Synbiotic 365 Review: Benefits, Effectiveness, Side Effects, Cost

By Derek Lakin
HighYa Staff
Published on: Sep 18, 2018

United Naturals advertises Synbiotic 365 as an advanced formula consisting of beneficial probiotic strains and prebiotic ingredients, that when combined, can deliver lasting relief from bloat and other embarrassing digestive issues.

Based on the available clinical evidence, can you realistically expect to experience benefits like these? Furthermore, is there supporting data that taking a combination product like Synbiotic 365 will deliver better results than a standalone probiotic supplement?

In this brief article, we’ll discuss the formula’s ingredients, pricing, and competition, all aimed at helping you make an informed decision. Before diving in, though, let’s clarify what we’re talking about.

What Is a Synbiotic Supplement?

Probiotics are specific bacteria strains that, when taken regularly as a dietary supplement, have been clinically shown to provide a wide variety of digestion-related benefits, in addition to boosting immune function.

Prebiotics, on the other hand, are certain ingredients that these bacteria use as an energy source upon arriving in your digestive tract.

With these details in mind, ScienceDirect explains, whether referencing Synbiotic 365 or another formula, “Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms.”

Writing for Health.com, Anthea Levi tells us “the idea behind synbiotics is that adding prebiotics to a probiotic supplement can help ensure that the digestion-friendly microorganisms arrive in the gut alive and well. These supplements are said to be particularly useful for people with conditions like IBS, other bowel disorders, and diabetes.”

Cynthia Sass, RD, Health contributing nutrition editor, adds that when combined with probiotics, prebiotics can “also increase nutrient absorption and support bowel regularity.”

Taking a Closer Look at Synbiotic 365’s Ingredients

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 2.4 mg
  • Vitamin B2 2.6 mg
  • Vitamin B3 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 60 mcg
  • Vitamin B5 10 mg
  • Probiotic Blend 30 billion CFU – Lactobacillus acidophilus La-14, Bifidobacterium lactis Bl-04, Lactobacillus paracasei Lpc-37, Lactobacillus plantarum LP-115, Streptococcus thermophilus ST-21, Lactobacillus casei LC-11, Lactobacillus reuteri, Lactobacillus salivarius LS-33, Lactobacillus rhamnosus LR-32, Bifidobacterium bifidum BB-06, Bifidobacterium longum BL-05, Saccharomyces boulardii
  • Chicory Root Inulin 300 mg

Sites like WebMD, the Natural Medicines Database, and Examine.com report that the first eight vitamins in this formula are essential for maintaining human health. For example, B1 (thiamine) is essential in the breakdown of carbohydrates, B2 also helps digest carbs, as well as proteins and fats, while Healthline tells us that every part of your body needs B3 (niacin) to function correctly.

However, they also report that unless someone’s deficient in these vitamins, supplementing them likely won’t deliver meaningful health benefits.

» Related: Do You Need to Take Vitamins or Dietary Supplements?

Probiotic bacteria are identified by their genus (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

Lactobacillus acidophilus (whether contained in Synbiotic 365 or another supplement) was the first probiotic strain widely used, which seems to work especially well for irritable bowel syndrome (IBS) symptoms and urinary tract infections in children.

Among others, paracasei may relieve allergic symptoms and decrease skin sensitivity, plantarum produces its own antibiotics, casei may improve allergy symptoms and reduce cholesterol (along with reuteri), and rhamnosus has even been shown to help obese women lose weight.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be effective for constipation and airway infections, in addition to IBS and ulcerative colitis.

Finally, Streptococcus thermophilus could decrease the chances of kidney stones and increase anti-tumor activity, while Saccharomyces boulardii seems to be especially useful for addressing different causes of diarrhea.

Potential Synbiotic 365 Side Effects

As genera (the plural of genus), WebMD, Examine.com, and the Natural Medicines Database report that Lactobacillus and Bifidobacteria are likely safe for adults and children when taken as directed. Common side effects, if any, for the genera include mild, temporary intestinal gas or bloating, as well as stomach or intestinal upset.

» Related: Common Probiotic Supplement Side Effects

Outside of this, WebMD indicates Saccharomyces boulardii could rarely “cause fungal infections that can spread through the bloodstream to the entire body (fungemia).” No dosages or other specifics listed.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering. In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

We didn’t encounter anything with the same (or very similar) formulation as Synbiotic 365 during our research.

