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Nucific Prebio Cleanse

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Nucific Prebio Cleanse


Prebio Cleanse from Nucific is a prebiotic that allegedly helps improve your gut health by providing smoother digestion, more energy, and suppresses appetite.

Nucific Prebio Cleanse Review: Is It Hype or Legit?

By Anthony Dugarte, M.D., C.S.C.S

Published on: Jan 6, 2020

Prebio Cleanse from Nucific is a prebiotic supplement that claims to offer smooth digestion, reduced cravings, and more energy.

Your digestive tract is densely populated with a variety of bacteria - many of which are necessary for normal digestion, as well as overall health. Balance in this system is affected by a number of factors: genetics, age, disease, and diet, to name a few.

As our diet is one factor that we can modify, we have the ability to strategically choose substances that can be beneficial. Prebiotics may be a helpful addition.

Prebiotics are non-digestible food ingredients, often classified as fiber, thought to improve health by stimulating the growth and activity of friendly bacteria in the digestive tract.

Read below to learn more about if Prebio Cleanse is a safe and effective option for improving gut health.

What is Prebio Cleanse and How to use it?

Prebio Cleanse is a dietary supplement that blends 5 different prebiotics in powder form. With daily use, Prebio Cleanse claims to support digestion.

One scoop is considered one serving, and each container has roughly 30 servings. To use, simply mix 1 scoop of Prebio Cleanse in 8oz of water and drink once per day. They recommend consuming just before bed, or when you wake up.

Prebio Cleanse Ingredients

Prebio Cleanse claims to reduce cravings, improve stool consistency, and boost energy through their blend of 5 prebiotics. The sum of all prebiotics included in the blend totals 4.5g, but they do not offer the amount of each.


Fiber is a carbohydrate that is neither digested nor absorbed. It can absorb water and expand while in your stomach, therefore creating a sensation of fullness. Other benefits above and beyond digestion include improving blood glucose levels, promoting weight loss, and enhancing digestion.

Inulin may offer similar benefits.

Hunger, desire to eat, and food consumption were reduced in obese adults randomized to inulin supplementation of 12-weeks when compared to controls. In another randomized trial, 12g of inulin daily for 4-weeks resulted in softer stools, increased stool frequency, and increased amounts of 3 different friendly gut bacteria in constipated adults.


Another non-digestible carbohydrate, fructooligosaccharides are thought to reduce hunger by creating a sensation of fullness in a similar mechanism to inulin and other forms of fiber.

Nonetheless, this may only be detectable with long durations of very high doses. Doses at 16/g per day for 3 to 4-months may be beneficial, whereas as supplementation at less than 10g/day do not seem to affect appetite or food intake.

Doses ranging from 4-15g/day were associated with positive effects on constipation, as well as boosting the friendly gut bacteria bifidobacteria in healthy subjects.


L-Arabinose is a naturally occurring simple sugar found in maize, wheat, rye, and rice. It’s benefits are thought to include the ability to block the absorption of sugar in the intestine allowing for regulation of glucose and insulin levels.

This action was illustrated in a randomized trial where 15 healthy subjects ingested sugar water supplemented with 0, 1, 2, and 3g of L-arabinose after fasting overnight. They found that the largest dose reduced post-meal glucose and insulin levels.

Oat Fiber Extract (15% B-Glucan)

B-glucan, the soluble fiber found in oats, is thought to have a role in appetite and craving reduction.

This action is likely related to B-glucan’s thick, sticky texture which allows it to slow digestion and signal a sensation of being full. Doses ranging from 2.2-5.5g/day seem to be effective in reducing hunger in healthy subjects over the course of a few hours.

Additionally, β-glucan supplementation at 3-3.5g/day doses for 5-weeks seems to promote increases in friendly gut bacteria in subjects with moderately elevated cholesterol.

Konjac Root

Also called elephant yam, this fiber is thought to absorb water and expand to create a sensation of fullness.

