
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  • 2 out 2 people found this review helpful

    Ripping off our healthcare!

    My experience with the company was fine. What I really really do not like is seeing a $2970 service charge to Blue Cross Blue Shield. No charge to me, but come on people, this is a TOTAL health care scam. I think healthcare system should do an investigation.

    Not cool!

    Bottom Line: No, I would not recommend this to a friend

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  • I had a great experience

    I had a great experience. So I saw an ad for a free SmartGut test and since I have ulcerative colitis, I would love to do it. I did the test, got the results, and they attempted to charge my insurance. My insurance denied it and as promised, uBiome ate the cost.

    A few months later, uBiome emailed me about an upgraded test. I did it, and this time my insurance did pay them $2900. I got the results but they didn't seem different from the first test, but I did get to see changes over time.

    Bottom Line: Yes, I would recommend this to a friend

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  • Never got product after insurance was charged

    • Arkansas,
    • Feb 1, 2018
    • Verified Reviewer

    This horrible company charged my insurance $2,900 for services. I performed the first of several tests and sent it in to be processed. I learned later, after trying to access results, that my kit had been registered to the wrong email. I tried to get in contact with their customer service, but they would not respond. I tried repeatedly, over and over again, to get them to respond. No response.

    I tried calling them. They would say their customer service line was busy and someone would take my number to be called back later. No one called back. I called multiple times over a few weeks. Nothing. I got more aggressive when I called. Still nothing. I threatened legal action. It has been a month since I've been trying to get this resolved and I have gotten exactly zero data from my $2900. This is fraud.

    Bottom Line: No, I would not recommend this to a friend

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  • 2 out 2 people found this review helpful

    Avoid this company

    • Connecticut,
    • Jan 30, 2018
    • Verified Reviewer

    I wish I had never made contact with this company. I sent my original sample in May 2017. I noted the tracking number on the package and followed it online all the way to California. Tracking noted that it was delivered to the front desk on May 26th.

    There was no status change on my account or anything that indicated they'd received it and were processing it. I finally emailed and asked the status of my sample. They replied that they never received it. I provided them with the tracking number to show that the package had, indeed, been received by someone there. The response was then that it must have gotten lost somehow. Wonderful. This is how they handle patient DNA samples? It's very careless, to say the least. And the fact that no one there seemed particularly concerned about it didn't fill me with much confidence.

    They sent another test kit. I returned it, and that one was delivered to them on July 12th. I emailed two weeks later asking if they could confirm they got it. No response. I emailed again on September 15th. On September 19th, FINALLY, I get an automated response saying, "We just received your sample." It was delivered to them 7/12. But they "just received it" on 9/19. Super.

    Included in that automated email was this line, "Your samples...are now safely awaiting processing in our lab." Which means, by default, that the samples they lost are unsafely waiting who knows what where.

    Now, somewhere throughout this process, they sent me an automated thing asking if I'd be interested in trying SmartJane. They ended up sending me a test kit. But I decided I did not want to go through all of this again with them and threw the kit away.

    So what do they do?? They keep sending me more kits! Stop sending me kits!

    On October 25th I got my test results, five months after I sent my first sample. I had hoped to receive these results in time for my gastroenterologist to look at them. But my appointment with him had already come and gone at that point.

    Unfortunately, they've popped into my life again. I am now getting an "invoice" email from them saying that my insurance company sent me a check and they want it. They have the date of service listed as 1/1/2018. I replied that I had never received a check from my insurance company. I got a response saying, "If you haven’t received this check due to a change in address or if the check has expired, please contact your insurance carrier..."

    No, my address has not changed. No, I have not received a check, so this non-existent check could not have expired. And what does the 1/1/2018 date of service refer to? I then got a response that this would be forwarded to their billing department.

    In the meantime, they are harassing me daily with the "you are out of network, send us the check" email. Daily. And yet I have heard nothing from billing.

    In short, this company is a mess. They mishandle samples, and they are extremely slow to respond (if at all). Every time you do get a response, it is from a new person so that none of them has any idea what's going on. And obviously, billing doesn't have their act together either.

    uBiome, stop sending me SmartJane kits and stop sending me harassing emails! If you want the account settled, have a real human being contact me who knows what they're doing. I would like to break up with you, but I can't seem to get rid of you!

    Bottom Line: No, I would not recommend this to a friend

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  • 1 out 1 people found this review helpful

    Customer support is terrible

    • San Francisco, CA,
    • Jan 29, 2018
    • Verified Reviewer

    I have had a great experience with a product, but when I stumbled on a couple of issues while ordering new kits, Customer Support turned out to be extremely unresponsive. First, you receive a funny automated response that your question will be reviewed. Then a Customer Service specialist replies with a note that somebody else will reply to my question soon. Then a couple of weeks pass and nothing.

