ProstaGenix Review: Benefits, Ingredients, Side Effects and More

By HighYa Research Team
Updated on: Jun 30, 2020

Medically Reviewed by Anthony Dugarte, M.D., C.S.C.S

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What Is ProstaGenix?

ProstaGenix is a sterol-based prostate supplement that allegedly helps ease the urinary symptoms of benign prostate hyperplasia (BPH), including frequent nightly urination and dribbling.

BPH can affect up to 50% of men over the age of 50. The associated urinary symptoms develop as the prostate gland enlarges and compresses your urethra, the duct that transports urine out of the body from the bladder.

ProstaGenix says their supplement’s mix of ingredients will reduce the effects of an enlarged prostate, also known as benign prostate hyperplasia.

By taking pills, the company alleges that you will:

  • Pee less frequently
  • Sleep better
  • See an increase in sexual performance.

ProstaGenix is based in Hollywood and is relatively well-known because of its lengthy TV commercials featuring famed interviewer Larry King.

This review examines the supplement's ingredients and safety to determine if it can work as advertised.


Each capsule of ProstaGenix contains eight different elements and vitamins as well as a pair of blends: one contains sterol and one contains polyphenols.

While each ingredient may provide a health benefit, the company focuses on sterols, which are plant-based fats that ProstaGenix says have the most significant impact on reducing your prostate-related symptoms.

This is because sterol, according to John Satino, the former research coordinator for Merck Pharmaceutical’s 1989 of BPH drug finasteride, makes the urinary track slicker so that it’s easier for urine to flow out of the bladder and past the prostate.

ProstaGenix contains four types of sterols:

  • Beta-sitosterol: 824 mg
  • Campesterol: 77.2 mg
  • Stigmasterol: 7.6 mg
  • Cholesterol: Less than 0.02 mg

ProstaGenix says that their prostate supplement contains more beta-sitosterol and more sterols, in general, than 157 other supplements on the market.

We contacted the laboratory at which ProstaGenix conducted their studies to verify the results but did not receive a response at the time of publishing.

For now, we’ll provide a list of the supplement’s other ingredients along with their dosages:

  • Polyphenol blend (grape seed and pomegranate extracts, quercetin): 300 mg
  • Vitamin D3 400 IU (about 10 mcg)
  • Zinc: 15 mg
  • Silicon: 10 mg
  • Boron: 3 mg
  • Copper: 2 mg
  • Manganese: 2 mg
  • Iodine: 150 mcg
  • Chromium: 120 mcg
  • Molybdenum: 75 mcg
  • Selenium: 70 mcg

Scientific Evidence

In addition to PostaGenix's purported actions of their sterol ingredients, there are a couple of the other ingredients that have been specifically tested in those with BPH which may also offer relief. notes that there are two studies from the ’90s that support the notion that beta-sitosterol can improve urine flow.

One of those studies, published in The Lance in 1995, indicated that men with BPH who took 60 mg per day of beta-sitosterol saw noticeable results.

“Significant improvement in symptoms and urinary flow parameters show the effectiveness of beta-sitosterol in the treatment of benign prostatic hyperplasia,” the study concluded.

Additionally, the study noted that the prostate sizes in the men taking the beta-sitosterol did not shrink.

The study was a randomized, placebo-controlled, double-blind study, which is the highest standard when it comes to research. It means the men in the study had no idea if they were taking the placebo (fake pill) or beta-sitosterol.

Another randomized, double-blind, placebo-controlled study found that men who took 130 mg of beta-sitosterol per day had better flow, less leftover urine in their bladders and overall better quality of life.

The Linus Pauling Institute referred to these two studies in their analysis of beta-sitosterol's effect on urinary symptoms of BPH. While they noted that the studies show success, they tempered their conclusions.

In 2000, a review of 4 randomized trials conclude that beta-sitosterol safely and effectively improve urinary symptoms in those with mild to moderate BPH.

They also stated that beta-sitosterol may be especially useful in those with a higher risk for adverse effects and complications related to medical or surgical management of their BPH.

