About Active-PK by LCR Health

Published on: May 24, 2017

LCR Health’s Active-PK supplement promises to use a three-ingredient blend of naturally occurring compounds that can promote AMPK activation, leading to boosted energy, clearer thinking, decreased intraabdominal (or "deep") fat, and a faster metabolism and flatter belly.

In fact, the promotional videos claims the supplement’s ingredients might even be able to help you lead a longer, healthier life.

Just take two capsules per day with a glass of water, with or without food, and the ingredients will go to work all day after being digested by your stomach. The company tells us Active-PK is safe and effective for all Americans, who should experience maximum benefits after a few months of regular use.

There’s no doubt that we’re in the midst of an obesity epidemic, which can have all sorts of health consequences. But can you expect LCR Health’s Active-PK supplement to boost AMPK levels? Even then, might this deliver meaningful results?

Let’s kick things off by discussing the basics.

What Is AMPK & How Does It Relate to Deep Fat?

5' AMP-activated protein kinase (AMPK) is an enzyme (a substance that causes a chemical reaction) that performs multiple functions in the body. These include:

  • Inhibiting the synthesis of fatty acids, cholesterol, and triglycerides
  • Inhibiting glycogen synthesis
  • Stimulating glycolysis (the breakdown of glucose, or sugar)
  • Stimulating glucose uptake in skeletal muscle
  • Regulating some aspects of cell function (removal of unnecessary and dysfunctional components)
  • Increasing mitochondrial (a cell’s “battery”) creation

Based on these benefits, we can see that AMPK plays an important role in energy sensing, as mentioned on the Active-PK website. So it’s no surprise that one of the best methods of boosting AMPK levels in the body is through exercise (although there is some controversy about this), since it’s thought to increase fatty acid metabolism and provide more energy for cells.

With this in mind, we didn’t encounter any substantive clinical evidence listed on authoritative websites like the National Institutes of Health’s PubMed during our research that AMPK, in humans:

  • Has any specific role related to deep fat (whether stopping buildup or improving its availability for energy production),
  • That activation declines with age or as a result of overeating (or “nutritional overload” as mentioned in the Active-PK promo video),
  • That elevated activation can lead to reduced weight and increased lifespan
  • That reduced AMPK signaling can cause chronic inflammation, increased belly fat, high cholesterol and triglycerides, elevated blood sugar, or insulin resistance,

Regardless, what about the ingredients found in Active-PK?

Have Active-PK’s Ingredients Been Shown to Boost AMPK Levels?

According to the Nutritional Facts label listed on the supplement’s website, Active-PK contains the following:

  • Gynostemma pentapyllum leaf extract (1.2% damulin A) (ActivAMP) 450mg
  • Quercetin dihydrate 100mg
  • Berberine HCl 100mg

Gynostemma Pentapyllum/ActivAMP

According to their summarizations of the available clinical evidence, websites like the Natural Medicines Database and WebMD indicate that 30mg per day of gynostemma pentapyllum (Jiaogulan) has been shown to reduce cholesterol, which could certainly have a beneficial impact on overall health.

The gynostemma pentapyllum in Active-PK is Gencor’s proprietary ActivAMP, which claims to have clinical evidence that the ingredient can significantly decrease body fat mass, percent body fat, body weight and BMI, and total abdominal area. We’ve requested a copy of this study and will follow up as soon as a response is received.

Quercetin & Berberine

These same sites also indicate that 1,000mg per day of quercetin may help address some aspects of prostatitis, and that some preliminary evidence indicates berberine may slightly reduce blood sugar levels in people with diabetes and help lower cholesterol levels in people with high cholesterol.

However, none of these sites reported conclusive evidence indicating these ingredients, whether alone or in conjunction, could meaningfully boost AMPK levels or produce any of the related benefits claimed by LCR Health.

What About LCR Health’s Test?

Despite this, the Active-PK promo video indicated that the supplement was tested on a group of user beginning in January 2016, which found that after two weeks:

  • 95% reported fewer cravings for unhealthy food
  • 73% reported losing weight
  • 81% reported losing belly fat
  • 95% had more overall energy than before

Then, after four weeks of use:

  • 100% fewer cravings for unhealthy food
  • 75% reported losing weight
  • 90% reported losing belly fat
  • 100% had more overall energy than before
  • 96% felt Active-PK could help them live longer

We also sent an email to LCR Health for a copy of this study and will update based on their response.

What Kinds of Side Effects Might You Experience From Active-PK’s Ingredients?

