Active-PK Review - Benefits, Ingredients, Efficacy, Side Effects

By HighYa Research Team
Updated on: Dec 27, 2019

Medically Reviewed by Anthony Dugarte, M.D., C.S.C.S

What Is Active-PK?

Active-PK claims to boost your energy without the use of caffeine, dairy, synthetic additives, or animal byproducts. This is thought to be achieved by its action on an enzyme called 5'-AMP-activated protein kinase (AMPK)

To achieve the purported benefits of this supplement, LCR Health says to take two capsules of Active-PK daily with a glass of water, either with food or on an empty stomach.

Can you realistically expect to experience these benefits? To help you gain a better understanding, in this Active-PK review we draw on the knowledge of professional opinion and discuss how the supplement works, its ingredients, efficacy, side effects and whether this is right for you.

How Does Active-PK Work?

To understand how Active-PK works, it's important to get familiar with AMPK. This enzyme is found in all mammalian cells and is activated an intensity-dependent manner during physical activity.

AMPK activation promotes glucose uptake and fatty acid oxidation, while decreasing protein and lipid synthesis. Simply put, this enzyme decreases energy consuming processes in favor of those that generate energy.

According to Dr. Barry Sears, “AMPK is an energy sensor that can be considered the enzyme of life, as it regulates every aspect of your metabolism leading to greater health and lifespan.”

LCR Health refers to AMPK as your body’s metabolic “master switch,” since it “tells your body to stop storing fat and start converting it into clean, usable fuel.”

Active-PK Ingredients and Their Efficacy

The Active-PK ingredients thought to be responsible for the purported benefits:

  • Gynostemma Pentaphyllum Leaf Extract 450 mg
  • Quercetin Dihydrate 100 mg
  • Berberine HCl 100 mg

Obese subjects randomized to 450mg daily of gynostemma pentaphyyllum over 12-weeks experienced significant reductions in body weight, body fat mass, percent body fat, and BMI.

Diabetic patients that were randomized to treatment with gynostemma pentaphyyllum at 6g daily over 12-weeks experienced significant decreases in fasting blood glucose levels, HbA(1C), and insulin resistance compared to controls.

In high-fat diet mice, supplementation with 0.8% quercetin produced short-term increases in energy expenditure; while present at 3-weeks, this was no longer evident after 8-weeks.

In 58 healthy subjects randomized to 1 g/day of quercetin or placebo, those receiving quercetin did not experience alterations in energy, fatigue, or sleep quality over 6-weeks.

Berberine reduced body fat and improved insulin sensitivity in obese, diabetic rats. Tese effects seemed to be related to berberine’s ability to activate AMPK in both fat and muscle cells. The AMPK-related effects of berberine were corroborated in another mouse study.

Regarding human studies, 30 randomized patients with heart disease, treatment with 300mg of berberine daily activated AMPK and reduced inflammation related to cholesterol.

In another trial, 24 subjects with metabolic syndrome were randomized; those that received 500mg of berberine three times daily over 3-months experienced remission, decreased waist circumference, and insulin secretion.

We contacted Dr. Erik A. Richter, professor of molecular physiology at the University of Copenhagen, for a professional opinion.

“In my professional opinion,” Richter said, “It’s not possible for over-the-counter ingredients to meaningfully boost AMPK levels and result in benefits such as increased energy, better brain function, and weight loss.”

However, he emphasized, “there are multiple pharma companies working on AMPK activators, so it is not an impossible future possibility.”

The Takeaway:

Gynostemma has been investigated in human subjects, specifically in obese and diabetic patients. Both studies found beneficial effects related to body weight, body fat, and blood glucose, though one study included doses more than 5x that which is found in Active-PK. More long-term research is needed to identify the benefits in other populations.

Quercetin has not been extensively studied. Animal studies point towards possible and short-lived benefits regarding energy, though this has not been corroborated in human subjects even at much higher doses than Active-PK offers.

Berberine has shown promise regarding its ability to reduce weight and insulin resistance. Most support is in animal models, while the limited human research has included larger doses than what is included in Active-PK.

As these ingredients have not been extensively studied, more long-term research with human subjects is needed to fully characterize the benefits.

Side Effects

The LCR Health website points out that because Active-PK contains all-natural ingredients, it’s safe to use and causes no known side effects. However, it’s important to emphasize that just because something is natural, this doesn’t automatically mean it’s completely safe.

While up to 5x the dose of quercetin found in Active-PK has been used safely over a 6-week span without serious adverse effects, it’s unknown if it’s safe for long-term use.

