Bio Complete 3 Review: Is It Safe and Effective

By Rocklend Davis, Ph. D.
HighYa Staff
Updated on: Sep 4, 2020

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Bio Complete 3 is a dietary supplement containing a proprietary blend of prebiotics, probiotics, and postbiotics that is alleged to support gut health.

To date, most gut health research focuses on gut microbiota, which serves as the site that contains the highest number of bacteria.

Gut health is an extension of your immune system which employs a group of good cells/bacteria that work with the host to promote health.

Because Bio Complete 3 relies on probiotics, its group of bacteria helps develop the microorganisms in the gastrointestinal tract to promote balance and ensure optimal function.

Gundry MD claims that you will experience the following benefits with daily use of their dietary supplement:

  • Weight loss
  • Decrease levels of fatigue
  • Improved digestion
  • Decrease cravings
  • Immune system support

In this article, we will help you understand if there is any science backing these claims by reviewing the available research for the active ingredients.

Effectiveness of the Ingredients: Do They Support the Proposed Benefits?

A serving size is four capsules that contains a proprietary blend of ingredients:

  • Tributyrin (as CoreBiome ®): 1000 mg
  • Sunfiber®: 200 mg
  • Bacillus coagulans (ProDURA®) (2 billion CFU): 16 mg

According to the company, you need to take two capsules, which are absorbed quickly, twice per day before eating to experience benefits for your gut.

Below, we will go over the roles of these ingredients to see if the evidence supports the claimed benefits of Bio Complete 3:

Gas, Bloating, Diarrhea, and Constipation Relief

One of the many claims proposed by Gundry MD is the ability to reduce gas, bloating, diarrhea, and constipation.

Sunfiber® is a dietary fiber contained in the proprietary blend of Bio Complete 3.

Studies have found that a diet that is rich in dietary fiber can be an alternative to promote healthy weight while serving to promote a positive balance in the GI tract, and releasing and regulating hormones that associate with feelings of fullness.

A study demonstrated that Sunfiber®, when given in doses of 5 g/day, was able to normalize stool consistency and promote gut microbiota changes.

Bacillus coagulans is lactic acid and a probiotic culture that aids in the digestion of carbohydrates and proteins. B. coagulans can help to enhance the benefits of prebiotics to help promote the growth of more healthy gut bacteria.

B.coagulans was supplemented in 36 patients diagnosed with Irritable Bowel Syndrome. These patients experienced a significant decrease in clinical symptoms of bloating, diarrhea, vomiting, abdominal pain, and stool frequency.

Immune Support

Medical literature suggests that diets should include probiotics and prebiotics to enhance the immune response. When consumed in adequate amounts, probiotics and prebiotics may provide various health benefits.

A review was able to recently reveal the benefits of prebiotic and probiotics to enhance the immune response to seasonal influenza vaccine in healthy older adults. However, the amount in this study was more than double the amount contained in Bio Complete 3

The functional properties of dietary fibers, such as Sunfiber®, help protect against intestinal infections, activate bowel function, aid in nutrient digestion and absorption, and stimulate the immune response.

However, the dosage amount contained in the proprietary blend of Bio Complete 3 is much less than was used in the available literature, so it may not be adequate in providing the proposed benefits for immune support.

Weight Loss Aid and Decreased Cravings

Partially hydrolyzed guar gum (PHHG), now named Sunfiber®, is currently being used in various forms in beverages, food products, and medicinal foods.

Guar Gum is a dietary fiber and, due to its gel-forming capabilities, is involved with reducing macronutrient absorption and slow gastric emptiness.

Tributyrin is a compound of butyrate that is composed of a short-chain fatty acid that serves as a versatile molecule that is produced in the gut by fermenting dietary fiber and can be enriched in butter and other dairy products.

Butyrate has shown some promising effects in various diseases, including obesity, diabetes, inflammatory bowel disease, and colorectal cancer.

A study of Tributyrin suggests that oral administration of 2g/kg of tributyrin 3 times per week effectively protects against a diet-induced obesity and insulin resistance in mice.

The study showed that tributyrin was directly linked to the inhibition of the proinflammatory mediator production of the white blood cells, protecting skeletal muscle against insulin resistance.

