Nucific BIO X4 Review: Effectiveness, Side Effects, Cost, and More

By Anthony Dugarte, M.D., C.S.C.S
Updated on: Mar 5, 2020

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Nucific BIO X4 is a probiotic-based supplement that claims to provide digestive support, suppress appetite, and support weight loss management. Each capsule includes:

  • 4 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins
  • Green tea to boost your metabolism
  • Caralluma Fimbriata to suppress cravings

Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regularly and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1–2 months.

This review will help you understand if this product works and if it is the right option for you.

BIO X4’s Ingredients: Are They Backed by Science?

According to BIO X4’s product label, the supplement contains:

Probiotic Blend: 4 billion (4x109) CFU per capsule

  • Lactobacillus acidophilus
  • L. rhamnosus
  • L. plantarum
  • Bifidobacterium lactis
  • B. animalis

Digestive Enzyme Blend: 88mg

  • Amylase (from Aspergilus Oryzae)
  • Bromelain
  • Lipase (from Rhizopus Oryzae)

Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)

Craving Control Blend: 166mg – Caralluma Fimbriata Extract

Below, we’ll detail the available research for each ingredient category included in BIO X4.

Probiotic Blend

Probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data available.

Note: As each capsule contains 4 billion CFUs, by taking the recommended 3 capsules per day, you’ll cumulatively be ingesting 12 billion CFUs.

This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

In terms of support for some of the strains included, here’s what we found:

Lactobacillus acidophilus is widely used in many available probiotic blends. It is thought to have an ability to improve symptoms related to diarrhea and stomach discomfort. Additionally, it may play a role in boosting immune function.

A review of 34 different randomized trials concluded that L. acidophilus at doses ranging from 2x108 to 1011 CFUs was able to reduce the risk for diarrhea when used alone or with other probiotics.

The combination of L. acidophilus NCFM and Bifidobacterium lactis Bi-07 twice daily at 1011 CFU/day reduced bloating in over 8-weeks. This same combination may also result in fewer sick days from respiratory infections.

L rhamnosus may reduce stomach flu symptoms. This family may also support immune system function and offer allergy relief.

L rhamnosus GG at 0.018mg doses reduced airway inflammation in mice with chronic asthma.

Over 5-days, kids treated with 1×1010 CFU of L. rhamnosus GG twice daily for the stomach flu did not relieve diarrhea or vomiting when compared to placebo.

Many Lactobacillus plantarum species may offer anti-inflammatory benefits. This was demonstrated in a laboratory study where L. Plantarum N14 reduced inflammation in intestinal cells. Similarly, mice injected with 100 mg/kg of L. plantarum K8 had reduced expression of enzymes and receptors involved in cardiovascular inflammation.

Bifidobacterium lactis is another strain that may offer immune-boosting benefits.

B. Lactis HN019 at 1.5x1011 CFU doses twice daily over 6-weeks improved blood tests used to indicate natural immunity in 13 elderly individuals. Similar doses of the same strain also boosted white blood cell levels in 30 elderly individuals.

The big takeaway here is that these effects are strain-specific. We can’t expect the same results from studies that investigated certain doses for certain strains as BIO X4 does not provide these details, but rather only the probiotic blend total.

Digestive Enzymes Blend

Carbohydrate metabolism begins in your mouth as the enzyme amylase is produced in your salivary glands.

This enzyme has not been extensively studied with respect to weight loss. Amylase levels were not found to be associated with weight loss or improvement in blood sugar regulation in obese individuals on weight maintenance programs.

Lipase is an enzyme involved in fat digestion. In healthy volunteers, those treated with 280mg of lipase experienced less stomach fullness after a fatty meal.

Bromelain plays a role in protein digestions, and may also offer anti-arthritic and anti-cancer benefits. It’s dietary role has not been well studied.

Weight Management Blend

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits.

Often included in dietary supplements that claim to boost metabolism or burn fat, green tea, and its proposed effects have been studied in humans.

