Nucific BIO X4 Review: Effectiveness, Side Effects, Cost, and More

By Anthony Dugarte, M.D., C.S.C.S
Updated on: Mar 5, 2020

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Nucific BIO X4 is a probiotic-based supplement that claims to provide digestive support, suppress appetite, and support weight loss management. Each capsule includes:

  • 4 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins
  • Green tea to boost your metabolism
  • Caralluma Fimbriata to suppress cravings

Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regularly and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1–2 months.

This review will help you understand if this product works and if it is the right option for you.

BIO X4’s Ingredients: Are They Backed by Science?

According to BIO X4’s product label, the supplement contains:

Probiotic Blend: 4 billion (4x109) CFU per capsule

  • Lactobacillus acidophilus
  • L. rhamnosus
  • L. plantarum
  • Bifidobacterium lactis
  • B. animalis

Digestive Enzyme Blend: 88mg

  • Amylase (from Aspergilus Oryzae)
  • Bromelain
  • Lipase (from Rhizopus Oryzae)

Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)

Craving Control Blend: 166mg – Caralluma Fimbriata Extract

Below, we’ll detail the available research for each ingredient category included in BIO X4.

Probiotic Blend

Probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data available.

Note: As each capsule contains 4 billion CFUs, by taking the recommended 3 capsules per day, you’ll cumulatively be ingesting 12 billion CFUs.

This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

In terms of support for some of the strains included, here’s what we found:

Lactobacillus acidophilus is widely used in many available probiotic blends. It is thought to have an ability to improve symptoms related to diarrhea and stomach discomfort. Additionally, it may play a role in boosting immune function.

A review of 34 different randomized trials concluded that L. acidophilus at doses ranging from 2x108 to 1011 CFUs was able to reduce the risk for diarrhea when used alone or with other probiotics.

The combination of L. acidophilus NCFM and Bifidobacterium lactis Bi-07 twice daily at 1011 CFU/day reduced bloating in over 8-weeks. This same combination may also result in fewer sick days from respiratory infections.

L rhamnosus may reduce stomach flu symptoms. This family may also support immune system function and offer allergy relief.

L rhamnosus GG at 0.018mg doses reduced airway inflammation in mice with chronic asthma.

Over 5-days, kids treated with 1×1010 CFU of L. rhamnosus GG twice daily for the stomach flu did not relieve diarrhea or vomiting when compared to placebo.

Many Lactobacillus plantarum species may offer anti-inflammatory benefits. This was demonstrated in a laboratory study where L. Plantarum N14 reduced inflammation in intestinal cells. Similarly, mice injected with 100 mg/kg of L. plantarum K8 had reduced expression of enzymes and receptors involved in cardiovascular inflammation.

Bifidobacterium lactis is another strain that may offer immune-boosting benefits.

B. Lactis HN019 at 1.5x1011 CFU doses twice daily over 6-weeks improved blood tests used to indicate natural immunity in 13 elderly individuals. Similar doses of the same strain also boosted white blood cell levels in 30 elderly individuals.

The big takeaway here is that these effects are strain-specific. We can’t expect the same results from studies that investigated certain doses for certain strains as BIO X4 does not provide these details, but rather only the probiotic blend total.

Digestive Enzymes Blend

Carbohydrate metabolism begins in your mouth as the enzyme amylase is produced in your salivary glands.

This enzyme has not been extensively studied with respect to weight loss. Amylase levels were not found to be associated with weight loss or improvement in blood sugar regulation in obese individuals on weight maintenance programs.

Lipase is an enzyme involved in fat digestion. In healthy volunteers, those treated with 280mg of lipase experienced less stomach fullness after a fatty meal.

Bromelain plays a role in protein digestions, and may also offer anti-arthritic and anti-cancer benefits. It’s dietary role has not been well studied.

Weight Management Blend

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits.

Often included in dietary supplements that claim to boost metabolism or burn fat, green tea, and its proposed effects have been studied in humans.

These benefits are probably related to 2 notable components; caffeine and catechin (an antioxidant).

Green tea given at 90, 200, 300 and 400mg doses up to 3x daily increased energy expenditure when combined with 200mg of caffeine; the effects of green tea were not dose-dependent.

Body weight, BMI, waist to hip ratio, and body fat percentage were improved when 500mg of green tea daily was combined with exercise. These effects were greater than those seen in exercise alone.

Craving Control Blend

Caralluma is a cactus indigenous to India that is thought to offer sliming benefits through curbing appetite.

In overweight subjects, 1g per day over 2-months significantly reduced waist circumference and appetite.

In children with a genetic disease that is associated with excessive eating, 1,000mg of Caralluma reduced this behavior.

Side Effects

As BIO X4 does not offer information regarding specific amounts or specific strains included in their probiotic blend, their ingredients can’t be readily compared to the available literature.

Nonetheless, most studies test strain in the order of billions CFUs without serious side effects. While this speaks to the safety of BIO X4, the individual strains may not be offered in large enough doses to achieve the desired effects supported by research.

