Synbiotic 365 Review: Benefits, Effectiveness, Side Effects, Cost

By Derek Lakin
HighYa Staff
Published on: Sep 18, 2018

United Naturals advertises Synbiotic 365 as an advanced formula consisting of beneficial probiotic strains and prebiotic ingredients, that when combined, can deliver lasting relief from bloat and other embarrassing digestive issues.

Based on the available clinical evidence, can you realistically expect to experience benefits like these? Furthermore, is there supporting data that taking a combination product like Synbiotic 365 will deliver better results than a standalone probiotic supplement?

In this brief article, we’ll discuss the formula’s ingredients, pricing, and competition, all aimed at helping you make an informed decision. Before diving in, though, let’s clarify what we’re talking about.

What Is a Synbiotic Supplement?

Probiotics are specific bacteria strains that, when taken regularly as a dietary supplement, have been clinically shown to provide a wide variety of digestion-related benefits, in addition to boosting immune function.

Prebiotics, on the other hand, are certain ingredients that these bacteria use as an energy source upon arriving in your digestive tract.

» Related: Probiotics 101: A Beginner’s Guide

With these details in mind, ScienceDirect explains, whether referencing Synbiotic 365 or another formula, “Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms.”

Writing for Health.com, Anthea Levi tells us “the idea behind synbiotics is that adding prebiotics to a probiotic supplement can help ensure that the digestion-friendly microorganisms arrive in the gut alive and well. These supplements are said to be particularly useful for people with conditions like IBS, other bowel disorders, and diabetes.”

Cynthia Sass, RD, Health contributing nutrition editor, adds that when combined with probiotics, prebiotics can “also increase nutrient absorption and support bowel regularity.”

Taking a Closer Look at Synbiotic 365’s Ingredients

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 2.4 mg
  • Vitamin B2 2.6 mg
  • Vitamin B3 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 60 mcg
  • Vitamin B5 10 mg
  • Probiotic Blend 30 billion CFU – Lactobacillus acidophilus La-14, Bifidobacterium lactis Bl-04, Lactobacillus paracasei Lpc-37, Lactobacillus plantarum LP-115, Streptococcus thermophilus ST-21, Lactobacillus casei LC-11, Lactobacillus reuteri, Lactobacillus salivarius LS-33, Lactobacillus rhamnosus LR-32, Bifidobacterium bifidum BB-06, Bifidobacterium longum BL-05, Saccharomyces boulardii
  • Chicory Root Inulin 300 mg

Sites like WebMD, the Natural Medicines Database, and Examine.com report that the first eight vitamins in this formula are essential for maintaining human health. For example, B1 (thiamine) is essential in the breakdown of carbohydrates, B2 also helps digest carbs, as well as proteins and fats, while Healthline tells us that every part of your body needs B3 (niacin) to function correctly.

However, they also report that unless someone’s deficient in these vitamins, supplementing them likely won’t deliver meaningful health benefits.

» Related: Do You Need to Take Vitamins or Dietary Supplements?

Probiotic bacteria are identified by their genus (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

Lactobacillus acidophilus (whether contained in Synbiotic 365 or another supplement) was the first probiotic strain widely used, which seems to work especially well for irritable bowel syndrome (IBS) symptoms and urinary tract infections in children.

Among others, paracasei may relieve allergic symptoms and decrease skin sensitivity, plantarum produces its own antibiotics, casei may improve allergy symptoms and reduce cholesterol (along with reuteri), and rhamnosus has even been shown to help obese women lose weight.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be effective for constipation and airway infections, in addition to IBS and ulcerative colitis.

Finally, Streptococcus thermophilus could decrease the chances of kidney stones and increase anti-tumor activity, while Saccharomyces boulardii seems to be especially useful for addressing different causes of diarrhea.

Potential Synbiotic 365 Side Effects

As genera (the plural of genus), WebMD, Examine.com, and the Natural Medicines Database report that Lactobacillus and Bifidobacteria are likely safe for adults and children when taken as directed. Common side effects, if any, for the genera include mild, temporary intestinal gas or bloating, as well as stomach or intestinal upset.

» Related: Common Probiotic Supplement Side Effects

Outside of this, WebMD indicates Saccharomyces boulardii could rarely “cause fungal infections that can spread through the bloodstream to the entire body (fungemia).” No dosages or other specifics listed.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering. In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

We didn’t encounter anything with the same (or very similar) formulation as Synbiotic 365 during our research.

However, we did come across dozens of competing synbiotic supplements like Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), and Renew Life Women's Daily Probiotics plus Prebiotics ($28, 60 capsules).

From a high-level perspective, these supplements are alike in that they’re priced competitively with one another, and that each combines a relatively similar blend of probiotics, prebiotics, and other vitamins and minerals.

