What Is Synbiotic 365?

By HighYa Staff
Published on: Sep 18, 2018

United Naturals advertises Synbiotic 365 as an advanced formula consisting of beneficial probiotic strains and prebiotic ingredients, that when combined, can deliver lasting relief from bloat and other embarrassing digestive issues.

Based on the available clinical evidence, can you realistically expect to experience benefits like these? Furthermore, is there supporting data that taking a combination product like Synbiotic 365 will deliver better results than a standalone probiotic supplement?

In this brief article, we’ll discuss the formula’s ingredients, pricing, and competition, all aimed at helping you make an informed decision. Before diving in, though, let’s clarify what we’re talking about.

What is a Synbiotic Supplement?

Probiotics are specific bacteria strains that, when taken regularly as a dietary supplement, have been clinically shown to provide a wide variety of digestion-related benefits, in addition to boosting immune function.

Prebiotics, on the other hand, are certain ingredients that these bacteria use as an energy source upon arriving in your digestive tract.

Related: Probiotics 101: Their Benefits, How They Work, & Foods That Contain Them

With these details in mind, ScienceDirect explains, whether referencing Synbiotic 365 or another formula, “Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms.”

In other words: Synergy + Probiotics = Synbiotics.

Writing for Health.com, Anthea Levi tells us “the idea behind synbiotics is that adding prebiotics to a probiotic supplement can help ensure that the digestion-friendly microorganisms arrive in the gut alive and well. These supplements are said to be particularly useful for people with conditions like IBS, other bowel disorders, and diabetes.”

Cynthia Sass, RD, Health contributing nutrition editor, adds that when combined with probiotics, prebiotics can “also increase nutrient absorption and support bowel regularity.”

Exactly which probiotics and prebiotics does Synbiotic 365 contain?

Taking a Closer Look at Synbiotic 365’s Ingredients

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 2.4 mg
  • Vitamin B2 2.6 mg
  • Vitamin B3 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 60 mcg
  • Vitamin B5 10 mg
  • Probiotic Blend 30 billion CFU – Lactobacillus acidophilus La-14, Bifidobacterium lactis Bl-04, Lactobacillus paracasei Lpc-37, Lactobacillus plantarum LP-115, Streptococcus thermophilus ST-21, Lactobacillus casei LC-11, Lactobacillus reuteri, Lactobacillus salivarius LS-33, Lactobacillus rhamnosus LR-32, Bifidobacterium bifidum BB-06, Bifidobacterium longum BL-05, Saccharomyces boulardii
  • Chicory Root Inulin 300 mg

Sites like WebMD, the Natural Medicines Database, and Examine.com report that the first eight vitamins in this formula are essential for maintaining human health. For example, B1 (thiamine) is essential in the breakdown of carbohydrates, B2 also helps digest carbs, as well as proteins and fats, while Healthline tells us that every part of your body needs B3 (niacin) to function correctly.

However, they also report that unless someone’s deficient in these vitamins, supplementing them likely won’t deliver meaningful health benefits.

Related: Do You Need to Take Vitamins or Dietary Supplements?

Probiotic bacteria are identified by their genus (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

Lactobacillus acidophilus (whether contained in Synbiotic 365 or another supplement) was the first probiotic strain widely used, which seems to work especially well for irritable bowel syndrome (IBS) symptoms and urinary tract infections in children.

Among others, paracasei may relieve allergic symptoms and decrease skin sensitivity, plantarum produces its own antibiotics, casei may improve allergy symptoms and reduce cholesterol (along with reuteri), and rhamnosus has even been shown to help obese women lose weight.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be effective for constipation and airway infections, in addition to IBS and ulcerative colitis.

Finally, Streptococcus thermophilus could decrease the chances of kidney stones and increase anti-tumor activity, while Saccharomyces boulardii seems to be especially useful for addressing different causes of diarrhea.

Potential Synbiotic 365 Side Effects

As genera (the plural of genus), WebMD, Examine.com, and the Natural Medicines Database report that Lactobacillus and Bifidobacteria are likely safe for adults and children when taken as directed. Common side effects, if any, for the genera include mild, temporary intestinal gas or bloating, as well as stomach or intestinal upset.

Related: Common Probiotic Supplement Side Effects

Outside of this, WebMD indicates Saccharomyces boulardii could rarely “cause fungal infections that can spread through the bloodstream to the entire body (fungemia).” No dosages or other specifics listed.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering. In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

We didn’t encounter anything with the same (or very similar) formulation as Synbiotic 365 during our research.

