Synbiotic 365 Review: Benefits, Effectiveness, Side Effects, Cost

By Derek Lakin
HighYa Staff
Published on: Sep 18, 2018

United Naturals advertises Synbiotic 365 as an advanced formula consisting of beneficial probiotic strains and prebiotic ingredients, that when combined, can deliver lasting relief from bloat and other embarrassing digestive issues.

Based on the available clinical evidence, can you realistically expect to experience benefits like these? Furthermore, is there supporting data that taking a combination product like Synbiotic 365 will deliver better results than a standalone probiotic supplement?

In this brief article, we’ll discuss the formula’s ingredients, pricing, and competition, all aimed at helping you make an informed decision. Before diving in, though, let’s clarify what we’re talking about.

What Is a Synbiotic Supplement?

Probiotics are specific bacteria strains that, when taken regularly as a dietary supplement, have been clinically shown to provide a wide variety of digestion-related benefits, in addition to boosting immune function.

Prebiotics, on the other hand, are certain ingredients that these bacteria use as an energy source upon arriving in your digestive tract.

With these details in mind, ScienceDirect explains, whether referencing Synbiotic 365 or another formula, “Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms.”

Writing for Health.com, Anthea Levi tells us “the idea behind synbiotics is that adding prebiotics to a probiotic supplement can help ensure that the digestion-friendly microorganisms arrive in the gut alive and well. These supplements are said to be particularly useful for people with conditions like IBS, other bowel disorders, and diabetes.”

Cynthia Sass, RD, Health contributing nutrition editor, adds that when combined with probiotics, prebiotics can “also increase nutrient absorption and support bowel regularity.”

Taking a Closer Look at Synbiotic 365’s Ingredients

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 2.4 mg
  • Vitamin B2 2.6 mg
  • Vitamin B3 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 60 mcg
  • Vitamin B5 10 mg
  • Probiotic Blend 30 billion CFU – Lactobacillus acidophilus La-14, Bifidobacterium lactis Bl-04, Lactobacillus paracasei Lpc-37, Lactobacillus plantarum LP-115, Streptococcus thermophilus ST-21, Lactobacillus casei LC-11, Lactobacillus reuteri, Lactobacillus salivarius LS-33, Lactobacillus rhamnosus LR-32, Bifidobacterium bifidum BB-06, Bifidobacterium longum BL-05, Saccharomyces boulardii
  • Chicory Root Inulin 300 mg

Sites like WebMD, the Natural Medicines Database, and Examine.com report that the first eight vitamins in this formula are essential for maintaining human health. For example, B1 (thiamine) is essential in the breakdown of carbohydrates, B2 also helps digest carbs, as well as proteins and fats, while Healthline tells us that every part of your body needs B3 (niacin) to function correctly.

However, they also report that unless someone’s deficient in these vitamins, supplementing them likely won’t deliver meaningful health benefits.

» Related: Do You Need to Take Vitamins or Dietary Supplements?

Probiotic bacteria are identified by their genus (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

Lactobacillus acidophilus (whether contained in Synbiotic 365 or another supplement) was the first probiotic strain widely used, which seems to work especially well for irritable bowel syndrome (IBS) symptoms and urinary tract infections in children.

Among others, paracasei may relieve allergic symptoms and decrease skin sensitivity, plantarum produces its own antibiotics, casei may improve allergy symptoms and reduce cholesterol (along with reuteri), and rhamnosus has even been shown to help obese women lose weight.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be effective for constipation and airway infections, in addition to IBS and ulcerative colitis.

Finally, Streptococcus thermophilus could decrease the chances of kidney stones and increase anti-tumor activity, while Saccharomyces boulardii seems to be especially useful for addressing different causes of diarrhea.

Potential Synbiotic 365 Side Effects

As genera (the plural of genus), WebMD, Examine.com, and the Natural Medicines Database report that Lactobacillus and Bifidobacteria are likely safe for adults and children when taken as directed. Common side effects, if any, for the genera include mild, temporary intestinal gas or bloating, as well as stomach or intestinal upset.

» Related: Common Probiotic Supplement Side Effects

Outside of this, WebMD indicates Saccharomyces boulardii could rarely “cause fungal infections that can spread through the bloodstream to the entire body (fungemia).” No dosages or other specifics listed.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering. In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

We didn’t encounter anything with the same (or very similar) formulation as Synbiotic 365 during our research.