However, we did come across dozens of competing synbiotic supplements like Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), and Renew Life Women's Daily Probiotics plus Prebiotics ($28, 60 capsules).

From a high-level perspective, these supplements are alike in that they’re priced competitively with one another, and that each combines a relatively similar blend of probiotics, prebiotics, and other vitamins and minerals.

These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins like C and many within the B family, and even secondary ingredients like chicory root and different fruit extracts as energy sources.

Zooming in, the differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Is either of these criteria important when choosing a synbiotic supplement? Perhaps not. Here’s why:

First, while probiotics and prebiotics are certainly beneficial on their own, Cynthia Sass, RD, Health contributing nutrition editor, emphasizes: “Right now we don’t have a lot of data to show that synbiotics are more effective than, say, taking probiotics [supplements] and eating a diet rich in prebiotics.”

Next, even if they are eventually shown equally as useful, Cynthia emphasizes that "Your overall pattern of eating still has the greatest impact on your health protection or risk,” so “don’t think that taking [one of these supplements] means you don’t have to pay attention to your diet.”

Together, from a value perspective, she recommends that “until more comprehensive research is conducted on synbiotics, consider sticking to swallowing a probiotic supplement or eating probiotic-rich foods in addition to prebiotic foods.”

Our Bottom Line on Synbiotic 365

At $45 per box, Synbiotic 365 seems priced at the upper end of the spectrum compared to some other popular synbiotic supplements but has a middle-of-the-road price compared to probiotic supplements in general—some of which can near the $100 mark.

And as we outline in our Probiotic Supplement Buyer’s Guide, paying more for one of these supplements doesn’t typically translate into improved results, as reported by customers.

Other pointers we mention in the article include making sure the manufacturer provides a complete list of all the bacteria strains, as well as their dosage (as measured in colony-forming units, or CFU), both of which United Naturals lists for Synbiotic 365.

However, the company also adds a handful of vitamins that, according to sites like Examine.com and WebMD, might not provide much value for the money unless you’re deficient. Furthermore, we didn’t encounter any online customer feedback for Synbiotic 365 at the time of our research, and the company wasn’t listed with the Better Business Bureau.

Still, they advertise that all purchases come with a 30-day refund policy if the supplement doesn’t meet your needs, less S&H charges. Just make sure that you talk with your doctor first about overall value based on your diagnosis before ordering, as well as potential side effects or medication interactions.

» Recommended Reading: Best Grains, Fruits, and Vegetables That Improve Digestion


Read 993 Synbiotic 365 Customer Reviews and Complaints

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Average Consumer Rating: 4.7
Rating Snapshot:
5 star: 789 4 star: 151 3 star: 20 2 star: 12 1 star:  21
Bottom Line: 96% would recommend it to a friend
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  • Gut ripped by antibiotic

    • Cypress, TX,
    • Oct 18, 2019
    • Verified Reviewer

    I am sincerely hoping that Synbiotic 365 helps to straighten out my gut. Since taking the strong antibiotic I have had bad changes in my bowel habits and I believe Synbiotic 365 has helped some to combat those changes.

    Bottom Line: Yes, I would recommend this to a friend

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  • It works!

    • Los Angeles, CA,
    • Oct 17, 2019
    • Verified Reviewer

    I've been taking vitamins and supplements for years, without seeing much difference in my energy levels and bodily functions. After researching some of my health concerns, I determined to "up my game" by ordering probiotics that would actually have an impact in my body. I thought I would give Synbiotic 365 a shot, and it sounded like a superior product with superior packaging. If I didn't like it, I didn't have to reorder it, right? Well, I did have more energy and more resistance to flu and cold, so I did reorder. I am sold on this product and recommend to anyone!

    Bottom Line: Yes, I would recommend this to a friend

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  • Feeling better!

    • Seattle, WA,
    • Oct 17, 2019
    • Verified Reviewer

    My sister, my adult daughter, and I have all been using the Synbiotic 365 for about 3 months now. All three of us have felt better, felt "lighter", less bloated, and have noticed an improvement in our bowel patterns. We have not changed our eating habits or any other routines. Each of us have lost a few pounds without trying. Of course, we would love to lose more weight! Weight loss was not our primary reason to try Synbiotic 365. We just wanted to feel a bit better - and we do! Just placed our second order.

