About Instaflex Advanced

By Anthony Dugarte, M.D., C.S.C.S
Updated on: Mar 20, 2020

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What Is Instaflex Advanced?

Instaflex Advanced is a joint support dietary supplement formulated by Dr. David Katz, Director and Co-Founder of the Yale Prevention Research Center.

Joint pain is one of the most common reasons for seeking the care of a doctor. With so many people affected, treatment options that aim to delay or prevent the need for joint replacement surgery remain a topic of much debate.

Per their website, Instaflex promises to “strive to provide the best science-backed products that deliver the best results possible.'' According to Dr. Katz, Instaflex Advanced accomplishes this goal.

Dr. Katz states that you can experience joint relief in just 7-days by taking 1 pill with water each day. The proposed benefits may be possible without glucosamine or chondroitin, the common joint relief supplement ingredients.

But is there any scientific support to back these claims?

In this article, we’ll review the safety and efficacy of Instaflex Advanced to help you determine if this supplement can relieve your joint pain.


According to their site, the original Instaflex formula was improved upon by Dr. Katz. The Instaflex Advanced formula allegedly helps relieve joint discomfort and improve flexibility through its blend of ingredients.

In this section, we’ll go through each ingredient and discuss the available support for the proposed benefits.

Turmeric (rhizome)(standardized to min 95% curcuminoids) 200 mg

Turmeric has been used in preparing food and creating clothing for thousands of years. Is there more to this spice?

Turmeric may help benefit heart health and brain function. Its proposed anti-inflammatory actions are likely why it has been included in Instaflex Advanced, however.

Your inflammatory response promotes healing after injury. Though this process is important, chronic activation can be associated with arthritis. Turmeric may limit the inflammatory response through curcumin, a molecule produced by turmeric plants.

Aspirin blocks the action of cyclooxygenase (COX), enzymes that play a key role in inflammation. Curcumin inhibited these enzymes in a laboratory model using human colon cancer cells.

In a recent review of 8 studies, the use of curcumin dosages ranging from 500-1500mg per day were found to benefit arthritis. The researchers did conclude, however, that more research is needed as the data available from these studies was not sufficient for a definitive conclusion.

While turmeric may have a role in the inflammatory response, evidence in human subjects is lacking.

Resveratrol (from Polygonum cuspidatum root extract) 100 mg

Resveratrol is a substance found in blueberries, grapes, and peanuts. It behaves as an antioxidant that combats free-radicals, or molecules that damage cells.

Resveratrol may also offer anti-inflammatory effects by acting on the same mediators as turmeric.

In rabbits with knee arthritis, those that received injections with resveratrol experienced decreased cartilage destruction when compared to the control group.

In 50 patients with inflammatory bowel disease, those treated with 500mg of resveratrol over 6-weeks reported improvements in quality of life; these results were, in part, due to resveratrol's ability to reduce inflammatory enzymes.

Most of the scientific support for resveratrol's ability to reduce inflammation has been in laboratory and animal models. While some human studies demonstrate the anti-inflammatory effects, these actions have yet to be demonstrated in human trials.

UC-II® (10 mg total collagen, 3 mg undenatured type II collagen) 40 mg

Type II collagen is a key component of cartilage. UC-II is a type of collagen that is obtained from the breastbone of chickens. It may improve joint function by reducing collagen destruction, inflammation, and pain.

In patients with hand, hip, or knee arthritis, those treated with type II collagen had better results for arthritis lab tests at 6-months and 1-year when compared to other treatments.

Arthritic rats treated with 1, 3, and 10 mg kg-1 doses of type II collagen over 2-weeks improved balance, weight-bearing and lab tests for arthritis.

Most recently, 39 patients with knee arthritis were randomized to either Tylenol alone or 10 mg/day type II collagen & Tylenol treatment; those treated with type II collagen reported improved function and quality of life at 3-months.

The early results for type II collagen’s ability to offer joint pain relief are promising. Joint pain often spans for decades, however. So the available short-term data must be taken with a grain of salt. More work is needed to identify its role in the long-term.