However, we did come across dozens of competing synbiotic supplements like Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), and Renew Life Women's Daily Probiotics plus Prebiotics ($28, 60 capsules).

From a high-level perspective, these supplements are alike in that they’re priced competitively with one another, and that each combines a relatively similar blend of probiotics, prebiotics, and other vitamins and minerals.

These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins like C and many within the B family, and even secondary ingredients like chicory root and different fruit extracts as energy sources.

Zooming in, the differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Is either of these criteria important when choosing a synbiotic supplement? Perhaps not. Here’s why:

First, while probiotics and prebiotics are certainly beneficial on their own, Cynthia Sass, RD, Health contributing nutrition editor, emphasizes: “Right now we don’t have a lot of data to show that synbiotics are more effective than, say, taking probiotics [supplements] and eating a diet rich in prebiotics.”

Next, even if they are eventually shown equally as useful, Cynthia emphasizes that "Your overall pattern of eating still has the greatest impact on your health protection or risk,” so “don’t think that taking [one of these supplements] means you don’t have to pay attention to your diet.”

Together, from a value perspective, she recommends that “until more comprehensive research is conducted on synbiotics, consider sticking to swallowing a probiotic supplement or eating probiotic-rich foods in addition to prebiotic foods.”

Our Bottom Line on Synbiotic 365

At $45 per box, Synbiotic 365 seems priced at the upper end of the spectrum compared to some other popular synbiotic supplements but has a middle-of-the-road price compared to probiotic supplements in general—some of which can near the $100 mark.

And as we outline in our Probiotic Supplement Buyer’s Guide, paying more for one of these supplements doesn’t typically translate into improved results, as reported by customers.

Other pointers we mention in the article include making sure the manufacturer provides a complete list of all the bacteria strains, as well as their dosage (as measured in colony-forming units, or CFU), both of which United Naturals lists for Synbiotic 365.

However, the company also adds a handful of vitamins that, according to sites like Examine.com and WebMD, might not provide much value for the money unless you’re deficient. Furthermore, we didn’t encounter any online customer feedback for Synbiotic 365 at the time of our research, and the company wasn’t listed with the Better Business Bureau.

Still, they advertise that all purchases come with a 30-day refund policy if the supplement doesn’t meet your needs, less S&H charges. Just make sure that you talk with your doctor first about overall value based on your diagnosis before ordering, as well as potential side effects or medication interactions.

» Recommended Reading: Best Grains, Fruits, and Vegetables That Improve Digestion

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Read 922 Synbiotic 365 Customer Reviews and Complaints

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Average Consumer Rating: 4.7
Rating Snapshot:
5 star: 726 4 star: 147 3 star: 17 2 star: 12 1 star:  20
Bottom Line: 96% would recommend it to a friend
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  • Editor’s Note: It is our understanding that this company has been asking its customers to leave feedback on HighYa. We assure you that each of these reviews has still been subjected to the same verification & vetting process that all submitted reviews go through. Learn More Here
  • I suffered horrible IBS for 4 years. Been taking Synbiotic 365 for 2 months. No more IBS.

    • Estes Park, CO,
    • Aug 24, 2019
    • Verified Reviewer

    I have been taking Synbiotic 365 for 2 months now.

    I have been suffering horrible IBS for 4 years. During a bowel movement, I would usually throw up and sometimes pass out. After taking my very first dose of Synbiotic 365, I have not experienced any further bad episodes. I now have bowel movements like I had as a kid. I am now 81 years young.

    I am so thankful that I found Dr. Pedre's website. I can't thank him enough for caring about others to do all the research it took to find these results and share them with us.

    Bottom Line: Yes, I would recommend this to a friend

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  • Great probiotic and digestive enzyme products

    • San Francisco, CA,
    • Aug 23, 2019
    • Verified Reviewer

    I've been using United Naturals' Synbiotic 365 and Enzyme 365 for about 4 months now. I really like the products as they seem to be helping restore my digestive system overall. I was very sick and anemic for a couple of years and am still low on iron, so my primary care naturopathic doctor looked at both the Synbiotic 365 and digestive enzyme and confirmed that they are well-formulated, high-quality products. While these products have not helped me lose weight yet, I think this is because of my unique situation recovering from major abdominal surgery this year and being low on iron, meaning that my body hasn't been metabolizing properly - so the main goal for me is to restore all functions and these products are helping me do that! My gut feels much better, and I plan to reorder these products again.