Muscle and Joint Pain Relief

More research is required to determine the role of the proprietary blend of the ingredients in Bio Complete 3 for alleviating symptoms of achy muscle and joints.

However, an older study found a decrease in the inflammatory response. Improved muscle integrity was the most effective when B. coagulans were administered with hydroxymethyl butyrate.

Further, butyrate may serve a role in strengthening the intestinal barrier function.

A study done in both humans and mice produced data that suggests a preventative approach for inflammatory diseases by targeting impaired intestinal barrier function.

This study suggests that a dose of 1 g butyrate may be able to decrease the onset of arthritis from occurring, which is similar to the dosage that is contained in Bio Complete 3.

The benefits proposed by Gundry MD for the Bio Complete 3 may provide varying results due to dosages that are much less than the ones used in the available studies.


Tributyrin, when taken orally, can be safe at lower doses, but higher doses greater than 10 g/kg can be toxic. However, the dosage contained in Bio Complete 3 is only 1 g.

No adverse effects were noted when PHGG/Sunfiber® was provided in a study at a dose of 5 g/day in patients with chronic abdominal pain and IBS.

B. coagulans have a history of safe consumption in humans, as indicated from a review of toxicology testing studies.

When comparing dosage amounts, a study found that a B. coagulans dose of 2x10(9) CFU/day was found to be safe and effective in diarrhea-predominant irritable bowel syndrome for 90 days of supplementation.

It is best to take the Bio Complete 3 dietary supplement as indicated on Gundry MD's website. Dosing of any amount should never be increased.

While the safety profile for Bio Complete 3 is favorable, it may not address the underlying cause of your problem.

Therefore, you should seek your physician's opinion if you are experiencing issues affecting your quality of life.

Pricing and Return Policy

Bio Complete 3 is available for sale on Gundry MD’s website and they have options available to provide you savings.

  • 1 Bottle (30 capsules): $49.95
  • 3 Bottles: $134.85
  • 6 Bottles: $254.70

Orders that are over $60 ship for free in the US.

Gundry MD provides a 90-day money-back guarantee, however, this does not cover shipping and handling. In order to process your refund, you will have to contact customer service.

Alternatives to Bio Complete 3

TruBiotics by One A Day could be another option to support digestive and GI health.

TruBiotics offers 2 probiotic strains that have been studied extensively and it is reasonably priced when compared to the many probiotic supplements we have reviewed.

TruBiotics is available in-store or online through Walgreens, CVS, and Rite Aid. It is likely that you will save more with this product but you would be missing out on certain probiotic strains.

  • Walgreens: 30-count $18.99; 45-count $29.99
  • CVS: 30-count $21.99
  • Rite Aid: 3-count $14.99

Pros and Cons

  • Research provides scientific support of probiotics for GI health
  • Prebiotics, probiotics, and postbiotics are identified as being generally recognized as safe
  • 90-day money-back guarantee
  • Lack of strong research supporting decreased levels of fatigue
  • Product effectiveness in weight loss and management requires exercise and diet

The Bottom Line

Bio Complete 3 ingredients may offer support in weight management, though some studies used higher doses to achieve results.

The available research also supports the benefits of probiotics in relieving GI issues, with clinical trials being performed in humans.

To achieve the effects of weight loss, however, you should also include a daily routine exercise, and a well-balanced diet to achieve the same results.

Probiotics may offer benefits that support a variety of digestive and health-related issues. However, it is important to first identify the source of any symptoms you may be experiencing.

Further, the proprietary blend of probiotics in Bio Complete 3 has been studied extensively, especially as it pertains to improving the balance of good and bad bacteria that lines your GI tract.

However, because the proprietary blend of ingredients contained in Bio Complete 3 is smaller when compared to dosage in studies, it may not provide the proposed benefits.

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Customer Reviews

Start your review of Gundry MD Bio Complete 3:
  • 141 Customer Reviews
  • 88% Recommend This Product
4.0 out of 5
5 star: 34% 4 star: 51% 3 star: 6% 2 star: 2% 1 star: 5%

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  • Did nothing noticeable

    • By Peter B.,
    • Vancouver, Canada,
    • Oct 16, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    It feels like I got the placebo of an experimental study. I bought four bottles and after the first, there is NO difference in how I feel - still weak and much pain in shoulder and knees. I feel like a member of the placebo group now that I read all the positive comments on this site.

