Heal-n-Soothe Review - Does It Work and Is It Safe?

By Anthony Dugarte, M.D., C.S.C.S
Updated on: Mar 20, 2020

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By combining 12 natural anti-inflammatory ingredients with enzymes, Heal-n-Soothe is a dietary supplement that allegedly helps promote healing and recovery, reduce muscle discomfort, and support healthy circulation and immune response.

All you have to do is take at least one capsule (up to four times daily, if needed), 30 minutes before or 60 minutes after meals, and the company reports the supplement's 'systemic enzyme therapy' could begin delivering results.

In this review, we'll examine the scientific evidence to help determine how effective Heal-n-soothe is for you.

What Is Systemic Enzyme Therapy and Is It Effective?

Writing for Science-Based Medicine, Scott Savura defines it as consuming enzymes orally "with the intent of whole-body effects."

Specifically, the therapeutic approach is often promoted as a way to address inflammation, which Scott reports is a "host of complex physiologic processes mediated by the immune system," often expressed as redness, heat, pain, and swelling.

From a clinical perspective, he points out that enzyme therapy "can be science-based," since it's often used to treat pancreatic disease and cystic fibrosis. Still, he tempers this by emphasizing that "those are not uses where the enzymes need to be absorbed from the gastrointestinal tract," since large doses aren't often injected.

Comparatively, "the concept of giving enzymes orally, and achieve meaningful therapeutic effects in the body, is one with a considerable number of drug design hurdles," he says.

As a result, "until better evidence appears to demonstrate the efficacy and safety of systemic enzyme therapy," he emphasizes, "their use can't be considered science-based."

Taking a Closer Look at Heal-n-Soothe's Ingredients

According to the supplement facts label listed on their website, Heal-n-Soothe contains the following ingredients:

Boswellia Extract 150 mg

Boswellia Serrata extract is obtained from trees found in the Middle East and may provide anti-inflammatory effects.

Heal-n-Soothe offers a larger dose than what was found to be effective in joint pain.

In 60 knee arthritis patients, those randomized to treatment with 100mg of Boswellia Serrata extract over 3-months improved joint pain and function.

Citrus Bioflavonoids 90 mg

There are thousands of varieties of these plant-based compounds. The flavonoids found in fruits vegetables may offer a vast array of health benefits, including antioxidant effects,

According to this recent review of 91 studies, it was not possible to establish daily intake recommendations as the available studies varied greatly in methodology.

They did note that the average intake in these studies was about 900 mg/day, much larger than the dose offered in Heal-n-soothe.

While the researchers concluded that a diet rich in these plant-based compounds minimize the risk for heart disease and other chronic medical conditions, they also pointed out that the methods in which these benefits are tested must be standardized.

Ginger Extract 90 mg

Ginger has been used in both diet and medicine for thousands of years. It may offer a wide variety of health benefits.

This review highlighted support for numerous benefits related to ginger.

They found that ginger can reduce muscle pain after intense physical activity, promote immune functions, and even fight some forms of cancer.

The ability of ginger to reduce muscle pain with physical activity was seen at 2g doses over 11-days. This dose is more than 20x larger than a single dose of Heal-n-Soothe.

Mojave Yucca (root) 90 mg

The edible fruits, seeds, and flowers of this plant may offer immune-boosting and anti-arthritic capabilities.

This review mentioned a few studies from the 70s that examined the effects of yucca in treating arthritis. While the pain and swelling relief demonstrated in these early studies have led to the use of yucca in both humans and animals, the available support for these effects remains sparse.

Much more work is needed in human subjects to identify the role of yucca in managing inflammatory conditions.

Turmeric 60 mg

This spice has been used for dietary and medicinal purposes by cultures all over the world. In addition to its suspected antioxidant and anti-inflammatory roles, turmeric may also offer weight loss benefits.

Curcumin, the active component of this extract, may help regulate inflammation.

In a laboratory setting, curcumin inhibited the same enzyme that is targeted by Aspirin.

More recently, a review of 8 studies examined curcumin's effect on arthritis. They found that doses ranging from 500-1500mg per day may relieve symptoms. Definitive recommendations can't be made, however, as the studies included lacked strong methodology.

