Gundry MD Bio Complete 3 Review - Does It Work?

By HighYa Research Team
Updated on: Jun 19, 2020

Medically Reviewed by Anthony Dugarte, M.D., C.S.C.S

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Bio Complete 3 is a supplement that claims to improve your gut health and combat leaky gut through butyrate and fiber.

A bottle of Bio Complete 3 has a 30-day supply of capsules. According to the company website, two capsules should be taken twice daily.

Our review of Gundry’s Bio Complete 3 will examine how to take it an what it does, what its ingredients are, and the scientific evidence for the supplement’s efficacy.

Bio Complete 3 Ingredients: Do They Work?

Each capsule contains the following main ingredients:

  • Tributyrin: 1,000 mg
  • Sunfiber: 200 mg
  • Bacillus coagulans: 16 mg (2 billion CFU)

Tributyrin is a form of butyrate, a short-chain fatty acid that probiotic bacteria produce as they break down starches. Butyrate is formed by the fermentation of unabsorbed carbohydrates and is known as a post-biotic.

Sunfiber is what’s known as a “prebiotic” or food that your body’s probiotics need. In addition to supporting the actions of probiotics, they are thought to benefit weight management, digestive health, and immune function.

The final ingredient, bacillus coagulans, is a probiotic. These friendly gut bacteria live in your gut and may offer a wide array of health benefits.

The core of Bio Complete 3’s claimed efficacy is butyrate, a “postbiotic” that your body typically produces as good bacteria work in your stomach and intestines.

By taking postbiotic as a supplement, you supply it to your intestines as an addition to what your body is already making.

Butyrate in low concentrations (<2mM) in your intestines can be helpful but that taking too much (5 or 8mM) of it can harm your intestinal barrier. The 1000mg of tributyrin in Bio Complete 3 falls well within the safe range.

The studies that analyzed butyrate’s effect on the intestinal lining were done in a laboratory setting, so it is unclear if these levels are comparable to what would be safe in real life.

As for helping with weight loss, the analysis said the current research indicates some positive results in mice, but there were no mentions of human studies.

With that said, the preliminary research is promising that butyrate can help with weight loss in obese individuals.

A few studies showed that levels of butyrate could contribute to obesity instead of combating it. Keep in mind, these findings were in laboratory and animal models; this does not guarantee the same effects in humans.

We talked with a Seattle-based doctor who told us that butyrate is helpful in some cases but not in most. That is because it takes evaluation to understand if taking supplemental butyrate will solve the issues the patient is dealing with.

Another source, board-certified gastroenterologist Dr. Lawrence Hoberman, told us that butyrate plays an important role in nourishing the lining of the colon.

While he didn’t say how effective butyrate could be when consumed as a supplement, he said you can boost your production of it by taking prebiotics and probiotics that promote the growth of the good bacteria that produce butyrate.

Finally, an additional study in a 2011 edition of the World Journal of Gastroenterology analyzing existing studies about butyrate’s effectiveness found myriad uses fatty acid. However, more studies would need to be done to pinpoint for which conditions it works best, HighYa’s medical advisor Dr. Jason Reed, PharmD, said.

As for Bio Complete 3’s other ingredients, there’s extensive literature supporting the benefits of taking fiber (Sunfiber) and probiotics.

Daily doses of B. coagulans MTCC 5856 at 2 billion CFU improved digestive symptoms and reduced inflammation in 40 patients with IBS.

Gundry MD does not share the specific strain of B. coagulans, however. This makes it challenging to compare to the available literature as the effects are strain specific.

Tthe study says the probiotic had a positive effect on IBS patients. This does not mean that it will have a positive effect on healthy patients. More studies would have to be done to find out if taking bacillus coagulans would be worth taking for healthy people, Reed said.

Sunfiber may also offer benefits, particularly in those with IBS. Three grams per day over a week improved bloating and gas when compared to placebo. Though benefits were seen, doses more than 10x higher than what is offered by Bio Complete 3 were used.

Also, similar results may not be seen in healthy subjects.

Takeaway: Although some support exists for these ingredients, results seen in laboratory and animal settings may not relate to human subjects. More research is needed to support the claims made by Gundry MD.

Safety and Side Effects

Earlier, we’d mentioned that the Gundry MD phone rep told us that those who are new to gut supplements should start with two capsules a day.

This is because taking four capsules could have a pretty substantial effect on your gut; the phone rep used the word “shock.”

Also, taking butyrate at doses much larger than what is found in Bio Complete 3 may actually damage the lining of your digestive tract.

