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Physio Omega

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Physio Omega is an omega 3 dietary supplement that is alleged to promote energy and support heart health through the omega 3s EPA, DHA, and DPA. While omegas may offer some cardiovascular benefits, the available research may not justify the high price point for this product.


  • Some evidence supporting the cardiovascular benefits of omega-3s
  • Available research for DPA is promising
  • Favorable return policy


  • Very expensive when compared to similar products
  • Much of the research is mixed regain the benefits of EPA and DHA
  • More cent investigations describe
  • little to no impact for omega supplementation
  • More long-term research is needed to identify DPA’s true role

Physio Omega Review - Is It Effective and Safe?

By Anthony Dugarte, M.D., C.S.C.S

Updated on: Jun 9, 2020

What is Physio Omega?

PhysioTru claims that Physio Omega will promote brain and heart health, as well as reduce inflammation.

Omega 3s are fatty acids that are commonly supplemented for their suspected ability to influence many health benefits. Alleged benefits include:

  • Reducing the risk of heart disease
  • Boosting mental function
  • Fighting inflammation
  • Improving joint health
  • Promoting skin hydration
  • Reducing anxiety and depression

According to PhysioTru, Physio Omega may offer these benefits as it contains an omega that is typically not included in dietary supplements.

While most products offer eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), Physio Omega also provides docosapentaenoic acid (DPA). PhysioTru states that the benefits of DPA are research-backed.

In this article, we'll help you decide if the addition of a less well-known omega can add benefits above and beyond standard omega supplements by reviewing the available research for Physio Omega's key ingredients.

The Active Ingredients: Do They Work?

While Physio Omega offers both EPA and DHA, PhysioTru credits DPA for distinguishing their supplement from other products. Here, we'll highlight the available support, if any, for these claims.

According to the Supplement Facts Label, every 2 softgel serving contains 280mg of EPA, 240mg of DHA, and 60mg of DPA.


Omegas have been supplemented for quite some time. While there are more than 10 Omega-3 fatty acids, EPA and DHA are widely considered to be among the most important.

As cardiovascular health remains an issue worldwide, the ability of omega dietary supplements to help modify the risk has been well-studied.

In 2009, researchers reviewed the results of 11 studies that investigated the effects of EPA and DHA on heart health. They found that EPA/DHA dosing at 1.8 +/- 1.2 g/day reduced the risk for cardiovascular deaths, sudden death, and non-fatal events.

A 2012 study reviewed 21 clinical trials and found that omega 3s were effective in preventing cardiovascular events and death in those with higher cardiovascular risk.

A recent systematic review analyzed the results of nearly 80 randomized trials that investigated the effects of omega 3s on cardiovascular health. In their analysis, researchers found that boosting fatty acids through diet or supplementation had little to no effect on reducing the risk of heart disease, cardiac events, irregular heartbeats, stroke, or death from heart disease.

Thus they concluded that the best available evidence demonstrates that increasing EPA and DHA does not reduce the risk for heart disease or reduce the risk from dying of it. The individual trials that previously highlighted potential benefits for supplementation were more likely to include biases.

These systematic reviews demonstrate that the results from individual studies are variable. Benefits were demonstrated in the 2 smaller studies, though these included studies of shorter duration.

As heart disease is often progressive, including studies of up to 72-months may account for poor results found in the more recent and larger review.


Of the 3 omegas offered in Physio Omega, DPA is less well-studied.

In a randomized study examining patients with a recent heart attack, those treated with 1g of DPA daily experienced a reduced risk for death. Researchers concluded that DPA may have an antiarrhythmic effect that should be investigated further.

Researchers also found a blood pressure-lowering benefit in a review of 11 trials, though doses greater than 3g per day were needed for these effects.

Yet another study points towards a potential ability for DPA to protect against plaque build-up in arteries. Similar findings were demonstrated even in lifetime smokers.

While the individual studies highlight a great potential for DPA, more long-term randomized trials are needed to identify the true role in cardiovascular health.

Is Physio Omega Safe?

Omega 3 dietary supplements are generally safe when used as directed.

Reported side effects include bleeding, impaired immune function, and impaired lipid and glucose metabolism, though they are likely safe up to even 5,000mg per day.

Other side effects may include bleeding and reduced platelet function as well as impaired wound healing.

What is most likely to encounter, however, is stomach upset and belching a fishy flavor. Typically these side effects are relieved by reducing the dose or discontinuing use.

Nonetheless, be sure to include your doctor in the decision to use Physio Omega or any other supplement, especially if you're experiencing symptoms that may be related to heart disease.

What Is the Cost?

Physio Omega is available directly from the website and shipping is always free. By taking 2 softgels in the morning with water daily, a single bottle is priced at $67 and will last you 1-month.

