Synbiotic 365 Review: Can It Address Your Digestive Issues?

By Anthony Dugarte, M.D., C.S.C.S
Updated on: May 9, 2020

What Is Synbiotic 365?

United Naturals claims that Synbiotic 365 will offer relief for digestive issues and bloating through a blend consisting of prebiotics, probiotics, and B vitamins.

Probiotics are the friendly bacteria that live in your gut. Prebiotics are a form of fiber that serve as a food source for probiotics and enhance their actions.

On their own, both may offer many health benefits related to digestion, immunity, weight loss, and more. Synbiotic supplements incorporate both pre- and probiotics, as their combined actions may offer even greater benefits.

In this article, we’ll review the science behind Synbiotic 365’s list of ingredients to help you determine if this supplement can help alleviate your digestive symptoms.

  • There is some research backing the individual ingredients
  • Added B vitamins are a bonus if you’re deficient
  • Favorable return policy
  • Favorable safety profile, though immunodeficient people should avoid
  • Research specific to synbiotics is needed to identify the potential role
  • Pricier compared to other synbiotic blends
  • A probiotic supplement with a high-fiber diet may be just as effective

Synbiotic 365’s Ingredients: Do They Work?

According to the supplement facts label listed on the United Naturals website, Synbiotic 365 contains:

  • Vitamin B1 (Thiamin) 2.4 mg
  • Vitamin B2 (Riboflavin) 2.6 mg
  • Vitamin B3 (Niacin) 32 mg
  • Vitamin B6 3.4 mg
  • Vitamin B9 800 mcg (480 mcg folic acid)
  • Vitamin B12 4.8 mcg
  • Vitamin B7 (Biotin) 60 mcg
  • Vitamin B5 (Pantothenic Acid) 10 mg
  • Probiotic Blend 20 billion CFU – Lactobacillus gasseri BNR17, OPTI-BIOME Bacillus subtilis MB40, Lactobacillus paracasei Lpc-37, Bifidobacterium lactic BI-04, Lactobacillus plantarum Lp-115, Streptococcus thermophilus St-21, Lactobacillus Casei Lc-11, Lactobacillus reuteri, Lactobacillus salivarius Ls-33, Lactobacillus rhamnosus Lr-32, Lactobacillus fermentum, Bifidobacterium bifidum Db-06, Bifidobacterium longum BI-05, Saccharomyces boulardii
  • Chicory Root Inulin 315 mg

In the following section, we’ll break up these ingredients into 3 main categories and highlight the available research supporting each group.


Vitamin B deficiency is common, especially in people that live a plant-based life. Deficiency can be associated with a variety of unwanted effects like nerve issues, dry skin, fatigue, and impaired mental capacity.

There are 8 B vitamins included in Synbiotic 365; with the exception of Biotin, this supplement offers close to, or well beyond, the RDA.

The folate in Synbiotic 365 plays a crucial role in growth and development, and also for preventing birth defects.

B12 supports the development of red blood cells; deficiency is associated with anemia.


Their genus identifies probiotic bacteria (e.g., Lactobacillus), which is like an extended family; their species (e.g., acidophilus), and their strain (La-14).

These friendly bacteria impact your digestion and support your immune function. They may also work to reduce allergies, as well as improve diarrhea and constipation. Each strain behaves differently and offers strain-specific effects.

L. casei may relieve digestive symptoms.

In 70 individuals with constipation, those treated with 65 mL of a Lactobacillus casei Shirota containing beverage had reduced symptoms when compared to placebo. A 100g (97 ml) drink with L. casei, L. bulgaricus, reduced the number of antibiotic-associated diarrhea cases in hospitalized patients.

Many L. plantarum species have been studied; the Lp-115 strain has been extensively investigated.

L. Plantarum N14 reduced inflammation in intestinal cells in a laboratory model. 100 mg/kg injections of L. plantarum K8 decreased enzymes associated with heart disease in mice.

  • L. Gasseri is also thought to aid digestion and reduce allergies.
  • L. Gasseri TMC0356 at 200mL decreased the level of antibodies associated with allergies in 15 subjects over 4-weeks. Subjects treated with L. gasseri OLL2716 at 109 CFU doses experienced improved indigestion symptoms over 3-months.
  • L. salivarius may offer antimicrobial effects.

In 59 children with oral disease, treatment with L. salivarius reduced bacterial and fungal levels.