These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins like C and many within the B family, and even secondary ingredients like chicory root and different fruit extracts as energy sources.

Zooming in, the differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Is either of these criteria important when choosing a synbiotic supplement? Perhaps not. Here’s why:

First, while probiotics and prebiotics are certainly beneficial on their own, Cynthia Sass, RD, Health contributing nutrition editor, emphasizes: “Right now we don’t have a lot of data to show that synbiotics are more effective than, say, taking probiotics [supplements] and eating a diet rich in prebiotics.”

Next, even if they are eventually shown equally as useful, Cynthia emphasizes that "Your overall pattern of eating still has the greatest impact on your health protection or risk,” so “don’t think that taking [one of these supplements] means you don’t have to pay attention to your diet.”

Together, from a value perspective, she recommends that “until more comprehensive research is conducted on synbiotics, consider sticking to swallowing a probiotic supplement or eating probiotic-rich foods in addition to prebiotic foods.”

Our Bottom Line on Synbiotic 365

At $45 per box, Synbiotic 365 seems priced at the upper end of the spectrum compared to some other popular synbiotic supplements but has a middle-of-the-road price compared to probiotic supplements in general—some of which can near the $100 mark.

And as we outline in our Probiotic Supplement Buyer’s Guide, paying more for one of these supplements doesn’t typically translate into improved results, as reported by customers.

Other pointers we mention in the article include making sure the manufacturer provides a complete list of all the bacteria strains, as well as their dosage (as measured in colony-forming units, or CFU), both of which United Naturals lists for Synbiotic 365.

However, the company also adds a handful of vitamins that, according to sites like Examine.com and WebMD, might not provide much value for the money unless you’re deficient. Furthermore, we didn’t encounter any online customer feedback for Synbiotic 365 at the time of our research, and the company wasn’t listed with the Better Business Bureau.

Still, they advertise that all purchases come with a 30-day refund policy if the supplement doesn’t meet your needs, less S&H charges. Just make sure that you talk with your doctor first about overall value based on your diagnosis before ordering, as well as potential side effects or medication interactions.

» Recommended Reading: Best Grains, Fruits, and Vegetables That Improve Digestion

Sign Up for HighYa Newsletter

Sign up for HighYa newsletter and get our best content delivered in your inbox as well as 3 free eBooks to help you save money and shop smarter. Enter your email below to get started!


Read 856 Synbiotic 365 Customer Reviews and Complaints

Write a Review
Average Consumer Rating: 4.7
Rating Snapshot:
5 star: 677 4 star: 132 3 star: 16 2 star: 12 1 star:  19
Bottom Line: 96% would recommend it to a friend
Showing 1-11 of 856
Sort reviews by:

  • Editor’s Note: It is our understanding that this company has been asking its customers to leave feedback on HighYa. We assure you that each of these reviews has still been subjected to the same verification & vetting process that all submitted reviews go through. Learn More Here
  • 111 out 118 people found this review helpful

    Best ever!

    • Corinth, NY,
    • Nov 1, 2018
    • Verified Reviewer

    I’m on opiates for back pain and have a very difficult time with my bowel movements, sometimes not going for days! I took a chance and ordered this product. After just a few days I started having bowel movements. They became more and more frequent, and now I’m beginning to go two or three times a day. I also noticed my stomach wasn’t bloated or sick as I would every day feel sick. I also noticed that I get up in the morning wide awake and cannot take any more small naps during the day. This is too hard to believe, but it’s true! All I can say is WOW! And I am very grateful for this product. It definitely is not s rip-off! I’m totally on board with this and suggest you do too.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

  • 68 out 71 people found this review helpful

    Tremendous improvement

    • Sarasota, FL,
    • Nov 26, 2018
    • Verified Reviewer

    I have been taking SYN 365 for three months now and see a huge difference in how I feel. I have always been very healthy but want to continue to improve. I have found that I am no longer hungry all the time despite eating less now than I did before taking SYN 365. I find myself satisfied with less and better food choices and having more energy. I walk 3 miles a day or more and sleep soundly. No stomach issues with taking the supplement.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

  • 54 out 63 people found this review helpful

    Very positive so far

    • Hazlet, NJ,
    • Dec 12, 2018
    • Verified Reviewer

    I only received Synbiotic 365 five days ago and I immediately took my first one that morning. So four days later I feel an increase in energy. But most important I don't feel bloated at all and am making regular bowel movements, although it's only five days. I will update my review.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

  • 44 out 52 people found this review helpful

    Excellent product

    • Olympia, WA,
    • Jan 6, 2019
    • Verified Reviewer

    I have used this for two weeks now and have found I am having more frequent bowel movements and greatly reduced bloating. I have Barrett's Disease of the esophagus and have to take an Acid Reducer prescription twice daily. I have reduced now down to once a day. My energy level has been refreshed as well.

