Synbiotic 365 Review: Benefits, Effectiveness, Side Effects, Cost

By Derek Lakin
HighYa Staff Published on: Sep 18, 2018

United Naturals advertises Synbiotic 365 as an advanced formula consisting of beneficial probiotic strains and prebiotic ingredients, that when combined, can deliver lasting relief from bloat and other embarrassing digestive issues.

Based on the available clinical evidence, can you realistically expect to experience benefits like these? Furthermore, is there supporting data that taking a combination product like Synbiotic 365 will deliver better results than a standalone probiotic supplement?

In this brief article, we’ll discuss the formula’s ingredients, pricing, and competition, all aimed at helping you make an informed decision. Before diving in, though, let’s clarify what we’re talking about.

What Is a Synbiotic Supplement?

Probiotics are specific bacteria strains that, when taken regularly as a dietary supplement, have been clinically shown to provide a wide variety of digestion-related benefits, in addition to boosting immune function.

Prebiotics, on the other hand, are certain ingredients that these bacteria use as an energy source upon arriving in your digestive tract.

» Related: Probiotics 101: A Beginner’s Guide

With these details in mind, ScienceDirect explains, whether referencing Synbiotic 365 or another formula, “Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms.”

Writing for Health.com, Anthea Levi tells us “the idea behind synbiotics is that adding prebiotics to a probiotic supplement can help ensure that the digestion-friendly microorganisms arrive in the gut alive and well. These supplements are said to be particularly useful for people with conditions like IBS, other bowel disorders, and diabetes.”

Cynthia Sass, RD, Health contributing nutrition editor, adds that when combined with probiotics, prebiotics can “also increase nutrient absorption and support bowel regularity.”

Taking a Closer Look at Synbiotic 365’s Ingredients

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 2.4 mg
  • Vitamin B2 2.6 mg
  • Vitamin B3 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 60 mcg
  • Vitamin B5 10 mg
  • Probiotic Blend 30 billion CFU – Lactobacillus acidophilus La-14, Bifidobacterium lactis Bl-04, Lactobacillus paracasei Lpc-37, Lactobacillus plantarum LP-115, Streptococcus thermophilus ST-21, Lactobacillus casei LC-11, Lactobacillus reuteri, Lactobacillus salivarius LS-33, Lactobacillus rhamnosus LR-32, Bifidobacterium bifidum BB-06, Bifidobacterium longum BL-05, Saccharomyces boulardii
  • Chicory Root Inulin 300 mg

Sites like WebMD, the Natural Medicines Database, and Examine.com report that the first eight vitamins in this formula are essential for maintaining human health. For example, B1 (thiamine) is essential in the breakdown of carbohydrates, B2 also helps digest carbs, as well as proteins and fats, while Healthline tells us that every part of your body needs B3 (niacin) to function correctly.

However, they also report that unless someone’s deficient in these vitamins, supplementing them likely won’t deliver meaningful health benefits.

» Related: Do You Need to Take Vitamins or Dietary Supplements?

Probiotic bacteria are identified by their genus (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

Lactobacillus acidophilus (whether contained in Synbiotic 365 or another supplement) was the first probiotic strain widely used, which seems to work especially well for irritable bowel syndrome (IBS) symptoms and urinary tract infections in children.

Among others, paracasei may relieve allergic symptoms and decrease skin sensitivity, plantarum produces its own antibiotics, casei may improve allergy symptoms and reduce cholesterol (along with reuteri), and rhamnosus has even been shown to help obese women lose weight.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be effective for constipation and airway infections, in addition to IBS and ulcerative colitis.

Finally, Streptococcus thermophilus could decrease the chances of kidney stones and increase anti-tumor activity, while Saccharomyces boulardii seems to be especially useful for addressing different causes of diarrhea.

Potential Synbiotic 365 Side Effects

As genera (the plural of genus), WebMD, Examine.com, and the Natural Medicines Database report that Lactobacillus and Bifidobacteria are likely safe for adults and children when taken as directed. Common side effects, if any, for the genera include mild, temporary intestinal gas or bloating, as well as stomach or intestinal upset.

» Related: Common Probiotic Supplement Side Effects

Outside of this, WebMD indicates Saccharomyces boulardii could rarely “cause fungal infections that can spread through the bloodstream to the entire body (fungemia).” No dosages or other specifics listed.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering. In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

We didn’t encounter anything with the same (or very similar) formulation as Synbiotic 365 during our research.

However, we did come across dozens of competing synbiotic supplements like Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), and Renew Life Women's Daily Probiotics plus Prebiotics ($28, 60 capsules).