    Bottom Line: Yes, I would recommend this to a friend

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  • Great stuff

    • Fallon, NV,
    • Oct 16, 2019
    • Verified Reviewer

    This product has made a notable improvement in my digestive system. Appetite is more even, as is my bowel health. I haven’t been sick since I started taking it six months ago. I have recommended it to my family with great results.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Synbiotic 365 is working great for me!

    • Boulder, CO,
    • Oct 16, 2019
    • Verified Reviewer

    I've been taking Synbiotic 365 for about 2 years now. I feel even more energetic and happy to report I have not gotten a cold, flu, headaches for these past couple of years! My physician convinced me how important gut health is for our overall well being and recommended both pre and probiotics! I'm sticking with Synbiotic 365!

    Bottom Line: Yes, I would recommend this to a friend

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  • Loose stools/diarrhea

    • Columbia, SC,
    • Oct 16, 2019
    • Verified Reviewer

    I have only been taking it for a month. Constipation is better but now I sometimes have to go so frequently it is like diarrhea and can hardly leave the bathroom. Very inconvenient planning your day, plus the gas.

    Bottom Line: No, I would not recommend this to a friend

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  • Synbiotic 365 - BEST PRODUCT EVER

    • Texas,
    • Oct 15, 2019
    • Verified Reviewer

    I never do reviews, but I am so glad I tried Synbiotic 365. After decades of taking many different (and expensive) probiotics, I finally found one that gives results I can actually feel!

    I suffered for years from severe brain fog and lethargy that was crippling me. It took everything I had in me to get out of bed in the morning and get myself ready to go to work. And then I struggled to get through the day, after which, I came home and went to bed for 10 hours so I could get to work the next day.

    Within a few weeks of starting Synbiotic 365, the brain fog was greatly diminished, and I had noticeably better mental clarity and energy. Now after several months on the product, there is no brain fog, my mood is much better, I'm sleeping better, and I'm working 12 hours a day. I never thought that was even possible!

    This probably sounds like a commercial, but I've been a vitamin nut most of my life. I've tried countless products, with no noticeable results. With Synbiotic 365, for the first time, I'm taking a product that I know is helping me and improving my quality of life. It's a great product and I highly recommend it. Thank you Dr. Pedre!

    Bottom Line: Yes, I would recommend this to a friend

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  • Synbiotic has improved health

    • Las Vegas, NV,
    • Oct 13, 2019
    • Verified Reviewer

    I was feeling tired all the time with intestinal problems. I have tried other supplements and probiotics with no success. I have more energy and better digestion with Synbiotic 365. I would recommend.

    Bottom Line: Yes, I would recommend this to a friend

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  • This stuff seems to work

    I'm 70 years old. I've always been fit and trim. I had a job that kept me strong and in shape. I retired at 63. An active lifestyle has kept me in good shape, but I was developing a little paunch and "love handles" in spite of an hour of working out each morning and doing ranch work all day. I started on the Synbiotic 365 2 and 1/2 months ago.

    Last week my lady friend asked me where my paunch had gone while we were working out. Damned if the thing wasn't smaller, a lot smaller!

    So, I ordered 3 packages for her and 3 more for me. Also, I've had hypertension (high blood pressure for years). It seems to be dropping and my doctor said to lay off the med for it.

    Your results may vary. But, the hour of working out, an active lifestyle, and this product have made me look and feel better. Now, if I can make this 70-year-old sun and wind-blasted skin look younger.

    Bottom Line: Yes, I would recommend this to a friend

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  • Happy

    • Georgia,
    • Oct 13, 2019
    • Verified Reviewer

    Love the product! Don't need to use laxatives, and it helps heal intestinal polyps. Just please keep this affordable.

    I will continue to use this product indefinitely.

    Bottom Line: Yes, I would recommend this to a friend

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  • Relief

    • Pennsylvania,
    • Oct 12, 2019
    • Verified Reviewer

    I had been suffering with bloating after eating, had scopes done, which were OK. I tried this product and after several doses bloating has gone away. Will continue using this product.

    Bottom Line: Yes, I would recommend this to a friend

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