On their website, LCR Health tells us that Active-PK is vegetarian, gluten-free, lactose-free, and friendly for all dietary considerations. And because it consists of naturally occurring nutrients found in food products and the body, that it’s safe to use and produces no known side-effects.

However, they note that this product isn’t intended for those with preexisting medical conditions. Also that because of its ability to reduce the size of fat cells, it shouldn’t be taken by those who are “severely underweight.” And as always, you should consult with your physician before beginning any new supplements.

According to the authoritative sites mentioned earlier, gynostemma pentapyllum may cause moderate reactions with immunosuppressants and medications that slow blood clotting, while berberine could potentially cause a major reaction with cyclosporine.

How much Does Active-PK Cost?

How much you pay for each bottle of Active-PK depends on how many you purchase:

  • 1 Bottle: $46.99
  • 3 Bottles: $152
  • 6 Bottles: $323

The single bottle option charges an extra $3.95 S&H, while all others are free.

LCR Health provides a 90-day money back guarantee, less S&H, on all Active-PK orders, which you can request by calling the company at (844)-650-5933 or sending an email to support@lcrhealth.com.

What else do we know about the company?

What Can We Learn From Reviews About Active-PK’s Manufacturer?

As is often the case when we write about nutritional supplements, we didn’t encounter any online customer feedback for Active-PK at the time of our research.

However, the supplement is manufactured by Los Angeles-based LCR Health, which is a division of Live Cell Research. LCR Health also manufactures another supplement called Active Stem, while Live Cell Research produces popular options like LA-3 and QL-5.

Overall, Live Cell Research’s products had an average customer rating of about four stars here on HighYa, with common compliments referencing beneficial results (reduced belly fat and weight, improved mobility, decreased cravings, etc.), while common complaints seemed related to no results and high price.

Obviously, Active-PK is a completely different formulation, so we’re not saying you’ll experience the same. However, we believe this information can provide you with a clearer overall picture of the situation.

From a company perspective, Live Cell Research had an A+ Better Business Bureau rating and six closed complaints at the time of our research. No details were provided.

Now, how do Active-PK's price and manufacturer reputation compare to the competition?

Are There Other AMPK-Boosting Supplements Like Active-PK?

If you search online, you’ll only find a couple of other AMPK activators currently on the market, such as Life Extension’s AMPK Activator ($25) and the previously mentioned LA-3 ($46.99).

In fact, comparing LA-3 and Active-PK’s formulations, they’re the exact same product, even down to the amount each ingredient. Despite this, LA-3 is marketed as a “longevity activator,” while Active-PK promises to target deep fat.

Which of these might provide the best results? We’ll conclude with our thoughts in just a second, but let’s first take a look at the person behind Active-PK.

Who Is Dr. Rand McClain?

According to his LinkedIn page, Dr. Rand McClain is a Medical Doctor at Performance Sports and Rejuvenation Medicine in Santa Monica, CA. Previously, he trained in Traditional Chinese Medicine and Acupuncture at the Yo San University of Traditional Chinese Medicine, and earned his Doctor of Osteopathic Medicine from Western University of Health Sciences.

In the Active-PK long form sales video, he tells us that some have called him one of the top regenerative health doctors in L.A.

Does Dr. McClain’s experience and medical training necessarily mean this supplement’s right for you, though?

Our Final Thoughts about Active-PK From LCR Health

In the end, based on the mostly positive feedback from customers for the company’s other products, it certainly seems like LCR Health and Live Cell Research are focused on creating supplements that provide value.

Just like any other supplement, though, what works fantastically for you might not work at all for someone else, which is why the company stands behind Active-PK with a 90-day refund policy. You will, however, lose a couple of bucks in return shipping.

Despite these positive aspects, it seemed that authoritative sites like the Natural Medicines Database and WebMD reported little-to-no clinical evidence that the supplement’s ingredients (singularly or synergistically) can meaningfully boost AMPK activation, or consequently deliver on its claims.

If you feel like giving Active-PK a shot, though, just be sure to speak with your doctor about any concerns you’re experiencing, what you’re expecting to achieve with the supplement, as well as any other supplements or medications you’re currently taking.

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47 Consumer Reviews for Active-PK by LCR Health

Average Consumer Rating: 3.7
Rating Snapshot:
5 star: 19 4 star: 14 3 star: 3 2 star: 1 1 star:  10
Bottom Line: 74% would recommend it to a friend
Showing 1-11 of 47
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  • I have lost a couple of pounds and I am experiencing more energy.

