Synbiotic 365 Review: Benefits, Effectiveness, Side Effects, Cost

By Derek Lakin
HighYa Staff
Published on: Sep 18, 2018

United Naturals advertises Synbiotic 365 as an advanced formula consisting of beneficial probiotic strains and prebiotic ingredients, that when combined, can deliver lasting relief from bloat and other embarrassing digestive issues.

Based on the available clinical evidence, can you realistically expect to experience benefits like these? Furthermore, is there supporting data that taking a combination product like Synbiotic 365 will deliver better results than a standalone probiotic supplement?

In this brief article, we’ll discuss the formula’s ingredients, pricing, and competition, all aimed at helping you make an informed decision. Before diving in, though, let’s clarify what we’re talking about.

What Is a Synbiotic Supplement?

Probiotics are specific bacteria strains that, when taken regularly as a dietary supplement, have been clinically shown to provide a wide variety of digestion-related benefits, in addition to boosting immune function.

Prebiotics, on the other hand, are certain ingredients that these bacteria use as an energy source upon arriving in your digestive tract.

» Related: Probiotics 101: A Beginner’s Guide

With these details in mind, ScienceDirect explains, whether referencing Synbiotic 365 or another formula, “Synbiotics are a combination of prebiotics and probiotics that are believed to have a synergistic effect by inhibiting the growth of pathogenic bacteria and enhancing the growth of beneficial organisms.”

Writing for Health.com, Anthea Levi tells us “the idea behind synbiotics is that adding prebiotics to a probiotic supplement can help ensure that the digestion-friendly microorganisms arrive in the gut alive and well. These supplements are said to be particularly useful for people with conditions like IBS, other bowel disorders, and diabetes.”

Cynthia Sass, RD, Health contributing nutrition editor, adds that when combined with probiotics, prebiotics can “also increase nutrient absorption and support bowel regularity.”

Taking a Closer Look at Synbiotic 365’s Ingredients

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 2.4 mg
  • Vitamin B2 2.6 mg
  • Vitamin B3 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 60 mcg
  • Vitamin B5 10 mg
  • Probiotic Blend 30 billion CFU – Lactobacillus acidophilus La-14, Bifidobacterium lactis Bl-04, Lactobacillus paracasei Lpc-37, Lactobacillus plantarum LP-115, Streptococcus thermophilus ST-21, Lactobacillus casei LC-11, Lactobacillus reuteri, Lactobacillus salivarius LS-33, Lactobacillus rhamnosus LR-32, Bifidobacterium bifidum BB-06, Bifidobacterium longum BL-05, Saccharomyces boulardii
  • Chicory Root Inulin 300 mg

Sites like WebMD, the Natural Medicines Database, and Examine.com report that the first eight vitamins in this formula are essential for maintaining human health. For example, B1 (thiamine) is essential in the breakdown of carbohydrates, B2 also helps digest carbs, as well as proteins and fats, while Healthline tells us that every part of your body needs B3 (niacin) to function correctly.

However, they also report that unless someone’s deficient in these vitamins, supplementing them likely won’t deliver meaningful health benefits.

» Related: Do You Need to Take Vitamins or Dietary Supplements?

Probiotic bacteria are identified by their genus (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

Lactobacillus acidophilus (whether contained in Synbiotic 365 or another supplement) was the first probiotic strain widely used, which seems to work especially well for irritable bowel syndrome (IBS) symptoms and urinary tract infections in children.

Among others, paracasei may relieve allergic symptoms and decrease skin sensitivity, plantarum produces its own antibiotics, casei may improve allergy symptoms and reduce cholesterol (along with reuteri), and rhamnosus has even been shown to help obese women lose weight.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be effective for constipation and airway infections, in addition to IBS and ulcerative colitis.

Finally, Streptococcus thermophilus could decrease the chances of kidney stones and increase anti-tumor activity, while Saccharomyces boulardii seems to be especially useful for addressing different causes of diarrhea.