    Bottom Line: Yes, I would recommend this to a friend

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  • Complete

    • Nicholasville, KY,
    • Aug 22, 2019
    • Verified Reviewer

    I've noticed more regular and complete wasting of solid material and a somewhat decompressed abdomen shortly after taking Synbiotic 365. I make sure I take it daily. I can tell if I miss a day.

    Bottom Line: Yes, I would recommend this to a friend

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  • Living again

    • Virginia,
    • Aug 21, 2019
    • Verified Reviewer

    Synbiotic 365 is helping my stomach and colon to get back to normal (whatever normal is). I have learned so many things that I did wrong to get to this place and the information I have been given, made me chose Synbiotic 365 as everything that was talked about made my spirit leap with "This is exactly what I need". I have tried many things and this one spoke to me the loudest and from studying food and supplements for many years, this one was the perfect one and it is already working and I can feel the difference from the 1st day I took the product. I have only been on the product for 4 days and I can tell you IT WORKS!

    Bottom Line: Yes, I would recommend this to a friend

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  • Works well

    • Boise, ID,
    • Aug 20, 2019
    • Verified Reviewer

    I didn't really know if these supplements were doing anything and whether they were worth the cost, until I stopped taking them and noticed a big difference. I didn't have weight to lose, but was taking them for digestion and mental health. I have been staying trim and feeling good, so I plan to keep reordering.

    Bottom Line: Yes, I would recommend this to a friend

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  • Love it!

    • Lugoff, SC,
    • Aug 19, 2019
    • Verified Reviewer

    I have been taking Synbiotic 365 for approximately 5 months now and I can truly tell the difference. It has helped me tremendously with bloating and my digestion. Also, I have been able to maintain my recent weight loss. I will continue taking it, since it simply makes me feel better! Love it!

    Bottom Line: Yes, I would recommend this to a friend

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  • Really works

    • West Palm Beach, FL,
    • Aug 19, 2019
    • Verified Reviewer

    I purchased pluse, Whey protein, and Phoenix. I have lost 4 pounds (about a half pound a week). Phoenix curbs cravings and pulse gives you an extra push during your workout. The protein shakes are pretty good, I mix mine with coconut milk.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Feeling better!

    • St. Charles, IL,
    • Aug 17, 2019
    • Verified Reviewer

    I was apprehensive to try something online. But I did and I’ve been taking it for a month and I can tell you for sure it definitely is helping in some fashion. I have some interesting, unique situations with autoimmune and aches and pains. Synbiotic 365 has definitely helped decrease these aches and pains. I believe it did help me sleep better and I will continue to take it and see if the results get even better.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    No more indigestion...

    • Sacrament, CA,
    • Aug 17, 2019
    • Verified Reviewer

    Before I tried Synbiotic 365, I was dealing with not only bloating and indigestion, but I was also experiencing hives from food allergies. I had been taking a basic probiotic and large amounts of coconut oil; to help with the food allergies. It was working but my doctor was concerned with how the oil might affect my gall bladder. Once I started taking this I have cut back on the oil, no more bloating and very seldom do I have indigestion.

    Another benefit is I am losing weight even without exercising. I am a Bikram Yoga practitioner but have not practiced for over a month and I am still losing weight.

    This is the best discovery I've made in a long time, please give it a try, you won't be sorry!

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Good product

    • Hot Springs, AR,
    • Aug 16, 2019
    • Verified Reviewer

    After taking Synbiotic 365, I experienced an increased level of energy. With the boost level of energy, I was not only more active but I was in a better mood and more motivated in life.

    In addition to a higher energy level, I also found that I was able to sleep more soundly even though I have no prior issues with sleeping. I woke up feeling that I had a good night.

    I used to have problems with bloating but after taking Synbiotic 365, it has improved. It has also helped in my regularity. I still have the occasional bloating issue but I have only taken Synbiotic 365 for a month. I feel that I should give it more time to reap the full benefits of Synbiotic 365. I love that it’s packed in a sealed foil. Will purchase again.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Awesome feeling now

    • Texas,
    • Aug 16, 2019
    • Verified Reviewer

    I've been taking this for about 6 months now and I no longer feel bloated or fat. I have even lost 15 pounds without trying. Great investment for health and mind. My boss is also now taking this supplement and we are both over 45.

    Bottom Line: Yes, I would recommend this to a friend

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