In the Bifidobacteria genus, lactis may reduce inflammation and aid in the management of diabetes, bifidum shows promise for addressing constipation and lung infections, and longum may also be useful for constipation and airway infections, in addition to IBS and ulcerative colitis.

Bifidobacterium lactis strains can offer immune support and allergy relief. B. longum may provide the same benefits.

In a laboratory model, B. Longum CCUG 52486 had anti-inflammatory, especially in samples from elderly individuals. These effects were confirmed in a trial with human subjects; BB536 boosted antibody and white blood cell levels in elderly individuals.

S. boulardii is a fungal probiotic. Its potential benefits have been researched, though most of the available data is found in animal and laboratory models.


Fiber is a type of carbohydrate that can’t be digested or absorbed. Prebiotics, also classified as fiber, pass into your gut fully intact and serve as food for probiotic bacteria.

Additionally, they can absorb water and expand to make you feel full. Prebiotics may also improve blood glucose levels, promote weight loss, and enhance digestion.

The inulin in Synbiotic 365 may offer these benefits.

Inulin reduced hunger, desire to eat, and food consumption in obese adults randomized treated for 12-weeks. 12g of inulin daily for 4-weeks resulted in softer stools, increased stool frequency, and increased amounts of probiotics in constipated adults.

Side Effects and Safety

The company provides details for the total amount of ingredients in the probiotic blend, though they don’t offer amounts for each ingredient. Also, strains behave in a strain-specific manner and may provide different effects when compared to similar strains within the same family.

These factors make it challenging to compare many of these ingredients to those that have been specifically studied.

Probiotic strains are often tested at doses comparable to the probiotic blend in Synbiotic 365. These amounts are generally safe in pre-and probiotic blends, with only mild side effects reported.

Most often, these include digestive symptoms like abdominal pain, gas, bloating, and diarrhea. These can typically be relieved by lowering your dose or discontinuing use.

Lastly, Synbiotic 365 contains a fungal probiotic. While the risk for fungal infections may be small, they are not uncommon. Therefore, critically ill patients, as well as those with a compromised immune system, should avoid using Synbiotic 365.

Whether you’re considering Synbiotic 365 or another probiotic-containing supplement, have an in-depth conversation with a healthcare provider before ordering.

In addition to making recommendations that could maximize value, they can also help minimize any potential side effects based on your diagnosis.

How Much Does Synbiotic 365 Cost?

Synbiotic 365 is only available on the United Naturals website, priced as follows:

  • 1 Box: $45
  • 3 Boxes: $119 ($39.67 per box)
  • 6 Boxes: $229 ($38.17 per box)

All orders come with a 30-day refund policy, less S&H, which customers can request by calling support at 844-794-7728.

Synbiotic 365 vs. Competing Probiotic & Prebiotic Supplements

While Synbiotic 365’s exact formulation is less common, there are a number of synbiotic supplements currently available.

Syntol AMD ($40, 90 capsules), Dr. Axe Formula SBO Probiotic ($41, 60 capsules), HLC Synbiotic Intensive ($43, 7 sachets), NutriCology SymBiotics with FOS ($23, 40 servings), are a few examples.

These supplements are alike in that they’re priced competitively, and each combines a relatively similar blend of probiotics, prebiotics, vitamins, and minerals. These often include many of the same species among the Lactobacillus and Bifidobacteria genera, vitamins C and B, and various extracts like apple cider vinegar or black pepper fruit.

The differences between Synbiotic and competing supplements mostly relate to the quantities of each ingredient they contain, as well as the form in which they’re available (e.g., capsules vs. loose powder).

Alternatively, you can opt for a diet rich in both pre- and probiotics. A diet would include adding fermented foods like yogurt, sauerkraut, or kimchi, as well as fiber-rich whole grains and vegetables to your daily meal plan.

The Bottom Line

While pre- and probiotic blends both seem to offer many desirable health benefits, more research is needed to determine the role of synbiotics. Also, the added vitamins might not provide much value unless you’re deficient.

Additionally, Ultra Naturals does not provide specific quantities for the ingredient offered in their blend. This makes a comparison to the available literature challenging.

Nonetheless, similar blends are generally safe to use though individuals with impaired immune function should use fungus containing supplements with caution.

Given the need for more research regarding synbiotic supplements, you may be better off opting for a more cost-effective option. You can also choose an effective probiotic supplement and increase the fiber-rich foods in your diet.

