Active-PK Reviews - Does It Really Work?

By HighYa Research Team
Updated on: Jun 11, 2019

Active-PK from LCR Health is a supplement that claims it can boost AMPK levels inside your body, resulting in reduced fatigue, a slimmer waistline, fewer cravings, and clearer thinking.

All of this is claimed to be done without the use of caffeine, dairy, synthetic additives, or animal byproducts.

To achieve the purported benefits of this supplement, LCR Health says to take two capsules of Active-PK daily with a glass of water, either with food or on an empty stomach.

Can you realistically expect to experience these benefits and are there other supplements claiming to deliver the same?

To help you gain a better understanding, in this Active-PK review we draw on the knowledge of professional opinion and discuss how the supplement works, its ingredients, efficacy, side effects and whether this is right for you.

How Does Active-PK Work?

To understand how Active-PK works, it's important to get familiar with what AMPK is. 5'-AMP-activated protein kinase (AMPK) is an enzyme found in all mammalian cells that “activates” during physical activity. In humans, AMPK activates in skeletal muscle, although in other mammals, such as mice, it also generates in other organs.

Once activated, a 2010 study reports that AMPK “stimulates energy generating processes such as glucose uptake and fatty acid oxidation and decreases energy consuming processes such as protein and lipid synthesis.”

The study’s authors are Dr. Erik Richter, professor of Human Physiology and Exercise Physiology at the University of Copenhagen, along with Dr. Neil Ruderman, director of the Diabetic Cardiovascular Disease Program Project at Boston Medical Center,

Richter and Ruderman state in the study that AMPK initiates the entry of glucose into cells and helps break down fatty acids inside tissues, both of which produce usable energy for the body.

The enzyme also inhibits cells from using energy for other tasks, such as creating proteins and lipids, thereby making more power available for immediate use by the body.

As a result, Dr. Barry Sears told us, “AMP kinase is an energy sensor that can be considered the enzyme of life, as it regulates every aspect of your metabolism leading to greater health and lifespan.”

Taken together, this is why LCR Health refers to AMPK as your body’s metabolic “master switch,” since it “tells your body to stop storing fat and start converting it into clean, usable fuel,” they say.

Active-PK Ingredients and its Efficacy

Per the supplement facts label listed on the LCR Health website, Active-PK contains the following ingredients:

  • Gynostemma Pentaphyllum Leaf Extract 450 mg
  • Quercetin Dihydrate 100 mg
  • Berberine HCl 100 mg

Sites like WebMD, Natural Medicines Database and report that taking between 500 mg and 1.5 grams of berberine per day could help ease conditions related to canker sores, high cholesterol, high blood pressure, and polycystic ovary syndrome (PCOS). Active-PK’s 100 mg dose is much lower.

Furthermore, taking 30 mg of Gynostemma pentaphyllum (also commonly known as jiaogulan) daily has been shown to help decrease total cholesterol and increase good HDL in individuals with high cholesterol levels.

Outside of these, however, these sites indicate there’s insufficient clinical evidence showing that quercetin can reliably deliver health benefits in humans.

Also, the sites didn’t indicate that any of these ingredients can deliver on LCR Health’s claims of boosting AMPK levels, trimming abdominal fat, increasing endurance, raising metabolism, supporting energy levels, or optimizing brain function.

We contacted Dr. Erik A. Richter for a professional opinion. Richter is one of the two men who wrote the study we mentioned earlier.

“In my professional opinion,” Richter said, “It’s not possible for over-the-counter ingredients to meaningfully boost AMPK levels and result in benefits such as increased energy, better brain function, and weight loss.”

However, he emphasized, “there are multiple pharma companies working on AMPK activators, so it is not an impossible future possibility.”

Potential Side Effects

The LCR Health website points out that because Active-PK contains all-natural ingredients, it’s safe to use and causes no known side effects. However, it’s important to emphasize that just because something is natural, this doesn’t automatically mean it’s completely safe.

For example, WebMD, Natural Medicines Database, and report that berberine is unsafe to take if you’re pregnant, nursing, have diabetes, or are experiencing low blood pressure.