These benefits are probably related to 2 notable components; caffeine and catechin (an antioxidant).

Green tea given at 90, 200, 300 and 400mg doses up to 3x daily increased energy expenditure when combined with 200mg of caffeine; the effects of green tea were not dose-dependent.

Body weight, BMI, waist to hip ratio, and body fat percentage were improved when 500mg of green tea daily was combined with exercise. These effects were greater than those seen in exercise alone.

Craving Control Blend

Caralluma is a cactus indigenous to India that is thought to offer sliming benefits through curbing appetite.

In overweight subjects, 1g per day over 2-months significantly reduced waist circumference and appetite.

In children with a genetic disease that is associated with excessive eating, 1,000mg of Caralluma reduced this behavior.

Side Effects

As BIO X4 does not offer information regarding specific amounts or specific strains included in their probiotic blend, their ingredients can’t be readily compared to the available literature.

Nonetheless, most studies test strain in the order of billions CFUs without serious side effects. While this speaks to the safety of BIO X4, the individual strains may not be offered in large enough doses to achieve the desired effects supported by research.

Mild side effects reported with the use of similar blends can include abdominal pain, gas, bloating, and diarrhea. These symptoms can be eased by lowering your dose or discontinuing the use of the product.

The remaining ingredients have all been safely tested at doses as much as 10x larger than what is offered in BIOX4. Again, it important to keep in mind that the Digestive Enzyme Blend offers only the total amount for all 3 ingredients. This number is far less than the doses that have been tested individually. While likely safe, BIO X4 may not offer a large enough dose for the desired effect.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants.

Pricing and Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle: $99 (30-day supply)
  • 3 Bottles: $261.36 ($87.12 per bottle)
  • 6 Bottles: $487.08 ($81.18 per bottle)

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. You'll have to send your unused portion left back to the company. You’ll need to contact Nucific’s customer service department at 888-679-5520 or support@nucific.com in order to initiate the refund process.

Company Reputation

As of 3/5/20, over 1,380 customers left their reviews of BIO X4 here on HighYa, for an average rating of 4.4 stars. On the Better Business Bureau, we found 286 customer reviews for an average rating of 4 stars.

Nucific also has an A+ rating with the BBB based on 98 customer complaints.

The Bottom Line

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor.

BIO X4 does include ingredients that have been studied in human trials. However, the amounts for each individual ingredient are not provided by the company. The total amounts provided likely mean that the individual ingredients are offered at safe amounts.

This also means that these ingredients are offered in doses less than what has been proven effective in research studies.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

Lastly, as your digestive symptoms and need for effective weight loss may be the result of more serious underlying conditions, it is important to include a medical professional in your management.

» Recommended Reading: Best Grains, Fruits, and Vegetables That Improve Digestion

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Customer Reviews

Start your review of Nucific BIO X4:
  • 1390 Customer Reviews
  • 89% Recommend This Company
4.3 out of 5
5 star: 63% 4 star: 24% 3 star: 2% 2 star: 2% 1 star: 6%

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  • Nucific

    • By Dani D,
    • Chicago,
    • Aug 1, 2015
    • Verified Reviewer
    Overall Experience:

    I have been using the Nucific probiotic bio x4 and I'm loving it so far. I feel so much better already. The customer service is awesome and shipping is super fast. The video makes 100% pure sense! I kept nodding through the whole thing and I usually do not like videos like this. I highly recommend!

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 2, 2015

      Company Response from Nucific, LLC

      Hey Dani, this is Naomi again! I noticed that you also left a great review along with your comment to the review above. I just wanted to thank you once more, and remind you to contact me at naomi.benson@nucific.com if you ever need anything. Take care.


  • I would recommend to all my friends.

    Overall Experience:

    I lost 8 lbs in one month. I love the product. First, it is natural. Second, it controlled my digestion. I feel very healthy and very energetic. I'm very happy and I will be recommending to everybody. Thank you for having Bio X4 on the market, I love it. It's a great product.

