Synbiotic 365 Review: Benefits, Effectiveness, Side Effects, Cost

By Derek Lakin
HighYa Staff
Updated on: Nov 27, 2019

United Naturals advertises Synbiotic 365 as an advanced formula consisting of beneficial probiotic strains and prebiotic ingredients, that when combined, can deliver lasting relief from bloat and other embarrassing digestive issues.

Based on the available clinical evidence, can you realistically expect to experience benefits like these? Furthermore, is there supporting data that taking a combination product like Synbiotic 365 will deliver better results than a standalone probiotic supplement?

In this brief article, we’ll discuss the formula’s ingredients, pricing, and competition, all aimed at helping you make an informed decision. Before diving in, though, let’s clarify what we’re talking about.

What Is a Synbiotic Supplement?

Probiotics are specific bacteria strains that, when taken regularly as a dietary supplement, have been clinically shown to provide a wide variety of digestion-related benefits, in addition to boosting immune function.

Prebiotics, on the other hand, are certain ingredients that these bacteria use as an energy source upon arriving in your digestive tract.

With these details in mind, ScienceDirect explains, whether referencing Synbiotic 365 or another formula, “Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms.”

Writing for Health.com, Anthea Levi tells us “the idea behind synbiotics is that adding prebiotics to a probiotic supplement can help ensure that the digestion-friendly microorganisms arrive in the gut alive and well. These supplements are said to be particularly useful for people with conditions like IBS, other bowel disorders, and diabetes.”

Cynthia Sass, RD, Health contributing nutrition editor, adds that when combined with probiotics, prebiotics can “also increase nutrient absorption and support bowel regularity.”

Taking a Closer Look at Synbiotic 365’s Ingredients

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 2.4 mg
  • Vitamin B2 2.6 mg
  • Vitamin B3 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 60 mcg
  • Vitamin B5 10 mg
  • Probiotic Blend 20 billion CFU – Lactobacillus gasseri BNR17, OPTI-BIOME Bacillus subtilis MB40, Lactobacillus paracasei Lpc-37, Bifidobacterium lactic BI-04, Lactobacillus plantarum Lp-115, Streptococcus thermophilus St-21, Lactobacillus Casei Lc-11, Lactobacillus reuteri, Lactobacillus salivarius Ls-33, Lactobacillus rhamnosus Lr-32, Lactobacillus fermentum, Bifidobacterium bifidum Db-06, Bifidobacterium longum BI-05, Saccharomyces boulardii
  • Chicory Root Inulin 315 mg

Sites like WebMD, the Natural Medicines Database, and Examine.com report that the first eight vitamins in this formula are essential for maintaining human health. For example, B1 (thiamine) is essential in the breakdown of carbohydrates, B2 also helps digest carbs, as well as proteins and fats, while Healthline tells us that every part of your body needs B3 (niacin) to function correctly.

However, they also report that unless someone’s deficient in these vitamins, supplementing them likely won’t deliver meaningful health benefits.

» Related: Do You Need to Take Vitamins or Dietary Supplements?

Probiotic bacteria are identified by their genus (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

Lactobacillus acidophilus (whether contained in Synbiotic 365 or another supplement) was the first probiotic strain widely used, which seems to work especially well for irritable bowel syndrome (IBS) symptoms and urinary tract infections in children.

Among others, paracasei may relieve allergic symptoms and decrease skin sensitivity, plantarum produces its own antibiotics, casei may improve allergy symptoms and reduce cholesterol (along with reuteri), and rhamnosus has even been shown to help obese women lose weight.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be effective for constipation and airway infections, in addition to IBS and ulcerative colitis.

Finally, Streptococcus thermophilus could decrease the chances of kidney stones and increase anti-tumor activity, while Saccharomyces boulardii seems to be especially useful for addressing different causes of diarrhea.

Potential Synbiotic 365 Side Effects

As genera (the plural of genus), WebMD, Examine.com, and the Natural Medicines Database report that Lactobacillus and Bifidobacteria are likely safe for adults and children when taken as directed. Common side effects, if any, for the genera include mild, temporary intestinal gas or bloating, as well as stomach or intestinal upset.

» Related: Common Probiotic Supplement Side Effects

Outside of this, WebMD indicates Saccharomyces boulardii could rarely “cause fungal infections that can spread through the bloodstream to the entire body (fungemia).” No dosages or other specifics listed.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering. In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

We didn’t encounter anything with the same (or very similar) formulation as Synbiotic 365 during our research.

However, we did come across dozens of competing synbiotic supplements like Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), and Renew Life Women's Daily Probiotics plus Prebiotics ($28, 60 capsules).

From a high-level perspective, these supplements are alike in that they’re priced competitively with one another, and that each combines a relatively similar blend of probiotics, prebiotics, and other vitamins and minerals.

