About Arthrozene

By HighYa Staff
Published on: Aug 9, 2018

Arthrozene is a three-ingredient dietary supplement that promises to soothe inflammation, slow down cartilage degradation, and increase lubrication, resulting in improved comfort, flexibility, and mobility.

And by attacking joint pain and stiffness at their root, Fisico Inc. advertises that their clinically tested, caffeine and stimulant-free formula can help you get back to the daily activities you love and enjoy—in as little as five days. Just take one capsule per day with water on an empty stomach.

Whether your joint pain levels are mild or off the charts, finding effective relief could be life-changing. But, is this what you can expect from Arthozene’s formulation? Is it really a next-generation joint pain solution, as advertised?

Let’s dive right in and take a closer look at its ingredients.

What Ingredients are Found in Arthrozene’s Formulation?

Like anywhere else on the body, ongoing pain, inflammation, and discomfort in the joints only signals that something’s wrong, but not specifically what’s going on.

For example, common causes of joint pain can range from everything between different types of arthritis (e.g., osteoarthritis, psoriatic arthritis, rheumatoid arthritis, gout) and autoimmune diseases like lupus, to Lyme disease, hypothyroidism, and fibromyalgia, not to mention trauma like strains, sprains, dislocations, and so forth.

Which of these will Arthrozene potentially help address? Per its supplement facts label, here’s what it contains:

  • AprèsFlex Boswellia Serrata Extract 100 mg
  • Mobilee Natural Chicken Comb Extract (Standardized to 60% hyaluronic acid, 5% collagen type II, and 10% glucosaminoglycans) 80 mg
  • B-2Cool Native Collagen type II (chicken sternum) 40 mg


AprèsFlex is a patented version of Boswellia serrata (more commonly known as Indian frankincense) and a registered trademark of Laila Nutraceuticals.

According to sites like WebMD, the Natural Medicines Database, and Examine.com, taking 100 mg of ApresFLEX (formerly known as Aflapin) daily is listed as possibly effective for reducing “pain and improve mobility in people with osteoarthritis in joints. Research shows that it might decrease joint pain by 32% to 65%.”

Some of this clinical data is provided directly on the Arthrozene website.

Mobilee and B-2Cool

Similarly, Mobilee and B-2Cool are licensed trademarks of BIOIBERICA, SA.

Mobilee is a GRAS ingredient in the US derived from chicken comb that’s naturally rich in components essential for joint health, including 60-75% hyaluronic acid, 10% polysaccharides, and 5% collagen. The BIOIBERICA website indicates the ingredients is backed by four double-blind, placebo-controlled, randomized clinical trials.

Again, several of these studies are listed on the Arthrozene website, many of which involved human participants (versus studies conducted only on rats or cultured cells).

B-2Cool is another proprietary collagen ingredient, this time derived from chicken sternums, which BIOIBERICA advertises is manufactured “through a strictly controlled process that preserves the active parts of the molecule.” They reference two clinical studies for support:

  • A 2013 study indicating that supplementation in rats “showed a significant prevention of pain threshold alterations.”
  • A 2016 study showing that the collagen supplement, when combined with 1500 mg per day of acetaminophen, was superior to acetaminophen alone for improving joint pain, function, and quality of life.

Could Arthrozene’s Ingredients Cause Potential Side Effects?

The supplement’s website reports “Arthrozene is an all-natural formula that is considered safe and extremely effective for nearly everyone.” Still, it’s always a good idea to have a discussion with your doctor before taking any new dietary supplement, who can (among other things) help you avoid potential side effects and drug interactions.

Related: Do CBD-Infused Creams, Oils, and Other Products Really Work?

With this said, WebMD and the Natural Medicines Database report that, while boswellia usually doesn’t cause significant side effects, some might experience digestive upset and diarrhea. No dosages or specifics were provided.

How Much Does Arthrozene Cost?

Arthrozene is priced as follows:

  • 1 Bottle: $49.95
  • 3 Bottles: $134.85 ($44.95 each)
  • 6 Bottles: $239.70 ($39.95 each)

The single-bottle option also comes with a $5.95 S&H fee, while the three- and- six-bottle options included free shipping.

Westford, MA-based Fisico Inc. provides a 90-day money back guarantee (less any S&H) on all Arthrozene purchases, which you can request by calling 800-392-4727 or sending an email to support@arthrozene.com.

Are these prices competitive?

Arthrozene vs. the Competition: How Can You Choose the Right Joint Supplement?