However, we did come across dozens of competing synbiotic supplements like Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), and Renew Life Women's Daily Probiotics plus Prebiotics ($28, 60 capsules).

From a high-level perspective, these supplements are alike in that they’re priced competitively with one another, and that each combines a relatively similar blend of probiotics, prebiotics, and other vitamins and minerals.

These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins like C and many within the B family, and even secondary ingredients like chicory root and different fruit extracts as energy sources.

Zooming in, the differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Is either of these criteria important when choosing a synbiotic supplement? Perhaps not. Here’s why:

First, while probiotics and prebiotics are certainly beneficial on their own, Cynthia Sass, RD, Health contributing nutrition editor, emphasizes: “Right now we don’t have a lot of data to show that synbiotics are more effective than, say, taking probiotics [supplements] and eating a diet rich in prebiotics.”

Next, even if they are eventually shown equally as useful, Cynthia emphasizes that "Your overall pattern of eating still has the greatest impact on your health protection or risk,” so “don’t think that taking [one of these supplements] means you don’t have to pay attention to your diet.”

Together, from a value perspective, she recommends that “until more comprehensive research is conducted on synbiotics, consider sticking to swallowing a probiotic supplement or eating probiotic-rich foods in addition to prebiotic foods.”

Should You Place an Order for Synbiotic 365?

At $45 per box, Synbiotic 365 seems priced at the upper end of the spectrum compared to some other popular synbiotic supplements but has a middle-of-the-road price compared to probiotic supplements in general—some of which can near the $100 mark.

And as we outline in our Probiotic Supplement Buyer’s Guide, paying more for one of these supplements doesn’t typically translate into improved results, as reported by customers.

Other pointers we mention in the article include making sure the manufacturer provides a complete list of all the bacteria strains, as well as their dosage (as measured in colony-forming units, or CFU), both of which United Naturals lists for Synbiotic 365.

However, the company also adds a handful of vitamins that, according to sites like Examine.com and WebMD, might not provide much value for the money unless you’re deficient. Furthermore, we didn’t encounter any online customer feedback for Synbiotic 365 at the time of our research, and the company wasn’t listed with the Better Business Bureau.

Still, they advertise that all purchases come with a 30-day refund policy if the supplement doesn’t meet your needs, less S&H charges. Just make sure that you talk with your doctor first about overall value based on your diagnosis before ordering, as well as potential side effects or medication interactions.

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19 Consumer Reviews for Synbiotic 365

Average Consumer Rating: 2.9
Rating Snapshot:
5 star: 8 4 star: 0 3 star: 0 2 star: 4 1 star:  7
Bottom Line: 42% would recommend it to a friend
Showing 1-11 of 19
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  • Void guarantee

    • Centreville, VA,
    • Feb 21, 2019
    • Verified Reviewer

    You have 30 days from the day of purchase to return the product. This laughable. Take my scenario. I paid on 11/26, they shipped on 12/4, and I received on 12/11. That’s already two weeks in. Any physician with their degree will tell you it takes a minimum of two weeks to feel the benefits of most vitamins or pharmaceuticals. Ok, this happens to fall around Christmas time. Do you think some people purchasing your products may be giving it to loved ones for a Christmas gift? Poof, the guarantee is gone! Both my daughter-in-law and son took it for 30 days and it had not improved their heartburn and digestive issues such as stool consistency, cramps, etc. $200 tossed into the wind.

    Bottom Line: No, I would not recommend this to a friend

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  • 11 out 13 people found this review helpful

    Didn't work, offered half of a refund

    • Oak Island, NC,
    • Feb 15, 2019
    • Verified Reviewer

    I wish I had read all the reviews before I ordered for a trial. The email received after placing my order said. "Congratulations...You will not regret it", but they failed to make good on their word. If your 30-day trial takes more than 30 calendar days, you will not get a full refund. But we'll see how my credit card company feels about it as I plan to dispute the charge. The product didn't work for me, and the reviews show that it's a pretty common occurrence.

    Bottom Line: No, I would not recommend this to a friend

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  • 27 out 29 people found this review helpful

    SCAM!

    • Ontario, Canada,
    • Feb 12, 2019
    • Verified Reviewer

    I purchased on January 10, 2019, and it is now February 4, 2019 and I have yet to receive my order. My credit card has been billed almost $500.00, yet no product. False info on United Naturals website, stating warehouse in Montreal, yet it does not exist.

