Nugenix GH-Boost Review - Can It Work or Is It Just a Fad?

By HighYa Research Team
Published on: Nov 21, 2019

What Is Nugenix GH-Boost?

Nugenix GH-Boost is a supplement that claims to boost your growth hormone production through a blend of amino acids and sleep-supporting ingredients.

Most men experience a decline in growth hormone when they hit their 30s, which leads to a decrease in energy and a slow degeneration of muscle strength. Supplements like Nugenix GH-Boost market themselves as a simple solution for those men.

What makes this supplement unique is that it combines ingredients that help you sleep better, as your body uses sleep to produce growth hormone.

Usage It and How It Works

You’ll take one packet of GH-Boost mixed with water before bed. Take it on an empty stomach. By doing so, Nugenix says you’ll boost your body’s ability to produce growth hormones.

However, GH-Boost doesn’t increase your growth hormone levels by putting them straight into your body (taking growth hormone without a prescription is illegal).

Rather, it helps you sleep better. Sleep is key to growth hormone production. About 70% of your growth hormone is produced in slow-wave sleep. However, that production decreases by 200% to 300% between the ages of 30 and 40.

Because your growth hormone production decreases so much, men in their 30s often experience a reduction in energy and muscle strength.

So, when Nugenix claims their supplement can help you produce more growth hormone through better sleep, the claim is in line with the general medical consensus.

Ingredients and Efficacy

How well Nugenix GH-Boost works (or doesn’t work) is based on the ingredients it includes.

If these ingredients have solid scientific evidence for helping you extend your slow-wave sleep, then there’s a good chance Nugenix GH-Boost can help you produce more growth hormone.

As such, we’ve done in-depth research on each ingredient to find out if they can help your growth hormone production. Our sources include, the National Institutes of Health, WebMD and Mayo Clinic. When possible, we have linked to our sources.


“GABA” stands for gamma-aminobutyric acid. This chemical operates in your brain. It binds to certain parts of your nervous system to calm you down, which leads to better sleep. This purpose meshes with Nugenix’s claim that GH-Boost can help you sleep better.

However, when taken in supplement form, GABA can’t provide the same results as the GABA already present in your body because supplemental GABA can’t cross over from your blood vessels to your brain.

Therefore, you’re most likely to notice little if any effect of Nugenix GH-Boost’s GABA on your mood and sleep habits.

That being said, there is at least one study indicating GABA can boost your growth hormone levels up to 400% 90 minutes after taking 3,000 mg of GABA.

Nugenix GH-Boost contains 5,000 mg of GABA in each serving, which exceeds what was used in the aforementioned study. However, keep in mind the study was done on 18- to 30-year-olds.

If you’re in your late 30s or in your 40s, you are outside the age range in the study. Therefore, there’s no guarantee that you’ll experience a 400% increase in your growth hormone levels.


This ingredient is an amino acid you get in high doses from “dairy products, meat, poultry and fish,” notes.

It’s also key to your body’s production of nitric oxide, which helps increase by relaxing your blood vessels. It can also increase human growth hormone production, though existing studies tested L-arginine on small groups of people.

Though small in their scope, those studies revealed a marked increase in growth hormone production in males who took the amino acid compared to men who didn’t.

Furthermore, Nugenix’s claim that GH-Boost can increase your growth hormone production by 100% is backed by a peer-reviewed study published in the Journal of Applied physiology.


This ingredient does not help with sleep nor does it aid in hormone production. There is some evidence that it can help with muscle growth in people with conditions that cause their muscles to deteriorate.

However, no credible sources we looked at linked L-glutamine to muscle growth in this supplement’s target audience: men aged 30 and older.


L-lysine is an amino acid that’s often present in the foods you eat.

The chemical is best known for preventing the onset of herpes sores and, if a sore appears, healing them quicker than they’d heal without treatment.

There are conflicting results from studies linking L-lysine to growth hormone production.

