Omega XL Review: Is It Safe and Effective?

By Anthony Dugarte, M.D., C.S.C.S
Updated on: Jun 23, 2020

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What Is Omega XL?

Omega XL is a nutritional supplement that allegedly addresses your joint pain and inflammation by utilizing a concentrated extract containing up to 22 times more free fatty acids than regular fish oil.

Omega XL is manufactured by Great HealthWorks based out of Hollywood, FL.

This review analyzes the product's efficacy and safety to help you determine whether it's right for you.

How Does It Work?

Omega XL claims to offer a highly concentrated formulation of 30 fatty acids.

The company lists the supplement’s active ingredients as a Perna canaliculus proprietary oil extract, natural monounsaturated olive oil, and Vitamin E.

They also boast about providing “22x more omega-3 fatty acids than standard fish oil capsules.” You won’t find any information detailing the amount of these active ingredients per capsule, or per serving, however.

Of the many omega-3s, the most discussed include alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Omega XL claims to offer EPA and DHA among the 30 fatty acid blend.

Omega-3s are thought to have wide-ranging effects such as improving mental health, reducing the risk for heart disease, fighting inflammation, and alleviating joint pain.

Perna canaliculus, or the New Zealand Green-Lipped Mussel, provides much of the fatty acids Omega XL claims to offer. They report that their supply of mussels are sourced from “pristine” waters where they are harvested after 18 months.

As there are 60 soft gels in a bottle, perceivably 1 serving is 2 soft gels. Omega XL recommends taking the capsule with meals if you have a sensitive stomach, though they provide no information regarding use beyond this.

Effectiveness of The Ingredients

Most of the research regarding this mussel seems to be related to arthritis.

In a 2017 study of a brand name supplement with green-lipped mussel extract known as BioLex, 80 patients with moderate to severe arthritis in their hips or knees were given either 600mg of BioLex daily or a placebo for twelve weeks.

The results of this study were mixed.

Studies such as this one have not provided a great deal of evidence that green-lipped mussel extract helped with immediate pain relief. However, after 12 weeks these subjects did reduce their paracetamol use compared to subjects who took a placebo.

A therapeutic evaluation from 2015 suggests this mussel does offer wider anti-inflammatory properties and may be able to boost the effects of NSAIDs medications when taken together.

In a review of 4 randomized trials, doses of green-lipped mussel extract ranging from 210-1150mg/day all seemed to offer clinical benefit. Two of the 4 studies were thrown out, however, as the scientific method and statistical analysis were unsatisfactory.

This review highlights the mixed nature of current data, as well as the need for much more work to characterize the benefits.

In 49 patients with rheumatoid arthritis, those randomized to receive olive oil capsules containing 6.8 gm of oleic acid had less benefit when compared to subjects receiving fish oil supplements, particularly at high doses.

In 43 patients with rheumatoid arthritis, those randomized to receive fish oil omega-3 fatty acids (3 g/d) and 9.6 mL of olive oil over 24-weeks experienced more relief than those that received placebo or fish oil alone.

A recent review of available research points to mixed results regarding any potential benefit with Vitamin E in those with joint pain, particularly osteoarthritis.

While 200-400mg doses were associated with improved walking, standing, and patient-reported benefits, many other studies found a negligible or negative relationship between vitamin E and joint health.

The Takeaway:

Scientific support for joint relief from Perna canaliculus use in human subjects is minimal. Furthermore, questionable methods and statistical analysis were used in much of the available literature. More work is needed to clarify any potential benefit for joint pain.

The available data regarding joint relief with olive oil supplementation is mixed, though when added to fish oil supplementation, the benefits may be greater than with fish oil alone.

Vitamin E and the potential for joint pain relief has been extensively studied in subjects with osteoarthritis. Though support exists, the results are mixed.

While strong support for the ingredients in this supplement is lacking, we also do not know the total, or individual, amounts of the ingredients.

