Penetrex Review – Pain Relief or Hype?

By Tyler Cooper
HighYa Staff
Published on: Feb 25, 2019

Penetrex is a pain-relieving, anti-inflammatory solution that is designed to be applied to the body anywhere you may be experiencing pain, discomfort, tingling, or numbness. This includes the back, neck, knees, shoulders, hands, and feet.

The product is billed as an effective treatment on its own, as well as an excellent complement to existing therapies such as heating pads, ice packs, arthritis gloves, massagers, supplements, and many other treatments.

In terms of the serum itself, the manufacturer insists that it has no overpowering odor; instead, the non-greasy, non-staining, paraben-free solution is infused with a small amount of chamomile oil extract which is said to provide a subtle, pleasant smell before vanishing entirely within a few minutes.

Of course, if you’re someone currently dealing with pain or discomfort, this may sound like just the product you’ve been searching for. Before we can know for certain that it will be effective, however, we need to learn a bit more about how it actually works. Let’s carry this thought over to the next section.

How Does Penetrex Work?

On the product’s main website, we’re told that Penetrex is a “cutaneous” anti-inflammatory solution. Simply put, this means that it is a topically-applied product, as opposed to an oral mechanism like ibuprofen or other medications.

The makers of Penetrex state that one of the advantages of their product is that it can be applied directly to the area where you are feeling pain or discomfort. They mention that it utilizes “state of the art dermal delivery systems” to penetrate the skin, getting right to the center of where the pain is.

Crucially, the manufacturer also mentions that they are unable to give a time-frame for when the product should begin working for each individual due to the fact that no two cases of inflammation are exactly alike. That said, they do mention that most users begin to feel a noticeable change within one week or so of following the recommended treatment plan.

So, what exactly is the recommended treatment plan? And for that matter, can you really trust that the formula in use within Penetrex can provide the benefits described here? We’ll explore both of these topics in-depth in the sections below.

How To Use Penetrex

On the product’s website, users are told to apply Penetrex liberally to the affected area, massaging it in thoroughly for a minute or two. From there, you’ll need to repeat this process 3-4 times per day over an initial treatment period of 7-10 days.

The makers of Penetrex recommend that you time these applications to be directly before you tend to experience the worst of the pain or discomfort you are dealing with, whether that be directly before bed or before a period of high activity. They claim that as your symptoms begin to subside, you can reduce the number of applications done per day gradually to follow suit.

Once again, for anyone dealing with chronic or frequent pain, this sounds like an ideal solution, provided the ingredients within its formula are truly effective. Let’s take a look at each of them, relying on evidence-based sources to give us a clearer idea of what to expect going into using Penetrex.

Penetrex Ingredients

According to the product’s website, Penetrex uses the following active ingredients:

  • Arnica
  • Pyridoxine (Vitamin B6)
  • MSM / DMSO2 methylsulfonylmethane
  • Boswellia serrata
  • Cetyl myristoleate

So, armed with this information, let’s take a brief look at each ingredient, and determine whether or not they have been clinically proven to help provide the benefits described by the makers of Penetrex.

First, according to WebMD, early research shows that arnica may improve symptoms of pain and stiffness in the hands or knees caused by osteoarthritis. In this example, a topical gel containing the herb was applied to the affected area twice daily for 3 weeks.

In addition, there is some evidence that MSM can reduce symptoms of pain stemming from osteoarthritis as well, though trials showed just mild improvement, and the chemical was taken by mouth as opposed to being applied directly to the skin.

Boswellia serrata (otherwise known as Indian frankincense) also holds some pain-relieving potential for arthritis patients. Researchers have shown that it could improve mobility and reduce pain in a localized area by anywhere from 32% to 65%.

Cetyl myristoleate also shows some clinical promise for users with osteoarthritis, but again, early research was conducted using oral medication.

So, where does this leave us? It appears that nearly all of the active ingredients found in Penetrex have at least some clinical link to pain relief, albeit specifically as it relates to osteoarthritis. Of course, this doesn’t mean that it won’t work for you if your pain stems from some other cause, but it also means that it’s no guarantee either way.

Knowing this, what about any potentially adverse side effects associated with these ingredients? We’ll take a closer look below.

Potential Penetrex Side Effects

Most of the ingredients used within Penetrex and listed above didn’t have any potential for serious side effects when used in small doses, according to WebMD and

That said, arnica can be poisonous, WebMD notes, and has even led to death when taken by mouth. No reports of these effects were listed when it comes to a topical application of the ingredient, however.

On the product’s website, no specific dosage amounts are listed for each ingredient. We contacted customer service, who let us know that they would get back with us with this information via phone. No further response was ever provided.

Without this info, it is difficult to say for certain whether or not you may experience any specific side effects.

Looking over dozens of reviews on Amazon, very few users reported experiencing anything adverse using Penetrex, and those that did were minor instances of discomfort. Despite this, if you are concerned about any potential issues, we’d recommend speaking with your doctor before making a purchase of any topical product.

Penetrex Pricing & Return Policy

As of this writing, Penetrex was available both directly on the manufacturer’s website as well as on The product came in several different quantities and was priced the same on both sites:

  • 1 penetrex (2 oz.) - $18.97
  • 1 large Penetrex (4 oz.) - $34.95
  • 6 -pack Penetrex (2 oz.) - $99.00
  • 3-pack Penetrex (4 oz.) - $97.50

As for the return policy through the manufacturer, the website terms state that each order comes fully backed by the company’s “no hassle, no time limit, no questions asked money back guarantee.”

This is important to note, because based on our experience reviewing hundreds of pain-relieving solutions in the past, we’ve found such return policies to be quite rare. To process your return, call (858) 356-5980 or use the company’s contact page.

Wrapping Up: Is Penetrex Effective?

Bringing together everything that we’ve learned about the product, can you really trust Penetrex to provide the pain-relieving benefits described on its website? It’s difficult to say for certain, but let’s look at the facts.

For one, authoritative sources such as WebMD, The Mayo Clinic and list that several of the ingredients found within Penetrex could potentially be effective for reducing pain and discomfort stemming from osteoarthritis.

It’s important to note that just as clinical evidence doesn’t prove without a shadow of a doubt that a substance will work for everyone, it is also true that the absence of evidence linked to a specific illness or injury doesn’t necessarily mean that the ingredients will be ineffective for you.

In fact, the product currently holds a high rating on, where it had more than 20,000 reviews as of this writing. Many of those reviews described positive results when using Penetrex for relief from a wide variety of issues.

Ultimately, if you’d like to give the solution a shot, you can do so knowing that if at any point you determine that it isn’t right for you, you can take advantage of the manufacturer’s all-encompassing return policy for a full refund of the purchase price. If purchased through Amazon, you can also utilize the marketplace’s own 30-day return policy as well.

Have you used Penetrex before? What was your experience like? Share your feedback with other readers below.

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