About Nucific BIO X4

Billed as a 4-in-1 weight management probiotic, Nucific BIO X4 claims to be a “revolutionary new compound” containing 4 proven nutrients that provide digestive support, suppress appetite, and support weight loss management. This includes:

  • 39 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins,
  • Green tea to boost your metabolism, and
  • Caralluma Fimbriata to suppress cravings.

Despite these benefits, Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regular and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1-2 months.

Whether you’re just starting with a weight loss regimen or have been at it for years, can Nucific BIO X4 provide the digestion support you need to break through your barriers? Consider the following:

Is BIO X4’s Ingredients Effective for Weight Loss?

According to BIO X4’s product label, the supplement contains:

  • Probiotic Blend: 4 billion CFU per capsule – Lactobacillus acidophilus, L. rhamnosus, L. plantarum, Bifidobacterium lactis, B. animalis.
  • Digestive Enzyme Blend: 88mg – Amylase (from Aspergilus Oryzae), Bromelain, Lipase (from Rhizopus Oryzae).
  • Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)
  • Craving Control Blend: 166mg – Caralluma Fimbriata Extract

As we detailed in our Probiotics Buyer’s Guide, probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data proving them to be effective.

Note: Although BIO X4’s website claims that it contains 39 billion CFUs, each capsule only contains 13 billion. In other words, by taking 3 capsules per day, you’ll cumulatively be ingesting 39 billion CFUs. This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

Amylase is “an enzyme that catalyses the hydrolysis of starch into sugars,” and bromelain “is an enzyme found in pineapple juice and in the pineapple stem” that’s used for “reducing swelling (inflammation), especially of the nose and sinuses, after surgery or injury,” and more. Finally, lipase “is an enzyme that catalyzes the hydrolysis of fats (lipids).”

While there are multiple studies related to the oral administration of amylase, clinical support for many of BIO X4’s claims appears to be on the slim side. Likewise, except for treating osteoarthritis and preventing muscle soreness after exercise, there isn’t enough clinical evidence showing that bromelain can provide other benefits.

And other than treating digestive problems related to pancreatic disorders, there is insufficient clinical evidence showing that lipase can provide any other benefits. Similarly, there isn’t enough clinical evidence showing that caralluma can provide any benefits, either.

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits, although there is insufficient evidence supporting any of them.

BIO X4 Side Effects

As with most nutritional supplements, even though many of BIO X4’s ingredients may not provide the benefits claimed by the manufacturer, they should be well tolerated by most individuals.

However, the probiotics in BIO X4 may cause a temporary increase in bloating or gassiness, although this side effect should resolve itself over the course of a couple days. Caralluma might also lead to gas, constipation, or stomach pain, which should subside after a week of use.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants.

What’s the Customer Buzz about Nucific BIO X4?

BIO X4 was a very new product at the time of our research (Nucific’s URL was registered in April 2015 and the company’s trademark was filed in June of 2015), so there weren’t any online reviews available.

Since Nucific is such a new company, they also weren’t listed with the Better Business Bureau.

Nucific BIO X4 Pricing & Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle (30-day supply): $49
  • 3 Bottles: $129
  • 6 Bottles: $240

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. Although no further details were provided, you’ll need to contact Nucific’s customer service department at 888-679-5520 or support@nucific.com in order to request a refund.

Can Nucific BIO X4 Support Digestion & Weight Management?

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor. On top of this, all of the supplement’s other ingredients have insufficient evidence to back up Nucific’s claims.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

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1009 Consumer Reviews for Nucific BIO X4

Average Consumer Rating: 4.4
Rating Snapshot:
5 star: 661 4 star: 236 3 star: 29 2 star: 26 1 star:  57
Bottom Line: 91% would recommend it to a friend
Showing 1-11 of 1009
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  • I don't hurt anymore!

    Originally I looked at the infomercial off of Facebook, hoping to find some helpful tips on weight loss. I had already decided to try one bottle to see if it would help curb appetite and weight loss. I have also been dealing with severe muscle pain and I have been taking 16 to 1800 ibuprofen a day with little relief. I blame this muscle pain on my weight.

    After taking BIO X4 for four days, I stopped taking ibuprofen for muscle pain at all! I could not believe it; I could finally move again without hurting. I also gave it to my daughter who has an intolerance to fatty and processed foods. Within a week her stools became more consistent. We have been looking for something to help her bowels for years.

    Bottom Line: Yes, I would recommend this to a friend

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  • Facts only

    • Porterville, CA,
    • Apr 25, 2018
    • Verified Reviewer

    I consumed 1-2 caps daily for six weeks and my target plate was 1/2 protein and half veggies/fruit and I lost 18 pounds. I quit taking BIO X4, maintained the same diet and lost ZERO pounds. I just had knee surgery, so exercise was not a part of this experience.