Lastly, be sure to seek the opinion of a medical professional before use. Symptoms that you’re experiencing may be related to a more serious cause that should be cared for by a physician.

Customer Reviews

Start your review of Synbiotic 365:
  • 1139 Customer Reviews
  • 95% Recommend This Product
4.7 out of 5
5 star: 79% 4 star: 14% 3 star: 2% 2 star: 1% 1 star: 2%

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  • It worked for me!

    • By Dan T.,
    • Hamilton, OH,
    • Jul 29, 2020
    • Verified Reviewer
    • Length of Use: 6–12 months
    Overall Experience:

    Before starting Synbiotic 365 my stomach would make this annoying noise several times a day. Going to the bathroom every morning was more like turning on a faucet. Now that has all changed. The noises are gone and the bathroom results are much more solid!

    It didn't affect my energy level much but I didn't try it for that reason. My weight has pretty much stayed the same.

    Bottom line is I'm very pleased with this product. It really feels like my gut health has improved a lot!

    Pros and Cons:

    • It worked for me.
    • One pill in the morning is easy to take.
    • No adverse effects. Just great results!
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Product and service

    • By Tonya C.,
    • Cincinnati, OH,
    • Jul 25, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I’ve been taking Synbiotic 365 for about 57 days, no noticeable changes. I will continue taking them for another 40 days, if there is still not change, I will discontinue taking them. I was very, very disappointed with the time it took for me to receive my last shipment. I had to use someone else’s Synbiotics until mine arrived, that was because they are unable to continue taking them. I wasn’t able to get in touch with anyone to get the status of my order. No one, to this day, has ever responded to my original email...but yet, you’re asking me now to complete a survey. Haha, funny. I am hoping that my current shipment arrives sooner than the last order.

    Bottom Line: No, I would not recommend this to a friend

  • Awesome!

    • By Sandra S.,
    • New York,
    • Jul 24, 2020
    • Verified Reviewer
    • Length of Use: 1–2 years
    Overall Experience:

    After years of a variety of tummy issues, and after trying many probiotics, I decided to try Synbiotic 365.

    There was not an "overnight result", but rather a gradual and steady healing of my gut issues.

    Somewhere between 30 and 60 days, I realized that I no longer had to take a laxative product for my lifetime constipation.

    That was over a year ago and I have not had to resort to laxatives since taking Synbiotic 365 daily.

    I no longer have bloating and discomfort. I'm now totally regular, and I could not be happier.

    I believe the daily cumulative benefit of this product is amazing!

    Pros and Cons:

    • It works
    • Easy to take 1st thing each morning
    • Great ingredients
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Happy gut in my house!

    • By Valerie R.,
    • Cambria, CA,
    • Jul 24, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    Following the Synbiotic 365 plan has changed my dietary health and general health well-being. I no longer suffer from bloating and heartburn. My energy levels have improved encouraging me to moderately exercise daily. An unexpected bonus was a weight loss of about 4 pounds.

    I would encourage others to try out the Synbiotic 365 program for three months. The program includes helpful diet plans and videos demonstrating delicious menus. I found them very helpful and encouraging.

    I am a 75-year-old female, so don't think only the young folks can achieve a healthy energetic body!

    Pros and Cons:

    • Product easily consumed
    • No physical side effects
    • Efficient packaging and delivery
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Living proof it works!

    • By Mick A.,
    • Las Vegas, NV,
    • Jul 22, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    Mick here, at the risk of sounding like a cliche, I do have to say that I sound just like any other person who was skeptical about trying the product. You see I am a permanently disabled person, and like many other patients, I am on pain and anti-inflammatory prescribed medication. So of course I suffered from constipation, and was given a prescription called Lactulose. However, since taking Synbiotic 365 I no longer take the prescribed Lactulose. But please, if there is anyone out there reading this testimony, consult your doctors before stopping any prescription medication. I take Synbiotic 365 every day with my medication and vitamin regiment. Not only is my system regulated, but I feel like a million bucks. So thank you very much United Naturals.

    Pros and Cons:

    • No more gastric stomach issues
    • No more constipation
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Feeling like I have a normal GI tract, again

    • By Daniel O.,
    • West Saint Paul, MN,
    • Jul 20, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I had Crohn's disease that was in somewhat remission, not requiring prescription inflammatory medications but not really normal symptoms, yet. Since I started this regimen, Synbiotic 365, I have felt more normal than I have in 30 years.