Hyaluronic Acid (HA) (min 89%) 5 mg

HA is the main component of joint fluid. Pain and dysfunction can occur when your joints dry up.

Injectable forms of HA are well studied, though current research does not demonstrate a benefit.

When taken orally, HA may help reduce joint pain and swelling.

In 20 patients with knee pain, those treated with 80mg/day of HA improved pain and function after 8-weeks. Similarly, 80mg/day of HA over 3-months improved muscle strength in subjects with mild knee pain.

While these findings demonstrated a possible role for HA and benefits in treating knee pain, Instaflex Advanced contains doses smaller than the amounts used in this study.

Apresflex®-Boswellia serrata Extract (resin) 100 mg

AprèsFlex® is a patented Boswellia Serrata extract. This herb is obtained from Middle Eastern Boswellia trees and may possess anti-inflammatory properties.

In 60 patients with knee arthritis, those treated with 100 mg of Boswellia Serrata extracts for 3-months had improved joint function and reduced pain.

It’s important to note that Laila Nutraceuticals, the owner of the AprèsFlex® patent, supports this study.

Some patients in this study experienced relief in as little as 7-days. This extract may be responsible for the quick-relief claims made by Dr. Katz. Still, these results were short-term, so we don’t know if there are lasting effects.

Bioperine®-Black Pepper Extract (BPE) (fruit) (standardized to min 95% piperine)

Bioperine®-Black Pepper Extract may have antioxidant and anti-inflammatory effects, as well as disease-fighting capabilities.

Additionally, it is thought to promote the many benefits of turmeric. The joint-related effects of (BPE) have not been well studied, however.

In a laboratory setting, 10 to 100 microg/ml of BPE reduced inflammatory lab results. In an animal model, BPE reduced signs of inflammation in rat ankles.

These early results highlight the need for further studies, particularly with human subjects.

Safety and Side Effects

Part of the potential benefit of nutraceuticals is their safety profile. Joint pain and arthritis are long-term issues, often requiring medical management. Even over the counter treatment options can be damaging to the liver and kidney over time.

These issues may be avoided with the ingredients offered in Instaflex Advanced, all of which are generally safe.

Turmeric offered even at 1500mg per day was without adverse effects. Similarly, according to tests, resveratrol is safe at doses 5x higher than what Instaflex Advanced contains.

Type II collagen was safely tested at doses higher than those offered in this supplement.

HA was safe in those treated with 80mg doses. Boswellia Serrata treatment at doses identical to those offered by Dr. Katz were not associated with adverse effects.

BPE is generally safe to use, but the studies examining its anti-inflammatory effects in human subjects with joint pain are lacking.

While the safety profile of this extract is likely favorable, your joint pain may be caused by an issue that should be medically managed. For this reason, you should speak with your doctor first to properly identify that cause.

Pricing and Where to Get It

The company offers a 14-day sample for $4.99 in shipping charges. Afterwhich, you'll automatically be enrolled in an autoship program for $69.99 per month. You'll continue receiving a 30-day supply until you cancel.

Should you enroll in the 14-day trial, you must cancel your membership within 18 days of enrollment to avoid being charged the full amount.

Additionally, a bottle of Instaflex Advanced (30-count) costs $69.99 plus $4.99 in shipping should you want to bypass the free sample.

Dr. Katz backs your purchase with a 30-day guarantee.

The 30-count can be purchased at Amazon for $57.99. GNC offers the 30-count at $64.99.

At Walgreens, 14 capsules are available for $29.99.

Instaflex Advanced

Buy Instaflex Advanced from Amazon:

Instaflex Advanced costs $57.99 for a 30-count bottle, with free shipping. It is recommended that you take 1 pill each day, so one bottle is equal to a 30-day supply. It is rated 4.1-stars based on 1,250+ reviews.

$57.99 (30 count)

Instaflex Advanced vs. Arthrozene

Arthrozene is another product with proposed joint relief benefits. It has some ingredients in common with Instaflex Advanced.

