Active-PK Reviews - Does It Really Work?

By HighYa Research Team
Updated on: Jun 11, 2019

Active-PK from LCR Health is a supplement that claims it can boost AMPK levels inside your body, resulting in reduced fatigue, a slimmer waistline, fewer cravings, and clearer thinking.

All of this is claimed to be done without the use of caffeine, dairy, synthetic additives, or animal byproducts.

To achieve the purported benefits of this supplement, LCR Health says to take two capsules of Active-PK daily with a glass of water, either with food or on an empty stomach.

Can you realistically expect to experience these benefits and are there other supplements claiming to deliver the same?

To help you gain a better understanding, in this Active-PK review we draw on the knowledge of professional opinion and discuss how the supplement works, its ingredients, efficacy, side effects and whether this is right for you.

How Does Active-PK Work?

To understand how Active-PK works, it's important to get familiar with what AMPK is. 5'-AMP-activated protein kinase (AMPK) is an enzyme found in all mammalian cells that “activates” during physical activity. In humans, AMPK activates in skeletal muscle, although in other mammals, such as mice, it also generates in other organs.

Once activated, a 2010 study reports that AMPK “stimulates energy generating processes such as glucose uptake and fatty acid oxidation and decreases energy consuming processes such as protein and lipid synthesis.”

The study’s authors are Dr. Erik Richter, professor of Human Physiology and Exercise Physiology at the University of Copenhagen, along with Dr. Neil Ruderman, director of the Diabetic Cardiovascular Disease Program Project at Boston Medical Center,

Richter and Ruderman state in the study that AMPK initiates the entry of glucose into cells and helps break down fatty acids inside tissues, both of which produce usable energy for the body.

The enzyme also inhibits cells from using energy for other tasks, such as creating proteins and lipids, thereby making more power available for immediate use by the body.

As a result, Dr. Barry Sears told us, “AMP kinase is an energy sensor that can be considered the enzyme of life, as it regulates every aspect of your metabolism leading to greater health and lifespan.”

Taken together, this is why LCR Health refers to AMPK as your body’s metabolic “master switch,” since it “tells your body to stop storing fat and start converting it into clean, usable fuel,” they say.

Active-PK Ingredients and its Efficacy

Per the supplement facts label listed on the LCR Health website, Active-PK contains the following ingredients:

  • Gynostemma Pentaphyllum Leaf Extract 450 mg
  • Quercetin Dihydrate 100 mg
  • Berberine HCl 100 mg

Sites like WebMD, Natural Medicines Database and Examine.com report that taking between 500 mg and 1.5 grams of berberine per day could help ease conditions related to canker sores, high cholesterol, high blood pressure, and polycystic ovary syndrome (PCOS). Active-PK’s 100 mg dose is much lower.

Furthermore, taking 30 mg of Gynostemma pentaphyllum (also commonly known as jiaogulan) daily has been shown to help decrease total cholesterol and increase good HDL in individuals with high cholesterol levels.

Outside of these, however, these sites indicate there’s insufficient clinical evidence showing that quercetin can reliably deliver health benefits in humans.

Also, the sites didn’t indicate that any of these ingredients can deliver on LCR Health’s claims of boosting AMPK levels, trimming abdominal fat, increasing endurance, raising metabolism, supporting energy levels, or optimizing brain function.

We contacted Dr. Erik A. Richter for a professional opinion. Richter is one of the two men who wrote the study we mentioned earlier.

“In my professional opinion,” Richter said, “It’s not possible for over-the-counter ingredients to meaningfully boost AMPK levels and result in benefits such as increased energy, better brain function, and weight loss.”

However, he emphasized, “there are multiple pharma companies working on AMPK activators, so it is not an impossible future possibility.”

Potential Side Effects

The LCR Health website points out that because Active-PK contains all-natural ingredients, it’s safe to use and causes no known side effects. However, it’s important to emphasize that just because something is natural, this doesn’t automatically mean it’s completely safe.

For example, WebMD, Natural Medicines Database, and Examine.com report that berberine is unsafe to take if you’re pregnant, nursing, have diabetes, or are experiencing low blood pressure.

Furthermore, it can cause a major interaction with Cyclosporine and minor interactions with medications changed by the liver.

While up to 500 mg of quercetin has been used in studies that lasted up to 12 weeks, it’s unknown if it’s safe for longer-term use. It can also cause moderate interactions with Cyclosporin, antibiotics, and medications changed by the liver.

Finally, while Gynostemma may be safe to take for up to fours months, these sites indicate it can cause side effects like severe nausea and increased bowel movements (no specific circumstances noted).

It’s also possibly unsafe for those who are pregnant or breastfeeding, as well as those with autoimmune diseases, bleeding disorders, diabetes, or who are scheduled to undergo surgery within two weeks (since it may slow blood clotting).

Together, the LCR Health website recommends speaking with your physician before purchasing Active-PK, which is certainly something we’d advise as well.

How Much Does Active-PK Cost?

