Clean Zone CPAP Cleaner Review: Is It Right for You?

By HighYa Editorial Team
Published on: Dec 26, 2019

The Clean Zone cleans CPAP machines using activated oxygen that’s meant to kill up to 99% of germs and bacteria.

A device like this presents an easy way to clean your CPAP machine. The traditional way to clean your CPAP device includes daily and weekly cleanings with soap and water. This can become labor-intensive and time-consuming.

Clean Zone promises to remove the labor-intensive part of owning a CPAP machine. Our review of this device will help you understand if its mix of features and pricing are a good fit for your needs.

How the Clean Zone Works

Cleaning your CPAP machine with this device is simple. The Clean Zone has two adapters that will fit most CPAP machines.

To use Clean Zone, remove your mask from your CPAP tube, attach one of the adapters to the tube, then plug the adapter into the cleaner.

Press the power button. The device will beep once and then begin a 30-minute cleaning cycle. During this cycle, your Clean Zone will circulate activated oxygen through your CPAP tube and into the reservoir. As the air moves through your device, it kills off bacteria and germs.

These bacteria and germs can give you skin rashes and skin infections if left unchecked. Also, germs and mold can build up in your CPAP machine’s water reservoir, increasing the likelihood you could get sick.

At the end of the cycle, the machine shuts itself off automatically. At any time during the cleaning cycle, you can press the power button to turn off the Clean Zone.

You also have the option of cleaning your entire machine in a sanitizing bag that comes with the device. Using this cleaning method allows you to clean your mask as well as the outside and inside surfaces of your reservoir.

The Clean Zone uses a rechargeable battery you can charge with a USB cord Clean Zone includes with your device.

The device can clean A-PAP and BI-PAP machines, too.

Activated Oxygen: Scientific Efficacy and Safety

Ozone is what’s known as an “unstable” molecule. This means that one of its three oxygen atoms is prone to break off. That molecule can then attach itself to things like bacteria, change their chemical make-up and kill them.

Ozone stabilizes in about two hours, at which point it no longer disinfects.

Jose Acosta, a certified respiratory therapist with The CPAP Shop, told us that ozone’s disinfecting powers are used in a variety of ways.

“The method of using activated oxygen for disinfection has been used commonly for water purification, in the handling of fruits and vegetables, and even in hospitals,” Acosta said. “It kills 99.9% of all germs and bacteria on the surface without the use of chemicals or water.”

There is substantial research to show that ozone treatments can kill many types of bacteria including MRSA, a bacterium commonly found in nursing homes and hospitals. Furthermore, in 2003, the FDA approved the use of ozone machines to sanitize medical devices.

What makes this research so promising is that it means there’s a good chance Clean Zone will give you the convenience and the effectiveness you’ve wanted for your CPAP machine.

Ozone CPAP machine cleaners are widely accepted as a safe way to clean your machines. While ozone in large doses can be dangerous (respiratory irritation), the Clean Zone ozone emissions are below the FDA-required limit of 0.05 parts per million.

Though you shouldn’t experience any side effects, take note of any breathing irritation or coughing you experience during a cleaning cycle, especially if you have a pre-existing lung condition.

Pricing and Return Policy

One Clean Zone device costs $99.99 plus $8.95 for shipping. Clean Zone ships via UPS and will take up to 30 days to arrive.

For $10 more, you can add CPAP cleaning wipes to your order. You can use these wipes to clean off debris like oil and dirt that could harbor bacteria.

If you need to make a return, you have 60 days to make a return. Call customer service at (800) 340-3418 to start your return.

How Clean Zone Compares to Handwashing Your Machine


Clean Zone’s main benefits over handwashing a CPAP machine is that it requires a few seconds of setup and you can use the device immediately after a 30-minute cleaning cycle.

A hand wash requires you to use soap, water and, when needed, a long brush you can use to scour the inside of your breathing tube. You’ll need to let your CPAP machine dry, too. The entire process can take more than an hour.

Clean Zone saves you a considerable amount of cleaning and drying time. This is important if you tend to procrastinate and don’t wash your machine until later in the day.