    Bottom Line: Yes, I would recommend this to a friend

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  • Worked great

    • Bensenville, IL,
    • Apr 25, 2018
    • Verified Reviewer

    This is my first review, and I would just like to hopefully give people researching this product some reassurance. I went back and forth for about two weeks reading every review and looking at many products. I've been on many diets and usually do very well, but love the boost this product gave me. I am down 32 pounds over three and a half months with a good diet. I plan to keep on track and hope this time I really follow through. Looking and feeling great, this product gave me a lot of energy, and I feel helped me with my portion control, which was always my weakness. I hope this review helps others to definitely give it a try with your diet. I don't know how much it would do if you weren't eating right because I really didn't cheat but once or twice.

    Bottom Line: Yes, I would recommend this to a friend

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  • Life changing!

    I have suffered from stomach issues for the past five years. A friend encouraged me to try BIO X4, and I figured I had nothing to lose. Within the first week of use, I was seeing a huge difference. The embarrassing gas and bloating that I would have after every meal was no longer an issue. I'm actually regular, no more going 4-5 days without being able to use the bathroom. Absolutely life changing!

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Positive changes

    • Pinellas Park, FL,
    • Apr 24, 2018
    • Verified Reviewer

    I've been taking Nucific's BIO X4 for about a month, and I'm pleased. One of my issues has been intestinal upset that often kept me confined to the "porcelain room."

    That's not an issue, unless I skip a day taking my capsules. Then it takes a couple of days to get things under control again. But it's nice to know I can go out with friends or to the store and not be frantically looking for the women's room!

    I have NOT experienced the weight loss that was described in the video, but when the product arrived, the information said it might take two months (not the two weeks as described) before I'll notice changes there. I'm willing to share if it happens!

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 3 people found this review helpful

    A great product

    • Elora, Canada,
    • Apr 23, 2018
    • Verified Reviewer

    I saw the online video and decided to try them out. I did and I've reordered. Not sure how much can be attributed to BIO X4 but I lost 10kg in nine months.

    I reordered on the strength of this. I have reconvened to friend in Hong Kong, and he has purchased both for himself and someone else.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Excellent product

    When I was in the market for a supplement that would provide the benefits I required, this was the obvious choice. The first thing was the credibility of the doctor in question. No problem. The second was the product itself. Great product.

    Bottom Line: Yes, I would recommend this to a friend

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  • 4 out 5 people found this review helpful

    Review

    • Florida,
    • Apr 20, 2018
    • Verified Reviewer

    I tried three bottles initially but stopped because I thought a little pricey. However, after a month I noticed a change in my stomach. I felt bloated, lack of bowels movement, overall just knew I was missing regular bowel movements.

    I figured maybe that Nucifica BIO X4 really worked so I ordered six bottles. It arrived within a week, and I definitely felt a difference.

    I will continue to take this for the remainder of my life. Although I wish it was a little more affordable.

    Bottom Line: Yes, I would recommend this to a friend

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  • 5 out 5 people found this review helpful

    BIO X4 review

    I’m on my second bottle of BIO X4, and I have to say, I have been pretty pleased with this product. I’ve been teaching group x classes for the last 17 years. And as I am nearing my later 39’s I’ve been noticing I was getting bloated and soft in my middle! What!

    So I cleaned up my eating, cutting out junk and refined sugar and pop, but still, not a lot was moving.

    So I started reading up on Nucific. It made total sense. I’ve been in the fitness industry a long time and have seen a lot of diets. But there’s nothing that beats a healthy whole foods diet and good digestive health.

    After my first bottle of BIO X4, I noticed my cravings for junk food and needing to graze most of the day had lessened. I had more energy teaching my classes. And my bathroom habits had greatly improved! And thankfully I wasn’t feeling or looking bloated. Huge win!

    Now I’ve got my husband on this amazing product, along with a healthier diet and lifestyle, and he’s already had people comment on how much trimmer he’s looking.

    Bottom Line: Yes, I would recommend this to a friend

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  • 3 out 3 people found this review helpful

    Great product

    NO complaints, other than I wish I could get a better price. It is not my only probiotic supplement. I also drink 8 oz. of raw home brewed Kombucha per day. I ferment it long enough to consume most of the sugar and use all organic ingredients.

    Bottom Line: Yes, I would recommend this to a friend

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  • 4 out 4 people found this review helpful

    BIO X4

    We have been taking these tablets for a couple of weeks now and are already feeling the benefits in our health. My husband has been feeling under the weather for some time, and these tablets seem to have started him on the way to full recovery. Be sure I shall be ordering more very shortly.

    Bottom Line: Yes, I would recommend this to a friend

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Showing 1-11 of 1009

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