Potential Synbiotic 365 Side Effects

As genera (the plural of genus), WebMD, Examine.com, and the Natural Medicines Database report that Lactobacillus and Bifidobacteria are likely safe for adults and children when taken as directed. Common side effects, if any, for the genera include mild, temporary intestinal gas or bloating, as well as stomach or intestinal upset.

» Related: Common Probiotic Supplement Side Effects

Outside of this, WebMD indicates Saccharomyces boulardii could rarely “cause fungal infections that can spread through the bloodstream to the entire body (fungemia).” No dosages or other specifics listed.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering. In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

We didn’t encounter anything with the same (or very similar) formulation as Synbiotic 365 during our research.

However, we did come across dozens of competing synbiotic supplements like Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), and Renew Life Women's Daily Probiotics plus Prebiotics ($28, 60 capsules).

From a high-level perspective, these supplements are alike in that they’re priced competitively with one another, and that each combines a relatively similar blend of probiotics, prebiotics, and other vitamins and minerals.

These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins like C and many within the B family, and even secondary ingredients like chicory root and different fruit extracts as energy sources.

Zooming in, the differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Is either of these criteria important when choosing a synbiotic supplement? Perhaps not. Here’s why:

First, while probiotics and prebiotics are certainly beneficial on their own, Cynthia Sass, RD, Health contributing nutrition editor, emphasizes: “Right now we don’t have a lot of data to show that synbiotics are more effective than, say, taking probiotics [supplements] and eating a diet rich in prebiotics.”

Next, even if they are eventually shown equally as useful, Cynthia emphasizes that "Your overall pattern of eating still has the greatest impact on your health protection or risk,” so “don’t think that taking [one of these supplements] means you don’t have to pay attention to your diet.”

Together, from a value perspective, she recommends that “until more comprehensive research is conducted on synbiotics, consider sticking to swallowing a probiotic supplement or eating probiotic-rich foods in addition to prebiotic foods.”

Our Bottom Line on Synbiotic 365

At $45 per box, Synbiotic 365 seems priced at the upper end of the spectrum compared to some other popular synbiotic supplements but has a middle-of-the-road price compared to probiotic supplements in general—some of which can near the $100 mark.

And as we outline in our Probiotic Supplement Buyer’s Guide, paying more for one of these supplements doesn’t typically translate into improved results, as reported by customers.

Other pointers we mention in the article include making sure the manufacturer provides a complete list of all the bacteria strains, as well as their dosage (as measured in colony-forming units, or CFU), both of which United Naturals lists for Synbiotic 365.

However, the company also adds a handful of vitamins that, according to sites like Examine.com and WebMD, might not provide much value for the money unless you’re deficient. Furthermore, we didn’t encounter any online customer feedback for Synbiotic 365 at the time of our research, and the company wasn’t listed with the Better Business Bureau.

Still, they advertise that all purchases come with a 30-day refund policy if the supplement doesn’t meet your needs, less S&H charges. Just make sure that you talk with your doctor first about overall value based on your diagnosis before ordering, as well as potential side effects or medication interactions.

» Recommended Reading: Best Grains, Fruits, and Vegetables That Improve Digestion

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Read 862 Synbiotic 365 Customer Reviews and Complaints

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Average Consumer Rating: 4.7
Rating Snapshot:
5 star: 681 4 star: 134 3 star: 16 2 star: 12 1 star:  19
Bottom Line: 96% would recommend it to a friend
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  • Editor’s Note: It is our understanding that this company has been asking its customers to leave feedback on HighYa. We assure you that each of these reviews has still been subjected to the same verification & vetting process that all submitted reviews go through. Learn More Here
  • 98 out 109 people found this review helpful

    No product received

    • Romeoville, IL,
    • Dec 15, 2018
    • Verified Reviewer

    I have called three times and tried to talk to a customer rep only to be disconnected after five minutes. I called their helpline and waited ten full minutes never to reach anyone. I traced the shipment to Salt Lake City where it is lost. You cannot even think of getting through to the USPS at this time of year. Therefore I want my order number 224481962 ordered on December 7th canceled immediately.