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 18, 2015

      Company Response from Nucific, LLC

      Hey there Silva, my name is Naomi, here with Nucific. Thank you so much for leaving feedback about your experience with Bio X4! We really love hearing what our customers have to say. I would love to hear more about your journey to weight loss with Bio X4. Please email me at your earliest convenience with an update at naomi.benson@nucific.com. I look forward to hearing from you!


  • Great Product!

    • By Beth,
    • SA, Florida,
    • Dec 17, 2015
    • Verified Reviewer
    Overall Experience:

    I am a complete skeptic when it comes to supplements. I have tried more than my fair share over the years without much success. If BIO 4X was not working for me, I would not publish this review.

    I am now on my second bottle and have noticed real changes. I was waking up every morning with stomach and bowel issues to the point where it was difficult for me to eat anything. I am so elated to admit those symptoms have diminished.

    I also have arthritis and experience joint pain daily, noticing a big change there also, getting much needed relief. I am still waiting for the weight loss but I will give that some time. I will continue with BIO 4X because I firmly believe things are only going to get better. Why stop a good thing?

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 18, 2015

      Company Response from Nucific, LLC

      Hey there Beth, my name is Naomi and I am the Customer Care Manager here at Nucific. Thank you so much for your detailed review of how Bio X4 has helped change your life. We really appreciate our customers here at Nucific and want to thank you for being a part of our family! It is amazing that not only has Bio X4 elated your digestive issues, but also your arthritis and joint pain. I am extremely happy for you. Please contact me at naomi.benson@nucific.com if you ever have any questions or concerns. Take care.


  • Amazing Product

    Overall Experience:

    I feel better no more bloating, sleep better, and my body does not feel tired all the time. I have already referred my sister and my niece and they are both taking BIO X4. Thanks for your product, it is really amazing! I haven't felt this good in years.

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 22, 2015

      Company Response from Nucific, LLC

      Hey there Evette, this is Naomi, Customer Care Manager here at Nucific. Wow! I am so happy to hear that you are feeling so great while taking Bio X4. Thank you for recommending our product to your family, we love to hear that. Please feel free to email me at naomi.benson@nucific.com if you ever have any questions or concerns. Thanks!


  • Very simple and honest

    • By Cindy Geilmann,
    • South Jordan, Utah,
    • Dec 25, 2015
    • Verified Reviewer
    Overall Experience:

    I have had colitis for almost a year. I am on a strong medication to heal it. I didn't feel as though it was getting any better. After just a couple days of Nucific BIO X4, I felt better inside and out of the bathroom. I now feel like I am healing. I will see my doctor after Christmas.

    Bottom Line: Yes, I would recommend this to a friend

    • Dec 31, 2015

      Company Response from Nucific, LLC

      Hey there Cindy, Naomi here with Nucific. I am so glad to hear that Bio X4 is helping you feel so much better! I hope that your doctors appointment went well! I would love for you to update me on your progress with Bio X4. Please feel free to email me at naomi.benson@nucific.com. Thank you.


  • Great Product!

    Overall Experience:

    I love this product! It helps to regulate my IBS and gives me added energy throughout my day.

    Bottom Line: Yes, I would recommend this to a friend


  • 60 years of doing it wrong

    • By Diane Ayers,
    • Tampa, Florida,
    • Feb 8, 2016
    • Verified Reviewer
    Overall Experience:

