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GenF20 Plus

GenF20 Plus

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GenF20 Plus is a dietary supplement that is intended to naturally restore your HGH levels through the combined actions of the ingredients offered in their tablets and oral spray.

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GenF20 Plus Review: What You Should Know

By Anthony Dugarte, M.D., C.S.C.S

Updated on: Apr 16, 2020

GenF20 Plus is a dietary supplement that combines tablets and an oral spray to allegedly help you restore your Human Growth Hormone (HGH) levels.

HGH is produced in your pituitary gland and has a number of actions that are related to growth and metabolism. These effects are wide-ranging and are associated with growth, development, metabolism, and physical performance.

Each effect is accomplished either by HGH directly or by insulin-like growth factor I (IGF-I), its primary mediator. Because of their roles in your body, ingredients that are proposed to support these hormones are often included in anti-aging supplements.

As HGH declines with age in both men and women, natural methods of maintaining levels may be advantageous. According to the product page, with daily use of GenF20 you will:

  • Look younger
  • Increase muscle mass and definition
  • Boost Metabolism and fat loss
  • Enhance libido
  • Increase energy

While these benefits are clearly desirable, can GenF20 Plus really live up to such lofty claims?

In this article, we’ll review any research associated with the proposed benefits to help you determine if GenF20 Plus can naturally boost your GHG levels.

Is There Any Scientific Support for GenF20 Plus Ingredients?

According to the website, the GenF20 Plus blend of ingredients is responsible for the alleged ability of the supplement to restore HGH levels.

For best results, GenF20 Plus recommends taking 2 tablets with breakfast and 2 tablets with dinner. Also, you should use 3 pumps of the oral spray under your tongue with each 2-tablet serving.

Each GenF20 Plus tablet contains the following (keep in mind that recommended use is to ingest 4 tablets each day, so multiply the above servings by 4 for the daily totals):

Amino Acids:

  • L-Arginine – 130mg
  • L-Glutamine – 115mg
  • L-Glycine – 100mg
  • L-Lysine – 100mg
  • L-Tyrosine – 100mg
  • L-Ornithine – 25mg
  • L-Valine – 40mg

Amino acids serve as the building blocks for all proteins – molecules that have a hand in virtually every chemical reaction in your body. As HGH is a protein hormone, the ability of amino acids to support its function has been investigated.

Thus, amino acids are common ingredients in products that claim to boost HGH.

A supplement offering a similar blend of amino acids to that of GenF20 Plus was recently studied. Over the course of 2-hours, the supplement boosted HGH levels more than 680% when compared to placebo.

Extracts, Minerals, and Other Ingredients:

  • Deer Antler Velvet – 50mg
  • Colostrum – 50mg
  • GABA – 50mg
  • GTF Chromium – 0.1mg
  • Phosphatidylcholine – 25mg
  • Astragalus Root Extract – 60mg
  • Anterior Pituitary Powder – 30mg

The above ingredients are commonly found in supplements with proposed HGH-boosting benefits.

Gamma-aminobutyric acid, or GABA, is one example. This chemical messenger acts in your brain and has an inhibitory function on the nervous system though it may also increase HGH levels.

In fit men, 3000mg of GABA boosted HGH up to 400% 90 minutes after taking 3,000mg of GABA. GenF20 Plus offers just a third of this amount each day, however.

Astragalus is another common ingredient that is alleged to support HGH. Most of its support is in laboratory and animal studies. In mice, astragalus reduced the metabolic stress of weight gain and insulin resistance.

Colostrum is a substance found in the breast milk of mammals. In addition to offering immune support, it may improve exercise performance.

According to this study, colostrum may reduce body fat and increase lean muscle by boosting IGF-1 levels.

Every pump of the oral spray provides a similar blend of ingredients:

  • B12
  • B6
  • SAMe
  • GABA
  • Mucuna Pruriens (seed)
  • Moomiyo Extract
  • Ornithine Alpha Ketoglutarate
  • L-Glutamine
  • L-Arginine
  • L-Lysine
  • L-Valine
  • L-Isoleucine
  • L-Tyrosine
  • Glycine

GenF20 Plus Clinical Studies

At the very least, it’s clear that GenF20 Plus includes ingredients that are commonly found in supplements that claim to elevate HGH levels, but does that mean they actually work?

We may be able to shed some light on this question by reviewing the results of a clinical trial that tested GenF20 Plus.

A 2015 study with 70 healthy adults examined the effect of GenF20 Plus on IGF-1 levels, memory, libido, energy, sleep, and body composition. Patients included in the study had at least 2 of the following conditions: decreased memory, decreased libido, low energy levels, or poor quality of sleep.

Compared to placebo, those that were randomized to treatment with GenF20 Plus experienced a greater increase in IGF-1, particularly if they were age 40 or greater. GenF20 Plus did not benefit memory, libido, energy, or quality of sleep, however.