In a 12-week study, there were no episodes of hypoglycemia or adverse effects at gynostemma doses more than 5x the dose included in Active-PK.

In a 12-week study, 1500mg of berberine daily was not associated with serious adverse effects, though mild gastrointestinal symptoms are possible.

The LCR Health website recommends speaking with your physician before purchasing Active-PK, which is certainly something we’d advise as well.

The Takeaway:

While likely safe even at much higher doses, these ingredients have not been extensively investigated in long-term studies. More work is needed to fully characterize the potential harm.

Active-PK Cost and Return Policy

Active-PK is only available for purchase on the LCR Health website, priced as follows:

  • 1 Bottle: $89.95
  • 3 Bottles: $242.85 ($80.95 per bottle)
  • 6 Bottles: $455.70 ($75.95 per bottle)

All orders come with LCR Health’s 90-day Ironclad Guarantee, less shipping, which you can request by calling (800) 384-8308 or sending an email to support@LCRHealth.com.

Active-PK vs. Similar AMPK Supplements

We found dozens of standalone jiaogulan, quercetin, and berberine dietary supplements during our research, many of which were priced well below $20 per bottle.

However, we encountered only a handful of top-rated options on Amazon that specifically advertised AMPK activation in their names. Here’s how their prices and ingredients compared to Active-PK:

Brand Price Ingredients
Active-PK by LCR Health $89.95 Gynostemma 450 mg, Quercetin 100 mg, Berberine 100 mg
Life Extension AMPK Metabolic Activator $21.97 Calcium 130 mg, Hesperidin 500 mg, ActivAMP Gynostemma 450 mg
LUZ AMPK Activator $35.97 Gynostemma 150 mg, Berberine 900 mg, Alpha-Lipoic Acid 300 mg, Resveratrol 150 mg
Takenutritionx AMPK Activator $36.99 Gynostemma 450 mg,
Quercetin 100mg,
Berberine 100mg
Botanic Choice AMPK Formula $50 ActivAMP Gynostemma 150 mg, Berberine 17 mg, Rosehip 400 mg
Horbaach AMPK Metabolic Activator $16.87 ActivAMP Gynostemma 450 mg

Price-wise, we can see that Horbaach’s AMPK Metabolic Activator is the lowest cost option among popular competitors above, by a decent margin.

It only contains 450 mg of Gynostemma, although as we discussed above, there’s insufficient reported clinical evidence that it can help humans lose weight, increase energy, or improve brain function.

Life Extension also contains the same level of Gynostemma as Active-PK, but at a much lower price. It doesn’t contain quercetin, but again, there’s insufficient clinical support that it can activate AMPK in humans.

From an ingredients perspective, Takenutritionx’s AMPK Activator features the same formulation and dosages as Active-PK, but at a meaningfully lower price.

Based on this, we can see that Active-PK isn’t necessarily the “revolutionary formula” advertised by LCR Health.

The Bottom Line: Is Active-PK Worth It?

So far, dozens of customers have given Active-PK an average rating of 4 stars here on HighYa, many of which reported excellent customer support, as well as benefits like reduced weight and inches around their waist, improved sleep, decreased cravings, and boosted energy.

LCR Health had similar Better Business Bureau feedback at the time of our research.

It’s important to balance the positives by pointing out that many HighYa readers reported no results with Active-PK, although a company representative responded in most of these instances to address the customers' concerns.

The available literature investigating these ingredients in human subjects is lacking. Also, there is no support for the energy boosting effect of Active-PK.

In terms of AMPK activation, the strongest support is in animal and laboratory models. Most of the benefits found in human subjects have been studied primarily in overweight and diabetic subjects.

Doses used in most investigations are much higher than what is offered in Active-PK – if the results are dose-related, you may not see a return on your investment with this product.

Erik Richter, seems to agree that the clinical evidence supporting LCR Health’s claims related to AMPK activation is currently insufficient.

While generally safe, these ingredients have not been studied in long-term human investigations. Discuss with your physician prior to use.

Finally, Active-PK comes with a much higher price than popular competitors on Amazon. Based on the available support for these products, it may be wise to start with a more cost effective supplement if you’re interested in boosting your AMPK.