    Bottom Line: No, I would not recommend this to a friend

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  • 18 out 18 people found this review helpful

    Great product

    • New Jersey,
    • Feb 5, 2019
    • Verified Reviewer

    This product has worked for me. I needed something that would keep me regular. At first, I doubted that it would, but it works. I no longer have to take psyllium every day. I’m on my last box and I’m reordering today so that I won’t run out.

    Bottom Line: Yes, I would recommend this to a friend

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  • 36 out 39 people found this review helpful

    Scam. Will not refund my money like they said.

    • Washington,
    • Feb 4, 2019
    • Verified Reviewer

    The product made my stomach worse. I have been trying to get my refund back since I returned it December 12th. This is now January 28th. They have given me excuse after excuse not to refund the money. I finally turned them over to my bank for fraud.

    Bottom Line: No, I would not recommend this to a friend

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  • 24 out 26 people found this review helpful

    Cured my low stomach acid condition

    • Mesquite, NV,
    • Feb 2, 2019
    • Verified Reviewer

    In 2014 I was diagnosed with a form of reflux called Laryngopharyngeal Reflux (LPR) and was put on a Proton Pump Inhibitor (PPI). The PPI made the condition worse, so I researched the condition and determined that the primary cause was low stomach acid. Insufficient acid translates to incomplete digestion and non-acidic gasses creeping up into the upper respiratory area. I had severe bouts of hoarseness, asthma and had a large polyp in my nose from the irritation. I fixed the problem by supplementing with Hydrochloric Acid with Pepsin (HCL). I started taking Synbiotic 365 a month ago and have been able to completely discontinue the HCL and have had no further incidences of LPR symptoms. I strongly suspect that Synbiotic 365 had a material effect on allowing my body to produce its own acid.

    Bottom Line: Yes, I would recommend this to a friend

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  • 60 out 66 people found this review helpful

    Nothing special

    • Boise, ID,
    • Jan 23, 2019
    • Verified Reviewer

    I have been taking "365" for about three weeks and nothing significant has happened to change my digestion. Don't waste your money, just go buy good B complex vitamins and a good probiotic from your local drugstore or health food store. Ask your pharmacist or health food expert for a good brand. I foolishly ordered, didn't even try for a refund because of the comments by other people.

    Remember, what you read online is not always true.

    Bottom Line: No, I would not recommend this to a friend

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  • 55 out 58 people found this review helpful

    Less than positive results

    • California,
    • Jan 20, 2019
    • Verified Reviewer

    I ordered this probiotic as I was told a probiotic would be helpful for me. I have used it for a week and it has caused stomach cramping and diarrhea. I called to see how to obtain a refund, but the mailbox was full. I have now written them and I hope I get an answer as this is obviously not the product for me and I bought three boxes of it.

    Bottom Line: No, I would not recommend this to a friend

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  • 29 out 30 people found this review helpful

    After 1 week: de-inflammation, sleep and mood improvement

    • Left Coast,
    • Jan 19, 2019
    • Verified Reviewer

    I am happy to report near elimination of back and joint pain at night that was previously interfering with sleep (for years). Also fewer night time bathroom pee trips. Along with less pain, this means better sleep, better mood, more energy, a better gauge on appetite, fewer bad cravings and more healthy ones. Bloating and gut discomfort persist, but previous overall malaise, which I’d linked to perimenopause, is gone. I will update later.

    Bottom Line: Yes, I would recommend this to a friend

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  • 29 out 31 people found this review helpful

    Stomach cramps

    • Archdale, NC,
    • Jan 14, 2019
    • Verified Reviewer

    My name is Cerrone Postell. I have been taking Symbiotic 265 for three months now. Before first taking Symbiotic, after every single meal, my stomach would cramp, and I would have to run straight to the bathroom. Now after three months, when I eat, there is virtually no pain after, and movements have become more regular. My stomach feels so much better. I just want to say thank you to Dr. Pedre, and his team, for creating this miracle supplement. It truly works. Thanks!

    Bottom Line: Yes, I would recommend this to a friend

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  • 72 out 78 people found this review helpful

    United Naturals doesn’t return your phone call

    • Albuquerque, NM,
    • Jan 11, 2019
    • Verified Reviewer

    I tried this supplement for 30 days with no positive results. I called three times within the 30-day return window and they never returned my calls. Finally, on the 4th attempt, they answered and told me I was beyond the 30-day return window. For breaking their return guarantee, they belong in the scam group.

    Bottom Line: No, I would not recommend this to a friend

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