Active-PK Review - Benefits, Ingredients, Efficacy, Side Effects

By Anthony Dugarte, M.D., C.S.C.S
Updated on: May 18, 2020

What Is Active-PK?

LCR Health claims that Active-PK will boost your 5'-AMP-activated protein kinase (AMPK) levels with just 3 active ingredients.

According to the company, by taking just 2 capsules daily, you’ll:

  • Reduce abdominal fat
  • Boost energy
  • Think more clearly
  • Minimize cravings
  • Support a strong, slimmer-feeling body

LCR Health says that these effects are possible without the use of caffeine, dairy, synthetic additives, or animal products.

In this article, we’ll help you gain a better understanding of the potential benefits of Active-PK by discussing the safety and efficacy of ingredients. But first, we’ll talk a bit more about AMPK and Active-PK’s proposed mechanism of action.

How Does Active-PK Work?

AMPK is an enzyme that is found in all mammalian cells. It is activated in an intensity-dependent manner during physical activity. This means that the more challenging the activity, the more active AMPK becomes.

AMPK serves to increase both glucose uptake and fatty acid oxidation, while limiting the synthesis of protein and fats. Essentially, AMPK plays a role in prioritizing energy-generating processes.

According to LCR Health, by boosting AMPK with Active-PK, you will begin to use fat as an energy source rather than storing it.

Active-PK Ingredients and Their Efficacy: Can They Help You Lose Weight?

The Active-PK ingredients thought to be responsible for the purported benefits:

  • Gynostemma Pentaphyllum Leaf Extract 450 mg
  • Quercetin Dihydrate 100 mg
  • Berberine HCl 100 mg

Obese subjects randomized to 450mg daily of gynostemma pentaphyyllum over 12-weeks experienced significant reductions in body weight, body fat mass, percent body fat, and BMI.

Diabetic patients that were randomized to treatment with gynostemma pentaphyllum at 6g daily over 12-weeks experienced significant decreases in fasting blood glucose levels, HbA(1C), and insulin resistance compared to controls.

In high-fat diet mice, supplementation with 0.8% quercetin produced short-term increases in energy expenditure; while present at 3-weeks, this was no longer evident after 8-weeks.

In 58 healthy subjects randomized to 1 g/day of quercetin or placebo, those receiving quercetin did not experience alterations in energy, fatigue, or sleep quality over 6-weeks.

Berberine reduced body fat and improved insulin sensitivity in obese, diabetic rats. These effects seemed to be related to berberine’s ability to activate AMPK in both fat and muscle cells. The AMPK-related effects of berberine were corroborated in another mouse study.

Regarding human studies, 30 randomized patients with heart disease, treatment with 300mg of berberine daily activated AMPK and reduced inflammation related to cholesterol.

In another trial, 24 subjects with metabolic syndrome were randomized; those that received 500mg of berberine three times daily over 3-months experienced remission, decreased waist circumference, and insulin secretion.

We contacted Dr. Erik A. Richter, professor of molecular physiology at the University of Copenhagen, for a professional opinion.

“In my professional opinion,” Richter said, “It’s not possible for over-the-counter ingredients to meaningfully boost AMPK levels and result in benefits such as increased energy, better brain function, and weight loss.”

However, he emphasized, “there are multiple pharma companies working on AMPK activators, so it is not an impossible future possibility.”

Side Effects

Active-PK offers a blend of natural ingredients, though this doesn’t necessarily guarantee safety.

While up to 5x the dose of quercetin found in Active-PK has been used safely over a 6-week span without serious adverse effects, it’s unknown if it’s safe for long-term use.

In a 12-week study, there were no episodes of hypoglycemia or adverse effects at gynostemma doses more than 5x the dose included in Active-PK.

In a 12-week study, 1500mg of berberine daily was not associated with serious adverse effects, though mild gastrointestinal symptoms are possible.

Though the risk for using Active-PK is low, and associated side effects are mild, it’s still a good idea to speak with your doctor before using any new supplements.

Cost and Return Policy

Active-PK is available directly from the LCR Health website. Current pricing is listed below:

  • 1 Bottle: $89.95
  • 3 Bottles: $242.85 ($80.95 per bottle)
  • 6 Bottles: $455.70 ($75.95 per bottle)

All orders are backed with LCR Health’s 90-day guarantee. To process your refund, call support at (800) 384-8308 or email them at

What Are the Alternatives to Active-PK?

This blend of ingredients is not unique to Active-PK. While formulations vary by pricing and dosing, as well as the included ingredients, there are a number of other supplements that offer similar blends.