Early studies examining the effects of turmeric are promising, though they highlight the need for long-term research in human subjects.

Alpha Lipoic Acid (ALA) 50 mg

ALA may offer powerful antioxidant and anti-inflammatory effects. Thus, its potential therapeutic roles remain of interest to researches.

The potential for ALA to treat nerve pain in diabetic subjects was recently demonstrated. Doses at 600mg daily reduced symptoms and improved their quality of life over 40-days.

Rutin 30 mg

Rutin is another flavonoid; it is abundant in apples. Like other flavonoids, it may offer antioxidant

In rats, 15mg/kg doses of rutin reduced oxidative stress and inflammation associated with arthritis. In a laboratory model, rutin demonstrated an ability to slow the effects of age-related bone loss.

While these studies are promising, research in human subjects is needed to characterize the ability of rutin to treat inflammatory conditions.

Devil's Claw Extract 30 mg

The roots of this South African plant may offer relief for muscle and joint pain.

Though this extract has been studied in relation to its potential to manage symptoms of arthritis, the available research can't offer a definitive answer regarding the safety and efficacy.

Larger randomized control trials are needed to investigate the effects of devil's claw in the long-term.

Systemic Enzyme Blend 750 mg: Protease AM 225 AP, Bromelain 6M FCCPU, Protease 6.0 60,000 HUT, Alkaline Protease 12,000 USP, Papain 1.5M FCCPU

The addition of these enzymes can maximize the digestion and absorption of proteins, while also eliminating the excess that may accumulate during inflammation.

In a randomized study, those treated with proteolytic enzyme doses around 1000mg for 7-days experienced better wound healing when compared to the placebo group.

This study corroborates the proposed benefits of Heal-n-Soothe, though subjects were treated for only a short duration and with larger protease enzyme doses.

Potential Side Effects Related to Heal-n-Soothe's Ingredients

The disclaimer at the bottom of Heal-n-Soothe's website emphasizes that some of these ingredients could thin blood and that the supplement shouldn't be taken by anyone who's allergic to pineapple or papaya, or by those who are pregnant or nursing.

They also note that it's possible to experience side effects (no dosages or other circumstances noted) like sinus drainage, gas or loosening of the stool, and decreased blood pressure.

Digestive symptoms are likely the most common side effects you may experience, though these are often mild and relieved by discontinuing the product.

Most of the ingredients have been safely studied at much larger doses than what is present in Heel-n-Soothe. This may make unwanted effects even less likely.

Despite a favorable safety profile, you should discuss this blend of ingredients with your doctor. This practice ensures your best of avoiding side effects or unsafe interactions with other medications or supplements you may be taking.

How Much Does Heal-n-Soothe Cost?

Heal-n-Soothe is only available directly from the manufacturer, through the following two options:

  • One-Time Order (90 vegetarian capsules): $59
  • Free Trial: $9.95 S&H

If you choose the trial option, you'll be billed the full price of $49.95 after 14 days have passed and will continue receiving a new bottle each month and paying $49.95 each time, until you cancel.

Living Well Nutraceuticals offers a 90-day refund policy on all Heal-n-Soothe orders, less S&H, which you can request by calling (888) 231-9901 or sending an email to info@livingwellnutraceuticals.com.

Heal-n-Soothe

Buy Heal-n-Soothe from Amazon:

Heal-n-Soothe costs $59.90 for one bottle (90 capsules) and $95.85 for two bottles (180 capsules). Shipping is free. It is rated 3.9-stars based on over 400 customer reviews.

$59.90 (1 bottle)

$95.85 (2 bottles)

A Look at Customer Reviews

Heal-and-Soothe is available through Amazon, where more than 440 customers had given the supplement an average rating of 3.9 stars.

Common compliments from customers included reduced pain and inflammation. However, complaints often referenced no results, difficulty obtaining a refund, and side effects like digestive upset.

As far as the company, Heal-n-Soothe is distributed by Living Well Nutraceuticals, based out of Glendale, CA.