    Bottom Line: No, I would not recommend this to a friend

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  • 2 out 2 people found this review helpful

    Terrible customer service and no results yet

    About two months ago, we sent a sample to uBiome to find out whether my partner, who is being treated with checkpoint inhibitors for cancer, has sufficient quantities of the bacteria that may mediate responsiveness to this immunotherapy treatment. It has been impossible to communicate with this company. They have no phone number, and one's emails are answered with weeks of delay. Although our doctor agreed to review the results with us and see what he could do with them, we did not request the kit through him, nor was it clear to us how to do that. I recommend finding a different company.

    Bottom Line: No, I would not recommend this to a friend

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  • 16 out 16 people found this review helpful
    Updated review

    Lesson learned

    • San Antonio, TX,
    • Dec 13, 2017
    • Verified Reviewer

    I was only ever able to get a response from the company via email after I posted the negative review above. They contacted me via my uBiome email account within a few hours of posting my review on HighYa. They directed me to the billing department where I had to convince them that the website did not have ANY mention of the amount of money they charged and that I would be happy to pay them the advertised price of $89. They didn't just roll over, I had to make a strong case letting them know I had recorded all website paperwork and that I was going to seek legal action against them if we were not able to reach a settlement. They gave me excuses about how their website was lacking the proper pricing information and they would get their website engineers to look into it.

    Then, the next day I get a voicemail from the billing department telling me they didn't realize my insurance account was an HRA (Health Reimbursement Account) and they were very sorry because they didn't realize $3,000 would be coming out of my pocket. I called them back to discuss this new revelation. I was told they would settle for the $89, but I would need to wait for their supervisor's approval before they could email me an invoice.

    After a few days of no contact, I called and left multiple messages with no responses. I was worried they were avoiding me. So I let a few weeks pass then called using a different phone number and left a bait voicemail saying I was a customer trying to pay my bill but hadn't received an invoice yet. They immediately called me back, LOL. Apparently, the person I had called was no longer with the company but said I should send an email to Reimbursments@ubiome.com.

    So I sent an email to them requesting to settle my bill, whatever it may be. They responded shortly saying, "I apologize for the confusion. Your account balance is settled and there is nothing left to pay. Thank you for following up on this issue".

    WHAT THE HECK?! So, in the end, I didn't have to pay anything. But it leaves me wondering what their game is. I suppose they're simply charging every single insurance provider hoping that some will pay and some won't even though they have never advertised the amount they're charging.

    The lesson learned is, don't give them your insurance information! Buying the "explorer" test kit would probably be a simple transaction without stress. But, if you give them insurance info, they will likely try to get away with charging for extra money. I may consider using uBiome again in the future but only after trying other companies first. And when I do, I will open a brand new account and avoid giving my insurance info.

    Bottom Line: No, I would not recommend this to a friend

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    Comments (5)
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    • Nov 13, 2017

      Charlotte

      Caleb, did uBiome actually bill you for the $2,900 or is that the amount your insurance carrier is showing you that was not paid?

      The same thing has happened to me but as I haven't received a bill from uBiome, it may be that they're scamming the insurance companies but not billing the consumer for the rest of it. Still, a scam nonetheless.

    • Nov 29, 2017

      Luke Witthoft

      I had the exact same issue. They told me it was free but then they billed my insurance for $2,900. The results that do not indicate positive or negative diagnoses. My insurance wants me to pay 100% of the costs. The customer service for uBiome is unresponsive. If you are taking legal action, I would like to join your lawsuit.

    • Dec 1, 2017

      Charlotte

      Again, I don't believe UBiome is actually charging customers the remainder of the $2,900 that insurance doesn't cover. Your insurance will not make you pay a provider, the provider either bills you or doesn't. UBiome doesn't seem to be billing customers as long as it gets something from insurance.

    • Dec 11, 2017

      lois

      Good to know. They keep on asking me for my insurance card. I was going to be a participant in a free screening. I paid a fee for expediting my results. It has been about 6 months, if not more. Has anyone their received results?

    • Dec 12, 2017

      Caleb Bryant

      I ended up contacting the billing department at Ubiome and I had to convince them that the website did not mention the amount of money they charged, and that I would be happy to pay them the advertised price of $89. They didn't just roll over, I had to make a strong case letting them know I recorded all website paperwork and that I was going to seek legal action against them if we were not able to reach a settlement. They gave me excuses about how their website was lacking the proper pricing information and they would get their website engineers to look into it.