AMPK Booster from SuperSmart offers more gynostemma and a comparable dose of berberine, though it lacks the quercetin content. Nonetheless, for a similar blend, you’ll pay just $42 for a 1-month supply.

AMPK-4 Activator contains more gynostemma, berberine, and quercetin when compared to Active-PK. Priced at just $35.99 for a 45-day supply, this is the most cost-effective option yet.

Pros and Cons

  • Early results for these ingredients are promising
  • Favorable return policy
  • More work is needed in human subjects to identify long-term safety and efficacy
  • 2 or 3x more expensive than other brands that offer larger doses

The Bottom Line: Is Active-PK Worth It?

Active-PK offers a blend of natural ingredients with some support for their ability to support fat loss, though much of the support is in animal and laboratory models. Oftentimes, benefits were found at doses higher than those offered in this supplement.

More randomized trials are needed to determine the long-term effects, if any, in human subjects.

With the lack of strong scientific support, it may be hard to justify the hefty price tag, especially with other more cost-effective products on the market.

Nonetheless, users seem to be generally pleased with Active-PK. More than 225 rated it 4.1 stars at HighYa. Those pleased report excellent customer service, as well as weight loss, improved sleep, fewer cravings, and more energy.

If you’re interested in using Active-PK or similar ingredients, be sure to discuss their safety with your doctor first.

Customer Reviews

Start your review of Active-PK:
  • 228 Customer Reviews
  • 85% Recommend This Product
4.1 out of 5
5 star: 52% 4 star: 31% 3 star: 3% 2 star: 1% 1 star: 10%

 Our Promise to You

To safeguard you and ensure helpfulness and relevance, our compliance team manually assess every customer review before it goes live.

We have a zero-tolerance policy for fake reviews, and companies cannot control or alter any reviews at any time.

Sort reviews by:

  • Brain fog going, going, GONE!

    Overall Experience:

    I have been taking Active-PK for almost a month now and my horrible "brain fog" is almost completely gone! I was so "foggy" that almost EVERY time I would walk into a different room, either at work or at home, I would forget what I was going after. My mind is SO MUCH clearer. I am thinking clearer and getting more done.

    This is what I currently notice, but as other bodily functions get better, I will let you all know.

    Bottom Line: Yes, I would recommend this to a friend

  • Fantastic drop in A1C level in first 90 days

    Overall Experience:

    My husband and I started taking Active-PK 90 days ago. He has seen a significant weight loss, but he was also making serious changes to his food intake. He is 66 and has seemed to have turned into the Energizer Bunny!

    Myself, one the other hand, have not seen the weight loss or incredible increase in my energy. However, I started taking the product hoping it would help me with my diabetes. I have been experiencing increasing A1C levels. I am 59 years old and had managed to get my A1C down to a "normal" reading of 6.0 just two years ago.

    I truly could not improve my diet anymore. I have spent endless hours studying glycemic loads of foods, tracked all my eating while recording glucose levels, cutting out foods that severely spiked my blood sugar, and given up all alcohol except an occasional glass (never more than two) of wine.

    All my doctor could say was that I was getting older. No way I was going to accept that answer. Then I watched this advertising video and understood the potential of Active-PK in helping my body improve the use of the glucose. And...

    Just 90 days after starting this supplement, I had my first appointment with my doctor to have my quarterly A1C level review. During my prior visits I saw my A1C go from 6.5 to 7.6 with each higher A1C reading, the doctor increased my oral medication.

    The last visit my A1C was 7.6 and this one 6.9! Hooray! I have made no other changes in my diet since starting this product. It is summer, and I am very active, but still, no way that much of a drop came from the additional activity. I'm looking forward to what the next 90 days reading will be!

    I have NEVER written a review of a product in my life. Then again, I have never had one effect my life so positively.

    If my A1C continues to improve, which I can't imagine it won't, I will be a customer for life!

    Bottom Line: Yes, I would recommend this to a friend

  • Progress not perfection

    Overall Experience:

    Both in our sixties, my wife and I started Active-PK two weeks ago. Without noticing, we both experienced a gradual energy increase, especially the Mrs. who seemed to be in an endless slump, never wanting to go anywhere or do anything. Our grandsons, 19 and 21, visited and she prepared meals every day while we also showed them around the Upstate. I was totally amazed. We also started eating healthier as our energy levels gradually increased with no jittery or uneasy side effects whatsoever. The wife has renewed past interests including doing more around the house and playing outdoor games. I enjoy the gym three times weekly.