    • Orangevale, CA,
    • Sep 19, 2018
    • Verified Reviewer

    I have been taking two Active-PK capsules every morning on an empty stomach, as directed, for a couple of weeks now. I am experiencing more energy and have lost a couple of pounds. I am very pleased.

    Bottom Line: Yes, I would recommend this to a friend

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  • Pleased with results

    • Gold River, CA,
    • Sep 18, 2018
    • Verified Reviewer

    I have lost about five pounds a week for the first three weeks. I've been following the hints given via email and hope to meet my goal in another month or two...my goal to go from 210 pounds to 185.

    I am having very little trouble avoiding tempting foods.

    Bottom Line: Yes, I would recommend this to a friend

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  • After two weeks

    • Lake Winnebago, MO,
    • Sep 17, 2018
    • Verified Reviewer

    After two weeks I see a reduction in my waistline and I have more energy. I am looking forward to seeing what will happen in another couple of weeks, then looking forward to two months, then three months.

    Bottom Line: Yes, I would recommend this to a friend

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  • I'm very surprised and happy.

    • California,
    • Sep 17, 2018
    • Verified Reviewer

    I'm 71. I'm only 5 feet tall. I've been using the product for less than one month, but I feel really well. I still work full time, so energy is always a factor. I live in an old building with four flights of stairs and no elevator. I think the best part of LCR is my tummy has gone down.

    It's refreshing when a product works like it's supposed to work.

    Thank you.

    Bottom Line: Yes, I would recommend this to a friend

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  • More energy, losing weight

    • Huntington, WV,
    • Sep 16, 2018
    • Verified Reviewer

    This product has helped me in eating better, and I have lost eight pounds. My energy and my balance seem much improved, both of which have motivated me towards a healthier lifestyle. I am seventy-one years old and feeling better than I have in years.

    Bottom Line: Yes, I would recommend this to a friend

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  • Active-PK comments

    • San Antonio, TX,
    • Sep 16, 2018
    • Verified Reviewer

    Taking two pills as directed in the morning, work out three times per week for 90 minutes each time to maintain good hips, knees, lower back, and joints. Feeling good as always. No change in weight or loss of any belly fat. I am three weeks into the start of taking Active-PK pills. I will continue until all three bottles are finished.

    Bottom Line: No, I would not recommend this to a friend

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  • Happy

    • Athol, MA,
    • Sep 16, 2018
    • Verified Reviewer

    I have been taking these pills now since August 29th. I feel more energized. That being said, I don't feel as though my belly is getting any flatter, and that has always been a concern of mine. I know that carrying excess weight in the belly area is not good for your general health.

    I shall continue to take it to see if this improves. Perhaps I haven't given it enough time.

    I must say that my thoughts are clearer having started taking this and for that, I'm most grateful.

    Warm regards!

    Bottom Line: Yes, I would recommend this to a friend

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  • 22 days into the program - positive change is happening

    • Lititz, PA,
    • Sep 14, 2018
    • Verified Reviewer

    I have been on the program for 22 days. I was hoping to experience some changes after the first 30 days. I am very pleased to be able to say I am already experiencing encouraging changes.

    I have lost over 4 lbs in a little over three weeks, but the most important change has been in my overall positive mental state and a significant amount of extra energy to be much more active.

    I am not going to measure my waist until I finish the first month, but I am certain that this will yield a positive change. I am confident that the Active-PK has brought about good results in a short period of time.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 2 people found this review helpful

    Active-PK

    • Macedon, NY,
    • Sep 13, 2018
    • Verified Reviewer

    The jury is still out, but it seems to be helping. I'm always a skeptic as everything you buy says they will work, but it is not always the case. I am just finishing my first bottle, and it does seem to be working. I'll reserve my final decision until my second bottle is finished.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Just not sure

    • Waterbury, CT,
    • Sep 11, 2018
    • Verified Reviewer

    I've taken two capsules on an empty stomach every day since I got my three-month batch. I'm about three weeks it. Nothing specific is happening. I feel good, have about the same energy, no weight loss yet. I am consciously eating better and maintaining my level of activity since starting to use Active-PK.

    I'll finish the three-month course - I already paid for it and it can't hurt, right?

    Bottom Line: No, I would not recommend this to a friend

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  • 3 out 3 people found this review helpful

    Increased energy

    • Haughton, LA,
    • Sep 9, 2018
    • Verified Reviewer

    I have noticed that I have more energy to perform any and all my tasks during the day. It starts almost from the moment that I wake up, and continues from that point. I can power through my workouts without the dragging feeling. I have especially noticed that my cravings have almost vanished.

    Bottom Line: Yes, I would recommend this to a friend

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