In 2012, researches provided an overview of BPH treatment with dietary supplements as the 2000 study represented the last time this information was updated. They corroborated the 2000 report, finding beta-sitosterol to be effective and associated with “mild and infrequent adverse events”.

“Although the results of a few clinical trials suggest that relatively low doses of phytosterols can improve lower urinary tract symptoms related to BPH, further research is needed to confirm these findings,” the site says.

Based on these studies, we’d say there is evidence that beta-sitosterol could help reduce the urinary symptoms of BPH. However, keep in mind the studies to support this conclusion are minimal and, in most cases, more than 20 years old.

Vitamin D is another ProstaGenix ingredient that has been studied in relation to BPH.

In fact, in 322 men, those with vitamin D deficiency also had a larger prostate volume, higher scores in a blood test used to screen for prostate issues, and a lower urinary flow.

In addition to being used as a potential sign of BPH, vitamin D may offer relief as well. Doses at 6000 IU/day can decrease prostate volume in those with BPH, according to this review.

Lastly, the polyphenol blend ingredient, quercetin, has also been studied as a potential BPH treatment option.

In 30 men with chronic pelvic pain, those treated with quercetin 500mg twice daily experienced significant pain improvement and also noted enhanced urinary flow. This hinted at a possible benefit for those with BPH.

In 200 men with BPH, those treated with 40 drops of quercetin daily experienced improved urinary flow rates when compared to placebo at 3-months.

Side Effects

The main side effects you may see come from the supplement’s beta-sitosterol. you may experience diarrhea, nausea, indigestion and other gastrointestinal issues.

A favorable safety profile can be valuable as medical treatment for BPH with alpha blockers may result in drowsiness, dizziness, or unsafe drops in blood pressure.

Though beta-sitosterol is rarely associated with side effects, the doses included in ProstaGenix are much larger than those used in the studies we reviewed.

Vitamin D was safe in doses more than 10x of what is offered in this supplement, while quercetin was safe at more than 3x the dose or ProstaGenix’s total polyphenol blend dose.

Nonetheless, your urinary symptoms may be caused by an underlying medical condition that should be managed by a medical professional.

Prior to starting a new supplement, discuss your symptoms with a physician to determine the best plan of action.

Pricing and Return Policy

At the time of publishing, you could buy one, three or five bottles of Prostagenix from the company’s website (free shipping):

  • One bottle: $49.95
  • Three bottles: $99.95
  • Five bottles: $149.95

The company offers a 100% money-back guarantee through which they’ll give you a refund in the first 90 days after your purchase.


Buy ProstaGenix from Amazon:

ProstaGenix costs $44.08 for one bottle (90 capsules) and $99.98 for three bottles. Shipping is free. You take three pills a day, so one bottle will last you 30 days. It is rated 4.0-stars based on over 650 reviews.

$44.08 (1 bottle)

$99.98 (3 bottles)

The Bottom Line: Is Prostagenix Worth It?

Studies that employ the randomized placebo-controlled double-blind research techniques say there is some merit to ProstaGenix’s claims. Namely, that it could help reduce your urgency to urinate as well as your frequency.

These effects are likely related to the large dose of beta-sitosterol, though vitamin D and quercetin may have supporting roles.

At the same time, there is one video on the site that indicates the supplement can reduce the size of your prostate. We found no research to back this up.

The downside to the supplement is that it, like any supplement, is not guaranteed to work. We saw enough negative reviews on Amazon to know that the claims ProstaGenix makes aren’t promises.

Second, the supplement’s price is expensive compared to other products like it. ProstaGenix says their sterols are of the highest quality, sourced from trees on the French coast.

While they could make a case their ingredients are better so their prices are higher, we found no scientific evidence that indicates sterols of certain origins are more effective.

And, finally, ProstaGenix doesn’t claim to eliminate your BPH symptoms. Rather, it says it can improve them, which is backed up by only limited research.

You could consider popular prescription drugs designed to open your bladder neck to make urination easier: Flomax and its generic counterpart tamsulosin. These drugs are FDA-approved, meaning they have reliable studies to back up their efficacy.

