Theraworx Relief Review - Does It Work and Is It Safe?

By Anthony Dugarte, M.D., C.S.C.S
Updated on: Jan 6, 2020

Theraworx Relief promises to prevent cramps with their non-prescription, fast-absorbing foam.

Leg cramps are involuntary and painful muscle contractions, most commonly occurring at night. Occuring in 50-60% of adults, they typically target your calf muscles, though anywhere from the thigh to foot can be affected.

The exact mechanism is unknown, but many variables are thought to be at play. Most cases are idiopathic - simply arising spontaneously without warning. Other causes may be related to nerve dysfunction, intense exercise, lack of exercise, pregnancy, electrolyte imbalance, vascular disease, and medications.

The possible sources of cramping are numerous, thus this condition affects a wide array of populations; from high level athletes to the elderly. Treatment options are also many, though finding relief can be challenging when the cause is unknown.

In this article, we review the scientific support for the safety and efficacy of this product.

How to Use Theraworx

In 3 easy steps, Theraworx is said to offer relief within the first 2-weeks with twice daily use:

  1. Shake bottle and apply 2 pumps of foam to the muscles where you get cramps
  2. Rub the foam into the muscle until it is completely absorbed
  3. Repeat and let dry

Theraworx Active Ingredient: Does It Work?

Theraworx believes relief is possible through the action of their active ingredient: Magnesium Sulfate (Magnesia sulphurica) 6X 0.05% HPUS (Homeopathic Pharmacopoeia of the United States - this indicates that this product is FDA-recognized and follows the HPUS rules)

Magnesium is involved in countless reactions in your body. As deficiency is thought to be associated with muscle cramping, treatment with magnesium is available in various forms.

While support for leg cramp relief through orally administered magnesium is mixed, Theraworx offers a topical formula.

Theraworx is thought to address a potential and important limitation of oral magnesium supplementation - many previous studies administered oral magnesium to those not deficient, resulting in the kidney likely removing the excess. If the excess magnesium is removed before its concentration is increased in cramping leg muscles, it is rendered useless.

Theraworx was found to decrease the severity and frequency of nighttime leg cramps over the course of 4-weeks when compared to placebo. A possible mechanism for these findings is that topical magnesium may pass through muscle tissue before absorption and excretion by the kidneys.

As the primary function of the skin is to serve as a protective barrier, its capacity to absorb is limited, however. Getting through water-tight layers of your skin requires special formulations of supplements and medications.

The Israeli army found that magnesium was not absorbed through the skin when soldiers administered a magnesium containing protective lotion. These findings were corroborated a few years later; there were no differences in magnesium levels for those using a magnesium rich lotion or placebo lotion.

A study supporting the possibility of magnesium absorption through the skin found elevated levels in 16 of 19 subjects that bathed in magnesium solutions for 12 minutes daily over 1-week.

The Takeaway:

Scientific support for oral administration of magnesium for leg cramps is mixed, though likely most promising in pregnant women. Shortcoming of this method of administration are thought to result from excess magnesium being removed by the kidneys before it can act on muscle.

Theraworx claims to get around this issue by applying topical magnesium for absorption directly into the muscle. Relief for your cramps with this method proved promising when compared to placebo. Evidence supporting the skin’s ability to absorb magnesium is just as mixed as that for oral formulations, however.

Though topical magnesium may be a more effective way to relieve muscle cramps, most studies, including the Therwarox trial, state that much more work is needed to fully characterize the role for this method of delivery.

With such limited support and difficulty identifying concentrations of magnesium used in older studies to compare to the contents of Theroworx, it is challenging to support claims that this product is effective in treating leg cramps.

Safety

The Theraworx trial claims that there are no known side effects, though their site states mild skin reactions are possible. This is likely because topical formulations bypass your gastrointestinal tract.

Three times daily application of 10ml magnesium-rich lotion was not associated with serious side effects, nor were toxic levels of magnesium found in either the treatment or placebo groups.

Similarly, there are no known medications that would interact dangerously with this topical application, though effectiveness may be reduced if used in conjunction with other creams as they can serve as a barrier.

The Takeaway:

Topical magnesium acts at the site of your symptoms and is unlikely to have whole-body effects or dangerous interactions as it is not ingested. It’s still a good idea to discuss use with a doctor first.

The Cost & Where To Buy

You can order Thereworx Relief directly from their site and expect to receive your order in 3-6 business days. Your 7.1oz bottle is $20.49 + shipping and handling. Theraworx is also available for purchase via phone or through Amazon. They do not offer automated shipping services.