Heal-n-Soothe vs. Other Systemic Enzyme Therapy Supplements

Browsing online marketplaces like Amazon and Google Shopping, we encountered several popular enzyme supplements competing with Heal-n-Soothe:

Supplement

Price

Active Enzyme(s)

Other Ingredients?

Heal-n-Soothe $49 - $59 Bromelain, Papain Boswellia, bioflavonoids, ginger, yucca, turmeric, ALA, rutin, devil's claw
NOW Super Enzymes $11+ Bromelain, Ox Bile, Pancreatin, Papain No
Doctor's Best Proteolytic Enzymes $21 Bromelain, Papain, Amylase, Lipase, Serratiopeptidase, Lipase Neutral, fungal, and bacterial protease, rutin
Enzymedica Repair Gold $30+ Bromelain, Amylase, Catalase, Papain, Serratiopeptidase, Lipase No
Source Naturals Daily Essential Enzymes $42 Pancreatin, Acid-Stable Protease, Lipase, Amylase, Amyloglucosidase, Cellulase, Lactase No
Wobenzym N $25+ Pancreatin, Papain, Bromelain, Trypsin, Chymotrypsin, Rutoside No

Given all these options, formulations, and price points, what's the best way to figure out which one—if any—is right for you?

As we always emphasize, start by talking with your doctor. They can help diagnose the underlying cause of your pain, discomfort, and inflammation, and then recommend a science-based treatment from there.

If they recommend pursuing a dietary supplement, we'd recommend only doing business with manufacturers who:

  • List all of their ingredients, including dosages, with no proprietary blends (which don't list dosages)
  • Support their claims with quality clinical evidence
  • Back their products with at least 30-day refund policies and don't charge restocking fees

Our Final Thoughts About Heal-n-Soothe

Pain is a complex process, and it will take the help of a physician to narrow down what's causing yours, and then prescribe a viable treatment. So—again—whether you're considering Heal-n-Soothe or another dietary supplement, they're perhaps your best option.

While systemic enzyme therapy as a whole might not seem to have much clinical support, several of Heal-n-Soothe's ingredients have been studied. However, most of the ingredients lack strong scientific support for the proposed benefits.

Also, most studied used doses much higher than those offered in Heal-n-Soothe. You may avoid some of the mild side effects, though you may not get quite enough of the active ingredients to see results.

Even when referencing the same source of pain, the reality is that everyone's body is different, so what works for one patient might be a total fail for another.

For this reason, it's positive that Living Well Nutraceuticals seems to stand behind Heal-n-Soothe with a 90-day refund policy—just keep in mind that you'll have to pay to send the bottle back if you're dissatisfied.


Read 21 Heal-n-Soothe Customer Reviews and Complaints

Write a Review
Average Customer Rating: 2.4
Rating Snapshot:
5 star: 5 4 star: 2 3 star: 0 2 star: 3 1 star:  11
Bottom Line: 33% would recommend it to a friend
Showing 1-11 of 21
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  • Very positive results from Heal-n-Soothe

    • By Annita D.,
    • San Clemente, CA,
    • Jun 22, 2018
    • Verified Reviewer

    I developed knee joint pain and aggravated osteoarthritis of my big toe after being prescribed Anastrozole (hormone inhibitor). I was not able to play pickleball without putting braces on my knees, couldn't get into some shoes due to swelling of the big toe, and couldn't walk beyond 2 miles versus the typical 5.5 - 6.5 miles I did regularly prior to the Anastrozole. I actually had surgery planned to address the pain in Stage 4 Rigid osteoarthritis.

    I started Heal-n-Soothe and noticed a difference by day 4. Ten days later I canceled the surgery on my big toe. I have been taking Heal-n-Soothe for 3 months now with no pain. I play pickleball approximately 3 - 5 hours a day, 3 times a week, and walk 6.5 miles once a week. I recommended it to several friends and 3 of the 4 have experienced the same reduction in pain as I experienced.