From a high-level perspective, these supplements are alike in that they’re priced competitively with one another, and that each combines a relatively similar blend of probiotics, prebiotics, and other vitamins and minerals.

These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins like C and many within the B family, and even secondary ingredients like chicory root and different fruit extracts as energy sources.

Zooming in, the differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Is either of these criteria important when choosing a synbiotic supplement? Perhaps not. Here’s why:

First, while probiotics and prebiotics are certainly beneficial on their own, Cynthia Sass, RD, Health contributing nutrition editor, emphasizes: “Right now we don’t have a lot of data to show that synbiotics are more effective than, say, taking probiotics [supplements] and eating a diet rich in prebiotics.”

Next, even if they are eventually shown equally as useful, Cynthia emphasizes that "Your overall pattern of eating still has the greatest impact on your health protection or risk,” so “don’t think that taking [one of these supplements] means you don’t have to pay attention to your diet.”

Together, from a value perspective, she recommends that “until more comprehensive research is conducted on synbiotics, consider sticking to swallowing a probiotic supplement or eating probiotic-rich foods in addition to prebiotic foods.”

Our Bottom Line on Synbiotic 365

At $45 per box, Synbiotic 365 seems priced at the upper end of the spectrum compared to some other popular synbiotic supplements but has a middle-of-the-road price compared to probiotic supplements in general—some of which can near the $100 mark.

And as we outline in our Probiotic Supplement Buyer’s Guide, paying more for one of these supplements doesn’t typically translate into improved results, as reported by customers.

Other pointers we mention in the article include making sure the manufacturer provides a complete list of all the bacteria strains, as well as their dosage (as measured in colony-forming units, or CFU), both of which United Naturals lists for Synbiotic 365.

However, the company also adds a handful of vitamins that, according to sites like Examine.com and WebMD, might not provide much value for the money unless you’re deficient. Furthermore, we didn’t encounter any online customer feedback for Synbiotic 365 at the time of our research, and the company wasn’t listed with the Better Business Bureau.

Still, they advertise that all purchases come with a 30-day refund policy if the supplement doesn’t meet your needs, less S&H charges. Just make sure that you talk with your doctor first about overall value based on your diagnosis before ordering, as well as potential side effects or medication interactions.

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Read 625 Synbiotic 365 Customer Reviews and Complaints

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Average Consumer Rating: 4.7
Rating Snapshot:
5 star: 490 4 star: 98 3 star: 11 2 star: 11 1 star:  15
Bottom Line: 95% would recommend it to a friend
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  • Editor’s Note: It is our understanding that this company has been asking its customers to leave feedback on HighYa. We assure you that each of these reviews has still been subjected to the same verification & vetting process that all submitted reviews go through. Learn More Here
  • Synbiotic 365 recommendation

    • Nashville, TN,
    • Jun 17, 2019
    • Verified Reviewer

    I have taken Synbiotic 365 for 60 days and can already tell a marked difference in my digestion issues. I have suffered from extreme indigestion that has caused much discomfort and the difference is positively remarkable! I have been suffering from over the top belching and abdominal pain. I no longer experience these extreme symptoms.

    Also, to my surprise, I am no longer on high blood pressure medicine as my blood pressure is now normal! Although this may not be usual, taking Synbiotic 365 is the only change I have made in the last 60 days when it comes to taking supplements. I can only attribute this to taking Synbiotic 365.

    Synbiotic 365 works for me and I highly recommend it to anyone!

    Bottom Line: Yes, I would recommend this to a friend

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  • No more bloat!

    • Texas,
    • Jun 17, 2019
    • Verified Reviewer

    I have used many probiotics in the past only to be disappointed and more uncomfortable. I was skeptical at first to try Synbiotic 365 because I hadn't heard of it before. But, I had reached a point of almost desperation. I was bloated all the time and acid reflux was constant. After a week of taking Synbiotic my acid reflux was calming down and my friends were asking me if I had lost weight. I hadn't realized how being bloated pushed my stomach out. Now my pants fit better and aren't tight around the middle. I am now at the end of 3 months using this product and I plan on continuing. I have recommended this product to several family members and friends.

    Bottom Line: Yes, I would recommend this to a friend

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  • Tried it and liked it

    • Talbott, TN,
    • Jun 17, 2019
    • Verified Reviewer

    After visiting my mother in GA last month she gave me a box of Synbiotic 365 and a bottle of the digestive enzymes to try. I have been taking them for about 2.5 weeks and I have noticed a considerable difference in my overall energy levels. I am on hypothyroid medicine and it seems after every 6 months of testing I have to increase my dosage of levothyroxine because my labs would come back out of range. After being on this for 2.5 weeks, I have begun running again in the mornings which I haven't done in over 7 years. I do feel that I have more energy especially in the morning and I feel better. I'm not sure if my increased energy is due to both the Synbiotic 365 and enzymes, or if I could just get by with the Synbiotic 365 and still feel better. I will find that out once I run out of the enzymes. Science is all about trial and error. I haven't lost any weight but the increase in energy gives me hope for the future!