Furthermore, Medicare Part D and Medicare Advantage members could pay between $0 and $18 for a monthly supply of tamsulosin. This is far more affordable than what ProstaGenix charges.

However, Flomax and tamsulosin carry with them the possible side effects of ejaculation issues and diminished sex drive.

For those with BPH wishing to avoid medical or surgical management, or at higher risk with these options, sterol-containing dietary supplements may offer a reasonable option.

Nonetheless, your urinary symptoms should be discussed with a physician to identify the underlying cause before you start taking any supplements. You can then work together to determine the best course of management.

Customer Reviews

Start your review of ProstaGenix:
  • 82 Customer Reviews
  • 73% Recommend This Company
3.9 out of 5
5 star: 71% 4 star: 0% 3 star: 1% 2 star: 2% 1 star: 24%

 Our Promise to You

To safeguard you and ensure helpfulness and relevance, our compliance team manually assess every customer review before it goes live.

We have a zero-tolerance policy for fake reviews, and companies cannot control or alter any reviews at any time.

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  • A big fraud

    • By Joe S.,
    • Miami, FL,
    • Jun 30, 2018
    • Verified Reviewer
    Overall Experience:

    ProstaGenix is a big fraud, and so is Larry King who Advertises. I have been taking this for 2 and 1/2 months with no result whatsoever. I bought it because of Larry King's strong recommendations and I believe he is supposed to be an honest person.

    Bottom Line: No, I would not recommend this to a friend

  • Not as advertised.

    • By William N.,
    • Red Lodge, MT,
    • Oct 5, 2018
    • Verified Reviewer
    Overall Experience:

    I have used this product for six months. The product is not as they advertise. I would not recommend to anyone to use it. I have not had a positive experience with this product. I have about $150.00 invested in product that did not work. I would advise people to try another product and not this one.

    Bottom Line: No, I would not recommend this to a friend

  • Now I can say it

    • By John R.,
    • Bronx, NY,
    • Jul 10, 2018
    • Verified Reviewer
    Overall Experience:

    I bought ProstaGenix back in November 2017. I used every bottle and every three capsules religiously. It is now July 2018. Now I can say it: Did it work? No. Was I satisfied with the product? NO. Did it improve urine stream? NO! That means all the money and time I spent was wasted and in vain. Maybe it worked for Larry King, but NOT for me. I’m sorry but I'll never order this product ever again.

    Bottom Line: No, I would not recommend this to a friend

  • ProstaGenix

    • By Joe S.,
    • Louisiana,
    • Sep 26, 2018
    • Verified Reviewer
    Overall Experience:

    DISAPPOINTED. I started taking this ProstaGenix on August 19, 2018. It is now September 26, 2018, and like other reviews, I purchased this item on Larry King's recommendation. Never again. I was really hoping this product would work for me so I could have shared my experience with my friends who are also suffering with pee issues. If there is a good product out there, please let me know, because ProstaGenix is not one of them.

    Bottom Line: No, I would not recommend this to a friend

  • Not effective enough

    • By Chris S.,
    • México,
    • Aug 22, 2018
    • Verified Reviewer
    Overall Experience:

    On Larry King's strong recommendation, I began taking ProstaGenix two and a half months ago, and quite frankly, if it made a difference, it is not noticeable. In fact, I made a prostate ultrasound before I started taking this supplement, and one after two months of taking it. The second test showed that my prostate had grown larger after ProstaGenix. My urine retention was slightly less, though, but my urine flow was no stronger. I am not satisfied, and am not persuaded by the results to recommend it with any conviction at all.

    Bottom Line: No, I would not recommend this to a friend

  • My results while taking ProstaGenix

    • By Raul E.,
    • Tucson, AZ,
    • Aug 19, 2018
    • Verified Reviewer
    Overall Experience:

    I started taking ProstaGenix on July 22, 2018 and have not seen any improvements in my prostate symptoms. It is now August 12, 2018, and I am still getting up at night to pee, and still running to the restroom during the day. I am very disappointed in this product, I don't recommend using it, waste of time and money.

