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The Arthrozene dietary supplement claims to attack joint pain and stiffness at their root, providing you with a meaningful reduction in inflammation, pain, and discomfort.

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Arthrozene Review: Ingredients, Side Effects, Cost

By Anthony Dugarte, M.D., C.S.C.S

Updated on: Dec 4, 2019

Joint pain is among the top reasons for doctor visits each year. Definitive care for this condition often includes joint replacement surgery, though many battle joint pain for years before this option is available.

For this reason, there is a strong push for less invasive treatments that may delay or prevent the need for a joint replacement. As symptoms can differ greatly from person to person, the possible treatment options may be just as variable.

Arthrozene may be one such option. This pill is reported to reduce your joint pain and stiffness through a blend of 3 ingredients.

In this article, we will review the safety and effectiveness of this product.

What is Arthrozene?

Arthrozene claims to have a variety of effects that all serve to promote overall joint health through their “3-step solution.” This solution is a combination of 3 “all-natural”, clinically tested ingredients. These ingredients are thought to attack the source of joint pain and provide relief “in as little as 5 days.”

Recommended use is described as 1 capsule to be taken once per day, with a glass of water, on an empty stomach.

Arthrozene is reported to slow the breakdown of joint cartilage, or the smooth lining that acts as a shock absorber at the end of bones. This product also works to promote the production of joint fluid, which is vital for reducing friction within the joint.

Lastly, Arthrozene claims to reduce inflammation, a key player in the process of joint pain.

The sum of these actions are said to battle joint pain, limit stiffness, and promote mobility.


Arhtrozene consists of 3 key ingredients offered in a capsule format: type II collagen, hyaluronic acid (HA), and Boswellia Serrata.

Type II Collagen (B-2Cool) - 40mg

As type II collagen is an important structural component of your cartilage, its role in joint pain has been studied extensively. Arthrozene boasts a patented form of this protein, B-2Cool®, that is obtained from the breastbone of chickens. B-2Cool® is thought to improve your joint function by limiting the destruction of collagen, inflammation, and pain.

Arthrozene sites a number of studies for clinical support of this ingredient. In 2008, a group of patients treated with type II collagen had lower levels of molecules found in urine that are used to track the progress of arthritis at 6-months and 1-year when compared to a group treated with glucosamine, another component of cartilage.3

In 2013, arthritis was induced in rats and they were treated with type II collagen over the course of 2-weeks; on day 14, balance and weight bearing was improved and lab markers for arthritis were reduced.4

More recently, 39 patients with knee arthritis were randomly assigned to either Tylenol or type II collagen + Tylenol treatment; patient reported outcomes related to function and quality of life were significantly better at 3-months in the type II collagen + Tylenol group.5

Key Takeaways

Animal studies are an important part of pre-clinical testing in which the safety and effectiveness of drugs and supplements are examined before being tested on humans. This does not mean that the effects a drug or supplement has on an animal are predictive for how they will affect a human, however. These products eventually need to be tested on human subjects – if they are not, beware.

A double-blinded, randomized controlled trial is often considered the “gold standard” for conducting research. Biases are minimized as both the subjects and investigators do not have knowledge of which treatment is being administered/received.

When compared to animal studies or retrospective reviews, the randomized trial provides stronger evidence that 10mg of type II collagen can improve patient reported outcomes in those with knee arthritis, particularly if taken along with Tylenol. The dosage of type II collagen in Arthrozene is 4x this amount.

Hyaluronic Acid (Mobilee) - 80mg

HA is the main component of joint fluid. This fluid is vital for joint health, making HA another hot button topic regarding possible treatment options.

There are a number of injectable HA treatments on the market, though a systematic review of the best available studies does not seem to point towards benefits.6

Mobilee® is an FDA approved and patented form of HA found in Arthrozene.2 Taken orally, this ingredient is thought to promote joint function by reducing joint pain and swelling.2 Arthrozene sites a number of clinical studies investigating the potential benefits of HA in those with joint pain.

A 2008 pilot study randomized 10 patients with a history of knee pain to either Mobilee® treatment or placebo, i.e. a sugar pill; after 8-weeks, Tylenol use was higher in the placebo group (as these subjects felt pain was not well controlled with treatment alone), while pain and function were improved in the Mobilee® group.7

A meta-analysis of 2 randomized trials reviewed the effects of oral HA treatment in individuals with mild knee pain; the HA group demonstrated increased knee flexion and reduced swelling when compared to the placebo group.8

In 2014, 68 patients with mild knee pain received either oral HA treatment or placebo; the HA group demonstrated reduced pain and swelling, as well as increased muscular strength.9

Key Takeaways

Meta-analyses of randomized controlled trials can provide the strongest evidence as these reviews aim to examine the best scientific studies available for a given research question.