Side Effects

According to the product’s website, there are no known side effects or drug interactions, and Omega XL is even safe to use for individuals with shellfish allergies.

This may not be the case, however, as mussels do possess a known allergenic protein, Per v 1. Mussels are the least likely shellfish to cause a reaction.

Even at doses up to 1150mg daily, no adverse effects were reported with green-lipped mussel extract. Olive oil supplementation was similarly safe at 9.6mL daily over 24-weeks. Vitamin E was safe up to 400mg daily.

Of course, this information is not as helpful as it could be as we do not have information regarding the amounts of each active ingredient offered in Omega XL.

For omega-3 supplements in general, reported side effects include bleeding, impaired immune function, and impaired lipid and glucose metabolism, though they are likely safe up to even 5,000mg per day.

The Takeaway:

While safe in general, we do not know the amount of each ingredient included in Omega XL. It is best to speak with a physician before use.

The Cost

At the time of writing, you can buy Omega XL directly from the manufacturer as a buy-one-get-one-free deal for $39.95, plus applicable taxes and $4.95 for shipping. For this, you’ll receive 120 soft gels (two bottles of 60 soft gels each), which translates into a 60-day supply.

Keep in mind that as soon as you place your order, you’ll be enrolled in the company’s auto-ship program. As a result, you’ll be sent a fresh 30-day supply of Omega XL once per month, and your credit card will be charged $39.95, plus shipping and handling.

Omega XL comes with a 60-day refund policy, which begins the day your order is placed, less shipping and handling charges. Outside this 60-day period, no refunds will be honored.

Omega XL

Buy Omega XL from Amazon:

Omega XL costs $47.99 for a 60-count bottle, with free shipping. (Single purchase, no subscription.) It is recommended that you take 2 soft gels each day, so one bottle is equal to a 30-day supply.

$48.99 (60 count)

Customer Reviews and Complaints

This supplement has several hundred reviews on Amazon and averages four stars.

Most positive reviewers wrote that the supplement soothed their pain symptoms and made their joints feel better. Many wrote that they had to take the supplements for several weeks before they started noticing any improvements.

The most common complaints include failure to work, too little transparency about ingredients, and the high price point. Others mentioned that the capsules arrived fused as if they had melted during shipping.

According to consumer reviews on our website, Omega XL isn’t a fan favorite. The supplement earned 2.4 stars after 35 reviews.

HighYa reviewers took issue with the company’s subscription policy and wrote that it was difficult to cancel their orders.

Others felt like the product didn’t deliver any of the promised benefits and that it cost too much compared to competing supplements.

Alternative Products

Omega XL isn’t your only option if you’re interested in trying out the benefits of New Zealand green-lipped mussel.

Two popular alternatives include the Swanson Green-Lipped Mussel supplement and the FoodScience of Vermont Sea Mussel supplement.

We chose to look at these products because they have high ratings on Amazon and contain Perna canaliculus as their main ingredient.

Each bottle of Swanson supplements contains 60 capsules and gives you 500mg of freeze-dried mussel per serving. Unlike Omega XL, the mussel is the only ingredient in the Swanson supplement.

Customer reviews on both Amazon and the Swanson store are primarily favorable. This product earns four stars out of five on both platforms, with many reviewers saying that it left them pain-free after numerous other remedies failed to work.

Most of the negative reviews we read seemed to come from people who didn’t appreciate the fishy aftertaste or who thought the supplement didn’t work as described for their symptoms.

Pricewise, you’ll pay between $4 and $8.99 for sixty capsules (a two-month supply).

In contrast, you’ll get 180 capsules from FoodScience of Vermont for $25. That’s about $0.14 per capsule, which is more expensive than Swanson ($0.06–$0.15) but cheaper than Omega XL ($0.37).

However, it’s suggested that you take two capsules at a time for both FoodScience and Omega XL, so the real price per serving is $0.30 and $0.74, respectively.

This brand averages four stars out of five after more than 120 reviews, and it contains nothing but mussel, alfalfa leaf, gelatin, and cinnamon oil for flavoring.