Furthermore, it can cause a major interaction with Cyclosporine and minor interactions with medications changed by the liver.

While up to 500 mg of quercetin has been used in studies that lasted up to 12 weeks, it’s unknown if it’s safe for longer-term use. It can also cause moderate interactions with Cyclosporin, antibiotics, and medications changed by the liver.

Finally, while Gynostemma may be safe to take for up to fours months, these sites indicate it can cause side effects like severe nausea and increased bowel movements (no specific circumstances noted).

It’s also possibly unsafe for those who are pregnant or breastfeeding, as well as those with autoimmune diseases, bleeding disorders, diabetes, or who are scheduled to undergo surgery within two weeks (since it may slow blood clotting).

Together, the LCR Health website recommends speaking with your physician before purchasing Active-PK, which is certainly something we’d advise as well.

How Much Does Active-PK Cost?

Active-PK is only available for purchase on the LCR Health website, priced as follows:

  • 1 Bottle: $69
  • 3 Bottles: $186.30 ($62.10 per bottle)
  • 6 Bottles: $330.15 ($55.03 per bottle)

All orders come with LCR Health’s 90-day Ironclad Guarantee, less shipping, which you can request by calling 800-384-8308 or sending an email to

Active-PK vs. Competing AMPK Dietary Supplements

We found dozens of standalone jiaogulan, quercetin, and berberine dietary supplements during our research, many of which were priced well below $20 per bottle.

However, we encountered only a handful of top-rated options on Amazon that specifically advertised AMPK activation in their names. Here’s how their prices and ingredients compared to Active-PK:

Brand Price Ingredients
Active-PK by LCR Health $69 Gynostemma 450 mg, Quercetin 100 mg, Berberine 100 mg
Life Extension AMPK Metabolic Activator $21.97 Calcium 130 mg, Hesperidin 500 mg, ActivAMP Gynostemma 450 mg
LUZ AMPK Activator $35.97 Gynostemma 150 mg, Berberine 900 mg, Alpha-Lipoic Acid 300 mg, Resveratrol 150 mg
Takenutritionx AMPK Activator $36.99 Gynostemma 450 mg,
Quercetin 100mg,
Berberine 100mg
Botanic Choice AMPK Formula $50 ActivAMP Gynostemma 150 mg, Berberine 17 mg, Rosehip 400 mg
Horbaach AMPK Metabolic Activator $16.87 ActivAMP Gynostemma 450 mg

Price-wise, we can see that Horbaach’s AMPK Metabolic Activator is the lowest cost option among popular competitors above, by a decent margin. It only contains 450 mg of Gynostemma, although as we discussed above, there’s insufficient reported clinical evidence that it can help humans lose weight, increase energy, or improve brain function.

Life Extension also contains the same level of Gynostemma as Active-PK, but at a much lower price. It doesn’t contain quercetin, but again, there’s insufficient clinical support that it can activate AMPK in humans.

From an ingredients perspective, Takenutritionx’s AMPK Activator features the same formulation and dosages as Active-PK, but at a meaningfully lower price. In fact, consumers can purchase two bottles of Takenutritionx for only a couple of dollars more than a single bottle of Active-PK.

Based on this, we can see that Active-PK isn’t necessarily the “revolutionary formula” advertised by LCR Health.

Bottom Line: Is Active-PK Worth It?

At the time of publishing, dozens of HighYa readers have given Active-PK an average rating of 3.6 stars, many of which reported excellent customer support, as well as benefits like reduced weight and inches around their waist, improved sleep, decreased cravings, and boosted energy. LCR Health had similar Better Business Bureau feedback at the time of our research.

So, if you’re looking to purchase your next dietary supplement from a reputable company, LCR Health appears to be safe to order from should you have concerns with your order in the future.

It’s important to balance the positives by pointing out that many HighYa readers reported no results with Active-PK, although a company representative responded in most of these instances to address the customers' concerns.