A review of studies investigating injectable forms of HA concluded that this method of delivery does not appear to offer benefits. A review of those that examined daily oral HA treatment at 80mg doses (the same dose included in Arthrozene) describes potential benefits to include improved strength and motion, as well as a reduction in pain and swelling.

Keep in mind that subjects in these studies had mild knee pain; these benefits may differ in those with arthritis.

Boswellia Serrata (AprèsFlex) - 100mg

AprèsFlex® is the patented, next-generation Boswellia Serrata extract found in Arthrozene, which the company claims is “10 times more powerful” than other extracts.

This herb comes from the Boswellia tree in the Middle East and is thought to have anti-inflammatory properties. Arthrozene eludes to research regarding this compound being carried out in India, though they do not cite specific articles.

Laila Nutraceuticals, the owner of the AprèsFlex® patent, completed a randomized trial comparing the effects 2 different Boswellia Serrata extract to placebo in 60 patients with knee arthritis.10 At 90 days, the Boswellia Serrata extracts improved joint function, and also reduced pain in as quickly as 7 days.10

Key Takeaways

Again, double-blinded, randomized controlled trials offer the best scientific method available when examining a research question. In this particular study, patients with knee arthritis receiving the Boswellia Serrata Extracts at 100mg doses, the same dosage offered in Arthrozene, experienced reduced pain and improved function.

On their web site, Arthrozene discloses that this investigation was carried out by a research center that is a division of the company that owns the AprèsFlex® patent. This is permitted, but ethically speaking, must be made known as there is a bias in that the company conducting the research would benefit more if the supplement was effective.

Is Arthrozene Safe?

Arthrozene is said to deliver results while avoiding liver damage, upset stomach, or bleeding risk – side effects common with over the counter anti-inflammatory medications often used to control joint pain.

With respect to type II collagen, the 40mg dose included in 1 Arthrozene capsule appears to be safe in humans, though occasional headaches and constipation were reported.3-5,11

Hyaluronic acid doses 2-3 times larger than the 80mg included in 1 Arthrozene capsule appear to be safe in humans.6-9,12

Lastly, a daily 100mg Boswellia Serrata extract was as safe as a placebo. The risk for adverse events is considered low, though it may interact with common arthritis medications like Tylenol or Aspirin.13

Who Is It Good For?

Arthrozene warns against using this supplement if you're pregnant, nursing, or under the age of 18, though it is billed as being safe and effective for nearly everyone.

The research regarding the key ingredients is similarly broad and included various arthritic joints, painful nonarthritic joints, and swollen joints.

The effects of type II collagen and Boswellia Serrata have been extensively studied in those suffering from osteoarthritis, whereas much of the data regarding the benefits of oral HA cites studies examining those with knee pain in the absence of arthritis.

Much of the interest regarding these types of products is that they are generally safe even when compared to common over the counter treatments like Tylenol or aspirin.

Nonetheless, “all natural” does not mean they are without risk. Peanut butter, protein powder, and pre-workout supplements seem safe but can also have adverse effects.

Joint pain can have a variety of causes, so it is always best to include a medical professional in your care. Discuss your interest in starting a new supplement with them to avoid any potential interaction with medications or other supplements you may already be taking.

How Much Does Arthrozene Cost?

Arthrozene can be ordered directly from their site. They do not offer a subscription service but do offer a few purchasing options.

  • One bottle: $49.95
  • Two Bottles: $44.95 Each
  • Six bottles: $39.95 Each

Keep in mind, 1 bottle contains 30 capsules, a one month supply.

Arthrozene offers refunds on all orders with a 90-day, full-money-back guarantee if you're not satisfied.

These prices place Arthrozene on the more expensive side in terms of joint health supplements. You may be able to obtain products that offer these ingredients independently – this is likely less convenient and may or may not result in savings.

The Bottom Line

The 3 ingredients included in Arthrozene are reported to combat joint pain by reducing the destruction of cartilage, promoting the production of joint fluid, and reducing inflammation.

These ingredients have been studied extensively; the available research is broad and includes animal studies, retrospective reviews, and randomized controlled trials – the latter representing the strongest evidence.

Taking in all of the available information, Arthrozene appears to be safe when used as described and a promising option for those with joint pain and/or osteoarthritis. Nonetheless, these studies range from 2-weeks to 12-months so we can’t comment on long-term benefits or risks with chronic Arthrozene use.