    Bottom Line: Yes, I would recommend this to a friend


  • Osteoarthritis on hands

    • By Lillian P.,
    • Ohio,
    • Dec 10, 2018
    • Verified Reviewer

    My hand pain was so bad I could not hold hands with my husband or twist off caps on a beverage. Using this product, my hands are so much better, and I also use the lotion that came with the product. Both items are very helpful. I only take two tablets a day. So far I've recommended it to two of my brothers and my mom. They have their own issues, one had knee pain, other one had shoulder paid, and the third one had back pain. So far all four of us are happy with the product.

    Bottom Line: Yes, I would recommend this to a friend


  • I love Heal-n-Soothe!

    • By Pamela C.,
    • Huntington Beach, CA,
    • Mar 13, 2019
    • Verified Reviewer

    I was very hesitant to try this product. I have not felt better after exercise in over a year. I retired and thought I was getting old and I should go back to work. I could hardly get up from the chair or car or bed without feeling pain. I could feel the difference after taking it for two weeks. And for a bonus, I had this scar almost completely disappear. I had some stomach upset with the product, so I emailed them. Their customer service rep told me to rinse off the capsules before taking them and to drink a glass of water 15 minutes after taking the capsule. It worked. I can't take Advil or Tylenol for very long before it bothers my stomach. This is a fantastic product. My husband is starting to take it too. I hope it helps him too.

    Bottom Line: Yes, I would recommend this to a friend


  • Very effective.

    • By Gabriel G.,
    • Auckland, New Zealand,
    • Apr 27, 2019
    • Verified Reviewer

    The product worked very well in my case. Helps me to keep under control my back and knee pain that I had in the past. Now I can move freely in the tennis court being able to be involved in many hours of tennis coaching a day, plus playing hard tennis 3+ hours, 3 times a week. I consider a great product to take which will improve your overall body mobility and overall body health.

    Best advice: Make sure you will take it exactly how they stated, 30 minutes before meals or 60 minutes after meals with plenty of water.

    Bottom Line: Yes, I would recommend this to a friend


  • So far, so good!

    • By Milton J.,
    • Arkansas,
    • Jan 23, 2020
    • Verified Reviewer

    For several years I have had issues with inflammation and cramping of my right leg. I had much success with Omega 3 for several years, but lately it wasn't doing it for me. Beginning about 3 months ago, I suffered increasing leg pain and hip joint discomfort; to the point that I was wincing in pain when I got out of my car. I was limping from pain in my right hip. I was taking NSAIDs with only moderate relief.

    I received my trial order of Heal-n-Soothe about three weeks ago, and have had a remarkable reduction in pain and inflammation. Currently no hip joint pain and no limping. The only side effect has been some mild acid-stomach symptoms, which are manageable. I have gone off the NSAIDs, and am experimenting with reduced dosages of Heal-n-Soothe.

    Hey folks, nothing's perfect, but when something works this well, what more can you ask? Oh, I forgot to mention...I'm age 85.

    Bottom Line: Yes, I would recommend this to a friend


  • Synergy

    • By Malvin Butler,
    • Los Angeles, CA,
    • May 3, 2018
    • Verified Reviewer

    I don't know how to put this, but you know how you have to stop taking one supplement to see if the other supplement is pulling its own weight? Well, I combined Heal-n-Soothe with Extreme Joint Care by NutraBio and within 8-13 days, I don't know exactly because I bent down for some reason yesterday and my left knee didn't hurt after 18 months or so of pain. So I squatted 5 more times, no pain, just creeking. Well, if I am on a good run, why stop now? So these two manufacturers might be expecting another visit from me jointly, which I'm sure they too are with that old sayin,' whatever works.

    Happy healing...

    Bottom Line: Yes, I would recommend this to a friend


  • Itching and hoarseness

    • By Richard F.,
    • California,
    • Sep 3, 2018
    • Verified Reviewer

    I was extremely excited by the rapid improvement in my knees. I had become embarrassed to get up when I was teaching in front of my students due to the grunts and groans and limitations in movement. After a week or two on Hea-n-Soothe my knees felt like had cushions and overall flexibility and movement was easier; specifically getting up and down to reach or perform minor household tasks.