      Then, the next day I get a voicemail from the billing department telling me they didn't realize my insurance account was an HRA (Health Reimbursement Account) and they were very sorry because they didn't realize that $3000 would be coming out of my pocket. It was at that time that I called them back to discuss this new revelation. I was told they would settle for the $89 but I would need to wait for their supervisor's approval. After a few days of no contact, I called, left messages, emailed with no responses. I was worried that were avoiding me.

      So I let a few weeks pass then called using a different phone number and left a bait voicemail telling them I was a customer trying to pay my bill but hadn't received an invoice yet. They immediately called me back, LOL. Apparently, the person I had called was no longer with the company but told me that I should send an email to Reimbursments@ubiome.com. So I sent an email to them requesting to settle my bill whatever it may be. They responded shortly saying, "I apologize for the confusion. Your account balance is settled and there is nothing left to pay.

      Thank you for following up on this issue. WHAT THE HECK? So, in the end, I didn't have to pay anything. It leaves me wondering what their game is. I suppose there simply charging every single insurance provider hoping that some will pay and some won't, even though they have never advertised the amount they're charging. The lesson I learned is that you DO NOT want to give them your insurance information.

      Buying the "explorer" test kit would probably be a simple transaction without stress. But, if you give them insurance information, they will likely try to get away with charging extra money. I may consider using Ubiome again in the future but only after trying other companies first. And when I do, I will open a brand new account and avoid giving my insurance information.

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    • Previous review
    • Nov 9, 2017

    I feel taken advantage of

    uBiome advertises their services at around $90-$400 depending on what you order. However, they also show that these costs are covered by most medical insurance plans. I use Blue Cross Blue Shield (Missouri) and decided to see if insurance would pay part of the cost.

    I selected my insurance company from the drop-down menu and ordered my kit. A few weeks after sending the sample back I see uBiome has charged my insurance company $3000! Most of this was not covered by my insurance, and I am now responsible for $2900! What the heck guys?! I received no emails from uBiome at any time after creating my login account. They didn't even email me the results of testing; I had to log in to my account to see that they were available.

    If you're considering using uBiome, I recommend avoiding the insurance option. I will be reviewing all documents I "accepted" and taking legal action against uBiome if applicable. I feel very taken advantage of and will not be using their services ever again.

    (read moreread less...)

  • 6 out 6 people found this review helpful

    Never got the kit

    I got a shipping a notice 9 days ago stating this: "This was shipped via USPS, USPS First Class Mail on 10/10/2017."

    Tracking info says that USPS got info on the shipping but doesn't have the item to ship yet. I've sent multiple emails to uBiome support. No response. Looks like I'm not missing anything.

    Bottom Line: No, I would not recommend this to a friend

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  • 9 out 11 people found this review helpful

    Terrible! Doubt the accuracy. Non-existent customer service.

    First, I did the test about a year ago. OK, all went well and I found it interesting. I tried to do again in the spring, and they completely lost the sample. They sent a new kit and this time it worked. However, the results were worse than in the fall when I first did it, and since I first did it, I implemented all sorts of things that should have made it better. Many fermented foods, pro and prebiotics, regular exercise, no antibiotics, and clean eating. So I can't help but really question the lab results.

    I tried contacting them four times, including calling (once I could find a phone number), and nobody ever replied to me. They obviously don't want to explain why their report seems so flawed. This makes me greatly distrust this company, and I wouldn't ever recommend them to anyone.

    Bottom Line: No, I would not recommend this to a friend

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  • 12 out 12 people found this review helpful

    Zero performance

    I ordered a kit on April 28, 2017, and sent it in promptly. I have sent emails in follow-up at least five times. The first two were answered with a typical corporate reply but no real information about when I could expect a report. Now it is September 28th, and I still have no report on my microbiome. The company did have time to bill my insurance company for thousands of dollars, but I don't recall giving it permission to do this; of course, my insurer denied the claim.

    As far as I can determine, this outfit is a scam. I did my part, including paying for the report. It has not done its part of our deal.

    To make it worse, there has been zero communication after my first two emails. I think any reasonable person would agree that the company has had enough time to do its work and make a report, or offer a decent explanation and get a resample or provide me a refund.

    uBiome is a waste of time and money. Don't fall victim to the marketing info; uBiome is all flash and no performance.

    Bottom Line: No, I would not recommend this to a friend

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  • 10 out 10 people found this review helpful

    Awful service

    • Massachusetts,
    • Sep 25, 2017
    • Verified Reviewer

    I had sent in my test kit with the promise it would be sequenced in 6-8 weeks. Ten weeks later I reached out for support and received none. Then two weeks later I sent another email inquiring about my sample and without a reply just sent off the results. They were not helpful nor apologetic, and didn't say what took them so long. I'm sure there are other services out there that are much quicker and better.

    Bottom Line: No, I would not recommend this to a friend

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