Furthermore, websites like WebMD and the Natural Medicines Database, along with medical professionals like Erik Richter, report insufficient clinical evidence supporting LCR Health’s claims related to AMPK activation, weight loss, or boosted energy or improved brain function for Active-PK’s ingredients.

Finally, Active-PK comes with a much higher price than popular competitors on Amazon. And based on our experience writing about hundreds of dietary supplements over the years, customers typically don’t report meaningfully better results after paying more for one.

Taken together, if you’re looking to explore potential AMPK activation, we think it’s difficult to justify paying a much higher price for Active-PK.

» Keep Reading: A Beginner’s Guide to Losing Weight and Getting in Shape

Read 137 Active-PK Customer Reviews and Complaints

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Average Consumer Rating: 3.9
Rating Snapshot:
5 star: 58 4 star: 47 3 star: 8 2 star: 3 1 star:  21
Bottom Line: 79% would recommend it to a friend
Showing 1-11 of 137
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  • 27 out 30 people found this review helpful

    Brain fog going, going, GONE!

    I have been taking Active-PK for almost a month now and my horrible "brain fog" is almost completely gone! I was so "foggy" that almost EVERY time I would walk into a different room, either at work or at home, I would forget what I was going after. My mind is SO MUCH clearer. I am thinking clearer and getting more done.

    This is what I currently notice, but as other bodily functions get better, I will let you all know.

    Bottom Line: Yes, I would recommend this to a friend

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  • 52 out 54 people found this review helpful

    Fantastic drop in A1C level in first 90 days

    My husband and I started taking Active-PK 90 days ago. He has seen a significant weight loss, but he was also making serious changes to his food intake. He is 66 and has seemed to have turned into the Energizer Bunny!

    Myself, one the other hand, have not seen the weight loss or incredible increase in my energy. However, I started taking the product hoping it would help me with my diabetes. I have been experiencing increasing A1C levels. I am 59 years old and had managed to get my A1C down to a "normal" reading of 6.0 just two years ago.

    I truly could not improve my diet anymore. I have spent endless hours studying glycemic loads of foods, tracked all my eating while recording glucose levels, cutting out foods that severely spiked my blood sugar, and given up all alcohol except an occasional glass (never more than two) of wine.

    All my doctor could say was that I was getting older. No way I was going to accept that answer. Then I watched this advertising video and understood the potential of Active-PK in helping my body improve the use of the glucose. And...

    Just 90 days after starting this supplement, I had my first appointment with my doctor to have my quarterly A1C level review. During my prior visits I saw my A1C go from 6.5 to 7.6 with each higher A1C reading, the doctor increased my oral medication.

    The last visit my A1C was 7.6 and this one 6.9! Hooray! I have made no other changes in my diet since starting this product. It is summer, and I am very active, but still, no way that much of a drop came from the additional activity. I'm looking forward to what the next 90 days reading will be!

    I have NEVER written a review of a product in my life. Then again, I have never had one effect my life so positively.

    If my A1C continues to improve, which I can't imagine it won't, I will be a customer for life!

    Bottom Line: Yes, I would recommend this to a friend

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  • 22 out 23 people found this review helpful

    Progress not perfection

    Both in our sixties, my wife and I started Active-PK two weeks ago. Without noticing, we both experienced a gradual energy increase, especially the Mrs. who seemed to be in an endless slump, never wanting to go anywhere or do anything. Our grandsons, 19 and 21, visited and she prepared meals every day while we also showed them around the Upstate. I was totally amazed. We also started eating healthier as our energy levels gradually increased with no jittery or uneasy side effects whatsoever. The wife has renewed past interests including doing more around the house and playing outdoor games. I enjoy the gym three times weekly.

    For us, embracing the fact that progress, not perfection, is do-able. A shared desire for fresh fruits and vegetables along with a more active life style kicked in and seems to be a natural course of action.

    Bottom line, give Active-PK a try. It's a win-win, especially with their 90-day money back guarantee. Will update our progress in the next couple of weeks. Thanks Cowboy.

    Bottom Line: Yes, I would recommend this to a friend

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  • 24 out 25 people found this review helpful

    This product WORKS.