The Bottom Line

Support for the efficacy of this supplement is lacking. Even the most extensively studied ingredient provides us only with mixed results.

There are many similar nutritional supplements on the market, so it may be worth your time to do some research.

Both the Swanson and FoodScience of Vermont supplements we referenced above are a fraction of the price of Omega XL and don’t automatically enroll you in an auto-ship program.

You might find that they are a better way to experiment with whether Perna canaliculus will work for you, though having a conversation with your primary physician before use is your best bet.


Customer Reviews

Start your review of Omega XL:
  • 36 Customer Reviews
  • 36% Recommend This Product
2.4 out of 5
5 star: 27% 4 star: 5% 3 star: 2% 2 star: 8% 1 star: 55%

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  • Easy to order, but difficult to cancel order

    • Length of Use: 3–6 months
    Overall Experience:

    I felt no difference with the product and decided to cancel within the 90 days.

    I was promised a 30-day supply for free, if I gave it another try, but that 30-day free supply didn't show up.

    After about an hour on hold to cancel, I called on a different line as a new customer and someone picked up the phone within like 20 seconds, but expressed he had no authority to cancel my subscription.

    Pros and Cons:

    • No “pros” were specified in this review
    • Customer service
    • Difficulty to cancel

    Bottom Line: No, I would not recommend this to a friend


  • Shameful hard sell when trying to cancel for my mother who is at end of life

    • By Charlotte C.,
    • California,
    • Aug 27, 2019
    • Verified Reviewer
    Overall Experience:

    I called to cancel a subscription for my mom who is dying, cannot swallow pills, and is hardly eating or drinking anything at all. The rep repeatedly tried to sell me on the product, tell me that the pills I was trying to cancel weren't for her, they were for my dad (I had already explained to him that my dad only ordered the pills for my mom). I told him I didn't want to hear sales, that I am trying to get my parents' affairs in order during a very difficult time, he told me he was just trying to tell me my options.

    When he came back from putting me on hold, he told me he suspended the account for the next few months. I told him it was completely inappropriate to do this and to cancel the order as I had asked because my mother is at the end of her life. He continued to argue with me that they weren't for her, they were for my dad, that he was trying to help me by telling me my options.

    When he came back from hold to say he had in fact canceled the order, I told him I wanted to speak to the manager. Previously he had said ok, and at that point, he said there was no manager there. He gave me a line about how he put all that I said into notes and that the company would know what my complaint was. It is absolutely outrageous and shameful their relentless efforts to keep you hooked in, and reps are not trained to deal with sensitive situations anywhere close to appropriately.

    Bottom Line: No, I would not recommend this to a friend


  • ALERT, do not buy Omega XL

    • By Adrianne B.,
    • Pensacola, FL,
    • Aug 1, 2019
    • Verified Reviewer
    Overall Experience:

    Omega XL is bad, it has fish oil and to those who are allergic BEWARE. And also it doesn't work, everything is a scam to make money off everyone who comes into this TRAP, don't let them TRAP you into their LIES. 100% SCAMMERS. If you are not allergic to fish they sell those at Walmart, Walgreen's, etc. Don't let them get away with their scam, it's not worth every dime you spend on this JUNK.

    Bottom Line: No, I would not recommend this to a friend


  • Can't turn them off!

    • By Rick M.,
    • Eden, NC,
    • Jun 18, 2019
    • Verified Reviewer
    Overall Experience:

    I signed up and started receiving my pills. After 6 months or so I wanted to stop. I called them up and told them to stop shipping pills and quit debiting my credit card. All these people did was transfer me to another person and put me on hold until I got tired. That is their method. You never get to the person that can stop your order. Now I'm going to my credit card company and have them reject/cancel the automatic payment. For that reason, I would not do business with these ass hats.