» Keep Reading: Weight Loss Pills and Supplements 101: Everything You Need to Know


Read 197 Active-PK Customer Reviews and Complaints

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Average Customer Rating: 4.1
Rating Snapshot:
5 star: 97 4 star: 64 3 star: 9 2 star: 3 1 star:  24
Bottom Line: 83% would recommend it to a friend
Showing 1-11 of 197
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  • Fantastic

    • By Evelyn W.,
    • East Haven, CT,
    • Jan 16, 2020
    • Verified Reviewer

    I feel more energetic since I've been taking it. It is the first thing I take in the morning. It seems like my digestion has improved as well. I would highly recommend this product.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Active-PK

    • By Judi V.,
    • Ohio,
    • Jan 14, 2020
    • Verified Reviewer

    Feeling better. This product is very good. Let's keep it up. I hope this will continue to work. For the money, it's totally worth it. I have more energy than before. I am looking forward to more good things to happen to me. Even my joints feel better.

    Bottom Line: Yes, I would recommend this to a friend

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  • 2 out 2 people found this review helpful

    Active-PK, working great

    • By Michael S.,
    • Ohio,
    • Jan 12, 2020
    • Verified Reviewer

    Thanks for asking for my feedback. I have been on this product now for a little while, I can definitely tell my energy levels have picked up, more important just feeling better in a good day of work. I believe even my whole outlook on life is better, because I feel better, so with that, thank you.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Active-PK

    • By Yolanda M.,
    • Chicago, IL,
    • Jan 11, 2020
    • Verified Reviewer

    I lost some pounds, it kept me energized. I FEEL GOOD. Thanks Active-PK! I WOULD RECOMMEND THIS TO EVERYBODY. When I first heard about it...I was like yeah, ok, whatever...I was wrong completely wrong.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Good results so far

    • By Eleanor S.,
    • Dover, DE,
    • Jan 8, 2020
    • Verified Reviewer

    I have been very pleased with the results. I feel my stomach reducing. I have been taking it for two weeks. I will continue to take it for more results and would be glad to write another review at that time.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    I feel better with Active-PK

    • By Shelly H.,
    • Lakewood, WA,
    • Jan 6, 2020
    • Verified Reviewer

    I’ve only been taking Active-PK for less than a month, but I’m more alert in the morning. I feel more energized. I’m in a better mood. So yes, I would recommend Active-PK to others.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Love this product!

    • By Kathy A.,
    • Oregon,
    • Dec 30, 2019
    • Verified Reviewer

    Love this product! Unfortunately, I have been injured and have not been able to exercise. I am getting better and will be in the pool doing laps soon. That being said I normally run twice a week and do weights 3 days a week. Even though I have not worked out in 3 weeks I have not gained any weight and my belly fat is going away.

    So I would say this product is a winner!

    I love the fact that it is stimulant-free!

    I love that this product is helping me with my concentration at work!

    This is a must-try folks.

    Thanks.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    More energy in Seattle-Tacoma

    • By Valerie D.,
    • Seattle-Tacoma, WA,
    • Dec 30, 2019
    • Verified Reviewer

    In these three weeks, just shy of four weeks, I can truly say that I am experiencing an energy boost.

    I've also noticed no hunger craving in the middle of the day. This alone is very good for me. Oh, I forgot to add more clarity I'm experiencing also. I can't wait to experience the results after my third bottle. Funny thing is that I will have to purchase a third bottle again. I gave one away for someone to try.

    I must say, when I made this purchase I was doubtful that it would have results, what a surprise. Happy I followed my instincts.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Great results

    • By Mary Jane J.,
    • Pennsylvania,
    • Dec 26, 2019
    • Verified Reviewer

    I have had a very positive result with Active-PK! Most supplements cause an allergic reaction for me so I was pleasantly surprised that I felt great after a couple of days.

    I have more energy than before and overall better. My thoughts are clearer and my body feels healthier.

    I have been able to work out more consistently and overcame a plateau in my weight loss.

    I highly recommend Active-PK.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Weight loss

    • By Lawrence C.,
    • Spring Hill, FL,
    • Dec 26, 2019
    • Verified Reviewer

    I have been taking Active-PK for only 3 weeks. I have noticed that I am not as bloated and have a sense that weight has been lost. My wife has said that I look to be thinner without changing any habits.

    Will have more info after another month.

    Thanks.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Feel it, see it working!

    • By Michelle G.,
    • Edmonton, Alberta, Canada,
    • Dec 26, 2019
    • Verified Reviewer

    I have only been using Active-PK for about a week now but I have really noticed that I feel warmer and during physical exercise, I actually get hot and start to sweat, without my heart racing from caffeine products I have used in the past. I also notice less bloating around my tummy, where I was starting to see a protruding tummy beginning. I am a smaller person and face the public as a fitness trainer, so seeing my tummy flatten out makes me happy! I have less discomfort in my lower abdominal area too, from the bloating I had before.

    Bottom Line: Yes, I would recommend this to a friend

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Showing 1-11 of 197

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