About Instaflex Advanced

By Anthony Dugarte, M.D., C.S.C.S
Updated on: Mar 20, 2020

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What Is Instaflex Advanced?

Instaflex Advanced is a joint support dietary supplement formulated by Dr. David Katz, Director and Co-Founder of the Yale Prevention Research Center.

Joint pain is one of the most common reasons for seeking the care of a doctor. With so many people affected, treatment options that aim to delay or prevent the need for joint replacement surgery remain a topic of much debate.

Per their website, Instaflex promises to “strive to provide the best science-backed products that deliver the best results possible.'' According to Dr. Katz, Instaflex Advanced accomplishes this goal.

Dr. Katz states that you can experience joint relief in just 7-days by taking 1 pill with water each day. The proposed benefits may be possible without glucosamine or chondroitin, the common joint relief supplement ingredients.

But is there any scientific support to back these claims?

In this article, we’ll review the safety and efficacy of Instaflex Advanced to help you determine if this supplement can relieve your joint pain.


According to their site, the original Instaflex formula was improved upon by Dr. Katz. The Instaflex Advanced formula allegedly helps relieve joint discomfort and improve flexibility through its blend of ingredients.

In this section, we’ll go through each ingredient and discuss the available support for the proposed benefits.

Turmeric (rhizome)(standardized to min 95% curcuminoids) 200 mg

Turmeric has been used in preparing food and creating clothing for thousands of years. Is there more to this spice?

Turmeric may help benefit heart health and brain function. Its proposed anti-inflammatory actions are likely why it has been included in Instaflex Advanced, however.

Your inflammatory response promotes healing after injury. Though this process is important, chronic activation can be associated with arthritis. Turmeric may limit the inflammatory response through curcumin, a molecule produced by turmeric plants.

Aspirin blocks the action of cyclooxygenase (COX), enzymes that play a key role in inflammation. Curcumin inhibited these enzymes in a laboratory model using human colon cancer cells.

In a recent review of 8 studies, the use of curcumin dosages ranging from 500-1500mg per day were found to benefit arthritis. The researchers did conclude, however, that more research is needed as the data available from these studies was not sufficient for a definitive conclusion.

While turmeric may have a role in the inflammatory response, evidence in human subjects is lacking.

Resveratrol (from Polygonum cuspidatum root extract) 100 mg

Resveratrol is a substance found in blueberries, grapes, and peanuts. It behaves as an antioxidant that combats free-radicals, or molecules that damage cells.

Resveratrol may also offer anti-inflammatory effects by acting on the same mediators as turmeric.

In rabbits with knee arthritis, those that received injections with resveratrol experienced decreased cartilage destruction when compared to the control group.

In 50 patients with inflammatory bowel disease, those treated with 500mg of resveratrol over 6-weeks reported improvements in quality of life; these results were, in part, due to resveratrol's ability to reduce inflammatory enzymes.

Most of the scientific support for resveratrol's ability to reduce inflammation has been in laboratory and animal models. While some human studies demonstrate the anti-inflammatory effects, these actions have yet to be demonstrated in human trials.

UC-II® (10 mg total collagen, 3 mg undenatured type II collagen) 40 mg

Type II collagen is a key component of cartilage. UC-II is a type of collagen that is obtained from the breastbone of chickens. It may improve joint function by reducing collagen destruction, inflammation, and pain.

In patients with hand, hip, or knee arthritis, those treated with type II collagen had better results for arthritis lab tests at 6-months and 1-year when compared to other treatments.

Arthritic rats treated with 1, 3, and 10 mg kg-1 doses of type II collagen over 2-weeks improved balance, weight-bearing and lab tests for arthritis.

Most recently, 39 patients with knee arthritis were randomized to either Tylenol alone or 10 mg/day type II collagen & Tylenol treatment; those treated with type II collagen reported improved function and quality of life at 3-months.

The early results for type II collagen’s ability to offer joint pain relief are promising. Joint pain often spans for decades, however. So the available short-term data must be taken with a grain of salt. More work is needed to identify its role in the long-term.

Hyaluronic Acid (HA) (min 89%) 5 mg

HA is the main component of joint fluid. Pain and dysfunction can occur when your joints dry up.

Injectable forms of HA are well studied, though current research does not demonstrate a benefit.

When taken orally, HA may help reduce joint pain and swelling.