Active-PK is only available for purchase on the LCR Health website, priced as follows:

  • 1 Bottle: $69
  • 3 Bottles: $186.30 ($62.10 per bottle)
  • 6 Bottles: $330.15 ($55.03 per bottle)

All orders come with LCR Health’s 90-day Ironclad Guarantee, less shipping, which you can request by calling 800-384-8308 or sending an email to support@LCRHealth.com.

Active-PK vs. Competing AMPK Dietary Supplements

We found dozens of standalone jiaogulan, quercetin, and berberine dietary supplements during our research, many of which were priced well below $20 per bottle.

However, we encountered only a handful of top-rated options on Amazon that specifically advertised AMPK activation in their names. Here’s how their prices and ingredients compared to Active-PK:

Brand Price Ingredients
Active-PK by LCR Health $69 Gynostemma 450 mg, Quercetin 100 mg, Berberine 100 mg
Life Extension AMPK Metabolic Activator $21.97 Calcium 130 mg, Hesperidin 500 mg, ActivAMP Gynostemma 450 mg
LUZ AMPK Activator $35.97 Gynostemma 150 mg, Berberine 900 mg, Alpha-Lipoic Acid 300 mg, Resveratrol 150 mg
Takenutritionx AMPK Activator $36.99 Gynostemma 450 mg,
Quercetin 100mg,
Berberine 100mg
Botanic Choice AMPK Formula $50 ActivAMP Gynostemma 150 mg, Berberine 17 mg, Rosehip 400 mg
Horbaach AMPK Metabolic Activator $16.87 ActivAMP Gynostemma 450 mg

Price-wise, we can see that Horbaach’s AMPK Metabolic Activator is the lowest cost option among popular competitors above, by a decent margin. It only contains 450 mg of Gynostemma, although as we discussed above, there’s insufficient reported clinical evidence that it can help humans lose weight, increase energy, or improve brain function.

Life Extension also contains the same level of Gynostemma as Active-PK, but at a much lower price. It doesn’t contain quercetin, but again, there’s insufficient clinical support that it can activate AMPK in humans.

From an ingredients perspective, Takenutritionx’s AMPK Activator features the same formulation and dosages as Active-PK, but at a meaningfully lower price. In fact, consumers can purchase two bottles of Takenutritionx for only a couple of dollars more than a single bottle of Active-PK.

Based on this, we can see that Active-PK isn’t necessarily the “revolutionary formula” advertised by LCR Health.

Bottom Line: Is Active-PK Worth It?

At the time of publishing, dozens of HighYa readers have given Active-PK an average rating of 3.6 stars, many of which reported excellent customer support, as well as benefits like reduced weight and inches around their waist, improved sleep, decreased cravings, and boosted energy. LCR Health had similar Better Business Bureau feedback at the time of our research.

So, if you’re looking to purchase your next dietary supplement from a reputable company, LCR Health appears to be safe to order from should you have concerns with your order in the future.

It’s important to balance the positives by pointing out that many HighYa readers reported no results with Active-PK, although a company representative responded in most of these instances to address the customers' concerns.

Furthermore, websites like WebMD and the Natural Medicines Database, along with medical professionals like Erik Richter, report insufficient clinical evidence supporting LCR Health’s claims related to AMPK activation, weight loss, or boosted energy or improved brain function for Active-PK’s ingredients.

Finally, Active-PK comes with a much higher price than popular competitors on Amazon. And based on our experience writing about hundreds of dietary supplements over the years, customers typically don’t report meaningfully better results after paying more for one.

Taken together, if you’re looking to explore potential AMPK activation, we think it’s difficult to justify paying a much higher price for Active-PK.

» Keep Reading: A Beginner’s Guide to Losing Weight and Getting in Shape

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Read 111 Active-PK Customer Reviews and Complaints

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Average Consumer Rating: 3.8
Rating Snapshot:
5 star: 45 4 star: 36 3 star: 8 2 star: 3 1 star:  19
Bottom Line: 77% would recommend it to a friend
Showing 1-11 of 111
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  • Active-PK

    • Sedona, AZ,
    • Sep 18, 2019
    • Verified Reviewer

    Active-PK is a real winner. I have more energy and a much brighter outlook on everything. Two weeks - no side effects. Probably will take it the rest of my life, I have recommended Active-PK to my banker, the VFW and a host of other groups I belong to. Can't say enough good things about this product.

    Bottom Line: Yes, I would recommend this to a friend

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  • Amazed with my results

    • Nevada,
    • Sep 11, 2019
    • Verified Reviewer

    I am on my second bottle. I didn't notice any change with the first bottle. With the second bottle, my stomach is so noticeable smaller. I still have more fat to shrink, but delighted with results so far.

    I am not exercising or changing my diet in any way. Can't wait for the results of my second and third bottle. I tried so many different ways to reduce my stomach that didn't work. I am amazed by my results with the Active-PK.

    Bottom Line: Yes, I would recommend this to a friend

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  • Interesting supplement

    • Virginia,
    • Sep 10, 2019
    • Verified Reviewer

    Male, 69 years old, 6 feet, 230.