    Pros and Cons:

    • The hype of the sales pitch
    • Like sugar pills

    Bottom Line: No, I would not recommend this to a friend

  • Disappointed

    • By Dawna C.,
    • The Dalles, OR,
    • Sep 23, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    Just hit the 90-day marker. At 30 days I was optimistic, 60 days discouraged, but kept on. 90 days, disillusioned. After reading all that taking Bio Complete # could do I whipped out my credit card and purchased 6 bottles. It sounded like the answer to my prayers. I gave 3 to my daughter feeling assured that a miracle was going to happen. We both have had problems with bloating and constipation, she's had tummy problems since birth. I've been also dealing with an ulcerated leg wound for over a year. I changed my eating habits, dedicated myself to this (every day my daughter and I remind each other to take 4 pills), and an open mind.

    During these 90 days, BMs are more frequent, I lost 10 lbs. But, the leg wound worsened, no energy, no feeling good. Still had occasional cramps, still have skin issues, my daughter experienced pretty much the same (except the wound). And I'm still paying on a credit card.

    Pros and Cons:

    • Banana flavor
    • Decent size capsule easily swallowed
    • More regular BM
    • Took forever to notice any benefits
    • Didn't heal my leg
    • Didn't make me feel better

    Bottom Line: No, I would not recommend this to a friend

  • What I have been missing for years

    • By Kristen Z.,
    • Denver, CO,
    • Jul 25, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I feel good again! I no longer have pain in my stomach or stomach aches. I can eat the food I want to and not experience discomfort. I no longer have bloating. I’m happy to have discovered this product, it has changed my daily life.

    Pros and Cons:

    • How quickly it works
    • No bloating
    • No more stomach pain
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Outstanding

    • By Frank C.,
    • Tinley Park, IL,
    • Jul 25, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I was very skeptical at first. I read all the reviews and was thinking to myself can this product really work. I liked everything I heard and read but in the back of my mind I thought to myself could this product really deliver?

    Well, it didn't take long, within the first week of taking Bio Complete 3 I was amazed by how I felt. It was a pure cleansing of my digestive system. I couldn't believe how good I felt. I had more energy and felt light on my feet. I really couldn't believe it. I am telling you this product works. Since my first bottle, I have bought 3 more. I take 2 tablets in the morning and 2 at night and I feel like a new man. I am 58 years old and since I started taking Bio Complete 3 I have been watching what I eat and have lost 9 lbs. Losing weight was just a bonus for me.

    Again, Gundry MD is not paying me to write this, I promise you. I found a great product and I just thought I would share this info with you. You will not be disappointed. God bless.

    Pros and Cons:

    • Cleansing
    • Felt freeing
    • Light on my feet
    • The first time I took the product I felt pain in my abdomen, that was the only time I felt pain

    Bottom Line: Yes, I would recommend this to a friend

  • My gut feels fantastic

    • By Yolanda C.,
    • Westerville, OH,
    • Jul 24, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    This product is everything. I noticed a big difference within a few days. I'm halfway through my first bottle. I was taking a pre and probiotic from another online doctor. I'm also taking Vital Reds and this combination has my insides feeling so good. I have switched my ordering to Dr. Gundry products. I love to watch and learn from his presentations, he is very clear and easy to understand.

    Bottom Line: Yes, I would recommend this to a friend

  • Bio Complete 3 has allowed me to eat in restaurants again

    • By Cynthia F.,
    • Allenwood, PA,
    • Jul 23, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    I have had side effects from radiation treatments. I could not eat at restaurants due to my digestive system going crazy. My surgeon recommended that a probiotic may be helpful. Perhaps they improved my system somewhat but not really noticeable. I watched your presentation on PBS, didn't act right away but did a little research before ordering.

    These have proven to be good for me. I feel much better and I am pleased with the results. I am eating in restaurants more successfully these days.

    Pros and Cons:

    • My digestive system is much more calm
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Bio Complete 3

    • By Judy J.,
    • Gainesville, GA,
    • Jul 22, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    The formula includes three of the key ingredients necessary for digestion and overall health. I'm very satisfied with my overall product purchases from this company and plan to build an arsenal of supplements necessary for bodily function.

