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Gundry MD Bio Complete 3 Reviews

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Gundry MD Bio Complete 3

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147 Customer Reviews

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Bio Complete 3 is a dietary supplement by Gundry MD offering prebiotic, probiotic, and postbiotics that are proposed to support optimal gut health. Probiotics have been studied extensively with scientific support for improving GI and immune health.


  • Research provides scientific support of probiotics for GI health
  • Prebiotics, probiotics, and postbiotics are identified as being generally recognized as safe
  • 90-day money-back guarantee


  • Lack of strong research supporting decreased levels of fatigue
  • Product effectiveness in weight loss and management requires exercise and diet

Bio Complete 3 Review: Is It Safe and Effective

By Rocklend Davis, Ph. D.

Updated on: Sep 4, 2020

This article contains links that should you click and make a purchase, we may earn a commission from the sale. See our Advertiser Disclosure.

Bio Complete 3 is a dietary supplement containing a proprietary blend of prebiotics, probiotics, and postbiotics that is alleged to support gut health.

To date, most gut health research focuses on gut microbiota, which serves as the site that contains the highest number of bacteria.

Gut health is an extension of your immune system which employs a group of good cells/bacteria that work with the host to promote health.

Because Bio Complete 3 relies on probiotics, its group of bacteria helps develop the microorganisms in the gastrointestinal tract to promote balance and ensure optimal function.

Gundry MD claims that you will experience the following benefits with daily use of their dietary supplement:

  • Weight loss
  • Decrease levels of fatigue
  • Improved digestion
  • Decrease cravings
  • Immune system support

In this article, we will help you understand if there is any science backing these claims by reviewing the available research for the active ingredients.

Effectiveness of the Ingredients: Do They Support the Proposed Benefits?

A serving size is four capsules that contains a proprietary blend of ingredients:

  • Tributyrin (as CoreBiome ®): 1000 mg
  • Sunfiber®: 200 mg
  • Bacillus coagulans (ProDURA®) (2 billion CFU): 16 mg

According to the company, you need to take two capsules, which are absorbed quickly, twice per day before eating to experience benefits for your gut.

Below, we will go over the roles of these ingredients to see if the evidence supports the claimed benefits of Bio Complete 3:

Gas, Bloating, Diarrhea, and Constipation Relief

One of the many claims proposed by Gundry MD is the ability to reduce gas, bloating, diarrhea, and constipation.

Sunfiber® is a dietary fiber contained in the proprietary blend of Bio Complete 3.

Studies have found that a diet that is rich in dietary fiber can be an alternative to promote healthy weight while serving to promote a positive balance in the GI tract, and releasing and regulating hormones that associate with feelings of fullness.

A study demonstrated that Sunfiber®, when given in doses of 5 g/day, was able to normalize stool consistency and promote gut microbiota changes.

Bacillus coagulans is lactic acid and a probiotic culture that aids in the digestion of carbohydrates and proteins. B. coagulans can help to enhance the benefits of prebiotics to help promote the growth of more healthy gut bacteria.

B.coagulans was supplemented in 36 patients diagnosed with Irritable Bowel Syndrome. These patients experienced a significant decrease in clinical symptoms of bloating, diarrhea, vomiting, abdominal pain, and stool frequency.

Immune Support

Medical literature suggests that diets should include probiotics and prebiotics to enhance the immune response. When consumed in adequate amounts, probiotics and prebiotics may provide various health benefits.

A review was able to recently reveal the benefits of prebiotic and probiotics to enhance the immune response to seasonal influenza vaccine in healthy older adults. However, the amount in this study was more than double the amount contained in Bio Complete 3

The functional properties of dietary fibers, such as Sunfiber®, help protect against intestinal infections, activate bowel function, aid in nutrient digestion and absorption, and stimulate the immune response.

However, the dosage amount contained in the proprietary blend of Bio Complete 3 is much less than was used in the available literature, so it may not be adequate in providing the proposed benefits for immune support.