    I highly recommend trying this product. You must drink your water as recommended. Good luck.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

  • 33 out 35 people found this review helpful

    Stomach cramps

    • Archdale, NC,
    • Jan 14, 2019
    • Verified Reviewer

    My name is Cerrone Postell. I have been taking Symbiotic 265 for three months now. Before first taking Symbiotic, after every single meal, my stomach would cramp, and I would have to run straight to the bathroom. Now after three months, when I eat, there is virtually no pain after, and movements have become more regular. My stomach feels so much better. I just want to say thank you to Dr. Pedre, and his team, for creating this miracle supplement. It truly works. Thanks!

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

  • 33 out 34 people found this review helpful

    After 1 week: de-inflammation, sleep and mood improvement

    • Left Coast,
    • Jan 19, 2019
    • Verified Reviewer

    I am happy to report near elimination of back and joint pain at night that was previously interfering with sleep (for years). Also fewer night time bathroom pee trips. Along with less pain, this means better sleep, better mood, more energy, a better gauge on appetite, fewer bad cravings and more healthy ones. Bloating and gut discomfort persist, but previous overall malaise, which I’d linked to perimenopause, is gone. I will update later.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

  • 32 out 34 people found this review helpful

    Cured my low stomach acid condition

    • Mesquite, NV,
    • Feb 2, 2019
    • Verified Reviewer

    In 2014 I was diagnosed with a form of reflux called Laryngopharyngeal Reflux (LPR) and was put on a Proton Pump Inhibitor (PPI). The PPI made the condition worse, so I researched the condition and determined that the primary cause was low stomach acid. Insufficient acid translates to incomplete digestion and non-acidic gasses creeping up into the upper respiratory area. I had severe bouts of hoarseness, asthma and had a large polyp in my nose from the irritation. I fixed the problem by supplementing with Hydrochloric Acid with Pepsin (HCL). I started taking Synbiotic 365 a month ago and have been able to completely discontinue the HCL and have had no further incidences of LPR symptoms. I strongly suspect that Synbiotic 365 had a material effect on allowing my body to produce its own acid.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    • Feb 22, 2019

      Company Response from United Naturals

      Dennis, I am glad you are seeing such great results. We love hearing positive feedback!


  • 22 out 22 people found this review helpful

    Great product

    • New Jersey,
    • Feb 5, 2019
    • Verified Reviewer

    This product has worked for me. I needed something that would keep me regular. At first, I doubted that it would, but it works. I no longer have to take psyllium every day. I’m on my last box and I’m reordering today so that I won’t run out.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no
    • Feb 22, 2019

      Company Response from United Naturals

      Samairah, I am glad to hear about your success! Remember, consistency is key. Keep it up!


  • 9 out 9 people found this review helpful

    Worked for me

    • Dallas, TX,
    • Feb 22, 2019
    • Verified Reviewer

    My acid reflux had gotten so bad that I bought a bed so I could sleep tilted. It took three weeks, but this product worked for me. No problem getting the order or reordering. I have recommended it to others.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

  • 11 out 12 people found this review helpful

    Impressive from the start

    • Los Angeles, CA,
    • Feb 22, 2019
    • Verified Reviewer

    I received my order of Synbiotic 365 a month ago, after having heard good things from a friend who is also using it. I've been using a probiotic for the last few years after hearing all it could be of help with, but had noticed minimal to no positive effect. After the first day I took Synbiotic 365, I told my wife, "either today was just a particularly good day, or this stuff really works!" 30 days later, they have all been good days. I can vouch for the effects and benefits of Synbiotic 365 compared to my previous probiotic. My gut is more settled and reacts better to the foods I eat, I am more clear-headed and energetic, more regular in my trips to the bathroom, and have even lost a few pounds with no other changes to my diet or exercise. The combo in this Synbiotic made a huge difference in comparison to what I'd tried in a probiotic previously, and I cannot recommend it highly enough.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

  • 7 out 7 people found this review helpful

    Synbiotic 365

    • Palm Bay, FL,
    • Mar 2, 2019
    • Verified Reviewer

    I have taken this for 30 days and feel more energy and my gut is calmer and more regular. I just reordered for this month. Thank you United Naturals. I was diagnosed with Crohn's in 2006.

    Bottom Line: Yes, I would recommend this to a friend

    Help others find the most helpful reviews

    Was this review helpful?

    yes no

Showing 1-11 of 856

Write a Review for Synbiotic 365!

Share your experience to help others shop smarter & discover great products.

Write a Review