As joint pain can span decades, more long-term data is needed to fully understand Arthrozene’s role in delaying or preventing the progression of arthritis. Always consult a medical professional before starting a new supplement.

Customer Reviews

3.3 Stars out of 15 Reviews
5 Star:53% 4 Star:0% 3 Star:0% 2 Star:13% 1 Star:33%
47% Recommend This Company
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Posted on Dec 30, 2020

Happy customer

By Linda T., Texas, Verified Reviewer

I have been taking Arthrozene for 8 months and am very happy with the results. I have found for me that it lasts about 12 hours and after that time I can feel a little discomfort in my knee. But during the 12 hours, I can walk and exercise with no pain.

Length of Use: 6–12 months

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 4 People Have Voted

Posted on Dec 5, 2019

Great, this works

By George K., Manitoba, Canada, Verified Reviewer

We've been on these pills for about a month-and-a-half and they are one of the best pills going. I've tried knee braces, I've tried living on Advil Alive, but this is the one to take it. Great. I believe that if you try this you will be amazed at how you feel in just 7 days. Thanks for making my life a lot easier, and I don't write a great thing about a thing that doesn't work. I hope people read this and try a bottle. I think you will be buying more. They're not cheap, but can you buy a peace on pain? Thanks for reading.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 22 People Have Voted

Posted on Oct 5, 2019

Sore knees

By Constance C., Bethlehem, PA, Verified Reviewer

Started last month taking Arthrozene. Took about a week for me, sure everyone is different, but I like to do my walking exercise. I have osteoarthritis, but after I start taking this, my knees seemed a lot better for my exercising. I'm out now so time for more, but I’d say they did help a bit, and my knees are not good, I’m 66. I guess with winter coming to the real test will come, and see how I feel.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 19 People Have Voted

Posted on Sep 20, 2019

Lost hope

By Robert F., Wyoming, Verified Reviewer

I was having painful knees, especially my left knee. I read about Arthrozene, and I couldn't wait to order 3 bottles. I finished the first bottle, and no relief. I thought to myself just give it some more time. Two bottles gone, no change. So, with high hopes, I used the 3rd bottle until I was out of supply. No change! Hence, I wasted my hard-earned money on what I hoped would have been a cure for my daily pain, that I am now stuck with. I would think that a refund of sorts would be in order, but I don't expect it!

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 34 People Have Voted

Posted on Sep 7, 2019

No relief after 5 weeks

By Teryn G., Florida, Verified Reviewer

I bought 12 bottles on my first order and am just into the second bottle now, but want people to know that I have had no joint relief yet. I will take all of the product bought, one a day for the rest of the year, but I am not one who can say I felt relief in the first few days or even weeks.

I made the mistake of also buying a product they call Bioslim at the same time I bought the Arthrozene and, after taking it as directed over these weeks, have lost no weight. Now I have added not eating after 6 pm and only drinking water for at least a 12 hour period each night, still taking the Bioslim 30 minutes before my big meal, and I hope on the next weigh-in to have lost at least a couple of pounds in the week. I don't know if I will be able to attribute any loss though to the Bioslim!

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 29 People Have Voted

Posted on Mar 8, 2019

Product integrity

By Sharon T., Hollister, CA, Verified Reviewer

These people are over the top. Watch out. I purchased a ninety day supply of their Arthrozene in 2018, small green-blue soft capsules. In February this year, I thought I was purchasing the same item. Pills are plastic looking capsules with white, beige and other color sprinkles in them. I have contacted Fisico three times regarding why the change. Their supervisor to return my call today. I finally called at 4:50 Eastern time. She said perhaps I was "taking" the other pills and thought they were Arthrozene. Said never made changes. She suggested that I take a photo of one of the capsules, email it to her and (uh she has family) so sometime Monday she’ll let me know if I am taking a valid product, no one knows of any changes, the pills are 100% different but identified as the same and they really aren’t concerned. I have spent over $300.00 on these pills and am very concerned about what I have been taking. I also referred a friend that has Lupus and she purchased three bottles also. These people should be in jail.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 69 People Have Voted

Posted on Feb 21, 2019

Works well

By Thomas W., Westborough, MA, Verified Reviewer

I was told 3 years ago that knee replacement surgery was in my future due to lateral meniscus damage and stage 1 arthritis. I was 62 when I started on Arthrozene, about 5 months ago. After 5 days my knee stiffness and joint pain related to the meniscus problem was much better. There have been no side effects. I take it on a very empty stomach at 5 or 6 am with about 8 oz of water, then relax or sleep until breakfast an hour or two later. After dealing with the knee pain for so long as it crept into my right side joint, I realized one day that I had almost forgotten I had that problem. I would get up and go without stiffness or pain. I know my knee is not repaired by taking Arthrozene. I have learned over 3 years to pace myself, and continue to do so.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 39 People Have Voted

Posted on Nov 26, 2018

Arthrozene works...able to delay hand surgery!