    I never buy infomercial products, but the video made a lot of sense, so I ordered. I have been on ActivePK for 90 days. My sugar cravings are gone. I'm able to sustain a 1350/daily calorie diet. I am losing weight! I feel good, and my blood sugar seems more stable than I can remember for a long time. I don't feel emotionally overwhelmed by "dieting" or feel "deprived." I want to eat healthy foods rather than bingeing on sugar and carbs. I feel that this product has "smoothed out" the weight loss process for me. I will stay on it until I hit my goal weight. 38 pounds to go!

    Bottom Line: Yes, I would recommend this to a friend

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  • 17 out 19 people found this review helpful

    Great product

    I lost 7 lbs in three weeks. I did not change my eating habits, but I did drink seven glasses of water a day, sometimes eight glasses, and I still lost 7 lbs. Yes I would recommend this to a friend and I am about to order again.

    Bottom Line: Yes, I would recommend this to a friend

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  • 24 out 26 people found this review helpful

    Pretty amazing stuff

    • California,
    • Nov 23, 2017
    • Verified Reviewer

    I have been taking Active-PK for a month now. I started the first two weeks with 2 a day and wasn't seeing much result. I bumped it up to 4 a day (I'm a pretty big guy). My cognitive functions have increased drastically. I'm sharper and think much clearer. My energy level has increased, and my desire for junk food has decreased immensely.

    Although I haven't seen much weight loss, all the other effects are far worth it. You must keep in mind this product talks about attacking deep tissue fat, the fat that is unseen. In researching belly fat, I've found there are two different fats the deep tissue fat and a fat just below the skin surface. You can't see the deep tissue fat.

    But none the less, I will keep using for the other effects and if I lose some weight with it, great.

    Bottom Line: Yes, I would recommend this to a friend

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  • 10 out 10 people found this review helpful

    I feel lighter and less tiered

    I have been taking Active PK early in the morning, and I feel lighter and less bloating and have less craving for food. My knees and legs and arms were swollen before and no diet would work, until my husband introduced me to Active PK. I feel great and I have more energy.

    Bottom Line: Yes, I would recommend this to a friend

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  • 18 out 18 people found this review helpful

    My results of Active-PK.

    • Queensland, Australia,
    • May 10, 2018
    • Verified Reviewer

    I am 72 years old, and get short of breath. I am very healthy in every other way, chest x-rays and all other tests keep coming back normal.

    I walk twice a day, but hills get me a bit and I have to slow down.

    I took Active-PK (3 months supply) for about 3 weeks with no outstanding results then suddenly noticed my breathing was getting better and better. It had in fact improved by about 85%.

    So I was absolutely wrapped. I am ordering another months supply. Even though I love the product, ordering 3 months in one go is a bit expensive for me.

    All the best.

    Bottom Line: Yes, I would recommend this to a friend

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  • 14 out 15 people found this review helpful

    It works fast!

    • California,
    • Jul 19, 2018
    • Verified Reviewer

    I lost 15 lbs in just over three weeks. I know it's not advertised as a weight loss product, but deep fat has weight just like body fat. Being an Exercise Physiologist I'm always a little apprehensive of this type of product, but this one works.

    Bottom Line: Yes, I would recommend this to a friend

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  • 10 out 11 people found this review helpful

    Very good product!

    • New South Wales, Australia,
    • Jul 23, 2018
    • Verified Reviewer

    The product is very good, it helps bring my blood sugars down and helps with my liver pain and I am ready to purchase more. I love it very much. I am going to definitely purchase another bottle ASAP.

    Bottom Line: Yes, I would recommend this to a friend

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  • 9 out 11 people found this review helpful

    So many people need this

    • Nevada,
    • Jul 26, 2018
    • Verified Reviewer

    There are so many others that Active-PK can work wonders for. I now have complete confidence when sharing this product with others on my network. Letting them know that it has increased my energy output and that my weight loss is also increasing.

    Bottom Line: Yes, I would recommend this to a friend

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