You'll save by buying more. A single 3-bottle order is $47 per bottle, whereas 5 bottles cost $37 per bottle.

You also have the option to subscribe for auto-shipments. Membership will save you an extra 10% whether you opt for 1, 3, or 5 bottles.

PhysoTru gives you 60-days to try Physio Omega, though they'll provide a full refund only if don't consume more than 2 bottles during this period. Similarly, you'll receive a full refund if you return 1 opened bottle within 30-days.

If you're unsatisfied for any reason, email customercare@physiotru.com for a return authorization.

You can also find Physio Omega at Amazon. A 1-month supply is priced identical and backed with a 30-day return policy.


While it does seem as though DPA is less commonly included in Omega dietary supplements, Physio Omega is not the only product that offers it. In fact, with a little research, you can find more cost-effective options.

For example, a 3-month supply of EZ Omega-3 from WonderLabs is just $27.79 and offers roughly double the EPA, DHA, and DPA.

Another option is Wild Fish Oil from Wild Foods Co. Their 60-day supply offers 120-140mg of EPA and DHA each, as well as 10-20mg of DPA for just $14.95. Though this product offers fewer omegas than Physio Omega, you can double or triple your dose and still save money.

Thus, as you get more for much less, these options are likely to be a much better starting point given the price points and available research.

The Bottom Line

Physio Omega is an omega 3 dietary supplement that offers both EPA, DHA, as well as DPA. While EPA and DHA have classically demonstrated various cardiovascular benefits, more recent systematic reviews point out the shortcomings of earlier works.

DPA is not nearly as well-studied, though the available research shows promise. More long-term research is needed to identify the role for this omega 3.

When combining the mixed results and price point for Physio Omega, this supplement probably isn't worth the extra money you'd pay when compared to other similar products.

Nonetheless, at Amazon, 240 users rate Physio Omega 4.2-stars and more than 60% of these were 5-star ratings. Happy customers reported a gradual increase in energy, more hydrated skin, and improved lab test results.

While omega 3s may offer some benefit to you, you're still probably better off opting for one of the more cost-effective options described above.

Always speak to your doctor before use, especially if you feel you are at risk for heart disease.

Customer Reviews

3.1 Stars out of 18 Reviews
5 Star:38% 4 Star:16% 3 Star:0% 2 Star:5% 1 Star:38%
56% Recommend This Product
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Posted on Mar 31, 2020

Happy customer

By Patricia M., Laurinburg, NC, Verified Reviewer

I’ve been taking the supplement daily for approximately three months. I see a tremendous difference in my health. At first, I didn’t know what to attribute it to. In hindsight, has to be the omegas. I’m 57 and was a candidate for knee surgery. As of late, my knees are phenomenal and I seem to have better stamina and vigor. Don’t get me wrong, I do exercise daily, but I have noticeably been literally pain-free. It had to be the good omegas that appear to have lubricated my joints in some manner. I ordered a big shipment and have given a couple of bottles away. From now on they’ll get their own lol. I’m an advocate.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 2 People Have Voted

Posted on Jan 30, 2020

Big scam!

By Elizabeth F., Erie, PA, Verified Reviewer

I had to stop using this product as I could not stand the citrus taste in my mouth. Unfortunately, I could not return the product as it was passed the 60 days.

Please save your money as this product did not help me in any way.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 2 People Have Voted

Posted on Aug 1, 2019

So far so good

By Tom and Connie C., Dixon, IL, Verified Reviewer

I am notorious for buying things and then asking for a refund later.

My husband and I decided to try PhysioTru after reading all the benefits.

I have had high cholesterol all my life. My last lab test a week ago show my cholesterol is well within the normal limits, as well as my LDL, HDL, and triglyceride levels.

My husband has had three heart attacks in the past, and high blood pressure. At his last doctor appoint just yesterday, his blood pressure was 113/70! Almost unheard of for him!

It seems my digestive system has improved, and my weight (which is always hard to maintain), has been staying steady, even though I eat more than I should (almost unheard of for me!).

I cannot absolutely prove it's because of PhysioTru, but we have changed nothing else...so what else could it be?

We will continue to use this product. Well worth, when you consider the dangers of high blood pressure and high cholesterol!

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 22 People Have Voted

Posted on Apr 19, 2019

Customer service and return policy needs 100% change - it's BAD!

By Phil D., California, Verified Reviewer

I have used this product for several months and do not notice any difference. I believe that this product may be beneficial, but have not seen any proof of that. If the product is as good as the company says it is, why is it so hard to get a refund if a customer is not satisfied. Any customer service person that is rude to their customers should go find another job or be forced by your company to find another job.