In 20 patients with knee pain, those treated with 80mg/day of HA improved pain and function after 8-weeks. Similarly, 80mg/day of HA over 3-months improved muscle strength in subjects with mild knee pain.

While these findings demonstrated a possible role for HA and benefits in treating knee pain, Instaflex Advanced contains doses smaller than the amounts used in this study.

Apresflex®-Boswellia serrata Extract (resin) 100 mg

AprèsFlex® is a patented Boswellia Serrata extract. This herb is obtained from Middle Eastern Boswellia trees and may possess anti-inflammatory properties.

In 60 patients with knee arthritis, those treated with 100 mg of Boswellia Serrata extracts for 3-months had improved joint function and reduced pain.

It’s important to note that Laila Nutraceuticals, the owner of the AprèsFlex® patent, supports this study.

Some patients in this study experienced relief in as little as 7-days. This extract may be responsible for the quick-relief claims made by Dr. Katz. Still, these results were short-term, so we don’t know if there are lasting effects.

Bioperine®-Black Pepper Extract (BPE) (fruit) (standardized to min 95% piperine)

Bioperine®-Black Pepper Extract may have antioxidant and anti-inflammatory effects, as well as disease-fighting capabilities.

Additionally, it is thought to promote the many benefits of turmeric. The joint-related effects of (BPE) have not been well studied, however.

In a laboratory setting, 10 to 100 microg/ml of BPE reduced inflammatory lab results. In an animal model, BPE reduced signs of inflammation in rat ankles.

These early results highlight the need for further studies, particularly with human subjects.

Safety and Side Effects

Part of the potential benefit of nutraceuticals is their safety profile. Joint pain and arthritis are long-term issues, often requiring medical management. Even over the counter treatment options can be damaging to the liver and kidney over time.

These issues may be avoided with the ingredients offered in Instaflex Advanced, all of which are generally safe.

Turmeric offered even at 1500mg per day was without adverse effects. Similarly, according to tests, resveratrol is safe at doses 5x higher than what Instaflex Advanced contains.

Type II collagen was safely tested at doses higher than those offered in this supplement.

HA was safe in those treated with 80mg doses. Boswellia Serrata treatment at doses identical to those offered by Dr. Katz were not associated with adverse effects.

BPE is generally safe to use, but the studies examining its anti-inflammatory effects in human subjects with joint pain are lacking.

While the safety profile of this extract is likely favorable, your joint pain may be caused by an issue that should be medically managed. For this reason, you should speak with your doctor first to properly identify that cause.

Pricing and Where to Get It

The company offers a 14-day sample for $4.99 in shipping charges. Afterwhich, you'll automatically be enrolled in an autoship program for $69.99 per month. You'll continue receiving a 30-day supply until you cancel.

Should you enroll in the 14-day trial, you must cancel your membership within 18 days of enrollment to avoid being charged the full amount.

Additionally, a bottle of Instaflex Advanced (30-count) costs $69.99 plus $4.99 in shipping should you want to bypass the free sample.

Dr. Katz backs your purchase with a 30-day guarantee.

The 30-count can be purchased at Amazon for $57.99. GNC offers the 30-count at $64.99.

At Walgreens, 14 capsules are available for $29.99.

Instaflex Advanced

Buy Instaflex Advanced from Amazon:

Instaflex Advanced costs $57.99 for a 30-count bottle, with free shipping. It is recommended that you take 1 pill each day, so one bottle is equal to a 30-day supply. It is rated 4.1-stars based on 1,250+ reviews.

$57.99 (30 count)

Instaflex Advanced vs. Arthrozene

Arthrozene is another product with proposed joint relief benefits. It has some ingredients in common with Instaflex Advanced.

Ingredient Instaflex Advanced Arthrozene
Type II Collagen
Boswellia Serrata

Keep in mind that you’ll miss out on 3 of the Instaflex ingredients. As turmeric, reservatrol, and BPE lack strong evidence for their efficacy in human subjects, you’re likely not missing out on much.

However, and you’ll pay nearly $80 for a 30-day supply of Arthrozene - $30 more expensive than Instaflex.

In this instance, Instaflex seems to be more cost-effective and also packs in a few more ingredients for your money. Though not inexpensive, the 30-day guarantee should give you enough time to determine if you find it to be effective.

The Bottom Line

Instaflex Advanced contains a blend of ingredients that may play a role in reducing the pain and inflammation associated with joint pain and arthritis, though more human trials are needed.

