Nugenix GH-Boost Review - Can It Work or Is It Just a Fad?

By HighYa Research Team
Updated on: Dec 27, 2019

Medically Reviewed by Anthony Dugarte, M.D., C.S.C.S

What Is Nugenix GH-Boost?

Nugenix GH-Boost is a supplement that claims to boost your growth hormone production through a blend of amino acids and sleep-supporting ingredients.

Most men experience a decline in growth hormone when they hit their 40s, which leads to a decrease in energy and a slow degeneration of muscle strength. Supplements like Nugenix GH-Boost market themselves as a simple solution for those men.

What makes this supplement unique is that it combines ingredients that help you sleep better, as your body uses sleep to produce growth hormone.

Usage and How It Works

You’ll take one packet of GH-Boost mixed with water before bed. Take it on an empty stomach. By doing so, Nugenix says you’ll boost your body’s ability to produce growth hormones.

However, GH-Boost doesn’t increase your growth hormone levels by putting them straight into your body (taking growth hormone without a prescription is illegal).

Rather, it helps you sleep better. Sleep is key to growth hormone production. About 70% of your growth hormone is produced in slow-wave sleep. However, that production decreases by 200% to 300% between the ages of 30 and 40.

Because your growth hormone production decreases so much, men in their 30s often experience a reduction in energy and muscle strength.

Nugenix claims their supplement can help you produce more growth hormone through better sleep; in this article, we review the safety and efficacy of this supplement.

Ingredients and Efficacy

How well Nugenix GH-Boost works (or doesn’t work) is based on the ingredients it includes.

If these ingredients have solid scientific evidence for helping you extend your slow-wave sleep, then there’s a good chance Nugenix GH-Boost can help you produce more growth hormone.

As such, we’ve done in-depth research on each ingredient to find out if they can help your growth hormone production.


“GABA” stands for gamma-aminobutyric acid. This chemical operates in your brain. It binds to certain parts of your nervous system to calm you down, which leads to better sleep. This purpose meshes with Nugenix’s claim that GH-Boost can help you sleep better.

However, when taken in supplement form, GABA can’t provide the same results as the GABA already present in your body because supplemental GABA can’t cross over from your blood vessels to your brain.

Therefore, you’re most likely to notice little if any effect of Nugenix GH-Boost’s GABA on your mood and sleep habits.

One study found that GABA can boost your growth hormone levels up to 400% 90 minutes after taking 3,000 mg of GABA. When mixed with the amino acid theanine, GABA improved the duration and quality of sleep in mice. In those treated with 300mg daily for 4-weeks, subjective and objective sleep quality improved.

Nugenix GH-Boost contains 5,000 mg of GABA in each serving, greatly exceeding what was used in the aforementioned studies. However, keep in mind the study was done on 18- to 30-year-olds – this does not guarantee the same results for other populations.


This ingredient is an amino acid you get in high doses from “dairy products, meat, poultry and fish,” notes.

In some older studies, pairing arginine with lysine demonstrated an ability to promote HGH secretion, though this was not corroborated by a recent study examining elderly female heart failure patients.

When part of an amino acid blend, arginine increased HGH levels 8-fold from baseline measurements in just 2-hours when compared to placebo, This study simply illustrated the ability of this supplement to boost HGH; we do not know if this results in the proposed benefits.


This amino acid is thought to support immunity, digestion, and muscle. Glutamine and HGH have been thought to work in concert for some time, though glutamines role in boosting HGH has been challenging to prove.

In less than 90 minutes, 2g of glutamine increased HGH in 8 of 9 subjects, though further evidence supporting this action is lacking. v


L-lysine is an amino acid that’s often present in the foods you eat.

The chemical is best known for preventing the onset of herpes sores and, if a sore appears, healing them quicker than they’d heal without treatment.

There are conflicting results from studies linking L-lysine to growth hormone production.

Lysine-containing amino acid mixes were shown to boost HGH secretion in early studies. This was not corroborated in elderly heart failure patients.