    Then I realized that I was hoarse on a daily basis. I'm a professional singer and voice teacher, so this was a serious issue. I also read on some sight that papain, the papaya enzyme can actually cause throat damage, a very serious concern given my work, not to mention that it was annoying.

    Also, I started having itching throughout my body, including my hand, just little annoying tings, irritating at night especially. After discontinuing, I continue to have this side effect, though diminished.

    I still recommend the product to my friends because I considered the positive aspect miraculous, especially because I thinking knee replacements would be in my future.

    The company has been pretty responsive as I've asked for advice on these side effect issues and ultimately sent me a dietary book which supposedly has similar results over a longer period of time.

    A friend also told me that papain has been banned in surgical procedures because it could lead to major heart problems, another good reason to be wary, yet given my very positive results, I still tell my friends.

    I am, however, seeking other supplements and would like to find a medically trained professional for advice; perhaps online info will suffice. It's not fun have major movement restrictions, so I'm highly motivated.

    Bottom Line: Yes, I would recommend this to a friend


  • Be very careful not to become auto enrolled

    • By John G.,
    • Florida,
    • May 9, 2018
    • Verified Reviewer

    The product ingredients are similar to other arthritis products that are sold at lower prices directly or through Amazon. The online sales pitch for Heal-n-Soothe is so enticing that is SO EASY TO MISS the AUTO ENROLL that appears only on the "Get another bottle for $10" window. They do not provide return shipping or return labels and Iris from customer service told me "many other companies have similar fine print so customers don't see the enrollment they have agreed to." While the placebo effect left me feeling like the product did not hurt me, returning unwanted bottles of something that was not helping me left a bad enough taste for me to write this negative review.

    Bottom Line: No, I would not recommend this to a friend


  • Side effects

    • By Michael P.,
    • Victoria, British Columbia, Canada,
    • Aug 22, 2018
    • Verified Reviewer

    I began taking Heal-n-Soothe as suggested. I began with one capsule in the morning and one in the afternoon.

    I got a nosebleed the second day and for two subsequent days. I have never experienced spontaneous nosebleeds before. I stopped taking the product because it was the only change in my diet. The nosebleeds stopped.

    I tried again two weeks later with the same results. I don't have enough pillowcases to continue with it.

    Next miracle pain cure anyone?

    Kidding...

    Bottom Line: No, I would not recommend this to a friend


  • No difference after second bottle

    • By Rose D.,
    • Aug 1, 2019
    • Verified Reviewer

    This is my second review. Finished first bottle with no results. Same with the second bottle. I will not buy any product online that touts miracles again. One bad apple spoils it for the rest.

    Bottom Line: No, I would not recommend this to a friend


  • 90-day money back guarantee - yeah, right!

    This isn't as much a review of Heal-n-Soothe as a complaint about the company I ordered it from, The Healthy Back Institute. I also ordered their product called Super Joint Support not knowing that it had Magnesium in it (the type of Magnesium not identified). I know from experience and advice that the only type of Magnesium that does not cause diarrhea is Magnesium Glycinate (which I already take to stop muscle cramps). So I wasn't at all surprised that by the second day of taking Heal-N-Soothe, sure enough, I was "trotting to the pot!"

    I called the company to ask the type of magnesium and they couldn't tell me, so I returned the Super Joint Support, giving the reason, and paying $10.92 for return it by USPS. After not receiving a refund, I called the company and was told I'd returned Heal-N-Soothe (the first bottle had cost me $29, while the Super Joint Support had cost me $39).

    I wrote a letter to the company enclosing the Return Form and telling them I would expose them on social media if I didn't get a refund! Still no refund! So it cost me a total of $49.92 for this experience! Whether Heal-N-Soothe works or not, it's hard to tell when I'm so mad at the company for being so dishonest!

    Oh, but the last time I had my blood pressure checked, it was low, but I'm surprised it wasn't "through the roof!" I was actually looking up something on WebMD when I got sucked in by this company, so watch out! Oh, and I forgot to mention all the newsletters at $14.95 a copy!

    Bottom Line: No, I would not recommend this to a friend


Showing 1-11 of 21

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