About Neo40

By HighYa Research Team
Published on: Jan 20, 2015

Formulated by a team of scientists and researchers, Neo40 is a daily dietary supplement lozenge that’s claimed to be proven in clinical studies to increase nitric oxide production, resulting in healthy blood pressure, and improved circulation and artery health. In order to accomplish this, Neo40 is claimed to contain a proprietary blend of ingredients backed by 4 clinical trials to help support falling nitric oxide levels as we age.

But before you hand over your hard-earned money to purchase Neo40, let’s take a closer look at what nitric oxide (NO) is and whether or not Neo40 is worth the high price:

What is Nitric Oxide? What Benefits Does it Provide?

Without getting too technical, nitric oxide is “a key vertebrate biological messenger, playing a role in a variety of biological processes.” Because of this, increased NO levels within the body can provide a variety of benefits, most of which have to do with increased circulation and blood oxygenation. This includes decreased blood pressure, relief from the symptoms of erectile dysfunction, and much more.

Can the Ingredients Contained in Neo40 Boost Your Nitric Oxide Levels?

While Neo40’s manufacturer doesn’t provide a list of ingredients the supplement contains, we did locate a third-party website that claims it contains the following (only those directly related to increased NO are listed, all others are related to flavor, etc.):

  • 100 mg of Vitamin C in the form of magnesium ascorbate and ascorbic acid
  • 100 mcg of Vitamin B12 in the form of methylcobalamin and cyanocobalamin
  • 420 mg of Proprietary Nitric Oxide Blend, which includes beetroot powder, L-citrulline, Hawthorn Berry Extract, and Sodium Nitrate

However, according to WebMD, vitamin C may help reduce artery hardening, although there is insufficient evidence showing that vitamin B12 or hawthorn can provide any kind of circulatory benefits, although the latter may have some heart disease-related benefits. Perhaps most importantly though, the Mayo Clinic claims that sodium nitrate “may damage your blood vessels, making your arteries more likely to harden and narrow, leading to heart disease. Nitrates may also affect the way your body uses sugar, making you more likely to develop diabetes,” so you’ll definitely want to consult with your physician first.

With this said, Neo40’s manufacturer claims that the supplement has been subjected to 4 clinical studies, although none of these are referenced on their website.

How is the 1998 Nobel Prize for Medicine Related to Neo40?

Although Neo40 is claimed to be based on research uncovered by the winners of the 1998 Nobel Prize, the link between the two is tenuous at best.

This is because, according to NobelPrize.org, the 1998 Nobel Prize for Physiology or Medicine was jointly awarded to Robert F. Furchgott, Louis J. Ignarro and Ferid Murad due to their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system.” However, based on the overview provided on the organization’s website, the winners’ findings were focused on nitric oxide’s interaction with cells, and doesn’t appear to mention anything about the ingredients contained in Neo40.

What Are Consumers Saying About Their Experiences with Neo40?

Neo40 had more than 120 reviews on Amazon.com at the time of our research, with an average rating of 3.5 stars (as of 1/15/15). Some of the most common compliments referenced the fact that it replenished NO levels, reduced arterial plaque and blood pressure, and increased circulation and energy. On the other hand, some of the most common complaints referenced failure to work and high price.

SupplementCritique gave Neo40 a 4-star review, despite stating that it’s not clear “how the product is supposed to work [or] what its benefits are, [so] buying Neo40 may not be a good idea.” ConsumerHealthDigest gave Neo40 a 2-star review, although this review referenced only the supplement’s ability to address erectile dysfunction, and not any of the other benefits claimed by the manufacturer.

From a company perspective, Neo40 is manufactured by NeoGenis Laboratories, Inc. based out of Austin, TX, although the company is not listed with the Better Business Bureau.

Neo40 Pricing & Refund Policy

Neo40 is available in 4 different purchasing options:

  • 30-day trial: $12.95
  • 3 Boxes w/Autoship: $99.90
  • 3 Boxes w/out Autoship: $109.90
  • 6 boxes w/out Autoship: $179.90

Regardless of which option you choose, your order will also include the Nitric Oxide Solution e-book and 3 patent-pending Nitric Oxide Indicator Strips that can help you monitor your nitric oxide levels almost instantly, using only your saliva.

Important note: As we’ve noted countless times, it’s our opinion that free trials and autoship programs are often more about getting more of your hard-earned money than they are about providing you with any kind of convenience. As such, you might want to think twice about ordering Neo40 using either of these methods.

With this said, Neo40 comes with a 30-day refund policy, less S&H charges. In order to request a refund or to cancel your autoship enrollment, you’ll need to call customer service at 855-636-4040 for RMA.

Can Neo40 Provide You with Any Real-World Benefits?

Chopping to the Point: Considering the fact that most of Neo40’s ingredients lack sufficient clinical evidence showing they can reliably boost NO levels, in addition to the supplement’s relatively high price and mixed online customer reputation, we’d strongly recommend speaking with your physician before placing an order.

Read 3 Neo40 Customer Reviews and Complaints

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Average Customer Rating: 3.0
Rating Snapshot:
5 star: 0 4 star: 2 3 star: 0 2 star: 0 1 star:  1
Bottom Line: 67% would recommend it to a friend
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  • 2 out 4 people found this review helpful

    I tried it but then they changed the recipe?

    • By Michael K.,
    • Buffalo, NY,
    • Jan 26, 2019
    • Verified Reviewer

    I first bought it several years ago and I was VERY pleasantly surprised at my renewed energy levels. My daughters even complained about how much housework we were doing if I took one on Saturday morning (so they noticed too).

    After a couple of years (and several re-orders), I noticed I did not feel as energetic. I called the company and they stated that they had changed their recipe to a different vitamin B (I think). I asked them why they would mess with "outstanding" product? To save a few bucks? I am going to order it one more time, and see. It STILL gave me an energy boost, but not as dramatic.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 4 people found this review helpful

    Relieved chest pains

    • By Chris Nolan,
    • Florida,
    • Jan 23, 2018
    • Verified Reviewer

    Following my heart attack (minor, if there is such a thing), my cardiologist attempted to prescribe statins, and I refused them. Instead, I decided to change my diet the past seven years and have been taking Neo40 as well daily. It was noticeable to me that the occasional pressure in my chest was rapidly subsiding after the first three months. Thereafter, I continued taking Neo40 for two years. Today, six months after stopping the Neo40, I feel no pressure of any kind and am satisfied there was a substantial improvement in my condition. I now walk three to four miles, three times a week. In my case, I would give Neo40 (HumanN) a thumbs up.

    Bottom Line: Yes, I would recommend this to a friend

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  • 43 out 46 people found this review helpful


    • By Wayne ,
    • Queens, NY ,
    • Feb 20, 2016
    • Verified Reviewer

    I tried this product, and it produced no noticeable effects to my Nitric Oxide levels (using the proprietary strips provided). In short, it doesn't perform as advertised.

    Bottom Line: No, I would not recommend this to a friend

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