    Bottom Line: No, I would not recommend this to a friend

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  • 93 out 98 people found this review helpful

    United Natural processed my incomplete order

    • New York,
    • Jan 11, 2019
    • Verified Reviewer

    I was in the process of ordering Synbiotics 365 online. I filled out the payment info and I was pushed to buy more bottles and Enzym 365. I started getting alarmed by the aggressive sales technique, so I went online to check out reviews of the product. I read the reviews here and decided not to buy. I closed out the website without getting to the end to place the order. But I got an email from United Natural that says the order has been processed. I immediately replied, telling them I didn't complete the order. I got no response. I called the phone number in the email and I was told the office is only open Monday - Friday.

    I'm pretty upset with the company right now. I'll report back whether the company cancels it.

    Bottom Line: No, I would not recommend this to a friend

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  • 89 out 95 people found this review helpful

    United Naturals doesn’t return your phone call

    • Albuquerque, NM,
    • Jan 11, 2019
    • Verified Reviewer

    I tried this supplement for 30 days with no positive results. I called three times within the 30-day return window and they never returned my calls. Finally, on the 4th attempt, they answered and told me I was beyond the 30-day return window. For breaking their return guarantee, they belong in the scam group.

    Bottom Line: No, I would not recommend this to a friend

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  • 57 out 61 people found this review helpful

    Scam. Will not refund my money like they said.

    • Washington,
    • Feb 4, 2019
    • Verified Reviewer

    The product made my stomach worse. I have been trying to get my refund back since I returned it December 12th. This is now January 28th. They have given me excuse after excuse not to refund the money. I finally turned them over to my bank for fraud.

    Bottom Line: No, I would not recommend this to a friend

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    • Feb 22, 2019

      Company Response from United Naturals

      Beth, please reach out to support@unitednaturals.com and include your order number and the subject "HIGHYA REVIEW" so I can look into this personally.


  • 56 out 59 people found this review helpful

    SCAM!

    • Ontario, Canada,
    • Feb 12, 2019
    • Verified Reviewer

    I purchased on January 10, 2019, and it is now February 4, 2019 and I have yet to receive my order. My credit card has been billed almost $500.00, yet no product. False info on United Naturals website, stating warehouse in Montreal, yet it does not exist.

    Bottom Line: No, I would not recommend this to a friend

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    • Feb 22, 2019

      Company Response from United Naturals

      Nelson, I am sorry you are experiencing a delay with your order. As you know, when we ship from the United States to Canada we cannot control the amount of time that Customs holds the package for review. Sometimes they are released the same day and sometimes they take much longer.

      Our website provides a Canadian address because we have a Corporate office there, not a shipping facility. Nothing on the website indicates that we would be shipping from Canada. I am sorry for any confusion.


  • 29 out 32 people found this review helpful

    Didn't work, offered half of a refund

    • Oak Island, NC,
    • Feb 15, 2019
    • Verified Reviewer

    I wish I had read all the reviews before I ordered for a trial. The email received after placing my order said. "Congratulations...You will not regret it", but they failed to make good on their word. If your 30-day trial takes more than 30 calendar days, you will not get a full refund. But we'll see how my credit card company feels about it as I plan to dispute the charge. The product didn't work for me, and the reviews show that it's a pretty common occurrence.

    Bottom Line: No, I would not recommend this to a friend

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    • Feb 22, 2019

      Company Response from United Naturals

      Greg, we offer a robust, 100% guarantee that starts the date of delivery and only requires you to have the return postmarked by day 30. That gives you an entire month to use the product to experience the results. Consistency is key, and we find giving more time allows for people to take days off and not experience the results they want. Our refund policy is top in class. I am sorry that the product didn't work for you.


  • 32 out 32 people found this review helpful

    Void guarantee

    • Centreville, VA,
    • Feb 21, 2019
    • Verified Reviewer

    You have 30 days from the day of purchase to return the product. This laughable. Take my scenario. I paid on 11/26, they shipped on 12/4, and I received on 12/11. That’s already two weeks in. Any physician with their degree will tell you it takes a minimum of two weeks to feel the benefits of most vitamins or pharmaceuticals. Ok, this happens to fall around Christmas time. Do you think some people purchasing your products may be giving it to loved ones for a Christmas gift? Poof, the guarantee is gone! Both my daughter-in-law and son took it for 30 days and it had not improved their heartburn and digestive issues such as stool consistency, cramps, etc. $200 tossed into the wind.

