Clean Zone CPAP Cleaner Review: Is It Right for You?

By HighYa Editorial Team
Published on: Dec 26, 2019

The Clean Zone cleans CPAP machines using activated oxygen that’s meant to kill up to 99% of germs and bacteria.

A device like this presents an easy way to clean your CPAP machine. The traditional way to clean your CPAP device includes daily and weekly cleanings with soap and water. This can become labor-intensive and time-consuming.

Clean Zone promises to remove the labor-intensive part of owning a CPAP machine. Our review of this device will help you understand if its mix of features and pricing are a good fit for your needs.

How the Clean Zone Works

Cleaning your CPAP machine with this device is simple. The Clean Zone has two adapters that will fit most CPAP machines.

To use Clean Zone, remove your mask from your CPAP tube, attach one of the adapters to the tube, then plug the adapter into the cleaner.

Press the power button. The device will beep once and then begin a 30-minute cleaning cycle. During this cycle, your Clean Zone will circulate activated oxygen through your CPAP tube and into the reservoir. As the air moves through your device, it kills off bacteria and germs.

These bacteria and germs can give you skin rashes and skin infections if left unchecked. Also, germs and mold can build up in your CPAP machine’s water reservoir, increasing the likelihood you could get sick.

At the end of the cycle, the machine shuts itself off automatically. At any time during the cleaning cycle, you can press the power button to turn off the Clean Zone.

You also have the option of cleaning your entire machine in a sanitizing bag that comes with the device. Using this cleaning method allows you to clean your mask as well as the outside and inside surfaces of your reservoir.

The Clean Zone uses a rechargeable battery you can charge with a USB cord Clean Zone includes with your device.

The device can clean A-PAP and BI-PAP machines, too.

Activated Oxygen: Scientific Efficacy and Safety

Ozone is what’s known as an “unstable” molecule. This means that one of its three oxygen atoms is prone to break off. That molecule can then attach itself to things like bacteria, change their chemical make-up and kill them.

Ozone stabilizes in about two hours, at which point it no longer disinfects.

Jose Acosta, a certified respiratory therapist with The CPAP Shop, told us that ozone’s disinfecting powers are used in a variety of ways.

“The method of using activated oxygen for disinfection has been used commonly for water purification, in the handling of fruits and vegetables, and even in hospitals,” Acosta said. “It kills 99.9% of all germs and bacteria on the surface without the use of chemicals or water.”

There is substantial research to show that ozone treatments can kill many types of bacteria including MRSA, a bacterium commonly found in nursing homes and hospitals. Furthermore, in 2003, the FDA approved the use of ozone machines to sanitize medical devices.

What makes this research so promising is that it means there’s a good chance Clean Zone will give you the convenience and the effectiveness you’ve wanted for your CPAP machine.

Ozone CPAP machine cleaners are widely accepted as a safe way to clean your machines. While ozone in large doses can be dangerous (respiratory irritation), the Clean Zone ozone emissions are below the FDA-required limit of 0.05 parts per million.

Though you shouldn’t experience any side effects, take note of any breathing irritation or coughing you experience during a cleaning cycle, especially if you have a pre-existing lung condition.

Pricing and Return Policy

One Clean Zone device costs $99.99 plus $8.95 for shipping. Clean Zone ships via UPS and will take up to 30 days to arrive.

For $10 more, you can add CPAP cleaning wipes to your order. You can use these wipes to clean off debris like oil and dirt that could harbor bacteria.

If you need to make a return, you have 60 days to make a return. Call customer service at (800) 340-3418 to start your return.

How Clean Zone Compares to Handwashing Your Machine


Clean Zone’s main benefits over handwashing a CPAP machine is that it requires a few seconds of setup and you can use the device immediately after a 30-minute cleaning cycle.

A hand wash requires you to use soap, water and, when needed, a long brush you can use to scour the inside of your breathing tube. You’ll need to let your CPAP machine dry, too. The entire process can take more than an hour.

