By combining 12 natural, powerful pain relievers and anti-inflammatory ingredients with enzymes, Heal-n-Soothe is a dietary supplement that promises to help promote healing and recovery, reduce muscle discomfort, and support healthy circulation and immune response.
All you have to do is take at least one capsule (up to four times daily, if needed), 30 minutes before or 60 minutes after meals, and the company reports the supplement’s ‘systemic enzyme therapy’ could begin delivering results.
But is Heal-n-Soothe really "Mother Nature's feel-good formula,” as advertised on the website? Does it actually contain ingredients that have been clinically proven to work? We’ll explore important questions like these in this article, starting with the topic of enzymes.
What Is Systemic Enzyme Therapy & Is It Effective?
While we didn’t encounter much detailed information about systemic enzyme therapy during our research, writing for Science-Based Medicine, Scott Savura defines it as consuming enzymes orally “with the intent of whole-body effects."
Specifically, the therapeutic approach is often promoted as a way to address inflammation, which Scott reports is a “host of complex physiologic processes mediated by the immune system,” often expressed as redness, heat, pain, and swelling.
From a clinical perspective, he points out that enzyme therapy “can be science-based,” since it’s often used to treat pancreatic disease and cystic fibrosis, but he tempers this by emphasizing that “those are not uses where the enzymes need to be absorbed from the gastrointestinal tract,” since they’re often injected in very large doses.
Comparatively, “the concept of giving enzymes orally, and achieve meaningful therapeutic effects in the body, is one with a considerable number of drug design hurdles,” he says. As a result, “until better evidence appears to demonstrate the efficacy and safety of systemic enzyme therapy,” he emphasizes, “their use can’t be considered science-based.”
With this core information in mind, which enzymes will Heal-n-Soothe’s formula deliver, and what does the clinical evidence have to say about their efficacy?
Taking a Closer Look at Heal-n-Soothe’s Ingredients
According to the supplement facts label listed on their website, Heal-n-Soothe contains the following ingredients:
- Boswellia Extract 150 mg
- Citrus Bioflavonoids 90 mg
- Ginger Extract 90 mg
- Mojave Yucca (root) 90 mg
- Turmeric 60 mg
- Alpha Lipoic Acid 50 mg
- Rutin 30 mg
- Devil’s Claw Extract 30 mg
- Systemic Enzyme Blend 7540 mg: Protease AM 225 AP, Bromelain 6M FCCPU, Protease 6.0 60,000 HUT, Alkaline Protease 12,000 USP, Papain 1.5M FCCPU
Before diving in, it’s important to point out that the HighYa team doesn’t have a scientific background when it comes to the biological effects of dietary supplements. This means that when reporting on whether or not an ingredient is effective for a specific claim, we rely on the cumulative clinical evidence reported by sites like the Natural Medicines Database, Examine.com, and WebMD.
According to these sites, some studies indicate that taking 100-333 mg of certain Indian frankincense (Boswellia serrata) extracts daily can improve joint pain and mobility by anywhere between 32 and 65 percent in those with osteoarthritis.
Similarly, taking between 250 and 500 mg of ginger extract, three to four times daily, has been shown in some studies to reduce arthritis-related hip and knee pain, as well as standing and walking pain and stiffness in those with osteoarthritis. In some instances, it worked about as well as 400 mg of ibuprofen, while in others it did not.
500 mg of turmeric (which contains an active chemical called curcumin), when taken two to four times daily for two to six month, has been shown to reduce pain and improve function in people with osteoarthritis. In some instances, it reduced pain as much as ibuprofen, but didn’t reduce inflammation as much as the drug diclofenac.
Rutin, whether contained in Heal-n-Soothe or another dietary supplement, is a type of plant pigment (flavonoid) that might have antioxidant and anti-inflammatory effects. And when combined with 288 mg of trypsin and 540 mg of bromelain, taking 600 mg per day has been shown to “be about as effective as the medication diclofenac (Voltaren) in relieving pain and improving knee function in people with osteoarthritis.”
Another potentially helpful ingredient related to osteoarthritis is devil’s claw. In some studies, taking between 400 mg and 2.6 grams per day for between two and four months has been shown to help decrease pain, often in the hip and knee.
Finally, while we learned earlier that a combination of rutin and bromelain might have some osteoarthritis-related benefits, these same sites didn’t indicate that it—or any of the remaining enzymes or ingredients found in Heal-n-soothe—will deliver on the manufacturer’s claims.
Potential Side Effects Related to Heal-n-Soothe’s Ingredients
The disclaimer at the bottom of Heal-n-Soothe’s website emphasizes that some of these ingredients could thin blood, and that the supplement shouldn’t be taken by anyone who’s allergic to pineapple or papaya, or by those who are pregnant or nursing.