By Louise L., Saugerties, NY, Verified Reviewer

I'll begin by saying that my Basel joint in my right hand was bone on bone. But I didn't need a picture to tell me...the pain was shocking. I couldn't even put on underwear, brush my teeth, open the cat's canned food...in short, any use of my right hand (my dominant hand) left me sometimes, gasping for air, due to the sharp jolts of pain. I'm a musician and a writer and the impact to my work was adding to my stress and depression. I live in severe chronic pain, with other parts of my body, but, our hands represent our ability to manage our lives. I was in the medical machine, dealing with surgeons and even had a date set for surgery to my hand. So, it was serious.

After I received Arthrozene, I took it faithfully and was told by my primary doctor to allow a window of, say, 6 hours...if you take morning meds, as the supplement can bind to your med and this would impact the effect of the Arthozene. He's a wonderful and enlightened doctor and supports alternative wellness programs. With me, it took about 6 weeks before I realized my pain level had dropped by a good 30% in my hand. I was doing things without the jolt of pain running up my arm. I hadn't even noticed when exactly it happened but it did.

My doctor felt the cock's comb and sternum in the formula was a major component of the success of the supplement. Also, I was taking Boswellia before Arthrozene, along with my regimen of supplements...but the dosage for the "therapeutic" need is key in any medicine or supplement/mineral use. Facing hand surgery, with tendon's removed and rolled up into an Anchovy roll, inserted into my joint would be a long recovery. I was worried about permanent "numbness" in the joint area as I need my thumb. Imagine doing anything without your thumb! Since I live alone, it was a huge worry for me, and I have had numerous surgeries and still have pain.

Well, that's my story. I stopped the surgery and believe firmly that there are other ways to get that joint regenerated. Important to know - everybody is different, anyone who has arthritis has to keep mobile, our diet is key to our health (I'm a vegetarian) and only eat organic foods. Certain foods wreck our ligaments. Long-term use of NSAID's will not help, but certainly, hurt you. Learn about Fibrin and how it works when we are injured. Knowledge is power. Do not put your precious body into the hands of a doctor...just because he is a doctor. I've met surgeon's I wouldn't let peel an apple!

Lastly, there are many, many remedies from other parts of the world that have been used for longer than this country has been a country! Learn about them because once you have gone under the knife, you can't go back. Offered in Health and Peace!

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 91 People Have Voted

Posted on Oct 25, 2018

Great product

By N C., Powder Springs, GA, Verified Reviewer

I started taking Arthrozene about three weeks ago. The pain and stiffness in my knees were unbearable. I could hardly stand or walk, especially any distance. I was considering knee replacement surgery. After three days the pain was considerably less. Now, the pain is gone, and each day it gets better. I have an ulcer and the product has not affected my stomach. I looking forward to seeing the progress in three months.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 89 People Have Voted

Posted on Oct 24, 2018

Side effects and interactions

By Lisa D., Pennsylvania, Verified Reviewer

I feel that the company that manufactures Arthrozene is negligent in not alerting their customers to possible side effects and interactions. One of the key ingredients is Boswellia serrata. It can cause diarrhea, skin rashes, nausea and more, and should NOT be taken in conjunction with NSAIDs, like Ibuprofen, Aleve, Naprosyn, etc. It can cause liver toxicity.

It had minimal effect on my knees. I took Ibuprofen with it and developed severe diarrhea. In searching for the cause, I examined recent changes in my habits and therefore did more research into the ingredients.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 109 People Have Voted

Posted on Oct 23, 2018

Arthrozene, it worked!

By Joan W., New Jersey, Verified Reviewer

I was almost to the point of having knee surgery when I saw an article on my phone regarding Arthrozene. I read it and with one last attempt to try something else, I placed the order. I have been suffering with knee pain for over 10 years. I have had injections, tried creams, water therapy and much more. Depression set in because my life changed. I could barely get up and move without pain. I am a Realtor, and I couldn't even drive my car without getting out to stretch my legs to give my knees a break. I received Arthrozene, took it a directed, and I am moving like I never had any knee problems at ALL! Today I am ordering 3 bottles and will continue to order because this actually works. I pay attention to my body and am experiencing NO SIDE EFFECTS AT ALL. I have recommended this to my sister and friends already!

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 79 People Have Voted
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