This chemical is an amino acid your body makes. It’s used to boost athletic performance and, in some cases, to aid sleep.

Ornithine and arginine increased HGH in athletes, as well as in rats. Support for this effect is otherwise limited, particularly regarding any benefit for sleep quality or sleep length.


Glycine is an amino acid, too. Unlike the other amino acids in this supplement, glycine has multiple studies indicating that taking at least 3 grams of glycine can improve sleep quality.

Keep in mind, these doses are more than 30x what is included in Nugenix GH-Boost.

The Takeaway

Nugenix has formulated their supplement with ingredients that, in theory, provide good sleep (GABA) and amino acids that stimulate growth hormone production.

Gaba and glycine seem to have the most support for their roles in sleep, though studies offered much latger glycine doses than what is in Goli. The remaining ingredients have weak to mixed literature supporting their roles in boosting HGH or improving sleep.

How that boost manifests in your body is what is most important. Keep a journal detailing your energy levels and overall alertness and feeling of strength. This method will help you see real changes or a lack of change.

Furthermore, the arginine studies we read emphasized the importance of exercise. Physical exercise boosts your growth hormone production more than arginine and arginine paired with exercise.

If your goal is to increase your growth hormone, you need to exercise. You may not have the energy at first because of your growth hormone decline. However, over time you should see measurable increases in your energy.

Side Effects

Four of the six main ingredients in GH-Boost have reported side effects:

L-arginine can cause nausea, cramps, diarrhea and low blood pressure. Doses at 3.6 g/kg body-weight/day are safe in rats. Long-term studies are needed to characterize the effects of chronic use in humans.

L-glutamine can cause constipation, cough, head pain, intense abdominal pain, nausea. Doses (>40g/day) may be problematic and associated with adverse effects rekated to digestion, liver, and kidney function.

L-lysine can cause stomach pain and diarrhea. Use is generally safe, even at doses up to 17,500mg/day.

Glycine can cause soft stool, nausea, vomiting and stomach upset. Glycine is generally safe, even at doses greater than 60g/day only being associated with gastrointestinal issues.

Pricing and Return Policy

You can buy one box of 30 servings of GH-Boost from Nugenix for $69.99. GNC sells the same box size for $79.99, with the option to go on a monthly subscription plan for $63 a month and free shipping.

You can make a return only if you haven’t opened the supplements box. If there’s any evidence the box was opened, you won’t get a refund.

To start your return, you’ll call (855)714-3234. The phone representative will give you a return merchandise authorization number (RMA) you’ll need to write on the outside of the box you send back to Nugenix. The company’s fine print says they will not accept your package without an RMA displayed on the outside of the box.

If you have to make a return, we suggest using a Sharpie to write the number on every side of the box.


  • Nugenix’s use of L-arginine has enough research behind its ability to boost your growth hormones to be a clear benefit of HG Boost.
  • Does a good job of leveraging your sleep-based growth hormone production by telling you to take it at night.
  • L-arginine’s growth hormone boost should coincide with the boost you get from your slow-wave sleep.


  • Not much evidence that Nugenix GH-Boost’s ingredients will help you sleep better.
  • This supplement is a better fit if you don’t have sleeping issues, especially during the first part of the night.

The Bottom Line

Your body gets the bulk of its slow-wave sleep in the first half of your night. So, prepare yourself for sleep by doing some physical activity during the day, ceasing screen time about 30 minutes to an hour before bed and making sure your room is between 60 and 67 degrees, if possible.

You may find the most success with this supplement if you exercise, create a sleep environment that will help you maximize your slow-wave sleep and take this supplement in the evening before bed.

Customer Reviews

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  • Side effects of GH-Boost

    • By Mark B.,
    • Tennessee,
    • Feb 6, 2020
    • Verified Reviewer

    Experienced a "flush" similar to niacin shortly after taking, also shortness of breath and heart palpitations. I did seem to sleep a little better, but I have discontinued until I consult with a physician.

    Bottom Line: No, I would not recommend this to a friend

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