They also note that it’s possible to experience side effects (no dosages or other circumstances noted) like sinus drainage, gas or loosening of the stool, and decreased blood pressure.
WebMD and the Natural Medicines Database report that in some instances (again, no dosages or other circumstances provided) turmeric can cause stomach upset, nausea, dizziness, or diarrhea.
They also tell us that while devil’s claw is possibly safe when used for up to one year and that the most common side effect is diarrhea, “other possible side effects include nausea, vomiting, stomach pain, headaches, ringing in the ears, loss of appetite, loss of taste,” and allergic skin reactions.
How Much Does Heal-n-Soothe Cost?
Heal-n-Soothe is only available directly from the manufacturer, through the following two options:
- One-Time Order (90 vegetarian capsules): $59
- Free Trial: $9.95 S&H
If you choose the trial option, you’ll be billed the full price of $49.95 after 14 days have passed, and will continue receiving a new bottle each month and paying $49.95 each time, until you cancel.
Living Well Nutraceuticals offers a 90-day refund policy on all Heal-n-Soothe orders, less S&H, which you can request by calling (888) 231-9901 or sending an email to email@example.com.
Are There Any Online Heal-n-Soothe Customer Reviews?
Heal-and-Soothe was previously available through Amazon, where more than 50 customers had given the supplement an average rating of 3.5 stars. Common compliments revolved around reduced pain and inflammation, while complaints often referenced no results, difficulty obtaining a refund, and side effects like digestive upset.
As far as the company, Heal-n-Soothe is distributed by Living Well Nutraceuticals, based out of Glendale, CA. They weren’t listed with the Better Business Bureau as of 2/21/18, although the company manufactures several other dietary supplements, including Rub on Relief natural pain cream, SleepZyme sleep aid, and ThinMist weight loss spray.
Heal-n-Soothe vs. Other Systemic Enzyme Therapy Supplements
Browsing online marketplaces like Amazon and Google Shopping, we encountered several popular enzyme supplements competing with Heal-n-Soothe:
|Supplement||Price||Active Enzyme(s)||Other Ingredients?|
|Heal-n-Soothe||$49 - $59||Bromelain, Papain||Boswellia, bioflavonoids, ginger, yucca, turmeric, ALA, rutin, devil's claw|
|NOW Super Enzymes||$11+||Bromelain, Ox Bile, Pancreatin, Papain||No|
|Doctor’s Best Proteolytic Enzymes||$21||Bromelain, Papain, Amylase, Lipase, Serratiopeptidase, Lipase||Neutral, fungal, and bacterial protease, rutin|
|Enzymedica Repair Gold||$30+||Bromelain, Amylase, Catalase, Papain, Serratiopeptidase, Lipase||No|
|Source Naturals Daily Essential Enzymes||$42||Pancreatin, Acid-Stable Protease, Lipase, Amylase, Amyloglucosidase, Cellulase, Lactase||No|
|Wobenzym N||$25+||Pancreatin, Papain, Bromelain, Trypsin, Chymotrypsin, Rutoside||No|
Given all these options, formulations, and price points, what’s the best way to figure out which one—if any—is right for you?
As we always emphasize, start by talking with your doctor. They can help diagnose the underlying cause of your pain, discomfort, and inflammation, and then recommend a science-based treatment from there.
If they recommend pursuing a dietary supplement, after writing about hundreds of different formulations over the years, we’d recommend only doing business with manufacturers who:
- List all of their ingredients, including dosages, with no proprietary blends (which don’t list dosages)
- Support their claims with quality clinical evidence
- Back their products with at least 30-day refund policies and don’t charge restocking fees
Does this mean you should do business with Living Well Nutraceuticals and place an order for Heal-n-Soothe?
Our Final Thoughts About Heal-n-Soothe
Pain is a complex process, and it will take the help of a physician to narrow down what’s causing yours, and then prescribe a viable treatment. So—again—whether you're considering Heal-n-Soothe or another dietary supplement, they're perhaps your best resource for achieving the most bang-for-your-buck.
With this in mind, based on what we learned earlier, while systemic enzyme therapy as a whole might not seem to have much clinical support, several of Heal-n-Soothe’s individual ingredients are reported by sites like Examine.com and WebMD to be possibly effective for osteoarthritis-related benefits. Which could be positive, as long as this is the cause of your pain. If not, you might be flushing your money down the drain.
Pro tip: However, many of these ingredients (ginger, turmeric, rutin, and devil’s claw) aren’t found in the same dosages in Heal-n-Soothe as referenced in supporting clinical trials.
Even when referencing the same source of pain, the reality is that everyone’s body is different, so what works for one patient might be a total fail for another. For this reason, it’s positive that Living Well Nutraceuticals seems to stand behind Heal-n-Soothe with a 90-day refund policy—just keep in mind that you’ll have to pay to send the bottle back if you’re dissatisfied.