    For us, embracing the fact that progress, not perfection, is do-able. A shared desire for fresh fruits and vegetables along with a more active life style kicked in and seems to be a natural course of action.

    Bottom line, give Active-PK a try. It's a win-win, especially with their 90-day money back guarantee. Will update our progress in the next couple of weeks. Thanks Cowboy.

    Bottom Line: Yes, I would recommend this to a friend

  • This product WORKS.

    Overall Experience:

    I never buy infomercial products, but the video made a lot of sense, so I ordered. I have been on ActivePK for 90 days. My sugar cravings are gone. I'm able to sustain a 1350/daily calorie diet. I am losing weight! I feel good, and my blood sugar seems more stable than I can remember for a long time. I don't feel emotionally overwhelmed by "dieting" or feel "deprived." I want to eat healthy foods rather than bingeing on sugar and carbs. I feel that this product has "smoothed out" the weight loss process for me. I will stay on it until I hit my goal weight. 38 pounds to go!

    Bottom Line: Yes, I would recommend this to a friend

  • Great product

    Overall Experience:

    I lost 7 lbs in three weeks. I did not change my eating habits, but I did drink seven glasses of water a day, sometimes eight glasses, and I still lost 7 lbs. Yes I would recommend this to a friend and I am about to order again.

    Bottom Line: Yes, I would recommend this to a friend

  • Pretty amazing stuff

    • By Bryan Arnold,
    • California,
    • Nov 23, 2017
    • Verified Reviewer
    Overall Experience:

    I have been taking Active-PK for a month now. I started the first two weeks with 2 a day and wasn't seeing much result. I bumped it up to 4 a day (I'm a pretty big guy). My cognitive functions have increased drastically. I'm sharper and think much clearer. My energy level has increased, and my desire for junk food has decreased immensely.

    Although I haven't seen much weight loss, all the other effects are far worth it. You must keep in mind this product talks about attacking deep tissue fat, the fat that is unseen. In researching belly fat, I've found there are two different fats the deep tissue fat and a fat just below the skin surface. You can't see the deep tissue fat.

    But none the less, I will keep using for the other effects and if I lose some weight with it, great.

    Bottom Line: Yes, I would recommend this to a friend

  • I feel lighter and less tiered

    Overall Experience:

    I have been taking Active PK early in the morning, and I feel lighter and less bloating and have less craving for food. My knees and legs and arms were swollen before and no diet would work, until my husband introduced me to Active PK. I feel great and I have more energy.

    Bottom Line: Yes, I would recommend this to a friend

  • My results of Active-PK.

    • By Hilda P.,
    • Queensland, Australia,
    • May 10, 2018
    • Verified Reviewer
    Overall Experience:

    I am 72 years old, and get short of breath. I am very healthy in every other way, chest x-rays and all other tests keep coming back normal.

    I walk twice a day, but hills get me a bit and I have to slow down.

    I took Active-PK (3 months supply) for about 3 weeks with no outstanding results then suddenly noticed my breathing was getting better and better. It had in fact improved by about 85%.

    So I was absolutely wrapped. I am ordering another months supply. Even though I love the product, ordering 3 months in one go is a bit expensive for me.

    All the best.

    Bottom Line: Yes, I would recommend this to a friend

  • It works fast!

    • By Chuck M.,
    • California,
    • Jul 19, 2018
    • Verified Reviewer
    Overall Experience:

    I lost 15 lbs in just over three weeks. I know it's not advertised as a weight loss product, but deep fat has weight just like body fat. Being an Exercise Physiologist I'm always a little apprehensive of this type of product, but this one works.

    Bottom Line: Yes, I would recommend this to a friend

  • Very good product!

    • By Wayne W.,
    • New South Wales, Australia,
    • Jul 23, 2018
    • Verified Reviewer
    Overall Experience:

    The product is very good, it helps bring my blood sugars down and helps with my liver pain and I am ready to purchase more. I love it very much. I am going to definitely purchase another bottle ASAP.

    Bottom Line: Yes, I would recommend this to a friend

  • So many people need this

    • By Amir K.,
    • Nevada,
    • Jul 26, 2018
    • Verified Reviewer
    Overall Experience:

    There are so many others that Active-PK can work wonders for. I now have complete confidence when sharing this product with others on my network. Letting them know that it has increased my energy output and that my weight loss is also increasing.

    Bottom Line: Yes, I would recommend this to a friend

Showing 1-11 of 228

Write a Review for Active-PK!

Share your experience to help others discover great products!

Write a Review
Active-PK Review: Benefits, Ingredients, Efficacy, Side Effects