You may experience mild gas and bloating, which are commonly reported side effects with probiotic use. These symptoms are easily relieved by reducing the dose or discontinuing the supplement.

Cost and Return Policy

This supplement comes at three price points:

  • 1 Bottle: $69.95
  • 3 Bottles: $188.95
  • 6 Bottles: $353.70

Gundry MD covers their supplements with a 90-day, money-back guarantee. If you aren’t happy with Bio Complete 3 within the first 90 days after your purchase, you can contact customer support at (800) 852-0477 to start your refund.

Their website says that they’ll process your refund with “no questions, no hassle.” We read through the fine print and found no hidden rules or exceptions that negate the guarantee.

The Bottom Line

This supplement presents some serious question marks about its ability to follow through on its claims to improve your gut health and help you lose weight.

There isn’t a consensus among medical experts that taking butyrate supplements will provide the benefits found in testing done in labs and on animals. Therefore, we think buying this supplement is a risk because the outcome is unknown.

That being said, the fiber and probiotics the supplement contains are a starting point if you’re looking to improve your gut health.

Fiber, in particular, is well-known for helping with regular bowel movements, lowering glucose levels, and dropping your blood cholesterol.

Probiotics are a burgeoning field with new research appearing regularly.

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Customer Reviews

Start your review of Gundry MD Bio Complete 3:
  • 125 Customer Reviews
  • 88% Recommend This Product
4.0 out of 5
5 star: 29% 4 star: 55% 3 star: 7% 2 star: 1% 1 star: 6%

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  • After 2 days my whole gut bloated out and sent me to the ER

    • By Jacqua M.,
    • Cheney, WA,
    • Jun 25, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    First, I'm not quitting.

    After that horrifying experience, I seriously thought I was going to explode.

    However, I made up my mind, paid the money, and truly believe this is cutting edge.

    I'd just never introduced pri/pro/post biotics to my system ever and the directions were to take for a day... I swelled like a hot air balloon.

    I figured out what must have taken place.

    Stopped for three days and took 2...I'm bloating again but I realize my body simply needs to clean out readjust and repair!

    Thank you Dr. Gundry.

    Pros and Cons:

    • Gives hope
    • Still in the beginning
    • Gas
    • Bloating
    • Difficulty breathing from the pressure

    Bottom Line: Yes, I would recommend this to a friend

  • Six bottles

    • By George P.,
    • Albuquerque, NM,
    • Jun 13, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I was so looking forward to this product working for me. Sadly, after finishing a bottle and half of Bio Complete 3 over the last month and a half, the product has not had any effect on me. I know there is a money-back guarantee, and I hope I can get my money back. Please advise on how to proceed, thank you.

    Pros and Cons:

    • I received the product promptly
    • It did not work for me

    Bottom Line: No, I would not recommend this to a friend

    • Jun 15, 2020

      Company Response from Gundry MD

      Hi George, thank you for giving Bio Complete 3 a try and I'm sorry to hear that our Bio Complete 3 was not the right fit for you. I've gone ahead and escalated your order for a full refund - please keep an eye out for a confirmation email within the next 3-5 business days. If you have any other questions, please don't hesitate to reach out to me at Thank you.

  • Week 3 and terrible pain in back

    • By Kim H.,
    • Dallas, TX,
    • May 30, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I am on week 3 of 4 Bio Complete 3 capsules every morning. I have been experiencing bloating all along and now have developed a worsening pain in my back at the waist which, I presume, is from gas. Will this eventually get better? Do I need to take fewer capsules? Advice?

    Bottom Line: Yes, I would recommend this to a friend

    • Jun 1, 2020

      Company Response from Gundry MD

      Hello Kim, I’m so sorry to hear that this was your experience. It sounds like you might be experiencing “Die Off” symptoms. This often occurs when probiotics are introduced to the gut and begin killing off the bad bacteria. As always, we ask that you consult your primary care physician prior to trying a new product to ensure that you do not experience any interactions while taking them. Because everybody is different, we do understand that our products may work well for some and not others. If you would like to return the product, I can begin the refund process for you right away! Just e-mail me at

  • Gut and muscle pain

    • By Karry P.,
    • Florida,
    • May 23, 2020
    • Verified Reviewer
    Overall Experience:

    It took a while but I started to feel better. I had severe gut pain that slowly tapered off. Now, I do not have that pain.

    In addition, I had very tight muscles that would pull my hips and back out of place. Those are loosening, and I feel much better. Thank you.