Ingredient Instaflex Advanced Arthrozene
Type II Collagen
Boswellia Serrata

Keep in mind that you’ll miss out on 3 of the Instaflex ingredients. As turmeric, reservatrol, and BPE lack strong evidence for their efficacy in human subjects, you’re likely not missing out on much.

However, and you’ll pay nearly $80 for a 30-day supply of Arthrozene - $30 more expensive than Instaflex.

In this instance, Instaflex seems to be more cost-effective and also packs in a few more ingredients for your money. Though not inexpensive, the 30-day guarantee should give you enough time to determine if you find it to be effective.

The Bottom Line

Instaflex Advanced contains a blend of ingredients that may play a role in reducing the pain and inflammation associated with joint pain and arthritis, though more human trials are needed.

Most of the ingredients have been studied at doses much higher than what is offered in this supplement. While this speaks to the probable safety of Instaflex Advanced, this also means that the reported benefits may be less likely.

Amazon users rate this product at 3.9 out of 5-stars on over 1000 reviews. Over 30% of the reviews are 3-stars or less. Most of the customers that offer negative reviews believe this supplement to be too pricey for the limited benefits it offers.

As much of the available research includes study durations of 3-months or less, we can’t speak to the long-term effects of these ingredients. The long term effects are an important piece of information that we lack as joint pain is a chronic condition.

Nonetheless, some of the other common treatments (Tylenol, for example), can be harmful when used for long periods. As the upside of finding relief with a nutraceutical can be delaying or avoiding medical and surgical management, they may be a reasonable option to try.

Be sure to speak with a doctor about your symptoms first, however. Identifying the cause of your pain is the first step in the plan of care.

Customer Reviews

Start your review of Instaflex Advanced:
  • 31 Customer Reviews
  • 29% Recommend This Product
2.4 out of 5
5 star: 25% 4 star: 3% 3 star: 6% 2 star: 9% 1 star: 54%

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  • Misrepresented

    • By Deborah,
    • Columbia, SC,
    • Nov 17, 2015
    Overall Experience:

    I had high hopes this would help me. Maybe it would butthis formula definitely has some chondroitin sulfate in it. I have suffered extensive endless diarrhea everyday since starting it. I didn't want to believe it had what other arthritis formulas that I am allergic have, shellfish, etc., but after doing research, I found that this Instaflex Advanced with UC II Collagen still has what its original formula does. Please do not misrepresent as there are people like me who cannot use stuff like this no matter how much pain we're suffering. I took it the full two-week bottle hoping I was wrong. Then my diarrhea became uncontrollable. Had to stop.

    Bottom Line: No, I would not recommend this to a friend

  • Bad product

    • By Jane Romanow,
    • Pittsburg, NH,
    • Feb 13, 2016
    • Verified Reviewer
    Overall Experience:

    I took InstaFlex Advanced. My joints felt better. However, I then got serious intestinal cramping, diarrhea, experienced hair loss, sores on skin, and dandruff. This was certainly not for me.

    Bottom Line: No, I would not recommend this to a friend

  • Very poor results

    • By G. Parries,
    • Las Vegas, NV,
    • Aug 28, 2017
    • Verified Reviewer
    Overall Experience:

    I have used Swanson's Glucosamine, Chondroitin and MSM with Hyal-Joint for many years.

    In order to determine the effect of Instaflex, I stopped taking the Swanson product for two weeks before starting Instaflex.

    Here are the results of my trial period:

    A. I took the Instaflex exactly as the customer service rep said to take it.

    B. I started to have mild consistent pain in my knees at all times. On a level of 1 to 10, this was a 2 to 3.

    C. When I played tennis, I started to get much more pain after about an hour. This reached a 6 to 7 level each time that I played. The pain would remain well into the evening.

    D. After the trail, I went back to the Swanson product, and after a few days, the consistent pain was gone again. When playing tennis there is only a mild pain (level 4-5) when a wrong twist is made, but it goes away in a minute or two.

    This product made my pain worse, but maybe it will work better for you.

