What Is Synbiotic 365?

By Derek Lakin
HighYa Staff Published on: Sep 18, 2018

United Naturals advertises Synbiotic 365 as an advanced formula consisting of beneficial probiotic strains and prebiotic ingredients, that when combined, can deliver lasting relief from bloat and other embarrassing digestive issues.

Based on the available clinical evidence, can you realistically expect to experience benefits like these? Furthermore, is there supporting data that taking a combination product like Synbiotic 365 will deliver better results than a standalone probiotic supplement?

In this brief article, we’ll discuss the formula’s ingredients, pricing, and competition, all aimed at helping you make an informed decision. Before diving in, though, let’s clarify what we’re talking about.

What is a Synbiotic Supplement?

Probiotics are specific bacteria strains that, when taken regularly as a dietary supplement, have been clinically shown to provide a wide variety of digestion-related benefits, in addition to boosting immune function.

Prebiotics, on the other hand, are certain ingredients that these bacteria use as an energy source upon arriving in your digestive tract.

Related: Probiotics 101: Their Benefits, How They Work, & Foods That Contain Them

With these details in mind, ScienceDirect explains, whether referencing Synbiotic 365 or another formula, “Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms.”

In other words: Synergy + Probiotics = Synbiotics.

Writing for Health.com, Anthea Levi tells us “the idea behind synbiotics is that adding prebiotics to a probiotic supplement can help ensure that the digestion-friendly microorganisms arrive in the gut alive and well. These supplements are said to be particularly useful for people with conditions like IBS, other bowel disorders, and diabetes.”

Cynthia Sass, RD, Health contributing nutrition editor, adds that when combined with probiotics, prebiotics can “also increase nutrient absorption and support bowel regularity.”

Exactly which probiotics and prebiotics does Synbiotic 365 contain?

Taking a Closer Look at Synbiotic 365’s Ingredients

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 2.4 mg
  • Vitamin B2 2.6 mg
  • Vitamin B3 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 60 mcg
  • Vitamin B5 10 mg
  • Probiotic Blend 30 billion CFU – Lactobacillus acidophilus La-14, Bifidobacterium lactis Bl-04, Lactobacillus paracasei Lpc-37, Lactobacillus plantarum LP-115, Streptococcus thermophilus ST-21, Lactobacillus casei LC-11, Lactobacillus reuteri, Lactobacillus salivarius LS-33, Lactobacillus rhamnosus LR-32, Bifidobacterium bifidum BB-06, Bifidobacterium longum BL-05, Saccharomyces boulardii
  • Chicory Root Inulin 300 mg

Sites like WebMD, the Natural Medicines Database, and Examine.com report that the first eight vitamins in this formula are essential for maintaining human health. For example, B1 (thiamine) is essential in the breakdown of carbohydrates, B2 also helps digest carbs, as well as proteins and fats, while Healthline tells us that every part of your body needs B3 (niacin) to function correctly.

However, they also report that unless someone’s deficient in these vitamins, supplementing them likely won’t deliver meaningful health benefits.

Related: Do You Need to Take Vitamins or Dietary Supplements?

Probiotic bacteria are identified by their genus (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

Lactobacillus acidophilus (whether contained in Synbiotic 365 or another supplement) was the first probiotic strain widely used, which seems to work especially well for irritable bowel syndrome (IBS) symptoms and urinary tract infections in children.

Among others, paracasei may relieve allergic symptoms and decrease skin sensitivity, plantarum produces its own antibiotics, casei may improve allergy symptoms and reduce cholesterol (along with reuteri), and rhamnosus has even been shown to help obese women lose weight.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be effective for constipation and airway infections, in addition to IBS and ulcerative colitis.

Finally, Streptococcus thermophilus could decrease the chances of kidney stones and increase anti-tumor activity, while Saccharomyces boulardii seems to be especially useful for addressing different causes of diarrhea.