If you are in a customer service job, you need to service the customer - politely, efficiently, and completely. OR FIND ANOTHER JOB.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 35 People Have Voted

Posted on Apr 3, 2019

What is the best Omega 3 oil

By Wilfred Bonner Pentreath M., Katikati, New Zealand, Verified Reviewer

Hi. I have been taking a well-known New Zealand band of Omega 3 oil for years. It is very good. They put the price up on an annual subscription by 14%, which rather annoyed me. So I looked around for the best Omega 3 oil. I did a lot of research and even did a chart comparison of the better Omega oil available. I looked at scholarly articles on Omega 3 oil and how much one should take. It sure was interesting learning about the balance of DHA - EPA - DPA.

Eventually, I settled on Physio Omega, and I am pleased I did as my blood pressure has dropped from 132/72 on March 6, 2019, to 118/67 on March 30, 2019. I sleep better, averaging seven hours sleep at 80 years of age with no toilet pit stops through the night. I am feeling more alerts. I take two tablets a day straight out of the deep freezer as recommended. One more thing about my blood pressure. I use to have to sit still for five or more minutes to get a low blood pressure reading. Now I can sit down and take it within a minute to get a great reading.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 35 People Have Voted

Posted on Feb 25, 2019

PhysioTru supplements

By Ken B., Ruidoso, NM, Verified Reviewer

I went to the doctor in November. Had a bad report. The doctor said my liver enzymes were high and that I had diabetes. Told me I had to lose weight to make sure my high liver enzymes were due to being diabetic and that he wanted to see me in 6 months. I ordered these supplements three days before my doctor's appointment. I ran out of my prescriptions so I had to see the doctor again. I have been taking these supplements faithfully. I was very nervous that the doctor was going to get upset since I had not changed my eating or drinking habits. Went in today and the doctor was scratching his head. No signs of high liver enzymes nor diabetes. He couldn’t explain it. The only thing I did change was taking these supplements. This is honestly quite surprising to me and the doc.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 26 People Have Voted

Posted on Feb 21, 2019

First time subscription

By Rhyanna B., Indiana, Verified Reviewer

After using this product for a couple of weeks now, I have noticed a slight change in digestion, not any significant change as of yet. I will write more of what I like later on. The one thing I don't exactly like about it is the size of the supplement, it's huge, almost like a horse pill, but not as big. It's also a long type of supplement, it's not round like a pill. I am not trying to scare you at all, but I figure if I can take this as frightened as I am, you should be fine with this.

I have a difficult time with huge pills, I am probably the worst ever cause I have panic attacks, if I have any effort swallowing a supplement or pill. I am able to get this down with little effort. I would suggest to please drink plenty of water while taking this, it just goes down better. Thank God it's a soft jell too, which does also help with swallowing.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 15 People Have Voted

Posted on Jan 16, 2019

PhysioTru products

By RJ J., New Jersey, Verified Reviewer

I have been taking all their products for over two months and I do not notice any change in the status of my stamina or my general health. They advertised a full refund if dissatisfied. I have contacted them twice and they have not even given me the courtesy of a response. These products may work for someone else, but if you are unfortunate like me, you will lose over $500 for something that does not do what it has stated.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 73 People Have Voted

Posted on Nov 14, 2018

This product sucks

By Kenneth S., Roanoke Rapids, NC, Verified Reviewer

This is a complete waste of time and money. They will not give you your money back, automatically send you the product without authorization, the product does not work as they advertise, it's a scam of some kind. They have no customer service that you can speak to. You send him an email and it gets rejected. This company's got serious issues.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 84 People Have Voted

Posted on Sep 25, 2018

Consumer beware...bad side affects and customer service.

By Joan M., Delray Beach, FL, Verified Reviewer

I experienced all of the bad side effects of this supplement, so I canceled my subscription. Having done so, I still received the next shipment without warning. Since that time I have kept all my correspondence with them in writing.

When I sent the order back (after several back and forth online conversations about doing so), they said they didn't receive it and refuse to give me a refund. The receipt for the return was in a car I owned that has since been stolen, so I cannot "prove" I sent it back. I found these "exchanges" with their customer service department to be snarky and offensive. So not only can they not follow directions, they are rude and condescending to deal with.

Consumer beware, not only of the side effects, but of the customer service.

Bottom Line: No, I would not recommend this to a friend

Helpful Review? 98 People Have Voted

Posted on Aug 25, 2018

Good product

By Rene P., Taunton, MA, Verified Reviewer

I have been using this product for just a short time, but it appears it is working already. I use to suffer fatigue in the afternoons, but I don't seem to be suffering from this condition anymore. I also anticipate an increase in energy in the next few weeks. I would recommend this product ONLY if you can afford the high price, which I consider unreasonable.

Bottom Line: Yes, I would recommend this to a friend

Helpful Review? 36 People Have Voted
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