    Bottom Line: No, I would not recommend this to a friend

  • Severe reaction

    • By Debbie Howe,
    • Ontario, Canada,
    • Nov 27, 2017
    • Verified Reviewer
    Overall Experience:

    After taking it for only two days (two capsules), I have had severe cramps and diarrhea for 5 days now, it has left me tired. I have never reacted to any products before, so this is a surprise for me. I now will seek out a physician to help me recover.

    I would not recommend this product.

    Bottom Line: No, I would not recommend this to a friend

  • Dishonest company

    • By Hesham Moselhy,
    • Burlington, Ontario, Canada,
    • Dec 27, 2017
    • Verified Reviewer
    Overall Experience:

    Customer care is not truthful, satisfaction is NOT guaranteed, and I was not able to return the product because it did not work. I would never recommend this product to anyone for any reason.

    Bottom Line: No, I would not recommend this to a friend

  • It doesn't work, scam

    Overall Experience:

    Hi, I have bad knee joints. I started using Instaflex with the ad you can try it for free. The catch is you have to give them your payment in advance. After one month use, I saw no difference so I figured I'd give it at least three months. So, they automatically charge you after the first month. Then when I realize this product is a fraud, I go to try and cancel, and there's no cancellation. I had to go to my bank to actually make them stop paying them for a product that does not work!

    Bottom Line: No, I would not recommend this to a friend

  • Don't waste your time or money

    • By Ron Kelley,
    • Myrtle Beach, SC,
    • Mar 13, 2018
    • Verified Reviewer
    Overall Experience:

    The only thing that was worse than trying this useless product was wasting my time talking to one of the worst customer service organizations on the planet. They didn't even have the decency to stand behind their advertised return policy as stated in their advertising. Trust me, you don't need the aggravation.

    Bottom Line: No, I would not recommend this to a friend

  • Is this a scam?

    • By Isabel Estrada,
    • Bayamon, Puerto Rico,
    • May 7, 2018
    • Verified Reviewer
    Overall Experience:

    I ordered the Instaflex free sample at the beginning of April, and the $4.99 were immediately withdrawn from my account on April 9, 2018.

    Today is May 3, 2018, and I still haven't received my "free" sample. Is it because I canceled within the 18 days after I placed my order?

    You still owe me $4.99. Is this a scam?

    Bottom Line: No, I would not recommend this to a friend

  • No I would not recommend this product

    • By Carole W.,
    • Ohio,
    • Aug 21, 2018
    • Verified Reviewer
    Overall Experience:

    I have been taking this product for almost two months and found little if any relief. It's very pricey. It may work for some, but based on my experience, I suggest don't waste your money! Don't waste your money.

    Bottom Line: No, I would not recommend this to a friend

  • Not what it is advertised to be

    • By Mary H.,
    • Memphis, TN,
    • Aug 28, 2018
    • Verified Reviewer
    Overall Experience:

    I ordered the sample pack of Instaflex for $4.99 and began taking it. I did not notice any difference in the first or second week but continued taking it just to see. Before I was through with the trial package, I received a bottle of Instaflex with a charge on my credit card for almost $80.00. This bottle was promptly returned, and I asked my credit card to reverse the charges because I did not order it.

    In my opinion, it is a SCAM of the worst kind, and this company continues to advertise on TV. I am not sure why with such reviews. I only wished I had read all the reviews before I ordered.

    People BEWARE! This is a scam, and if you cannot get your bank or credit card company to participate, you will be paying for a big bottle of Instaflex for a long time, and it does NOT work. Thank you and please heed this warning.

    Bottom Line: No, I would not recommend this to a friend

  • Terrible and deceptive marketing

    • By David P.,
    • Porcupine, SD,
    • Sep 20, 2018
    • Verified Reviewer
    Overall Experience:

    I ordered the free 14-day sample pack and agreed to pay for the shipping. The sample pack never arrived. Then I receive a large bottle in the mail and my account is billed nearly $75.00. I never felt any pain in my joints as I left my living room floor on my way to the ceiling. The only severe pain I felt was a severe and debilitating pain in the pocketbook.

    Bottom Line: No, I would not recommend this to a friend

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