Clean Zone saves you a considerable amount of cleaning and drying time. This is important if you tend to procrastinate and don’t wash your machine until later in the day.

Cleaning Effectiveness

You should consider effectiveness, too, as one of the goals of cleaning a CPAP machine is to prevent bacteria and germ growth.

This is where ozone machines are on equal footing with handwashing, according to an interview Harvard Health did with Dr. Lawrence Epstein, a doctor at a Harvard-affiliated hospital.

Epstein told Harvard Health that ozone cleaners work but that he is “not aware of any comparative trials to say the machines are better than hand washing.”

So, while your Clean Zone provides a convenient, non-messy way to clean your CPAP machine, it likely isn’t any more or less effective than handwashing the machine.

The Bottom Line

Clean Zone uses proven ozone disinfecting methods to clean your CPAP machine without the hassle of handwashing its parts every day. In our opinion, this device provides a lot of value for CPAP owners.

Who Clean Zone Is Good For

  • You Are Forgetful: If you have a hard time remembering to clean your CPAP machine, the Clean Zone’s 30-minute clean cycles are a lifesaver. You can forget to clean your machine all day, remember around bedtime and turn a cleaning cycle on. You’ll have to wait 30 minutes. However, that wait time is shorter and less labor-intensive than handwashing the machine and waiting overnight for it to dry.

  • You Care About Convenience More Than Price: The Clean Zone’s $99.99 price tag is well worth it if you’re tired of handwashing your device every day and you want a neat, quick alternative.

Who Clean Zone Isn’t Good For

  • You Have a Sensitive Respiratory System: While the Clean Zone puts out ozone levels below FDA limits, the FDA says you could still be at risk of coughing and respiratory irritation. “Some healthy people are more sensitive to ozone,” the organization says. “They may experience health effects at lower ozone levels than the average person.”

Customer Reviews

Start your review of Clean Zone CPAP Cleaner:
  • 30 Customer Reviews
  • 13% Recommend This Company
1.9 out of 5
5 star: 10% 4 star: 0% 3 star: 16% 2 star: 13% 1 star: 60%

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  • Works just fine for me

    • By D H.,
    • Yarmouth, ME,
    • Oct 21, 2020
    • Verified Reviewer
    • Length of Use: 6–12 months
    Overall Experience:

    Customers complain of smell, the smell is the ozone at work. I put my hose tank and facemask in the ziplock bag and turn the unit on in the morning. When I get home from work I do a quick rinse to get the face oils out of the mask and hose and then let everything air out overnight.

    I have two hoses, tanks, and mask so use them every other day. The 24 hours of air out is key to the smell complaint.

    I get about six cleanings per battery charge. I have had the unit for six months plus and have no issues.

    Try a different charging cable that works with another device you own if the unit will not charge for you.

    Pros and Cons:

    • No direct contact with company
    • Love small size especially for travel
    • Since all ozone is in a ziplock bag vs others, a lot less offset is in the room while cleaning
    • Unit arrived about 10 days after order
    • No easy options to buy supplies or bag and second hose adapter

    Bottom Line: Yes, I would recommend this to a friend

  • Product lasted 2 weeks - won't respond to customer service complaints

    • By Mick J.,
    • Wisconsin,
    • Sep 1, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    Pretty poor. Within the first week, the zipper broke and needed to be repaired daily. Now the main unit won't take a charge. And they don't respond to issues. Money wasted - buy something else.

    Pros and Cons:

    • No “pros” were specified in this review
    • Product and customer service sucked

    Bottom Line: No, I would not recommend this to a friend

  • Crooked company

    • By Terry B.,
    • Jackson, OH,
    • Aug 20, 2020
    • Verified Reviewer
    Overall Experience:

    I ordered one. They didn't ship it to me and won't give me a refund. Everyone with problems please report them to the Federal Trade Commission. Let's get them put out of business.