    Bottom Line: No, I would not recommend this to a friend

  • BPH

    • By William H.,
    • Evans, GA,
    • Nov 14, 2018
    • Verified Reviewer
    Overall Experience:

    I have tried ProstaGenix for over a month with absolutely no help with prostate. I still have two unopened bottles yet and have given up on the product being of any help. I will undergo surgery, "Rezum Therapy," to correct the problem...

    Bottom Line: No, I would not recommend this to a friend

  • Didn't do anything

    • By Timothy M.,
    • Florida,
    • Nov 18, 2018
    • Verified Reviewer
    Overall Experience:

    I took three pills a day along with their free supplement, and like all other prostate issue pills, it did absolutely nothing for me. Now I will attempt to get my money back. As in other products, there was no reduction in my many night trips to the bathroom and no increased flow.

    Bottom Line: No, I would not recommend this to a friend

  • Made my BPH symptoms worse

    • By Michael M.,
    • Watsonville, CA,
    • Dec 7, 2018
    • Verified Reviewer
    Overall Experience:

    I had been taking Saw Palmetto (6-8 450mg capsules per day) for about a year with some improvement but still needing 2-3 nighttime excursions. I stumbled upon Larry King's smooth sell and ordered 7 bottles of this crap. Trustingly, I have been taking it religiously for one month instead of my dose of Saw Palmetto. The result has been a gradual worsening of my condition with increased pain and lower flow. I'm writing this because things got so bad that I considered visiting the ER at our local hospital because I just could not pee and suffered greatly trying. I have started taking Saw Palmetto again and am getting some relief. My conclusion is that either Larry King is a dishonest salesman who will say anything for a lot of bucks or the success of this snake oil is highly variable, depending upon who takes it. If you buy it, don't be a fool like me and waste so much money. Buy just a little, and if it fails to work, don't drag on your suffering hoping that it will eventually kick in. Good luck.

    Bottom Line: No, I would not recommend this to a friend

  • Positive and negative results so far

    • By Richard B.,
    • Indiana,
    • Dec 6, 2018
    • Verified Reviewer
    Overall Experience:

    On the strong recommendation of Larry King I thought, "what the hell?" and ordered it. The price seemed a little steep, but I thought that if it did work it would be worth it. I only ordered one bottle to see if I got any results after the first 2 weeks like other people were reporting on their website. I also figured if it didn't work, then I would only be out the price of one bottle and would just not order any more. The claims of improved urine flow and actual shrinking of the prostate, and Larry's claims of improved sexual function made me quite curious.

    So after about ten days on the product, I did notice more complete emptying and much improved urinary symptoms, and a slight improvement in sexual function. I was quite impressed and quite pleased. I was so pleased that I ordered a second bottle, which I am now finishing up. But I am noticing while going through the second bottle that the improved urine flow has kind of reversed and is back to being closer to where I started before taking this product. The thought of forking over a bunch of money to take this stuff is not turning me on, to say the least. I would imagine there are other products and possibly even natural solutions I could get for much cheaper. Was there an improvement? Absolutely. Did the product really live up to its impressive claims? Absolutely not!

    Bottom Line: No, I would not recommend this to a friend

  • Product actually works

    • By Wayne R.,
    • Reno, NV,
    • Sep 27, 2018
    • Verified Reviewer
    Overall Experience:

    I was a skeptic at first of ProstaGenix, but after taking it, I'm 100% convinced. It is an amazing product. I was having to get up around five times per night to use the bathroom, and now I only have to get up one time MAX. It honestly has changed a large part of my life, and I'm able to sleep better now.

    Now that I can sleep better, I can wake up better and healthier, and give me family the best side of me.

    Truly a fantastic experience.

    Also, I spoke with a customer service representative named Tamara who handled all of my worries and concerns, and I'm glad that she did. Thanks again!

    Bottom Line: Yes, I would recommend this to a friend

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ProstaGenix Review: Benefits, Ingredients, Side Effects and More