Mild side effects reported with the use of similar blends can include abdominal pain, gas, bloating, and diarrhea. These symptoms can be eased by lowering your dose or discontinuing the use of the product.

The remaining ingredients have all been safely tested at doses as much as 10x larger than what is offered in BIOX4. Again, it important to keep in mind that the Digestive Enzyme Blend offers only the total amount for all 3 ingredients. This number is far less than the doses that have been tested individually. While likely safe, BIO X4 may not offer a large enough dose for the desired effect.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants.

Pricing and Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle: $99 (30-day supply)
  • 3 Bottles: $261.36 ($87.12 per bottle)
  • 6 Bottles: $487.08 ($81.18 per bottle)

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. You'll have to send your unused portion left back to the company. You’ll need to contact Nucific’s customer service department at 888-679-5520 or in order to initiate the refund process.

Company Reputation

As of 3/5/20, over 1,380 customers left their reviews of BIO X4 here on HighYa, for an average rating of 4.4 stars. On the Better Business Bureau, we found 286 customer reviews for an average rating of 4 stars.

Nucific also has an A+ rating with the BBB based on 98 customer complaints.

The Bottom Line

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor.

BIO X4 does include ingredients that have been studied in human trials. However, the amounts for each individual ingredient are not provided by the company. The total amounts provided likely mean that the individual ingredients are offered at safe amounts.

This also means that these ingredients are offered in doses less than what has been proven effective in research studies.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

Lastly, as your digestive symptoms and need for effective weight loss may be the result of more serious underlying conditions, it is important to include a medical professional in your management.

» Recommended Reading: Best Grains, Fruits, and Vegetables That Improve Digestion

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Customer Reviews

Start your review of Nucific BIO X4:
  • 1391 Customer Reviews
  • 89% Recommend This Company
4.3 out of 5
5 star: 63% 4 star: 24% 3 star: 2% 2 star: 2% 1 star: 6%

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  • Energy again

    • By Anne P.,
    • Roanoke, VA,
    • Jul 20, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I ordered the 3 bottles for a discount, and I am a third of the way through my first bottle. I have had a lot of digestion problems and very sluggish energy for about a decade. I eat well and avoid foods that give me a hard time, but still can’t get back to feeling "right". Within a week I noticed far fewer digestive problems, and a big plus has been that my energy has returned dramatically. As far as weight, I don’t weigh myself very often so I can’t give you data, but I feel lighter and am looking slimmer in my clothes. Still have the post-menopausal fat around the middle but I feel like with the return of my energy I could shrink it. It might already be shrinking. (I should weigh myself and keep a record for a future comment.)

    Pros and Cons:

    • Product is effective for improving digestion and energy
    • I hate the hard sell, “wait, there’s more...” kind of ad
    • Hate the long video, just get to the point

    Bottom Line: Yes, I would recommend this to a friend

  • Bad reaction

    • By Jose C.,
    • Yonker, NY,
    • May 6, 2020
    • Verified Reviewer
    Overall Experience:

    I’ve been on this product for 1 week and so far I’ve been running to the toilet every 20 minutes, my back area hurts and I have to use Desitin...

    My stomach hurts and is extremely bloated...

    When I decided to pay for this product the website tried to force 3 bottles on me, but I kept pressing for the one, just to see if I’ll get good results. But my hunch was right - bad results.

    I do not recommend this product at all.

    Bottom Line: No, I would not recommend this to a friend

    • May 7, 2020

      Company Response from Nucific, LLC

      Hello Jose, we're sorry to hear about your experience. We always recommend speaking to your primary physician before starting a new product to ensure it is right for you. Some of our customers see a difference in 30 days, while others may see results in 90 days. We understand that everyone is different which is why we offer a 90-day money-back guarantee. I've gone ahead and initiated a refund for your order. Please keep an eye out for a confirmation email. If you have any other questions or concerns, my email is Thank you!

  • They are a SCAM, overcharged my credit card

    • By IHD I.,
    • Boston, MA,
    • Apr 20, 2020
    • Verified Reviewer
    Overall Experience:

    I went to get 6 bottles for the $199 price just two days ago, then as soon as I clicked "confirm" they gave me the confirmation with almost $300 charge for two orders of 3 and 6 bottles!

    I NEVER confirmed or authorized that payment!

    I called and they said to email because no one is working there to pick up phones.

    I emailed AND used their online form with details of my order and asked for them to cancel it.

    As of today, I have heard nothing, just an automated email that they have shipped the order already! I am SO upset. I will contact my credit card and leave them bad reviews!

    Horrible that they take advantage of people like this at such a terrible time too. Shame on them!

    Bottom Line: No, I would not recommend this to a friend

    • Apr 21, 2020

      Company Response from Nucific, LLC

      Hello, I want to start by apologizing that this was your experience with our checkout process. It sounds like you may have added additional products into your order, that we offer at a discounted price. We would never charge additional fees without your authorization. Please email me at and I can look into your account and get you refunded for any extra orders. Thank you and I look forward to hearing from you soon.

  • Changed my life!