Whether or not this effect relates to weight loss remains to be seen as available research is mixed.

In a randomized trial with overweight and obese subjects, treatment with 1.3g of glucomannan (konjac root extract) over the course of 8-weeks did not alter weight loss, body composition, or hunger when compared to placebo.

While not a randomized study, treatment with glucomannan at 500mg twice daily for 6-weeks in overweight and obese subjects resulted in significant decreases in weight, fat mass, and blood glucose.

The Takeaway:

Due to the growing rates of obesity and associated medical conditions, the proposed benefits of prebiotics are a hot topic. While many studies with human subjects exist, the effects of prebiotics are often examined in overweight and obese subjects.

In this population, the ingredients included in Prebio Cleanse’s prebiotic blend seem to be associated not only with reduced appetite and weight loss, but also an ability to soften stool, improve constipation, and boost friendly gut bacteria.

Fructooligosaccharides, L-arabinose, and B-glucan seem to be effective in healthy populations as well.

Nonetheless, as the prebiotic blend in Prebio Cleanse totals 4.5g, we do not know how much of each ingredient is in this supplement. Assuming a relatively equal distribution of each, research studies test one prebiotic at doses comparable, or considerably more than the total dose offered in Prebio Cleanse.

Is It Safe?

Prebiotic blends are generally safe to use.

Inulin and fructooligosaccharides have been studied at doses 3-4x larger than what is offered in the combined total of Prebio Cleanse, without serious side effects.

L-arabinose, B-glucan, and konjac root have been tested at doses that are likely greater than the amount of each that is offered in Prebio Cleanse, again no serious side effects were reported.

For prebiotics in general, mild and self-limiting side effects have been reported and may include abdominal pain, gas, bloating, and diarrhea.

The Takeaway:

As many of the beneficial effects of prebiotics are related to the digestive tract, side effects can include some of the symptoms you are trying to relieve. Gas and bloating are most common, though these side effects can be relieved by lowering your dose or discontinuing use. Seek medical opinion before use.

How Much Does It Cost?

Prebio Cleanse is currently offered only on their website. They do not offer AutoShip, but do offer discounts with larger purchases.

The deals running on their site at the time this article was published:

  • 1 Jar: $49 ($50 savings) + $4.95 Shipping
  • 3 Jars: $129 ($168 savings) + Free Shipping
  • 6 Jars: $240 ($364 Savings) + Free Shipping

Nucific backs their products with a 90-day guarantee. If you’re not satisfied with the results, call for a full refund.

Are There Any Alternatives?

Prebiotic supplements are easily obtained from a variety of vendors. The Nue Co offers a blend that offers 5g of prebiotics per serving, though you get 20 servings per $55 container.

You can get 60 chewable tablets for $13.50 with Life Extension’s Florassist supplement; one tablet offers 1,000mg xylooligosaccharides.

The US Department of Agriculture completed a dietary review of more than 15,000 Americans from 1994-1996 and found that, although results varied by gender and age, the American diet provided an average of 2.6g of the prebiotic inulin alone. Inulin is found naturally in foods like artichokes, asparagus, bananas, garlic, onions, leeks, and wheat.

It seems as though diet is a reasonable source of prebiotics as we may obtain more than half of the total serving offered in Prebio’s blend from just one prebiotic alone.

The Bottom Line

Softer stools, constipation relief, appetite reduction, and weight loss may be possible through the blend of ingredients offered in Prebio Cleanse. Each has been tested in human subjects, though many of their proposed benefits have been investigated in overweight and obese individuals.

Despite support for benefits in this population, as well as some healthy subjects, the issue is that these research studies tested individual prebiotics at daily doses often 3x higher than the total for all ingredients in a 4.5g single serving of Prebio Cleanse.

We also do not have information providing the breakdown for each ingredient - some may be represented in higher amounts than others with in a single serving.

Nonetheless, prebiotics are generally safe for use and may offer medication-free relief for your symptoms, though speaking with a physician before starting a supplement is ideal

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