These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins like C and many within the B family, and even secondary ingredients like chicory root and different fruit extracts as energy sources.

Zooming in, the differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Is either of these criteria important when choosing a synbiotic supplement? Perhaps not. Here’s why:

First, while probiotics and prebiotics are certainly beneficial on their own, Cynthia Sass, RD, Health contributing nutrition editor, emphasizes: “Right now we don’t have a lot of data to show that synbiotics are more effective than, say, taking probiotics [supplements] and eating a diet rich in prebiotics.”

Next, even if they are eventually shown equally as useful, Cynthia emphasizes that "Your overall pattern of eating still has the greatest impact on your health protection or risk,” so “don’t think that taking [one of these supplements] means you don’t have to pay attention to your diet.”

Together, from a value perspective, she recommends that “until more comprehensive research is conducted on synbiotics, consider sticking to swallowing a probiotic supplement or eating probiotic-rich foods in addition to prebiotic foods.”

Our Bottom Line on Synbiotic 365

At $45 per box, Synbiotic 365 seems priced at the upper end of the spectrum compared to some other popular synbiotic supplements but has a middle-of-the-road price compared to probiotic supplements in general—some of which can near the $100 mark.

And as we outline in our Probiotic Supplement Buyer’s Guide, paying more for one of these supplements doesn’t typically translate into improved results, as reported by customers.

Other pointers we mention in the article include making sure the manufacturer provides a complete list of all the bacteria strains, as well as their dosage (as measured in colony-forming units, or CFU), both of which United Naturals lists for Synbiotic 365.

However, the company also adds a handful of vitamins that, according to sites like Examine.com and WebMD, might not provide much value for the money unless you’re deficient. Furthermore, we didn’t encounter any online customer feedback for Synbiotic 365 at the time of our research, and the company wasn’t listed with the Better Business Bureau.

Still, they advertise that all purchases come with a 30-day refund policy if the supplement doesn’t meet your needs, less S&H charges. Just make sure that you talk with your doctor first about overall value based on your diagnosis before ordering, as well as potential side effects or medication interactions.

» Recommended Reading: Best Grains, Fruits, and Vegetables That Improve Digestion


Read 1009 Synbiotic 365 Customer Reviews and Complaints

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Average Customer Rating: 4.7
Rating Snapshot:
5 star: 801 4 star: 153 3 star: 21 2 star: 12 1 star:  22
Bottom Line: 96% would recommend it to a friend
Showing 1-11 of 1009
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  • 1 out 1 people found this review helpful

    Exceptional product

    • Ohio,
    • Dec 4, 2019
    • Verified Reviewer

    I was skeptical, to say the least, when I first came across Synbiotic 365. After years of trying to regulate my digestive system by diet and supplements, I had nothing to lose by trying this product. I have battled unstable blood sugar levels, low energy and IBS/colitis problems for quite a few years. After about 4 weeks of taking Synbiotic 365, I started to notice not only a regulation in my bowel habits, but also I had more energy. Another benefit is that because my gut health is finally in balance, I am mentally happier. I am so grateful for this wonderful product.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Not enough research to go behind the affects and side-affects, deposits on kidneys, eyes, bones, etc.

    • California,
    • Dec 3, 2019
    • Verified Reviewer

    Noticed positive effect on my skin and nails. Prompt communications from support, was told it is designed to help with digestive issues. After 3 months using it, I felt fine with no drastic change. Noticed heavy build-up of mineral on my teeth where I never had combined in the past 4 years. Had a question about the effect on my kidneys. I was told I need to come off of it. Even though it sounds logical, "every body is different," but was not excited that they did not have enough research to figure it out and could not stand by their product. I would like to give it 2.5 even though it is a good product.

    Bottom Line: No, I would not recommend this to a friend

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  • 2 out 2 people found this review helpful

    Helped with daughter’s acne

    • Princeton, NJ,
    • Nov 22, 2019
    • Verified Reviewer

    I’ve been using it for five weeks now. Not sure if I notice any real benefits for myself. I did notice that I’m a little more constipated. I’ve never had constipation issues ever as I have always been extremely regular. Hopefully, this will go away once it’s in my system longer and continue to take. The real AMAZING thing that I did notice is that it has helped my daughter clear her acne. She started taking a week after me and the results are absolutely incredible! She has not changed anything in her diet other than taking the probiotic. She would only get bad breakouts on the right side of her face along with milia. Her acne is almost completely gone and the milia are prettying much non-existent except for a couple. I’ve always believed that gut health contributes to your overall health and skin. I will continue to use and purchase for my daughter as well. She is so happy and will not go a day without taking her probiotic. Thank you so much for this product. Please do not change the ingredients!