    Bottom Line: No, I would not recommend this to a friend


  • Bad for heartbeat

    • By Ross Y.,
    • Toronto, Ontario, Canada,
    • May 17, 2019
    • Verified Reviewer
    Overall Experience:

    Please whoever has an irregular heartbeat or AF, please do not take it. I was suffering for 3 days after I took only 2 pills, I almost wanted to call an ambulance. I don't know about the benefits, but be alert.

    Bottom Line: No, I would not recommend this to a friend


  • Still haven’t received my refund

    • By Gwendolyn E.,
    • Brooklyn, NY,
    • May 7, 2019
    • Verified Reviewer
    Overall Experience:

    Great HealthWorks withdrew money from my account without my authorization. When I checked my bank statement online, I noticed money was taken out so I called and asked for my money back. I was told that I would have to wait 10-15 business days for my refund because of their policy. I waited and my 15 days ended last Friday, April 26, 2019 and still no money in my account. I told the customer service representative that if I do not receive my money by the end of today that I will file a complaint and open an investigation with my bank. Each customer service representative I talk to gives me the same run around to wait it takes time to show up on my account but with my bank, it always shows up automatically even though the money is pending. I would not recommend anyone to deal with this company because they are quick to take your money out from your account and are slow to give you your money back. I am currently still waiting for my money! If you can stay avoid dealing with this company!

    Bottom Line: No, I would not recommend this to a friend


  • Don’t buy

    • By Maria S.,
    • Vancouver, British Columbia, Canada,
    • Feb 28, 2019
    • Verified Reviewer
    Overall Experience:

    My left knee suddenly was in so much pain that I had to walk with a cane. By chance, my daughter saw the advertisement and thought this Omega-XL would do miracles. I ordered and finished the two bottles. It did not reduce my pain one bit! My pain got worse and at the end, I had to see my doctor.

    Bottom Line: No, I would not recommend this to a friend


  • Worst customer service

    • By Lila P.,
    • Sayreville, NJ,
    • Feb 12, 2019
    • Verified Reviewer
    Overall Experience:

    I have tried to cancel their mailing orders and it is impossible to reach the Cancellation Department, after been on the phone for 50 minutes each time you get disconnected, or they give you the runaround. Very disappointed. They also increased the price twice in two months without notification.

    Bottom Line: No, I would not recommend this to a friend


  • Scammers

    • By Avtar R.,
    • Victoria, British Columbia, Canada,
    • Jan 20, 2019
    • Verified Reviewer
    Overall Experience:

    We have canceled our subscription three times! We keep getting products and charged. I have waisted 10 hours of my life on hold trying to get this rectified! I’m on hold as we speak!

    These guys are scammers!

    Bottom Line: No, I would not recommend this to a friend


  • Not what it claims.

    • By Raul N.,
    • Abbotsford, British Columbia, Canada,
    • Dec 5, 2018
    • Verified Reviewer
    Overall Experience:

    After trying this product for three months I was completely let down. It did not relieve pain at all! Nothing claimed in the infomercial is true about this product. The product is available at Walmart - contrary to the claim made in the infomercial that it is not available anywhere but through the company itself. As well, customer service is almost non-existent. Rude. Pushy. Terrible customer service. I DO NOT recommend this product.

    Bottom Line: No, I would not recommend this to a friend


  • Buy this stuff

    • By Judy P.,
    • Illinois,
    • Oct 27, 2018
    • Verified Reviewer
    Overall Experience:

    If you have joint pain of any kind, especially if nothing has worked for you to relieve the pain, BUY THIS STUFF! I have a painful ankle from being broken many years ago and never set. Nothing ever worked to keep me from hobbling around in pain all day, especially if I was on my feet a lot. I tried this and after about a month or so of taking this, I was completely pain free and remain so to this day. You have to be patient and diligently take this for about a month to let it build up in your system. After that, you will have a big smile on your face! I rarely write reviews on products, but I just had to write this one. Kudos to Omega XL! BUY THIS STUFF!

    Bottom Line: Yes, I would recommend this to a friend


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