Thus, there is some support for the ability of GenF20 to boost IGF-1, though this did not translate into any real benefits for the study subjects.

The researchers believe that perhaps the trial did not allow for a long enough time period to see tangible benefits. While this could be true, there are not any studies that evaluate the long-term use of GenF20.

It is also important to mention that articles published in the Open Access Journal of Clinical Trials (OAJCT) do go through a peer-review process. However, the impact factor of this journal is less than 1. This indicates that the articles published in OAJCT are not cited very often.

Is GenF20 Plus Safe?

A common benefit of using a nutraceutical is that the risk for serious adverse effects is often lower than traditional medical treatment. GenF20 Plus likely falls into this category as many of the ingredients in their blend are obtainable from a regular diet.

Much of the research regarding the ingredients has been done in animals or in a laboratory setting, however. These types of trials are not necessarily indicative of the safety or efficacy in human subjects.

Thus, the best indication we have so far is the GenF20 Plus Clinical Trial.

There were 7 total adverse events in the GenF20 Plus group and 5 in the placebo group. These included mainly acid reflux and stomach pain, though headaches and rash were also reported. Most events were considered mild and all resolved by the end of the study.

Despite a low risk for use, it is best to speak with a doctor before using GenF20 Plus. If you are experiencing decreased memory, libido, energy levels, or sleep, your doctor can help you identify the source of these issues.


GenF20 Plus is available directly from their site. You can purchase packs that include both the tablets and oral spray (recommended use), just the tablets, or just the spray. Purchasing options are:

Both tablets and oral spray:

  • 6-month supply – $399.99
  • 5-month supply – $349.99
  • 4-month supply – $287.99
  • 3-month supply – $220.99
  • 2-month supply – $159.99
  • 1-month supply – $82.99

Tablets only:

  • 6-month supply – $359.94
  • 5-month supply – $299.95
  • 4-month supply – $239.96
  • 3-month supply – $179.97
  • 2-month supply – $119.98
  • 1-month supply – $59.99

Oral spray only:

  • 6-month supply – $239.94
  • 5-month supply – $199.95
  • 4-month supply – $159.96
  • 3-month supply – $119.97
  • 2-month supply – $79.98
  • 1-month supply – $39.99

Also, if you purchase a 4-month supply and send your before and after pictures, you’ll be awarded a one-year supply of GenF20 Plus absolutely free if your pictures are selected for the website.

Lastly, your purchase is backed by a 60-day guarantee. If you are unsatisfied for any reason, process your return by sending your used GenF20 Plus to: Leading Edge Health, c/o 129, Roweland Drive, Johnson City, TN, 37601.

For additional questions, call (866) 269-3487.

The Bottom Line

While there is some support for GenF20 Plus to boost your IGF-1 levels, there is no evidence that this effect will translate into any meaningful health benefits.

Thus, claims that you will look younger, build muscle, burn fat, recharge your sex life, or increase energy with daily use are not supported at this time.

Nonetheless, GenF20 Plus is generally safe when used as directed, though acid indigestion, stomach pain, and headaches may occur.

Between the lack of science to back up the lofty claims and the expensive price tag, GenF20 is likely not your best first option. Your best bet is to first speak with a doctor to identify the source of symptoms you may be experiencing.

Customer Reviews

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Posted on Nov 29, 2022

Down 9 pounds in a month

By George F., Newport Beach, CA, Verified Reviewer

I've been taking GenF20 Plus for the last 6 weeks and noticed an increase in energy after 3 weeks.

I've improved how much I stay asleep and have noticed that I'm not as sore after I work out.

One of the reasons I took this supplement in the first place was because GenF20 Plus is the only HGH supplement I found that was backed by a clinical study.

I showed it to my doctor and he was totally fine with me taking it. I'm incredibly pleased with my weight loss so far and will continue to take it.

Length of Use: 3–6 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Quick, free shipping.

Discounted price for buying multiple boxes.

The spray doesn't taste bad like others I've had.

Supplement is not cheap.

Posted on Jul 30, 2019


By David B., Phoenix, AZ, Verified Reviewer

My wife and I have been taking GenF20 HGH Releaser pills for over a year. The vendor's claims have been completely false. We haven't lost any belly fat, in spite of diligent daily diet control and exercise. We feel woozy, "out-of-it" and lethargic most of the time, feelings we never experienced before beginning the GenF pill regimen. In my opinion, this product is a waste of money and ineffective. I say this based on the results my wife and I have experienced over a period of more than a year of taking this supplement. We plan to discontinue paying their rip-off price for an ineffective dietary supplement once our current supply is depleted. We are still hoping to experience the benefits touted by the vendor, in which case we would continue using the product, but I seriously doubt anything will change within the next six months.

Bottom Line: No, I would not recommend this to a friend

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