Most of the ingredients have been studied at doses much higher than what is offered in this supplement. While this speaks to the probable safety of Instaflex Advanced, this also means that the reported benefits may be less likely.

Amazon users rate this product at 3.9 out of 5-stars on over 1000 reviews. Over 30% of the reviews are 3-stars or less. Most of the customers that offer negative reviews believe this supplement to be too pricey for the limited benefits it offers.

As much of the available research includes study durations of 3-months or less, we can’t speak to the long-term effects of these ingredients. The long term effects are an important piece of information that we lack as joint pain is a chronic condition.

Nonetheless, some of the other common treatments (Tylenol, for example), can be harmful when used for long periods. As the upside of finding relief with a nutraceutical can be delaying or avoiding medical and surgical management, they may be a reasonable option to try.

Be sure to speak with a doctor about your symptoms first, however. Identifying the cause of your pain is the first step in the plan of care.

Customer Reviews

Start your review of Instaflex Advanced:
  • 31 Customer Reviews
  • 29% Recommend This Product
2.4 out of 5
5 star: 25% 4 star: 3% 3 star: 6% 2 star: 9% 1 star: 54%

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  • Try it and then Stop, see what happens

    • By Mark Brodeur,
    • Pacific Grove, CA,
    • Apr 19, 2016
    • Verified Reviewer
    Overall Experience:

    I'm a skeptic, but the osteoarthritis in my knees convinces me to try every snake oil potion on the planet. I have taken enough over-the-counter pills claiming to help to kill a horse.

    I recently saw an ad for this product and given the price per pill, I was intrigued. All other pills need to be taken at least twice if not three times per day. This one was claiming one a day. Wow. Really?

    So, I started with a full 60 day supply and after 5 days I hadn't noticed much improvement. By the time I finished bottle of 60 pills, I could actually feel the difference. I wasn't using ibuprofen anymore or rubbing Voltaren cream on my knees.

    But again, I am a skeptic and thought maybe it was something else, but I wasn't doing anything else different.

    So, I stopped and didn't purchase a new bottle. 10 days went by.

    I can now say with confidence that when I stopped my knees started barking really bad.

    Your results may differ but I can tell you that there is no doubt in my mind that NOT USING this product made my knees worse.

    Bottom Line: Yes, I would recommend this to a friend

  • Can not live without the Instaflex Advanced

    Overall Experience:

    I am an EMT/Firefighter. Fell 15 feet off a truck. T11 compression fracture, wrist shattered, extruded discs, ankle injury, Bursa. Have rotary damage, both shoulders and knee bad. This product is amazing. Approximately 3 days in, the pain eased up. Had trigger finger right hand. It resolved. I can bend, kneel on calls, drive, and function. I also teach firefighting and CPR. Can do it without the pain. Usually take a double dose for a day if I abuse my body. Opted for physical therapy instead of surgery. If I go without product a couple days, it all comes back. Love my Instaflex Advanced. Recommend to others.

    Bottom Line: Yes, I would recommend this to a friend

  • Instaflex Advanced

    • By Peg Liebel,
    • Erie, PA,
    • Mar 7, 2017
    • Verified Reviewer
    Overall Experience:

    I had a lot of pain on my feet from a past injury. The pain was so bad that I could barely walk after sitting for any period of time. A friend told me about Instaflex Advanced. I was skeptical, but I tried it. I can say that in a short period of time the pain decreased and then disappeared.

    I used it for a period time and then thought my problem was resolved, so I stopped taking the capsule. That was a big mistake because the pain returned, and I was back to square one. Now today, I take one capsule a day and am pain-free. The price is a little high, but I have no pain, so I make the adjustment to make sure I have my Instaflex daily.

    Bottom Line: Yes, I would recommend this to a friend

  • A believer

    • By Jill Wing,
    • Saratoga Springs, NY,
    • Oct 4, 2017
    • Verified Reviewer
    Overall Experience:

    I've had extensive spine and knee surgery. I am fused on my back from the top (cervical) to the bottom (lumbar) and thorax in between.

    While the surgery has straightened me out, the 24 3-inch screws and two rods that hold me together can get cranky. And my left knee was replaced 20 years ago and it's pretty angry, too.

    Now I have a dog that I walk several times a day and even with tramadol and 6 ibuprofen a day, I was still pretty uncomfortable.

    I, too, have tried everything from steroid shots and nerve blocks and they weren't very effective.