Though this product may be obtained in-person elsewhere; Target, Walmart, CVS, and Walgreens. Keep in mind that their 30-day money-back guarantee is only supported through the website, phone, or Amazon purchases.

Are There Any Alternatives?

There are other magnesium sulfate-based topical ointments on the market. Kirkman offers similar products, though you get about half the amount for the same price when compared to Theraworx.

Cryoderm offers a cream that is said to calm muscles and nerves though magnesium harvested from the Dead Sea. This product differs in that magnesium chloride is the active ingredient, and that it costs more than double for a similar amount when compared to Theraworx.

Lastly, there are a number of oral magnesium supplements offered by various retailers. Available in tablet and capsule form, these products are also said to provide relief for muscle cramps.

Keep in mind that while topical creams and foams act locally, and are therefore much less likely to affect you systemically, the effects of ingestible supplements may not be contained to the cramping muscles.

Seek medical opinion before use of these products.

What Are Users Saying?

Here on HighYa, 38 users rated the product at 4.1 out of 5 stars. Users seem to be generally satisfied with Theraworx.

Happy customers report fast and effective relief with Theraworx.

One negative reviewer describes his cramps returning after discontinuing the use of Theraworx. Another describes effectiveness at other painful sites, though it does not seem to work on the pain associated with his total knee replacement.

The Bottom Line: Is Theraworx Worth It?

Both oral and topical magnesium supplements have mixed support regarding efficacy. While topical magnesium was most effective in reducing the severity and frequency of leg cramps in pregnant women, report in other populations is lacking.

Topical magnesium works at the site of application and is not associated with whole-body effects or drug interactions that may be possible with oral magnesium.

Despite mixed research results regarding effectiveness, Theraworx may be a reasonable option for those that battle leg cramps because of its favorable safety profile. The upside would be pain relief and avoiding medical treatment.

The downside would be continued pain and the need to find relief elsewhere. Speaking with your doctor before use is still your best bet.


Customer Reviews

Start your review of Theraworx Relief:
  • 39 Customer Reviews
  • 85% Recommend This Company
4.1 out of 5
5 star: 64% 4 star: 12% 3 star: 5% 2 star: 5% 1 star: 12%

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  • Cramp relief while taking oral magnesium supplements

    • By Brian H.,
    • Blaine, WA,
    • Jul 3, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    Took magnesium oxide for over one year with excellent results (no cramps period), changed to magnesium glycinate because it was more absorbable. Also no leg cramps for months but started golfing and the weather got hotter. Then started to have a dull pain in the lower right calf. First thought it was circulation problems but the pain subsided with ankle exercise which lead me to think "dull cramp pain". I had purchased Theraworx a year before but never used. After being woken up with dull calf cramps pain, decided to try Theraworx. Applied as directed and the pain disappeared in 30 minutes. No more dull pain for 3 days but did return during the afternoon of the fourth day. Reapplied, resulting in pain disappearing in 20 minutes. Decided to look up Theraworx review resulting in this testimony.

    Pros and Cons:

    • No “pros” were specified in this review
    • Never heard of them

    Bottom Line: Yes, I would recommend this to a friend


  • Side effects

    • By James S.,
    • Barker, NY,
    • Nov 19, 2019
    • Verified Reviewer
    Overall Experience:

    After using the product for several weeks, it seems to be addictive. What I mean is that if you try to quit, the cramps return and are much worse. Also, the cramps sometimes come back but in a different place in the muscle like where they are attached. Might have to consult my doctor.

    Bottom Line: No, I would not recommend this to a friend


  • Worked!

    • By Anita M.,
    • Newburgh, NY,
    • Nov 12, 2019
    • Verified Reviewer
    Overall Experience:

    Started with excruciating leg cramps all of the sudden. Woke me up at night. Had to get out of bed and stand up and stretch. Interrupted my sleep a few times a night. I was in agony! The doctor told me to drink more water, take calcium and magnesium which I was already taking, stretch, etc. A friend told me about the ad on TV for Theraworx. I found it at Walmart and used it right away. Didn't help right away, took about a week of rubbing it on and finally, a decent night's sleep. Let's hope it keeps up!

    Bottom Line: Yes, I would recommend this to a friend


  • Doesn’t work with artificial replacements.

    • By Roger J.,
    • Chattanooga, TN,
    • Oct 28, 2019
    • Verified Reviewer
    Overall Experience:

    Excruciating pain using on my artificial knee. Works great with my regular knee. Perhaps doesn’t work with artificial joints. Would not recommend using on areas of artificial appliances.