Weight Loss Aid and Decreased Cravings

Partially hydrolyzed guar gum (PHHG), now named Sunfiber®, is currently being used in various forms in beverages, food products, and medicinal foods.

Guar Gum is a dietary fiber and, due to its gel-forming capabilities, is involved with reducing macronutrient absorption and slow gastric emptiness.

Tributyrin is a compound of butyrate that is composed of a short-chain fatty acid that serves as a versatile molecule that is produced in the gut by fermenting dietary fiber and can be enriched in butter and other dairy products.

Butyrate has shown some promising effects in various diseases, including obesity, diabetes, inflammatory bowel disease, and colorectal cancer.

A study of Tributyrin suggests that oral administration of 2g/kg of tributyrin 3 times per week effectively protects against a diet-induced obesity and insulin resistance in mice.

The study showed that tributyrin was directly linked to the inhibition of the proinflammatory mediator production of the white blood cells, protecting skeletal muscle against insulin resistance.

Muscle and Joint Pain Relief

More research is required to determine the role of the proprietary blend of the ingredients in Bio Complete 3 for alleviating symptoms of achy muscle and joints.

However, an older study found a decrease in the inflammatory response. Improved muscle integrity was the most effective when B. coagulans were administered with hydroxymethyl butyrate.

Further, butyrate may serve a role in strengthening the intestinal barrier function.

A study done in both humans and mice produced data that suggests a preventative approach for inflammatory diseases by targeting impaired intestinal barrier function.

This study suggests that a dose of 1 g butyrate may be able to decrease the onset of arthritis from occurring, which is similar to the dosage that is contained in Bio Complete 3.

The benefits proposed by Gundry MD for the Bio Complete 3 may provide varying results due to dosages that are much less than the ones used in the available studies.


Tributyrin, when taken orally, can be safe at lower doses, but higher doses greater than 10 g/kg can be toxic. However, the dosage contained in Bio Complete 3 is only 1 g.

No adverse effects were noted when PHGG/Sunfiber® was provided in a study at a dose of 5 g/day in patients with chronic abdominal pain and IBS.

B. coagulans have a history of safe consumption in humans, as indicated from a review of toxicology testing studies.

When comparing dosage amounts, a study found that a B. coagulans dose of 2x10(9) CFU/day was found to be safe and effective in diarrhea-predominant irritable bowel syndrome for 90 days of supplementation.

It is best to take the Bio Complete 3 dietary supplement as indicated on Gundry MD's website. Dosing of any amount should never be increased.

While the safety profile for Bio Complete 3 is favorable, it may not address the underlying cause of your problem.

Therefore, you should seek your physician's opinion if you are experiencing issues affecting your quality of life.

Pricing and Return Policy

Bio Complete 3 is available for sale on Gundry MD’s website and they have options available to provide you savings.

  • 1 Bottle (30 capsules): $49.95
  • 3 Bottles: $134.85
  • 6 Bottles: $254.70

Orders that are over $60 ship for free in the US.

Gundry MD provides a 90-day money-back guarantee, however, this does not cover shipping and handling. In order to process your refund, you will have to contact customer service.

Alternatives to Bio Complete 3

TruBiotics by One A Day could be another option to support digestive and GI health.

TruBiotics offers 2 probiotic strains that have been studied extensively and it is reasonably priced when compared to the many probiotic supplements we have reviewed.

TruBiotics is available in-store or online through Walgreens, CVS, and Rite Aid. It is likely that you will save more with this product but you would be missing out on certain probiotic strains.

  • Walgreens: 30-count $18.99; 45-count $29.99
  • CVS: 30-count $21.99
  • Rite Aid: 3-count $14.99

The Bottom Line

Bio Complete 3 ingredients may offer support in weight management, though some studies used higher doses to achieve results.

The available research also supports the benefits of probiotics in relieving GI issues, with clinical trials being performed in humans.