    So when I saw reviews for Instaflex Advanced, I thought of it as another snake oil, but worth a try. I got the two-week trial and, after a few days, felt better.

    By the time my trial was over, I had not felt so good in 15 years. I thought I'd wait and see if my pain returned and it did, so I ordered a 30-day supply.

    It's expensive; the cheapest was on Amazon. I took the first pill today and eagerly awaiting relief in a few days.

    Bottom Line: Yes, I would recommend this to a friend

  • Magic pill?!

    Overall Experience:

    I have been disabled since 1987 with mega injuries from head to toe; wheelchair stuck, cane, no nothing (malls, stores).

    Through the years I have literally purchased every joint/pain relief on the market but to no avail. I spent thousands and thousands of money looking for relief.

    I ordered the Instaflex 14-day trial. I saw a marked improvement in pain, flexibility, and overall mood.

    I ran out of IA two days ago and am really feeling the loss. Those old pains were on the way. I can feel pain creeping in!

    A life pain-free...never ever thought you would hear this from me.

    People claim the price is too high. you have a choice: purchasing meds that do not work ($35 to $69), or Instaflex Advanced ($35-$69). So aren’t you worth it? What is the price of pain?

    Bottom Line: Yes, I would recommend this to a friend

  • Really works

    • By Patti R.,
    • Gresham, OR,
    • Jul 15, 2019
    • Verified Reviewer
    Overall Experience:

    I usually go in for Cortizone Shots every three months. I’m on my third bottle this month and no shots. These pills work, the knee pain is 75% better and I’m happy for that. Just ordered 5 bottles!

    Bottom Line: Yes, I would recommend this to a friend

  • It works for me!

    • By Brenda G.,
    • California,
    • Sep 25, 2019
    • Verified Reviewer
    Overall Experience:

    September 19, 2019 is my second week of taking Instaflex Advanced. A friend recommended this product as it helped her with arthritis pain. I have lived in 24/7 pain due to Osteoarthritis. I refuse to take prescription medication so I was willing to try anything. I felt better from day one. I have arthritis in my back, hips, pelvic bones and left knee. Walking was very difficult and painful. I took one capsule of Instaflex and 2 extra strength Tylenol in the morning and I was able to walk better with very little pain. I'm about 80% better! This product works for me and I'm very thankful to have found something natural to help me. I got the 14-day free trial to test the product. I'm now on monthly auto-refill. Thank you, Dr. Katz, for creating something that works great!

    Bottom Line: Yes, I would recommend this to a friend

  • How well the product works

    • Length of Use: 6–12 months
    Overall Experience:

    I work in a doctor's office and I have been taking this product daily for my knee pain from standing and walking a lot. I recommend this product to our patients because it works so great.

    Pros and Cons:

    • Product does what it says on the label
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • Seems to be effective.

    • By Ron L.,
    • Roswell, GA,
    • Jan 16, 2019
    • Verified Reviewer
    Overall Experience:

    I've been taking Instaflex for about three months...I find it to have helped quite a bit. My knee is arthritic and probably has limited cartilage. I'm trying to hold off knee replacement as long as possible...I have better joint flexibility and less pain.

    Bottom Line: Yes, I would recommend this to a friend

  • Should I keep taking it?

    • By Laura Amedeo,
    • Watertown, NY,
    • Jul 29, 2017
    • Verified Reviewer
    Overall Experience:

    I have been taking Instaflex Advanced for 28 days. It has not really helped me at all, but two days ago, I noticed a rash around my knees and the inside of my thighs. I am wondering if this is from the turmeric and should I stop taking it? I hope not. I just bought a new bottle, thought I would give it one last try. Please advise.

    Bottom Line: No, I would not recommend this to a friend

  • For knee pain

    • By Estella S.,
    • Jacksonville, FL,
    • Nov 17, 2018
    • Verified Reviewer
    Overall Experience:

    After trying many over-the-counter medications for knee pain, I saw this advertisement for Instaflex Advanced and decided to give it a try. I ordered it online from Walgreens, two for one, 14 pills in each bottle. I took it for about 10 days and did notice some relief from pain, however, on the 11th day started to experience severe diarrhea and vomiting, to the point that I had to go to the emergency, and found out that an ingredient in this pill was the problem and caused a bad bacteria infection. So if you are going to take this pill, please check with your primary care doctor to make sure you can take this med. I am not saying it does not work, but everyone should make sure before taking it.

    Bottom Line: No, I would not recommend this to a friend

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