    Pros and Cons:

    • No “pros” were specified in this review
    • They are liars
    • They are cheats

    Bottom Line: No, I would not recommend this to a friend

  • Poor customer service

    • By Ronald P.,
    • West Bloomfield, MI,
    • Aug 18, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    After only a short couple of months the connecting charger failed to operate properly. When I called customer service they told me I was beyond the 60-day warranty and would have to purchase another device! Product is not made well and certainly did not hold up for me. I will purchase a competitor product that has better customer service and stands behind its product. I was not asking for a refund but rather just a product that works for more than 60 days!

    Pros and Cons:

    • No “pros” were specified in this review
    • Poor quality
    • Poor customer service for repair of defective device

    Bottom Line: No, I would not recommend this to a friend

  • Cleaner not working after three months

    • By Judith A.,
    • Sarasota, FL,
    • Aug 3, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I ordered my cleaner during the shutdown in March 2020. I was very happy with it for a little while, but about two months later, I noticed that it wasn't keeping the charge so I recharged it. Now it is not working at all. It won't charge and it won't turn on. I am very disappointed and would really like a replacement.

    Bottom Line: No, I would not recommend this to a friend

  • Does not do the job!

    • By Colleen R.,
    • Florida,
    • Jul 25, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    If zero was a choice that would be my rating. Bought this for my husband. It is inconvenient to put everything in their stupid little bag and they have to reassemble the system. IT DOES NOT CLEAN. The mask still had residue that had to be cleaned by hand in soapy water! RUN FAST AWAY FROM THIS CRAP.

    Bottom Line: No, I would not recommend this to a friend

  • Misleading advertising

    • By John T.,
    • Durango, CO,
    • Jul 7, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    It takes 1-1/2 hours to complete the cleaning cycle not just a 1/2 hour as advertised. It's true that the machine's cycle takes 30 minutes, but you must also leave everything in the tightly sealed plastic cleaning zip bag for another hour to allow the ozone to revert to ordinary oxygen. According to the Clean Zone operating instructions, elevated concentration of Ozone is HARMFUL to your health. The instructions state that the Clean Zone does not remove skin oils or mucus from the mask, so it must be cleaned manually.

    Bottom Line: No, I would not recommend this to a friend

  • Absolutely no customer service

    • By Michael O.,
    • Waterford, MI,
    • Jun 23, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    Bought Clean Zone in January 2020. By June it will no longer charge. Have attempted to call the company's Customer Service. No one available and their mailbox is full. Get the picture! Chinese RIPOFF COMPANY!

    Pros and Cons:

    • No “pros” were specified in this review
    • Chinese ripoff company
    • Not reliable or can it be trusted to back its product

    Bottom Line: No, I would not recommend this to a friend

  • Buyer beware

    • By Keith B.,
    • New Jersey,
    • Jun 16, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    Bought in December 2019 and used for the first time in June 2020 as I had not traveled due to the virus. I have SoClean at home so bought this for travel. First time I used it the port did not work and it would not charge so I called customer service and was told sorry, the warranty is up, but they will escalate my request for an exchange. Four days later no return call. Total rip off!

    Pros and Cons:

    • Size
    • It never worked from day 1

    Bottom Line: No, I would not recommend this to a friend

  • My experience

    • By Kathy N.,
    • Kansas City, KS,
    • Jun 16, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I tried the Clean Zone and the problem I had with it was the strong smell. I didn't like breathing in the smell at night. My Respiratory therapist told me not to use it. I still have the odor in my mask.

    Pros and Cons:

    • No “pros” were specified in this review
    • I had a difficult time contacting them.

    Bottom Line: No, I would not recommend this to a friend

  • Leaves a horrid chlorine smell behind

    • By Ramona W.,
    • Minneapolis, MN,
    • Jun 10, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I would not recommend this product. I used it once, and it left a very strong chlorine smell in my mask. I promptly returned it and received a full refund.

    Pros and Cons:

    • Prompt customer service
    • Prompt refund when I sent it back
    • No “cons” were specified in this review

    Bottom Line: No, I would not recommend this to a friend

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Clean Zone CPAP Cleaner