    It is so nice to be able to plan a day without a worry about how far away a bathroom might be. I certainly feel better since beginning to use this product.

    Pros and Cons:

    • I take it once in the morning before breakfast
    • There are no side effects
    • I have normal bowel habits
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Highly recommended for a natural approach

    • By Sara M.,
    • Hartford, CT,
    • Jul 17, 2020
    • Verified Reviewer
    • Length of Use: 3–6 months
    Overall Experience:

    I highly recommend United Naturals to anyone who's looking to have a holistic, natural approach to healing their physical body. I've been using Synbiotic 365 and GutConnect 365 for the last 3 months and it has had a positive effect on my gut health and my overall health. My energy levels have improved and I’m sleeping more easily, which has a positive impact on my mental health and well being. I also appreciate all the educational support they offer you as you work to heal your gut. Taking supplements is important, but it's vital we are also mindful of what we are and are not putting in our bodies. They offer wonderful guidance to assist with this. If you follow their guidance and stay consistent with the supplements they offer, I believe you'll have great success with their products. Thank you United Naturals for helping me along my journal of healing.

    Pros and Cons:

    • Improved digestive health
    • Improved energy levels
    • Sleeping much better
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Making peace with my menopausal body

    • By Carey S.,
    • Halifax, Nova Scotia, Canada,
    • Jul 11, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    Last fall I went to my doctor, I was just not feeling myself and she said "you are in full menopause," yippee, I thought.

    I am a clean eater, I lift weights, run, walk, yoga, you name it, six days a week, and have one cheat day on Sunday. I maintained this lifestyle for the winter but my clothes were not fitting the way they used to.

    I heard about Synbiotic 365 on the internet and decided why not give it a shot. The day I received my package on April 19 I weighed myself, I couldn't believe it, the scale said 138. I had gained 6.5 lbs over the winter and my body fat was 26%.

    After taking my supplements, not changing anything else, I am now at 132.9 lbs with 24.6% body fat. That was after two months.

    The scale is going in the right direction.

    Bottom Line: Yes, I would recommend this to a friend

  • Excellent product! It improves my sleeping quality.

    • By Ha D.,
    • Charlotte, NC,
    • Jul 9, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I got to know Synbiotic 365 in an online search for a multivitamin product. After watching the video (~10 minutes long), I gave it a try. I took one tablet per day, and in just 2 days, I started to feel better with my digestion, my sleeping quality. As of today, I took 18 tablets and feel absolutely amazed with its effect on my body: my skin looks better, my body loses weight (1lb). I now in the process of buying Synbiotic 365 for my family members.

    Pros and Cons:

    • Simple to take: 1 tablet a day, before breakfast
    • It has a light smell I don't like

    Bottom Line: Yes, I would recommend this to a friend

  • Synbiotic 365

    • By Diane B.,
    • Forks, WA,
    • Jul 8, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    My doctor approved of Synbiotic 365. I am a diabetic and have a few health issues. My doctor checked out what was in Synbiotic 365 and said everything I need for good health is right in these pills. Since I've been taking Synbiotic 365. I have lost 30 pounds and feel better. I haven't really changed my eating habits. I don't get around very good because of a car accident I was in 5 years ago. The only exercise I get is working in my garden. I have chairs around my yard because I cannot stand for long periods of time. I was shocked when I went in for a check-up, this was after only takeing Synbiotic 365 for maybe a month, I lost weight, had to see a foot doctor 2 weeks later and once again was shocked, lost more weight. I just started my 3 months of Synbiotic 365 and have lost 30, maybe more, pounds. Thank you for a great product.

    Pros and Cons:

    • It has helped me lose weight
    • I feel better health wise
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • It was not easy to complete and I reordered by mistake. I need to cancel one of the orders. How?

    • By Janis K W.,
    • Canton, GA,
    • Jul 8, 2020
    • Verified Reviewer
    Overall Experience:

    The Super Foods are bundled into one capsule that is in a protected wrapper. It contains the chicory root, TCP probiotics, and the vitamin B complex. I am hoping that this really works to lose weight, increase energy, and repair any digestive problems.

    Pros and Cons:

    • Bundled super foods
    • Elimination of GMOs, antibiotics, and weed killer in the mix
    • The hope of better health with weight loss
    • I am not so sure about the last two additions to my order
    • A more comprehensive list of good food to eat

    Bottom Line: Yes, I would recommend this to a friend

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