Cleaning Effectiveness

You should consider effectiveness, too, as one of the goals of cleaning a CPAP machine is to prevent bacteria and germ growth.

This is where ozone machines are on equal footing with handwashing, according to an interview Harvard Health did with Dr. Lawrence Epstein, a doctor at a Harvard-affiliated hospital.

Epstein told Harvard Health that ozone cleaners work but that he is “not aware of any comparative trials to say the machines are better than hand washing.”

So, while your Clean Zone provides a convenient, non-messy way to clean your CPAP machine, it likely isn’t any more or less effective than handwashing the machine.

The Bottom Line

Clean Zone uses proven ozone disinfecting methods to clean your CPAP machine without the hassle of handwashing its parts every day. In our opinion, this device provides a lot of value for CPAP owners.

Who Clean Zone Is Good For

  • You Are Forgetful: If you have a hard time remembering to clean your CPAP machine, the Clean Zone’s 30-minute clean cycles are a lifesaver. You can forget to clean your machine all day, remember around bedtime and turn a cleaning cycle on. You’ll have to wait 30 minutes. However, that wait time is shorter and less labor-intensive than handwashing the machine and waiting overnight for it to dry.

  • You Care About Convenience More Than Price: The Clean Zone’s $99.99 price tag is well worth it if you’re tired of handwashing your device every day and you want a neat, quick alternative.

Who Clean Zone Isn’t Good For

  • You Have a Sensitive Respiratory System: While the Clean Zone puts out ozone levels below FDA limits, the FDA says you could still be at risk of coughing and respiratory irritation. “Some healthy people are more sensitive to ozone,” the organization says. “They may experience health effects at lower ozone levels than the average person.”

Customer Reviews

Start your review of Clean Zone CPAP Cleaner:
  • 29 Customer Reviews
  • 10% Recommend This Company
1.8 out of 5
5 star: 6% 4 star: 0% 3 star: 17% 2 star: 13% 1 star: 62%

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To safeguard you and ensure helpfulness and relevance, our compliance team manually assess every customer review before it goes live.

We have a zero-tolerance policy for fake reviews, and companies cannot control or alter any reviews at any time.

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  • Company and equipment

    • By Bob J.,
    • Pennsylvania,
    • May 5, 2020
    • Verified Reviewer
    Overall Experience:

    I purchased the device after seeing an ad on TV. Once I started using it was very good. After a short time had an issue with the device and dealing with the company was excellent. They replaced equipment without issue. Nice to deal with a company that values its customers and makes a product that is valuable. Should have purchased sooner.

    Bottom Line: Yes, I would recommend this to a friend

  • Trying to get a replacement clean zone white sanitizing bag and I am unable to get to customer service.

    • By Susan K K.,
    • Georgia,
    • May 13, 2020
    • Verified Reviewer
    Overall Experience:

    All they do is want you to place an order for the whole kit. If anyone can help I would appreciate hearing from you.

    Very happy with the machine but really need a new sanitizing bag. My sister bought it for her husband but either the bag was not there or they didn't see it. He is cleaning his equipment in the travel bag.

    Bottom Line: Yes, I would recommend this to a friend

  • GOOD, BUT!

    • By Judith S.,
    • Kentucky,
    • Feb 24, 2020
    • Verified Reviewer
    Overall Experience:

    Why would a company "NOT" include a USB adapter for this unit. Without a USB Adapter, you can't use it?

    Remember when you were a kid and received a Christmas gift without batteries and couldn't use it? I got the same feeling upon receiving this unit.

    I bought a USB unit for less than $2.89 retail but it should have been included!

    WHY WOULD you "NOT" include the USB?

    Bottom Line: No, I would not recommend this to a friend

  • Clean Zone charging

    • By Terry B.,
    • Durham, NC,
    • Apr 20, 2020
    • Verified Reviewer
    Overall Experience:

    I have a great experience with this machine. Fresh every single time. It’s easy to use, very little time spent for the whole process. I do have a problem charging it, however. The red light indicating the machine is charging does not always come on. I’ve experienced this problem regularly and it gets to be very frustrating for me. Other than this I have no complaints.