While we didn’t encounter any identical formulations to Arthrozene during our research, a quick online search for joint supplements revealed hundreds of different options competing for your money, many of which contained several of the same generic ingredients. Here were some of the more popular options:

Supplement Price Ingredients
Arthrozene $39.95+ AprèsFlex, Mobilee Chicken Comb Extract B-2Cool Native Collagen type II
Life Extension ArthroMax Advanced $18 Glucosamine Sulfate 1500 mg, ApresFlex 100 mg, UC-II Collagen 40 mg, Boron 1.5 mg
MDrive Joint $30 UC-II Collagen 40 mg, Sodium Hyaluronate 20 mg, Boswellia Serrata 230 mg, Bromelain 210 mg, Turmeric 110 mg
Instaflex Advanced $61 Turmeric 200 mg, Resveratrol 100 mg, ApresFlex 100 mg, UC-II Collagen 40 mg, Hyaluronic Acid 5 mg, Bioperine 5 mg
Puritan’s Pride Youtheory Joint Collagen Type 2 $24 Hydrolyzed Chicken Collagen 500 mg, Advanced Joint Blend 500 mg (Boswellia, Cinnamon, Turmeric, Quercetin
Osteo Bi-Flex $40 Vitamin C 60 mg, Manganese 2 mg, Glucosamine HCl 1.5 g, Joint Shield Boswellia serrata Extract 100 mg, Chondroitin/MSM Complex 1103 mg (Chondroitin Sulfate, MSM, Hydrolyzed Collagen Gelatin, Boswellia, Boron, Hyaluronic Acid)

Given the fact that this is just a small sample of your joint supplement options, how can you use these details to make a more informed decision?

Not to sound like a broken record, but any time you’re considering taking a new dietary supplement, the first person you should turn to for advice is your regular healthcare professional. This is especially important when it comes to chronic conditions like pain, which can have a big impact on quality of like.

If they recommend pursuing a dietary supplement like Arthrozene for some measure of relief, we can see from the table above that it’s one of the higher priced formulations (especially if you choose to purchase one bottle), which could be important if the lowest price is your main factor.

Another potentially important thing to keep in mind is that some of these formulas are available at national retailers, which could potentially save on S&H charges, while also getting them in your hands faster.

Outside of these, after reviewing hundreds of dietary supplements over the years, the HighYa team has learned that you’ll want to do business with companies who:

  • Provide clinical support for their claims
  • Back their products with at least 30-day refund policies and no restocking fees
  • Come with mostly positive online customer feedback

Looking at the Arthrozene supplement through this lens, how does everything stack up?

Should You Order Arthrozene for Your Joint Pain?

If your doctor gives you the green light, it appears that Arthrozene comes from a company with several years in business, and who has a mostly positive online customer reputation. In fact, Fisico Inc. held an A rating with the Better Business Bureau, based on 25 customer reviews and two closed complaints, as of 7/18/18.

Furthermore, the companies behind each proprietary ingredient in their formulation support their claims with robust clinical data—at least related to osteoarthritis.

Regardless of the cause, if Arthrozene ultimately doesn’t meet your needs, Fisico provides a 90-day refund policy, which should be more than enough time to discern if it’s right for you. Just remember that you'll have to pay to ship your bottle(s) back.

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2 Consumer Reviews for Arthrozene

Average Consumer Rating: 1.0
Rating Snapshot:
5 star: 0 4 star: 0 3 star: 0 2 star: 0 1 star:  2
Bottom Line: 0% would recommend it to a friend
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  • No magic pill here!

    • Lutz, FL,
    • Oct 14, 2018
    • Verified Reviewer

    The last time I fall for a slick lying cheating magic-pill-in-a-bottle company. The pills were shipped incorrectly so they had my money for three weeks prior to me trying them and then they were smaller than an aspirin. I took them all as directed and even took raw turmeric to assist. While I was waiting for the shipment, they must have sent a dozen emails offering additional products, and then when it arrived, they all stopped. Hmmm, I wonder why. SCAM.

    Lose weight and eat healthy with exercise Samuel! I must get it through my head what it really takes. NO MAGIC PILL! None!

    Bottom Line: No, I would not recommend this to a friend

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  • 116 out 131 people found this review helpful

    I received seven bottles of Arthrozene that is expired as of 5/2018 last week.

    • Summerville, SC,
    • Aug 15, 2018
    • Verified Reviewer

    The invoice didn't include price or phone number to return the seven bottles that expired 5/2018. I received it the first week of August. I worked in hospital pharmacies for 42 years, we always checked the dates. l called BBB. they sent me a form to file a complaint. But if they just tell me the address and refund my money, l won't do that. l'm disabled and need my money back. Also, I don't remember ordering so many bottles. Thank you for any assistance that anyone can give me.

    Bottom Line: No, I would not recommend this to a friend

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    • Aug 16, 2018

      Tom G.

      Fisico Inc.

      6 Lyberty Way, Suite 103

      Westford, MA 01886

      Customer Support Phone: 800-392-4727

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