To achieve the effects of weight loss, however, you should also include a daily routine exercise, and a well-balanced diet to achieve the same results.

Probiotics may offer benefits that support a variety of digestive and health-related issues. However, it is important to first identify the source of any symptoms you may be experiencing.

Further, the proprietary blend of probiotics in Bio Complete 3 has been studied extensively, especially as it pertains to improving the balance of good and bad bacteria that lines your GI tract.

However, because the proprietary blend of ingredients contained in Bio Complete 3 is smaller when compared to dosage in studies, it may not provide the proposed benefits.

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Customer Reviews

4.1 Stars out of 147 Reviews
5 Star:36% 4 Star:48% 3 Star:6% 2 Star:2% 1 Star:6%
88% Recommend This Product
Start your review of Gundry MD Bio Complete 3:
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Posted on Mar 6, 2021

Finally relief

By Sharon T., Athens, GA, Verified Reviewer

Bio Complete 3 has saved me. I have irregular movements, several times daily. Usually loose and with urgency. I could never bend over with confidence or let gas pass. Now, urgency is gone and I am regular with normal consistency and frequency. What a relief to be free again without fear of accidents.

Length of Use: 3–6 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Promote regularity

Promote good consistency/shape of BM

Removes urgency, one and done

Symptoms return when product stopped

Price makes hard to keep constant use

Posted on Mar 6, 2021

Better than I could have hoped for!

By Bridget W., Alabama, Verified Reviewer

I have combined the Bio Complete 3 supplement with a 30-day Arbonne program. I feel better than I have in 20+ years! My stomach issues have disappeared and I was able to stop taking my stomach meds that I thought I'd be on for the rest of my life!

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

How I feel

Better bowel movements (once per day)

Easy to take

No “cons” were specified in this review

Posted on Mar 6, 2021

Feeling much better!

By Laura U., Milwaukee, WI, Verified Reviewer

I was skeptical but willing to try anything to feel better. I am pleased to report it worked as advertised.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Works like advertised

Too many pills to take

Too expensive

Posted on Mar 5, 2021


By Barbara B., Woodstock, GA, Verified Reviewer

More energy, digestion greatly improved, and problem with gas after eating is gone. I am a senior (91) and in good health (no prescriptions). This product is excellent.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Capsules easy to swallow

Results showed improvement in 2 weeks

Digestion greatly improved

No “cons” were specified in this review

Posted on Jan 21, 2021

Back to business

By Joseph B., Wildomar, CA, Verified Reviewer

I had digestive issues for two months that resulted in a 30-pound weight drop. Not good. I started using Bio Complete 3 and in less than 2 weeks, my body was back on schedule. I could eat like normal and started having my morning meetings in the bathroom as I once had. I'm getting back to my healthy weight and couldn't be happier.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons


Pill size

Ingredients found nowhere else

Price, if I had to pick something

Helpful Review? 1 Person Has Voted

Posted on Jan 4, 2021

I have used this for 6 weeks now and find absolutely no effects

By Ian K., Edmonton, Alberta, Canada, Verified Reviewer

From my 6-week usage, I believe that this product is truly useless. I have found no effects, positive or negative. I think that it is a complete waste of money and would recommend that people avoid this.

Length of Use: Less than 3 months

Bottom Line: No, I would not recommend this to a friend

Pros and Cons

No “pros” were specified in this review

It did not have any effect that I was able to see

Company Response from Gundry MD

Jan 6, 2021

Hi Ian, this is Aria from Gundry MD here! I apologize for your negative experience using this product. Some of our customers see a difference in 30 days, while others see a difference in 90 days - it really does depend on the person. We always stand by our 90 Day Money Back Guarantee! Please feel free to email me directly at aria@gundrymd.com for more information on this.