    Bottom Line: Yes, I would recommend this to a friend


  • Wife apparently allergic to Aloe Vera oil

    • By Alec S.,
    • Alberta, Canada,
    • Sep 30, 2019
    • Verified Reviewer
    Overall Experience:

    Your product sounds great and I think would benefit most people but it appears that my wife is allergic to Aloe Vera oil. She experiences severe pain anyplace that the product touches on her skin. Sorry, we will be unable to use this product further.

    Bottom Line: Yes, I would recommend this to a friend


  • Surprising results

    • By Mickey C.,
    • Saginaw, TX,
    • Sep 30, 2019
    • Verified Reviewer
    Overall Experience:

    I do not really suffer from leg cramps on a large scale, I do, however, suffer greatly from muscle pain in my right leg. I've tried Icy Hot, Bio Freeze, Blue Emu, and Topricin to name a few topicals. I also paid big money for CBD Oil, both topical and under the tongue. No help from any of them. My wife does have leg cramps and did try Theraworkx with some success. On a whim, I tried her foam and the stuff worked much to my surprise and joy. It knocked down the pain to almost zero during sleep time, and to bearable during daily activity.

    The packaging is lousy and tends to leak, especially the liquid, the Foam is a much better delivery system.

    Bottom Line: Yes, I would recommend this to a friend


  • Sciatic pain and cramps greatly helped.

    • By Kenneth H.,
    • Las Vegas, NV,
    • Sep 9, 2019
    • Verified Reviewer
    Overall Experience:

    Pain meds for sciatic pain in lower back, hips and leg were unable to stop the cramps that drove the onset of severe pain. Theraworx works. Literally applied it works. Use the spray liquid that both my wife and I find a wonderful relief for cramps. We heard about it from a our friends who were also helped. Small back and deep hip pain may require liberal applications several times. Hope the spray remains available. Wish there was a price break or coupon. It works and that is the bottom line.

    Bottom Line: Yes, I would recommend this to a friend


  • Theraworx Relief

    • By Barbara V.,
    • Cherry Hill, NJ,
    • Jul 18, 2019
    • Verified Reviewer
    Overall Experience:

    Theraworx Relief is the best product out there that I have found that actually works for leg cramps. It starts working immediately when applied to the skin area of a severe muscle cramp. I've never used a product that worked so fast and so efficiently. I started out using Theraworx Relief to stop the pain of active leg cramps and I have recently started using it at bedtime to prevent being wakened by painful leg and foot cramps overnight. This is an excellent product. I can't say enough good about it.

    Bottom Line: Yes, I would recommend this to a friend


  • Okay but not the best

    • By Alex W.,
    • Boston, MA,
    • Jul 10, 2019
    • Verified Reviewer
    Overall Experience:

    I am prone to really painful foot cramps that can keep me up at night. I tried Theraworx and while it did eventually help, I had to repeat the spraying several times over about 15 minutes period because as soon as the cramps started to pass they then came back. Admittedly, several sprays a number of times did finally seem to do the job. However, I had been using the leg cramp pills at the drug store and they took just about just as long to work and were a lot cheaper. Maybe it works better for leg cramps though, but I don't experience those.

    Bottom Line: Yes, I would recommend this to a friend


  • Thank you Theraworx!

    • By Penny N.,
    • Chatham, Ontario, Canada,
    • Jun 22, 2019
    • Verified Reviewer
    Overall Experience:

    I have suffered from leg and foot cramps for years. Have a very good diet, have taken vitamin supplements and drink plenty of water - yet get the extreme cramps in my shins, feet, and calves. I have had blood tests, etc. ordered by doctor, yet no answers. My husband asked a pharmacist in Southfield, Michigan and he suggested THERAWORX! Thank you - instant relief - "amazing" product! Love THERAWORX! I have three bottles of spray and he just picked me up the foam which I have not used yet. Sort of anticipating a cramp just so I can try the foam. Again, THANK YOU! We cannot purchase Theraworx in Canada, yet - hence the purchase in Michigan, USA.

    Bottom Line: Yes, I would recommend this to a friend


  • Didn’t work for me at all.

    • By Lisa M.,
    • Philadelphia, PA,
    • Jun 6, 2019
    • Verified Reviewer
    Overall Experience:

    I have had leg cramps at night since age 6. I was praying this stuff would work. It was difficult to dispense and simply did not prevent or stop cramps! Also, it was very expensive. Can't recommend this at all.

    Bottom Line: No, I would not recommend this to a friend


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