    Bottom Line: Yes, I would recommend this to a friend

  • Bio Complete 3

    • By Robin R.,
    • Summerton, SC,
    • May 23, 2020
    • Verified Reviewer
    Overall Experience:

    Still trying at less dosage, it does help, nothing further at this time. Thanks. I will continue using until I get to 30 days then decide if I will continue or cancel my subscription, not there yet.

    Bottom Line: Yes, I would recommend this to a friend

  • Parameters to know if product is working

    • By Krista A.,
    • Stouffville, Ontario, Canada,
    • May 22, 2020
    • Verified Reviewer
    Overall Experience:

    I am taking Bio Complete 3 because I see the importance of a healthy colon. My dad died of colon cancer so it is important to me. I do find it difficult to know if there is an improvement or not. It would be great to have some sort of test to determine this. I like the idea of this product and will continue to take it in hopes that it will heal and prevent illness down the road. I haven't had a supply for over a month due to delivery issues and because I am not perfect on the Gundry diet I am not sure if it is my eating or the lack of this supplement which may be causing the cramping and constipation issues. Unfortunately, it takes a long time for the product to arrive and the cost goes up with the exchange rate and additions fees coming from the US.

    Bottom Line: Yes, I would recommend this to a friend

  • I am not hungry anymore!

    • By June S.,
    • Savannah, GA,
    • May 22, 2020
    • Verified Reviewer
    Overall Experience:

    Before I took Bio Complete 3, my issue was not digestion. It was more about over digestion and constant feeling of hunger. Of course, I gained weight over the last year. Since I took this, the most noticeable change is that I don't feel hungry anymore. I was able to control my unhealthy eating habit a lot more mindfully, and slowly but surely, I've been losing weight. Hope it keeps moving this way!

    Bottom Line: Yes, I would recommend this to a friend

  • Review of Bio Complete 3

    • By Connie C.,
    • Tennessee,
    • May 21, 2020
    • Verified Reviewer
    Overall Experience:

    I'm feeling better each day. I'm going on week 3 of the Bio Complete. But I still feel weak and tired. I have lost 10 pounds so far. I can't wait to see how much I'll improve in a 6 to 8 week time for overall health.

    Bottom Line: Yes, I would recommend this to a friend

  • Making major changes to a "healthy diet."

    • By Patricia V.,
    • Vacaville, CA,
    • May 21, 2020
    • Verified Reviewer
    Overall Experience:

    My abdominal pain is mostly gone but I can't tolerate iceberg lettuce with the evening meal. I live in a senior facility with limited choice and have been confined to my apartment for meals since 3/17. It took me a while to understand the diet evolution even after I got the book but I have been following it as best I can. After the abdominal pain was conquered, my concentration is on weight loss and I am in the 1st phases which is working (my scale is unreliable but there is one in our activity room that I can use). I think I've lost 7 pounds and will keep at it until I lose at least 20. Maybe then I can try to follow the very restrictive Leaky Gut Diet.

    Bottom Line: Yes, I would recommend this to a friend

  • I'm not sure just yet.

    • By Melinda L.,
    • Ontario, CA,
    • May 21, 2020
    • Verified Reviewer
    Overall Experience:

    I was using the Bio Complete 3 along with two tsp of Metamucil in water every morning. I've been experiencing some trapped gas pain at night when laying down, enough to hurt all the way through to my back. I have to get up and walk around and sometimes take Gas-X to stop the pain. I stopped using the Bio Complete 3 for a few days and now I've stopped the Metamucil I was also using and have re-started the Bio Complete 3. We will see if this resolves my issues. Fingers-crossed.

    Bottom Line: Yes, I would recommend this to a friend

    • May 21, 2020

      Company Response from Gundry MD

      Melinda, thank you for sharing and for giving Bio Complete 3 a try. As always, we ask that our customers consult their physician prior to starting any new supplement to ensure it is the right fit for them. Please keep us updated and feel free to reach out to me at if you decide that Bio Complete 3 is not the right fit for you and you'd like to return the product. Thank you.

  • Better life

    • By Lubna D.,
    • Arizona,
    • May 21, 2020
    • Verified Reviewer
    Overall Experience:

    It's a great way to have energy, I eat a lot less than before, I absolutely don't want to eat anything sweet. Within one week I didn't want anything sweet, if I drink juice I will take a sip and stop drinking because it tastes absolutely horrible. I'm more alive.

    Bottom Line: Yes, I would recommend this to a friend

Showing 1-11 of 125

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