    Bottom Line: Yes, I would recommend this to a friend

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  • Feel better

    • New York,
    • Jun 17, 2019
    • Verified Reviewer

    More energy since taking the Synbiotic 365. No bloating after eating. The B Complex in it has helped with stress. Sleep is solid and I even have lost some weight. Feel better all around.

    Bottom Line: Yes, I would recommend this to a friend

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  • Great product but...

    • Plainville, MA,
    • Jun 17, 2019
    • Verified Reviewer

    I can see obvious signs after a few weeks that this is a great quality product, superior to previous variations that I have tried. The only complaint that I have is that you can only get either one (30-day supply) but then it jumps up to a quantity of three. There are only two of us who will be taking the product so it is a waste for us to get three boxes. But getting one box means that we would only have enough for both of us to take for only half of the month. One star off for this.

    Bottom Line: Yes, I would recommend this to a friend

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  • Great product

    • California,
    • Jun 17, 2019
    • Verified Reviewer

    Have been taking Synbiotic 365 for over a month and it has helped me in several ways - much more energy, I'm sleeping much better, and I am not having cravings as much. My husband is taking it also and has had an increase in energy. I've just ordered more!

    Bottom Line: Yes, I would recommend this to a friend

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  • I did lose weight

    • Pawling, NY,
    • Jun 17, 2019
    • Verified Reviewer

    When I watched the infomercial that Dr. Pedre filmed, I was fascinated. I know how important the Vitamin B spectrum is to good health, and this supplement offers complete coverage of all the B's. That, combined with a good source of probiotics, have helped my parents (93 and 97) and myself (64) achieve "Happy Gut" status! Constipation is significantly reduced. We all feel better, and we also feel like we've done something good for our bodies. We feel our food is utilized more completely, and no longer feel guilty about enjoying an occasional slice of pizza for dinner!

    Thank you for creating such a good product!

    Bottom Line: Yes, I would recommend this to a friend

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  • Great results

    I was somewhat skeptical of claims for Synbiotic 365 but decided to try the product after reading up them. I was surprised when after a few days I actually was feeling better and my IBS was much improved. After a few weeks I was having more energy and I actually was feeling better than I had for quite a long time. I had an issue reordering and ran out of my Synbiotic 365 and I woke up today missing the extra energy I had experienced after taking my 365. I am anxiously awaiting my next order and will be sure not to run out again.

    Bottom Line: Yes, I would recommend this to a friend

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  • Better than the average vitamin

    • Kingsland, GA,
    • Jun 17, 2019
    • Verified Reviewer

    I started taking this supplement because I was given antibiotics twice in January. I knew it was bad to take but I had shingles and didn't want to deal with that. Also, I watch the 700 Club on TBN and they had a week-long segment on gut health. I seem to have more energy and hoping it will increase. I am 74 and needed a boost. The only problem I have is I have a hard time drinking 8 oz of water on an empty stomach and the capsule is rather large and hard for me to swallow. Once I forgot to take it before I ate but took it anyway. Thank you for the discount, which I appreciate since I am on a limited budget of pension and SSA.

    Bottom Line: Yes, I would recommend this to a friend

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  • I feel better!

    • Los Angeles, CA,
    • Jun 17, 2019
    • Verified Reviewer

    I have diabetes and take medicine that made me sick. I used to vomit and gag all the time. I feel so much better since I starting on this program. No nausea at all! I’m really happy with the results.

    Bottom Line: Yes, I would recommend this to a friend

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  • Finally a product that relieves that bloated feeling.

    • Durango, CO,
    • Jun 17, 2019
    • Verified Reviewer

    Very pleased to have found Synbiotic 365. I have been struggling with bloating and finally a product that works for me. I did experience feeling sick the first couple of days as it was cleaning me out fast. But decided to continue with it and I am SO glad I did! I feel great having lost 6 lbs, my digestion is considerably improved and my energy has definitely increased. It works naturally without the fear of having to run to the bathroom constantly. Customer Service was courteous, helpful and fast to reorder...arrived in 4 days. I highly recommend United Naturals and Synbiotic 365.

    Bottom Line: Yes, I would recommend this to a friend

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