    I'm not sure what I expected to feel or what I really expected to happen. My routine is simple. Get up about 5:30 M-F, take 2 pills with my morning meds (vitamins, allopurinol, Aleve,) and then off for a light walk and workout (45 min). A morning snack of red bell pepper. Lunch of tortilla, cheese, and bacon, PM snack of red bell pepper, dinner chicken/other meat, light vegs. Average about 10K steps per day.

    Results: Waist tightened by about an inch in 3 weeks. Weight down about 5 lbs.

    Started at 230; now at 225. Avg 7+ hours of sleep per night.

    Bottom Line: Yes, I would recommend this to a friend

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  • Did not expect the vivid dreams (non sexual business ventures)

    • Mississippi,
    • Sep 10, 2019
    • Verified Reviewer

    So far, the product is living up to expectations. More energy, clearer thoughts, more vivid dreams at night (I did not expect), frequent recollections of past experiences, weight loss, and my belly is shrinking. Can tell you more once I finish re-planking my second story rear deck. The new energy comes in handy.

    Bottom Line: Yes, I would recommend this to a friend

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  • Active-PK

    • Kapiti, New Zealand,
    • Sep 9, 2019
    • Verified Reviewer

    I have been taking these for a couple of months and have noticed more energy, coping better with a big workload, less stressed and a general more positive attitude. Would recommend giving these a go.

    Bottom Line: Yes, I would recommend this to a friend

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  • My health improved!

    • Surrey, British Columbia, Canada,
    • Sep 9, 2019
    • Verified Reviewer

    I have mild arthritis - the condition that affects my life - not too much but anyway...I’ve been using Active-PK for a while. I can say it works! Going up and down stairs with no problem and it's getting better. I am 62, but pretty active - gym 4-5 days a week, working for my business, gardening, playing badminton with my grandson, etc.

    Well - overall - I am feeling different now and hope my health will be improved day after day. Please keep in touch and I'll keep you posted! Thanks.

    Bottom Line: Yes, I would recommend this to a friend

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  • Feeling better

    • Illinois,
    • Sep 6, 2019
    • Verified Reviewer

    I have been taking this for about 4 weeks. The hardest part is remembering to take it first thing in the morning. I am on other medications and need to schedule what I take, and when I take them.

    I am feeling more energized, haven't needed a nap in weeks. Waiting for some lab work to check on my cholesterol. I am trying to get a healthier lifestyle. I think the Active-PK has made the changes easier.

    Bottom Line: Yes, I would recommend this to a friend

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  • Seeing some results

    • Myrtle Beach, SC,
    • Sep 4, 2019
    • Verified Reviewer

    Have noticed some weight loss and seemingly a reduction in fat on my arms.

    I haven’t noticed a lot of additional energy yet.

    My appetite seems suppressed more than usual and cravings are not as prominent.

    Bottom Line: Yes, I would recommend this to a friend

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  • Changed my energy level and stamina!

    • Santa Clarita, CA,
    • Sep 4, 2019
    • Verified Reviewer

    First off, I have never done a review of a product but Active-PK really works, so I want to share my experience to encourage others to give it a try.

    I was forever and ALWAYS trying different supplements because no matter how well I took care of myself I always had such low energy, especially at the end of the day.

    I could not enjoy my life because any spare moment I had I just wanted to sleep.

    Like I said I was always trying new things to fix me and I have finally found the one that did.

    The first week I felt different, second week better, and by the end of the first month, I am a new person. I have energy again!

    After work I can do things whether it’s house chores, enjoying my swimming pool, shopping, meeting up with friends...the list goes on and on. I can’t say I have lost weight because that wasn’t my goal but if I chose to exercise I would now have the energy to do so.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Telling you how I feel

    • Lafayette, OR,
    • Sep 3, 2019
    • Verified Reviewer

    I started using it a month ago. Read that you do not feel a whole lot different. I did start feeling different in a way it is hard to say. I had to have an iron infusion that sorta set me back but now I am doing just fine. Hoping that I will start showing things that are telling me that the fat around my organs is starting to dissipate. I notice a difference in my tummy and spare tire. That's a good sign.

    Bottom Line: Yes, I would recommend this to a friend

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  • Help

    • La Jara, CO,
    • Sep 2, 2019
    • Verified Reviewer

    I've been taking Active-PK, I just felt terrible after I took it, just want to know if that's how it starts off like.

    Stomach just hurt, I felt tired, no energy. Please let me know.

    I am a diabetic, does that have something to do with it? I did ask my doctor about the medication and he said it was alright to take it.

    It was like pain at the pit of my stomach and like a burning sensation in my stomach.

    HELP with answers.

    Bottom Line: Yes, I would recommend this to a friend

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    • Sep 3, 2019

      Company Response from LCR Health

      Hi Josie. I am Taylor with LCR Health. I am sorry to read your review of Active-PK. Your experience is not typical and I would like more information. As a courtesy, I would like to offer you a full refund for your purchase. Please email me at taylor@lcrhealth.com so that I may get started on this promptly. Again, I apologize for your reaction and I look forward to hearing from you soon.


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