    • By Taylor L.,
    • Missouri,
    • Apr 12, 2020
    • Verified Reviewer
    Overall Experience:

    Hey, I just wanted to share my experience with the Nucific BIO X4. I was a straight-up skeptic, nothing has worked for me. I have thyroid issues and everything. Well, I decided I finally break down and try it even though it is kind of expensive. I've been taking it for about 3 weeks now and there is such a huge improvement. No, I haven't lost any weight, which I'm okay with that, but my energy levels are through the roof. I was a person that would fall asleep during work, fall asleep at home, I couldn't do anything extra with my kids. I'm a mother of four, I have three dogs, so I needed my energy. I can go to sleep easier, I wake up without being groggy. I get out to do yard work, I play with my kids after work, my life has completely changed, and I feel like now I'm finally enjoying life instead of just living life.

    Bottom Line: Yes, I would recommend this to a friend

  • Only one week in and terrible bloating

    • By Buck W.,
    • North Carolina,
    • Mar 17, 2020
    • Verified Reviewer
    Overall Experience:

    Have taken the product 3 times daily for one week and bloating is severe. Hard to button my pants and face is puffy. Just stopped taking it yesterday. My body/system is obviously not responding well.

    Bottom Line: No, I would not recommend this to a friend

    • Mar 18, 2020

      Company Response from Nucific, LLC

      Buck, thank you for giving Bio-X4 a try! I'm so sorry to hear that this was your experience. It sounds like you might be experiencing "Die Off" symptoms. This often occurs when probiotics are introduced to the gut and begin killing off the bad bacteria. As always, we ask that you consult your primary care physician prior to trying a new product to ensure that you do not experience any interactions while taking them. Because everybody is different, we do understand that our products may work well for some and not others. If you would like to return the product, I can begin the refund process for you right away! Just e-mail me at I look forward to hearing from you!

  • I was skeptical

    • By Jeanne N.,
    • Michigan,
    • Feb 15, 2020
    • Verified Reviewer
    Overall Experience:

    I was skeptical at first but three weeks in, my stomach feels flatter. Excited to see what the next three weeks bring. Exercise and watching what I eat is bringing the desired results.

    Bottom Line: Yes, I would recommend this to a friend

  • BIO X4 is helping my skin heal

    • By Vicki S.,
    • Indianapolis, IN,
    • Feb 15, 2020
    • Verified Reviewer
    Overall Experience:

    I purchased this product because I felt that I possibly was suffering from leaky gut and for approximately 10 years now, I have been dealing with serious skin issues that have been very painful. I have been seeing a dermatologist for skin lesions all over my body, including my scalp. I've learned that I have allergic contact dermatitis. I am allergic to several products that I had been using on my skin. I have eliminated these products but have still had ongoing issues with my skin. The elimination of the products helped a lot but it did not completely clear up my skin and I was still getting new lesions. While my skin is much better than it was, I knew something else was going on, possibly my diet, possibly something in my system that my physicians were not able to diagnose. I came across an article talking about BIO X4 and I just had to try it. I am just on my first bottle and I have noticed that some of the inflammation in my skin was decreasing little by little. Although I have gotten new lesions, they have decreased in severity. I am just on my first bottle and I am hoping that the continuation of this product will help more and more while it heals my gut and hopefully my skin too. I have arthritis too and it seems to have helped eliminate some of my arthritic and joint pain too.

    Bottom Line: Yes, I would recommend this to a friend

  • Worth trying it

    • By Daena A.,
    • Lombard, IL,
    • Feb 15, 2020
    • Verified Reviewer
    Overall Experience:

    I like this product. I have used one bottle so far but I know I will need to keep using it longer for better results. I recommend it. It’s not easy to find a company that makes good probiotics and I think this is a good product.

    Bottom Line: Yes, I would recommend this to a friend

  • BIO X4

    • By John V.,
    • Feb 15, 2020
    • Verified Reviewer
    Overall Experience:

    Started using BIO X4 about 3 weeks ago. I’ve lost about 10 lbs so far. Using X4 with healthy smart eating choices and regular exercise seems to work. I want to give this product 3 months to see where I am and how I feel! So far great!

    Bottom Line: Yes, I would recommend this to a friend

  • BIO X4

    • By Hugh B.,
    • Miramar, FL,
    • Feb 15, 2020
    • Verified Reviewer
    Overall Experience:

    I recommend this product to anybody who’s interested in weight loss. I walk daily, I don’t go to the gym, I’m a 45-year-old man and I have lost 15 pounds in 18 days.

    I’m not hungry all the time anymore. My energy went up. I will do another review in a few months after I get in the gym and start eating better.

    Bottom Line: Yes, I would recommend this to a friend

  • What an awesome product.

    • By Michele G.,
    • Georgia,
    • Feb 15, 2020
    • Verified Reviewer
    Overall Experience:

    I started using this product about a month ago, my stomach and waistline reduced remarkably. I have adjusted the way I eat, however, I am not exercising, so I can just imagine what my results would be when I incorporate exercise with it. I am very happy, will be telling everyone.

    Bottom Line: Yes, I would recommend this to a friend

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Nucific BIO X4 Review: Effectiveness, Side Effects, Cost, and More