Posted on Oct 16, 2020

Did nothing noticeable

By Peter B., Vancouver, Canada, Verified Reviewer

It feels like I got the placebo of an experimental study. I bought four bottles and after the first, there is NO difference in how I feel - still weak and much pain in shoulder and knees. I feel like a member of the placebo group now that I read all the positive comments on this site.

Length of Use: Less than 3 months

Bottom Line: No, I would not recommend this to a friend

Pros and Cons

The hype of the sales pitch

Like sugar pills

Company Response from Gundry MD

Nov 25, 2020

Hi Peter, this is Aria from Gundry MD here! We're sorry to hear that you did not enjoy your experience. We understand that while the majority of our customers are happy with our products, everyone is different. We always stand by our 90 Day Money Back guarantee. Please feel free to email me directly at aria@gundrymd.com for more information on this.

Helpful Review? 1 Person Has Voted

Posted on Sep 23, 2020


By Dawna C., The Dalles, OR, Verified Reviewer

Just hit the 90-day marker. At 30 days I was optimistic, 60 days discouraged, but kept on. 90 days, disillusioned. After reading all that taking Bio Complete # could do I whipped out my credit card and purchased 6 bottles. It sounded like the answer to my prayers. I gave 3 to my daughter feeling assured that a miracle was going to happen. We both have had problems with bloating and constipation, she's had tummy problems since birth. I've been also dealing with an ulcerated leg wound for over a year. I changed my eating habits, dedicated myself to this (every day my daughter and I remind each other to take 4 pills), and an open mind.

During these 90 days, BMs are more frequent, I lost 10 lbs. But, the leg wound worsened, no energy, no feeling good. Still had occasional cramps, still have skin issues, my daughter experienced pretty much the same (except the wound). And I'm still paying on a credit card.

Length of Use: 3–6 months

Bottom Line: No, I would not recommend this to a friend

Pros and Cons

Banana flavor

Decent size capsule easily swallowed

More regular BM

Took forever to notice any benefits

Didn't heal my leg

Didn't make me feel better

Helpful Review? 1 Person Has Voted

Posted on Jul 25, 2020

What I have been missing for years

By Kristen Z., Denver, CO, Verified Reviewer

I feel good again! I no longer have pain in my stomach or stomach aches. I can eat the food I want to and not experience discomfort. I no longer have bloating. I’m happy to have discovered this product, it has changed my daily life.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

How quickly it works

No bloating

No more stomach pain

No “cons” were specified in this review

Helpful Review? 2 People Have Voted

Posted on Jul 25, 2020


By Frank C., Tinley Park, IL, Verified Reviewer

I was very skeptical at first. I read all the reviews and was thinking to myself can this product really work. I liked everything I heard and read but in the back of my mind I thought to myself could this product really deliver?

Well, it didn't take long, within the first week of taking Bio Complete 3 I was amazed by how I felt. It was a pure cleansing of my digestive system. I couldn't believe how good I felt. I had more energy and felt light on my feet. I really couldn't believe it. I am telling you this product works. Since my first bottle, I have bought 3 more. I take 2 tablets in the morning and 2 at night and I feel like a new man. I am 58 years old and since I started taking Bio Complete 3 I have been watching what I eat and have lost 9 lbs. Losing weight was just a bonus for me.

Again, Gundry MD is not paying me to write this, I promise you. I found a great product and I just thought I would share this info with you. You will not be disappointed. God bless.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons


Felt freeing

Light on my feet

The first time I took the product I felt pain in my abdomen, that was the only time I felt pain

Helpful Review? 2 People Have Voted

Posted on Jul 24, 2020

My gut feels fantastic

By Yolanda C., Westerville, OH, Verified Reviewer

This product is everything. I noticed a big difference within a few days. I'm halfway through my first bottle. I was taking a pre and probiotic from another online doctor. I'm also taking Vital Reds and this combination has my insides feeling so good. I have switched my ordering to Dr. Gundry products. I love to watch and learn from his presentations, he is very clear and easy to understand.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 1 Person Has Voted
Showing 1-11 of 147

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