Potential Synbiotic 365 Side Effects

As genera (the plural of genus), WebMD, Examine.com, and the Natural Medicines Database report that Lactobacillus and Bifidobacteria are likely safe for adults and children when taken as directed. Common side effects, if any, for the genera include mild, temporary intestinal gas or bloating, as well as stomach or intestinal upset.

Related: Common Probiotic Supplement Side Effects

Outside of this, WebMD indicates Saccharomyces boulardii could rarely “cause fungal infections that can spread through the bloodstream to the entire body (fungemia).” No dosages or other specifics listed.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering. In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

We didn’t encounter anything with the same (or very similar) formulation as Synbiotic 365 during our research.

However, we did come across dozens of competing synbiotic supplements like Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), and Renew Life Women's Daily Probiotics plus Prebiotics ($28, 60 capsules).

From a high-level perspective, these supplements are alike in that they’re priced competitively with one another, and that each combines a relatively similar blend of probiotics, prebiotics, and other vitamins and minerals.

These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins like C and many within the B family, and even secondary ingredients like chicory root and different fruit extracts as energy sources.

Zooming in, the differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Is either of these criteria important when choosing a synbiotic supplement? Perhaps not. Here’s why:

First, while probiotics and prebiotics are certainly beneficial on their own, Cynthia Sass, RD, Health contributing nutrition editor, emphasizes: “Right now we don’t have a lot of data to show that synbiotics are more effective than, say, taking probiotics [supplements] and eating a diet rich in prebiotics.”

Next, even if they are eventually shown equally as useful, Cynthia emphasizes that "Your overall pattern of eating still has the greatest impact on your health protection or risk,” so “don’t think that taking [one of these supplements] means you don’t have to pay attention to your diet.”

Together, from a value perspective, she recommends that “until more comprehensive research is conducted on synbiotics, consider sticking to swallowing a probiotic supplement or eating probiotic-rich foods in addition to prebiotic foods.”

Should You Place an Order for Synbiotic 365?

At $45 per box, Synbiotic 365 seems priced at the upper end of the spectrum compared to some other popular synbiotic supplements but has a middle-of-the-road price compared to probiotic supplements in general—some of which can near the $100 mark.

And as we outline in our Probiotic Supplement Buyer’s Guide, paying more for one of these supplements doesn’t typically translate into improved results, as reported by customers.

Other pointers we mention in the article include making sure the manufacturer provides a complete list of all the bacteria strains, as well as their dosage (as measured in colony-forming units, or CFU), both of which United Naturals lists for Synbiotic 365.

However, the company also adds a handful of vitamins that, according to sites like Examine.com and WebMD, might not provide much value for the money unless you’re deficient. Furthermore, we didn’t encounter any online customer feedback for Synbiotic 365 at the time of our research, and the company wasn’t listed with the Better Business Bureau.

Still, they advertise that all purchases come with a 30-day refund policy if the supplement doesn’t meet your needs, less S&H charges. Just make sure that you talk with your doctor first about overall value based on your diagnosis before ordering, as well as potential side effects or medication interactions.

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Read 265 Synbiotic 365 Customer Reviews and Complaints

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Average Consumer Rating: 4.6
Rating Snapshot:
5 star: 203 4 star: 41 3 star: 4 2 star: 7 1 star:  10
Bottom Line: 93% would recommend it to a friend
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  • 1 out 1 people found this review helpful

    Healthier and happier

    • Brookhaven, NY,
    • Apr 19, 2019
    • Verified Reviewer

    I read the literature and liked what it said. I know that B Complex vitamins are beneficial to me and liked that it is paired with probiotics which I take. I was unfamiliar with some of the other ingredients but decided it was worth a try.

    Knowing that it would take some time to reap the benefits, I simply took them. Suddenly I was feeling much more energetic and focused. Before long I noticed that I was fitting into clothes that I had not worn in a long time. I was really surprised how quickly I could button pants that I had not worn in years! I have to say that it is one of the few products that I have tried that actually delivers on its claims.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    None

    • Florida,
    • Apr 19, 2019
    • Verified Reviewer

    I have only taken 25, I have not noticed any difference as today.