    Bottom Line: Yes, I would recommend this to a friend

  • Not happy

    • By Bernard P.,
    • Leslie, MI,
    • Apr 30, 2020
    • Verified Reviewer
    Overall Experience:

    Just got it, charged up (which by the way they don't tell you to charge from the wall plug, you need an adaptor plug that you can put the charging device in but I got it charged through my PC tower). Then they say put everything in the bag and turn it on but ohhhhhhhhhhhhh nooooooo, you need a large plastic bag to put their cleaning bag and device in.

    You should be upfront with the people on how this works.

    Bottom Line: No, I would not recommend this to a friend

  • Smell

    • By Cheryl F.,
    • Ohio,
    • May 7, 2020
    • Verified Reviewer
    Overall Experience:

    I love the fact that it is easy to clean, and easy to charge.

    The carry bag is nice to have as well. But it has a funky smell when I use it at night. Am I doing something wrong or is there something that can be done for that?

    Bottom Line: No, I would not recommend this to a friend

  • Love how it works but.

    • By Frank H.,
    • Pensacola, FL,
    • May 25, 2020
    • Verified Reviewer
    Overall Experience:

    I love how it works but, after a few times of charging it, the charging port apparently has become loose already, and I only recharge something like every other day. Now when I plug in the charger I have to position it in a manner so it will not be moved or bumped during the charging phase or it will quit charging. I know it's not the block or cord because I also charge a phone with it with no problems. I won't recommend this product until that issue is fixed. I certainly hope you do fix this issue because I really love how the rest of it works!

    Bottom Line: No, I would not recommend this to a friend

  • Poor customer service

    • By Diane M.,
    • Tarpon Springs, FL,
    • Mar 2, 2020
    • Verified Reviewer
    Overall Experience:

    I emailed to return one of two of the machines I purchased due to my CPAP breaking. No response by email so I called TopDog Direct to return one machine. The rep was short with me and rude. I had to drag it out of her how to go about returning the device. How hard would it be to explain the process and give the address? I explained that she might want to consider a different line of work since customer service is clearly not her forte'. She said "thank you for the compliment" and we parted ways. The device itself works fine but you have to wonder about a company that tolerates poor customer service.

    Bottom Line: No, I would not recommend this to a friend

  • Can't get past the odor

    • By Charley B.,
    • Lakeside, CA,
    • Apr 30, 2020
    • Verified Reviewer
    Overall Experience:

    Bought this at Bed Bath & Beyond. Got a good price. Can't attest to if it is killing germs or not. What it is doing is leaving a very foul odor embedded in the hose, head gear, and nasal pillow. Even after not using the cleaner and running my CPAP all night for several nights, the odor concentrates and is very strong when I go to turn the CPAP machine on at night. I literally have to let the hose, mask, and pillow vent for a minute before I can put it on my face for the night. This is not good.

    I am a real buyer.

    Bottom Line: No, I would not recommend this to a friend

  • Misleading advertising

    • By John T.,
    • Durango, CO,
    • Jul 7, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    It takes 1-1/2 hours to complete the cleaning cycle not just a 1/2 hour as advertised. It's true that the machine's cycle takes 30 minutes, but you must also leave everything in the tightly sealed plastic cleaning zip bag for another hour to allow the ozone to revert to ordinary oxygen. According to the Clean Zone operating instructions, elevated concentration of Ozone is HARMFUL to your health. The instructions state that the Clean Zone does not remove skin oils or mucus from the mask, so it must be cleaned manually.

    Bottom Line: No, I would not recommend this to a friend

  • Cleaner not working after three months

    • By Judith A.,
    • Sarasota, FL,
    • Aug 3, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I ordered my cleaner during the shutdown in March 2020. I was very happy with it for a little while, but about two months later, I noticed that it wasn't keeping the charge so I recharged it. Now it is not working at all. It won't charge and it won't turn on. I am very disappointed and would really like a replacement.

    Bottom Line: No, I would not recommend this to a friend

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