    When Coke came out with a diet soda, I learned to like it. No calories is a wonderful gift I thought. I could drink soda and not gain more weight. That was the beginning of my 60 or so years of diet products. I have tried and spent thousands of dollars on all the best weight loss programs only to gain it all back again. The spiral to miserable started as a teen, continued till Bio X4. By the time I found Nucific I was close to being frantic. I wanted to feel better in the worst way. My energy levels were pathetic, weight gain out of control, heading for 300 pounds. The threat of diabetes always on the horizon. Then the other aspects of my declining health were getting more difficult to manage. The diarrhea was out of control, always so hungry, even with a full stomach. Food cravings all the time, frustration rampant. Feeling bloated and full of gas never ending. I was searching for a plausible answer. I found Nucific. Having tried so many other avenues searching for an answer, I tried one more. Within 2 weeks I knew this was different. I was not running for the bathroom, the gassy feeling was gone, I did not need a nap at 1pm everyday, and oh yes I was not always hungry. I could eat what I wanted and was loosing some pounds, fantastic. Hope returned.

    In the 2 months I have been on the Bio X4 I have dropped 15 pounds. For me that is significant, since I have felt so much better along the way. Have not had a diet product since I started the product and miss them not. I was a diet soda junkie, Splenda and all the other artificial sweeteners were my everything all day. When I read the information about Bio X4, it fit all of my symptoms, I had to try just one more possible "cure". It was and is one of the best things to enter my life in many years. About 60 years of crazy eating got me into this mess. Bio X4 started my return to health within 2 weeks. I am so thankful.

    Bottom Line: Yes, I would recommend this to a friend

    • Feb 11, 2016

      Company Response from Nucific, LLC

      Hello Diane, Naomi here. I am the Customer Care Manager for Nucific. It truely makes me happy to hear of your story. We appreciate such great stories from our Bio X4 users. I can assure you that our Highya readers appreciate it as well! Please feel free to contact me directly at naomi.benson@nucific.com if you ever have any questions or concerns for me. Thank you!


  • Don't want to be without it!

    Overall Experience:

    Bio X4 has helped me lose four pounds without dieting. I have less cravings and more energy. I absolutely cannot live without this product!

    Bottom Line: Yes, I would recommend this to a friend

    • Feb 11, 2016

      Company Response from Nucific, LLC

      Hello Barbara, Naomi here with Nucific. I am so happy to hear that you are loosing weight and feeling more energetic with Bio X4. I hope that you continue to see these awesome benefits for months to come! Please feel free to contact me at naomi.benson@nucific.com with any future questions you may have. Thank you.


  • No more gastrointestinal pain & discomfort.

    • By Priscilla,
    • Phoenix, AZ,
    • Feb 9, 2016
    • Verified Reviewer
    Overall Experience:

    I have had many allergy symptoms from foods, especially in the last 10 years or so. I am gluten & lactose sensitive and have always endured constipation, gas & bloating.

    I read about Nucific Bio X4 on Facebook & was compelled to try it after reading a very information-packed message from a doctor. That convinced me to at least give it a try.

    I was pleasantly surprised after starting the capsules how my stomach issues were just gone.

    Bottom Line: Yes, I would recommend this to a friend

    • Feb 11, 2016

      Company Response from Nucific, LLC

      Hello Priscilla, my name is Naomi and I am the Customer Care Manager here at Nucific. Thank you for your honest feedback. I am thrilled to hear that your food allergy symptoms have finally subsided with Bio X4. Please do not hesitate to contact me directly at naomi.benson@nucific.com with any future questions or comments you may have.


  • Very Pleased So Far

    Overall Experience:

    I have been taking it for 6 days. No weight loss yet to report but I have not craved food of any kind or sweets.

    Bottom Line: Yes, I would recommend this to a friend


  • Healthy weight loss

    • By Deborah,
    • Gravette, AR,
    • Feb 17, 2016
    • Verified Reviewer
    Overall Experience:

    I am enjoying a slow healthy weight loss. My waist line is getting smaller. I can also say the reason why I bought this product is mainly because it states it helps to decrease flatus (gas), which I had more than my share. I still have some flatus but nothing compared to what I used to have.

    Bottom Line: Yes, I would recommend this to a friend


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Nucific BIO X4 Review: Effectiveness, Side Effects, Cost, and More