    I have given some to my daughter and she is happy as they DO NOT bother her stomach like the ones she was taking, so I am happy and will continue with them.

    Bottom Line: Yes, I would recommend this to a friend

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  • Great product

    • New Mexico,
    • Apr 19, 2019
    • Verified Reviewer

    I have only used Synbiotic 365 for one month but it has helped in several ways. My digestive issues are better, my skin seems to be clearing up, and overall I feel better. It's easy to take and helps with drinking enough water.

    Bottom Line: Yes, I would recommend this to a friend

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  • 0 out 1 people found this review helpful

    I feel great

    • Idaho,
    • Apr 18, 2019
    • Verified Reviewer

    Hi there. After having a full knee replacement and having a very slow recovery, my gut was so out of balance, I would be bloated all the time. Or could not stay off the toilet. I came across Synbiotic 365 and after watching the video I ordered it. I have been taking them for a week now an I cannot believe how much better I feel. The bloating is gone, and I dropped 6 lbs. And my stomach feels flatter and with more energy. I'm looking forward to getting healthier, thanks for this real product.

    Bottom Line: Yes, I would recommend this to a friend

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  • Helping me have energy and drive

    • Tampa, FL,
    • Apr 18, 2019
    • Verified Reviewer

    It has given me the energy and focus that I was lacking. I have better workouts and my day last longer because I have stamina. It has also helped me focus. I’m probably hooked for life. Thanks!

    Bottom Line: Yes, I would recommend this to a friend

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  • Give it a fair chance

    • Apr 17, 2019
    • Verified Reviewer

    Due to some of my medical issues it seems to be taking a little more time. But I have only taken 365 for four weeks. But have noticed some changes. My heartburn has almost stopped and my IBS has started to get much better. So I ordered 365 again. I am feeling better. And want to give 365 a fair chance.

    Bottom Line: Yes, I would recommend this to a friend

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  • Amazingly clean

    • Hackensack, NJ,
    • Apr 17, 2019
    • Verified Reviewer

    I ordered this product with a bit of skepticism, but the first week in I definitely noticed a difference, "angry noises" weren’t coming from my get any more and I felt strangely different. At first I thought I was hungry but had no desire to eat, it’s like feeling clean, the bloating was gone.

    I completed the first 30 days and thought my experiment was done and over. It’s been a week without the product and I quickly reordered.

    Bottom Line: Yes, I would recommend this to a friend

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  • Worth trying!

    • California,
    • Apr 17, 2019
    • Verified Reviewer

    I was impressed by the video explaining the product. Used for the 3 months and my migraines were reduced and my blood glucose levels showed improvement. Just reordered, hoping for even more of an improvement!

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Positive benefits from using Synbiotic 365!

    • Benton, ME,
    • Apr 17, 2019
    • Verified Reviewer

    I have been taking Synbiotic 365 for about two months now (one capsule per day) and have experienced several benefits. My digestion has significantly improved - less indigestion, bloating, and much better elimination. I am extremely pleased with the results I have received at this point and believe they will continue to improve! Thank you, Dr. Pedre, for developing such a beneficial product.

    Bottom Line: Yes, I would recommend this to a friend

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  • Very satisfied

    • Wayne, PA,
    • Apr 17, 2019
    • Verified Reviewer

    Synbiotic 365 has helped me with my stomach issues and help with regularity. I have lost a few pounds too! I take my supplement in the morning before breakfast and find I have a feeling of being full before I even eat.

    Bottom Line: Yes, I would recommend this to a friend

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  • Best probiotic I've tried

    • Dexter, MI,
    • Apr 17, 2019
    • Verified Reviewer

    I have tried other probiotics before (the kind you have to keep in the refrigerator) but they exacerbated my chronic constipation and I had to stop taking them. These probiotics actually helped with that problem instead. I've recently made some pretty dramatic changes to my diet and my GI system had a bit of trouble adjusting to the change. I realized that I hadn't taken my probiotics for a while, so I started them again and within a day or two, things had sorted themselves out.

    Bottom Line: Yes, I would recommend this to a friend

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