For example, a study done in the 1980s indicated taking lysine with arginine could stimulate growth hormone production. However, a study done in the 90s came to the opposite conclusion.

This tells you that there’s a good chance the lysine included in this supplement won’t have as much of an impact on your growth hormone production as arginine, a relatively well-established catalyst for producing growth hormone.


This chemical is an amino acid your body makes. It’s used to boost athletic performance and, in some cases, to aid sleep.

While WebMD notes ornithine has some promise for athletes, there isn’t enough existing research to support the claim that L-ornithine can “improve sleep quality or sleep length in healthy adults”


Glycine is an amino acid, too. Unlike the other amino acids in this supplement, glycine has multiple studies indicating that taking at least 3 grams of glycine can improve sleep quality.

This ingredient zeroes in on the importance of getting good sleep so your body can produce growth hormone.

Unfortunately, GH-Boost contains 100 mg of glycine per dose, which is far below what was used in studies supporting glycine’s positive effect on sleep. Because of this, our opinion is that the glycine available in GH-Boost won’t improve your sleep in a significant way.

Efficacy Conclusions

Nugenix has formulated their supplement with ingredients that, in theory, provide good sleep (GABA) and amino acids that stimulate growth hormone production.

However, our analysis indicates you’ll find the most benefit from arginine because it has the most research backing its ability to boost growth hormone production.

How that boost manifests in your body is what is most important. Keep a journal detailing your energy levels and overall alertness and feeling of strength. This method will help you see real changes or a lack of change.

Furthermore, the arginine studies we read emphasized the importance of exercise. Physical exercise boosts your growth hormone production more than arginine and arginine paired with exercise.

If your goal is to increase your growth hormone, you need to exercise. You may not have the energy at first because of your growth hormone decline. However, over time you should see measurable increases in your energy.

Side Effects

Four of the six main ingredients in GH-Boost have reported side effects:

  • L-arginine: Nausea, cramps, diarrhea and low blood pressure.
  • L-glutamine: Constipation, cough, head pain, intense abdominal pain, nausea
  • L-lysine: Stomach pain and diarrhea.
  • Glycine: Soft stool, nausea, vomiting and stomach upset

WebMD points out that L-glutamine is safe up to 40 grams a day (Nugenix GH-Boost has 1.5 grams per serving), and that L-lysine is safe if used for up to one year.

Pricing and Return Policy

You can buy one box of 30 servings of GH-Boost from Nugenix for $69.99. GNC sells the same box size for $79.99, with the option to go on a monthly subscription plan for $63 a month and free shipping.

You can make a return only if you haven’t opened the supplements box. If there’s any evidence the box was opened, you won’t get a refund.

To start your return, you’ll call (855)714-3234. The phone representative will give you a return merchandise authorization number (RMA) you’ll need to write on the outside of the box you send back to Nugenix. The company’s fine print says they will not accept your package without an RMA displayed on the outside of the box.

If you have to make a return, we suggest using a Sharpie to write the number on every side of the box.


  • Nugenix’s use of L-arginine has enough research behind its ability to boost your growth hormones to be a clear benefit of HG Boost.
  • Does a good job of leveraging your sleep-based growth hormone production by telling you to take it at night.
  • L-arginine’s growth hormone boost should coincide with the boost you get from your slow-wave sleep.


  • Not much evidence that Nugenix GH-Boost’s ingredients will help you sleep better.
  • This supplement is a better fit if you don’t have sleeping issues, especially during the first part of the night.

The Bottom Line

Your body gets the bulk of its slow-wave sleep in the first half of your night. So, prepare yourself for sleep by doing some physical activity during the day, ceasing screen time about 30 minutes to an hour before bed and making sure your room is between 60 and 67 degrees, if possible.

You may find the most success with this supplement if you exercise, create a sleep environment that will help you maximize your slow-wave sleep and take this supplement in the evening before bed.

Write a Review for Nugenix GH-Boost!

Share your experience to help others shop smarter & discover great products.

Write a Review