    Bottom Line: No, I would not recommend this to a friend

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    • Feb 22, 2019

      Company Response from United Naturals

      Andrew,

      I am sorry to hear you were not satisfied with our product. We provide a robust 30-day policy for our customers that starts the date of delivery and just needs you to have it postmarked back to us by the 30th day. This gives you a full month to experience the product. If you believe you were still in that time frame please reach out to support@unitednaturals.com so we can make this right.


  • 7 out 16 people found this review helpful

    Order error

    • Seymour, MO,
    • Mar 15, 2019
    • Verified Reviewer

    I was in the process of ordering 3 packages of Synbiotic when I was offered 3 more packages at a discount. I began to click the NO THANKS when the screen changed, and all I could see were the words "your order is not complete." I feel concerned because I have provided you with my credit card number, and I've not received a validation number for the 3-package automatic order. I do not want additional products at this time. Unfortunately, my ground-line phone is not functioning.

    Bottom Line: No, I would not recommend this to a friend

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    • Mar 15, 2019

      Company Response from United Naturals

      Hi Rachel,

      We're sorry you had an issue with our site. We found your order, which had already shipped, and was only for the three boxes you'd initially meant to order. No additional boxes were sent. We hope this is of help. Though you are having landline issues, I'm adding our phone number and e-mail address here as well, in hopes you have another method to contact us in case you are in need of further support: 1-844-794-7728 support@unitednaturals.com.

      Thank you,

      United Naturals


  • 12 out 12 people found this review helpful

    Severe skin issues

    I started getting severe breakouts of little blisters that itched SEVERLY and would break upon me scratching them. They didn't actually spread. I would just break out all over my body with clusters of little blisters that itched SO BADLY that I thought I was going to LOSE MY MIND. After a trip to STAT CARE and a trip to a DERMATOLOGIST, I finally stopped taking the Synbiotic and at the moment I am struggling to keep my hair as the severe itching and breakouts have moved to MY SCALP, AND MY HEAD is now covered with BLISTERS AND SEVERE ITCHING.

    Bottom Line: No, I would not recommend this to a friend

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  • 4 out 5 people found this review helpful

    Did not like

    • Boynton Beach, FL,
    • Apr 2, 2019
    • Verified Reviewer

    Made me feel worse - had to stop taking them. Wish I could return the balance for a credit.

    I do not recommend this product.

    It took me a long time to get my system feeling good.

    Bottom Line: No, I would not recommend this to a friend

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    • May 30, 2019

      Company Response from United Naturals

      M H,

      I am sorry you did not get the results you were looking for with the Synbiotic 365. As you can see from our reviews here, we have many satisfied users. However, everyone's body is different. Some people see results almost immediately, some take a little longer, and some don't get the results they wanted. This is why we are sure to back every order with a money back guarantee. I thank you for putting your faith in United Naturals and I hope you can find a product that gives you the results you are looking for.


  • 0 out 1 people found this review helpful

    Have not received

    • Iowa,
    • Apr 24, 2019
    • Verified Reviewer

    I ordered Synbiotic 365 ten days ago and have not received the product. An email from UN stated that my probiotic will be shipped from a warehouse in Utah, however, the tracking number they provided showed the package is being shipped from North Carolina. There is also a note from DHL that there was a problem with the shipment. I'm not sure what's going on. I don't like the idea that my probiotics are just sitting somewhere in the U.S. in a hot truck!

    Bottom Line: No, I would not recommend this to a friend

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    • Apr 24, 2019

      Company Response from United Naturals

      Rob,

      We maintain facilities in both UT & SC for shipping. Unfortunately, some shipping issues happen and are out of our control. Rest assured that we package our Synbiotic 365 in Nitrogen filled Blister Packs to protect the ingredients during transit. Your product will still be safe and effective for you to use. If you have any questions please reach out to support@unitednaturals.com.

      Thank you!


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