    Pros and Cons:

    • Formulation
    • Healthy feeling
    • Ease and convenience
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Review of Bio Complete 3

    • By Susan T.,
    • York, PA,
    • Jul 21, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I have been taking the product for 3 weeks and feel confident about this product. The proof is in the pudding as I am now doing at least 2 bowel movements per day, which is healthy. The product never made me feel queasy as some customers have said but I imagine it takes time for the body to adjust to it anyway so hang in there. I added Total Restore in there about 1 week ago and I feel fine. A few other results are that I have a better night's sleep now and only seem to need to eat smaller meals 3x per day with no desire for snacking. However, I do take a whole course of supplements to help with nutritional balance. I am hoping to lose that final 10 pounds with my lower calorie intake! I am retired so I am hoping that the price on Bio Complete and Total Restore comes down after my initial 6-month run.

    Pros and Cons:

    • Got a good deal on a 6-month supply
    • Sleep better
    • Have better bowel movements more regularly
    • The individual bottle is quite expensive

    Bottom Line: Yes, I would recommend this to a friend

  • Bio Complete 3 is helping my digestion every day

    • By James L.,
    • Scottsdale, AZ,
    • Jul 20, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    Bio Complete 3 helping my digestion every day. I could tell it was working on Day #2, and now I find it is even more effective when I take one extra pill in the evening (2 each with my two biggest meals, plus 1 more in the evening.) I was very, very skeptical that I would be able to detect any improvement, but am relieved that I can tell the difference each and every day. Try it out!

    P.S. My first 7 bottles arrived on a blazing hot Arizona day (about 105 degrees) and the U.S. Postal service left it in the direct sunlight near my front door without ringing my doorbell. NOT good for digestive products. No one knows if it would be MORE effective if it had not sat in the blazing hot sun for an hour! (Dumb.)

    Pros and Cons:

    • It did not take weeks and weeks to be effective
    • It actually helps my digestion, despite my huge skepticism
    • It is not dangerous for me to take an extra pill, like many medications warn
    • My first 7 bottles arrived on a blazing hot Arizona day (about 105 degrees) and the U.S. Postal service left it in the direct sunlight near my front door without ringing my doorbell.

    Bottom Line: Yes, I would recommend this to a friend

  • Migraines almost disappeared!

    • By Andrea B.,
    • Vancouver, British Columbia, Canada,
    • Jul 17, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    I started taking Bio Complete 3 because I suspected I had leaky gut syndrome and didn't want to do an extreme diet to help heal it. I am overall a very healthy person but as a result of taking pain medications from 20+ years of migraine headaches, it was taking its toll on my gut health. My migraines have reduced by more than 80% and it has improved my regularity and reduced gas and bloating.

    Pros and Cons:

    • Reduction of migraine headaches after 30 days of regular use
    • Improved digestion
    • I had some episodes of extremely heavy periods while taking it and wondered if it had an effect of building up my endometrial lining too much, or just coincidence?

    Bottom Line: Yes, I would recommend this to a friend

  • My Bio Complete 3 satisfaction success story

    • By Steve G.,
    • Mentor, OH,
    • Jul 16, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    I feel excellent after my morning smoothie and 2 capsules of Bio Complete 3. I also take M Vitality for an extra immune system boost. Two more capsules before dinner. I am 66 and frankly, I've never felt better. I feel strong and I've stayed healthy all of 2020. I've peaked on my weight loss plan, a keto diet with the aid of MCT Wellness. Since the 1st of the year, after losing 35 lbs, the weight loss leveled off and I needed to change up my strategy. I still avoid carbs and lectins, I fast during lunch, keep hydrated the rest of the day and have a sensible protein and dark green vegetable dinner. Now, with Bio Complete 3, I have more energy in the early afternoon, I'm more alert in the evenings. I am maintaining the lower weight and am starting to now see belly fat reduction. Much kinder bathroom visits as well. I believe my new health plan is a winner! Thanks, Dr. Gundry.

    Pros and Cons:

    • Gut health and weight loss benefits
    • Small, easy to swallow capsules
    • Reasonable pricing
    • Noticeable benefits
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

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