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Great probiotic

    • New Smyrna, FL,
    • Nov 18, 2019
    • Verified Reviewer

    Didn’t realize how much this was helping my digestion until I ran out. It will be my routine now, as I will select the auto-ship option.

    The energy it gives me all day is what I need to keep up with our active lifestyle.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Will definitely reorder United Natural's Synbiotic 365!

    • Pennsylvania,
    • Nov 12, 2019
    • Verified Reviewer

    I've suffered with gastro and IBS issues for years. After almost six weeks taking UN Synbiotic 365, I've found my stomach issues to be very much improved - less bloating, gas and general discomfort. I can even occasionally have a cup of coffee without suffering (and that's huge for me). I will definitely be reordering again. I feel terrific!

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    Synbiotic 365 saved me

    • Oro Valley, AZ,
    • Nov 11, 2019
    • Verified Reviewer

    About a year ago, I came down with weird gastrointestinal symptoms. I lost my appetite, I started to get extremely nauseous in the morning particularly (dry heaving and also throwing up). I had uncontrollable diarrhea. It affected my life. It was hell. I couldn’t go anywhere because I had to be close to the bathroom or risk having accidents. This was for three months.

    I came across Synbiotic 365 during a web search to try to find a solution. I was up for anything at that point. I started taking it in the morning on an empty stomach. Three days later, after experiencing my symptoms every day for three months, my symptoms were gone. And I enjoyed relief for three months with my three-month supply of 365.

    I thought I was cured so I didn’t order more. Three or four days after my last dose, all my symptoms returned. I ordered more.

    I was late in ordering more after that supply ran out. And yet again as I waited for my shipment, all my symptoms reappeared again like clockwork.

    Without this supplement, I would be in agony and depressed over being in agony. I recommend this supplement to anyone with weird gastrointestinal symptoms. I enjoy a problem-free gastrointestinal system now. I have more energy because that is what happens when you can eat, aren’t throwing up and not dehydrated.

    Bottom Line: Yes, I would recommend this to a friend

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  • 9 out 11 people found this review helpful

    Warning

    • Front Royal, VA,
    • Nov 11, 2019
    • Verified Reviewer

    The company repeatedly encouraged me to use it for the entire 60-day period to experience the best results. After 60 days, I contacted them for a refund stating that I did not have any improvement in my symptoms. I told them that, in fact, the product seemed to increase by bloating and gas. I was told that I was outside the 60-day trial period and did not qualify for a refund.

    Bottom Line: No, I would not recommend this to a friend

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  • 2 out 2 people found this review helpful

    So far, so good

    • St. Louis, MO,
    • Nov 9, 2019
    • Verified Reviewer

    I have been taking this product for a month, and so far I am pleased with it. The positive effects I have experienced are improved sleep and weight loss. If things continue on this path, I expect to use this product passed the three-month supply I purchased. I have taken very high-quality probiotics in the past, and I feel that this one falls right in line with them, if not surpassing them, specifically because of the weight loss component. The only negative effect I have felt is mild constipation, but that is also a good sign that strains are very robust. I would definitely recommend this product to others, especially those who need to address significant health issues.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Energized!

    • Bowie, MD,
    • Nov 9, 2019
    • Verified Reviewer

    At first I was reluctant about purchasing this product, but decided to give it a try since I am vegan. Now I am so happy I did. I feel more energetic than I did with switching to vegan. I am more ready to assist my husband with every-day activities because of his total knee replacement. Knowing that I am receiving the proper B complexes puts my mind more at ease on becoming a vegan. In addition, I gave my daughter a 3-month supply for her birthday. She also is vegan.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Helped with digestion!

    • Arizona,
    • Nov 6, 2019
    • Verified Reviewer

    This product helped with digestion. I found that I had less cramping, discomfort, and gas while taking it. I ran out and noticed a difference so am ordering again! Would definitely recommend to a friend. Very nice, convenient packaging and no refrigeration necessary is great!

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    So far so good

    • Traverse City, MI,
    • Nov 1, 2019
    • Verified Reviewer

    I have had stomach/gallbladder issues for years...so I am always looking for help. Then I can across an article by Dr. Vincent Pedre.

    He started to make sense so I decided to order Synbiotic 365. I have been taking this for almost 60 days now and I can finally feel a difference in my digestion system. I have not had an attack in the middle of the night for some time now but was a little slow to start. I didn't notice a major difference in my gut health until after I was into my second box of capsules. The weight loss has not kicked in yet, as I have an issue with bloating and I really don't feel a difference in my energy level due to there hasn't really been an issue there so far. I do feel your product is the real thing that will balance my gut issue until there is no longer an issue and I thank you for that and all the research that was done to come up with this product in the first place.

    Bottom Line: Yes, I would recommend this to a friend

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