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Unify Health Labs Multi-GI 5

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175 Customer Reviews

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Unify Health Labs claims to offer a dietary supplement that will support healthy digestive to improve whole-body health. This product may be able to offer a reasonable option for digestive, immune, and overall health. However, the dosages contained in this dietary supplement are much lower when compared to clinical studies.


  • Prebiotics and probiotics blends are generally recognized as safe (GRAS)
  • Blend of ingredients and their strains all relate to promoting gut microbiota
  • 90-day money-back guarantee


  • Certain strains can provide side effects that may include diarrhea, cramping, flatulence, and constipation
  • Longer than normal shipment, taking as long as 15-20 days

Unify Health Labs Multi-GI 5 Review: Is It Safe and Effective?

By Rocklend Davis, Ph. D.

Updated on: Jul 13, 2020

What Is Multi-GI 5

Multi-GI 5 is a dietary supplement from Unify Health Labs that contains prebiotics, probiotics, and a blend of ingredients alleged to improve gut health.

In your gastrointestinal tract (GI), prebiotics allows for changes in the composition and/or activity of microorganisms to occur in the GI tract.

Probiotics help to develop the microorganisms in the GI to help ensure an appropriate balance of the bacteria that is necessary to maintain normal function in the GI.

Specifically, improved digestion is associated with more efficient absorption of important nutrients that we get from a well-balanced diet.

Unify Health Labs claims that you will experience benefits with daily use of their dietary supplement. According to their website, by taking 1 scoop, the company alleges that you may experience:

  • Healthy digestion
  • Improved weight management
  • Increased energy
  • Healthy GI lining
  • Balanced gut flora

In this article, we’ll help you determine if there is in fact support to back the claims made by Unify Health Labs by reviewing available research for the active ingredients.

Multi-GI 5 Ingredients: Do They Work?

Multi-GI 5 contains 3 blends of ingredients to support gut health: GI Health Blend, Prebiotics, and Probiotics. It is easy to see that the proposed benefits of this supplement are related to this blend of prebiotic and probiotic strains.

First, we’ll discuss GI Health Blend ingredients.

Fermented L-Glutamine, 200 mg

Glutamine is an amino acid in the human body and is primarily used by the cells in the intestinal wall.

While there appears to be some progress made with glutamine supplementation in the role of GI health, most of the progress is based on observational studies.

Acute oral glutamine supplementation, even at lower dosages (0.25 g kg), was able to support GI health in a study of healthy active males.

Magnesium BHB (KetoVantage ®), 70 mg

Beta-Hydroxybutyrate (BHB) is a ketone body that is used by the brain as fuel. Further, BHB may aid in transporting energy from the liver to the surrounding tissues while fasting or during exercise.

Results from a study of healthy trained cyclists found that BHB supplementation increased exercise performance by 2%.

Studies, however, are limited with regards to understanding BHB supplementation and performance of higher intensity exercise. A study of trained endurance athletes experienced a decrease in endurance at a higher intensity. This effect may be present due to decreased representation of carbohydrates.

Deglycyrrhizinated Licorice Root Extract, 50 mg

Deglycyrrhizinated licorice (DGL) extract had the glycyrrhizin removed. Due to the removal of this compound may limit or even decrease adverse effects in its true form licorice.

A laboratory study found that deglycyrrhizinated licorice may play a role in alleviating ulcers from aspirin-induced mucosal damage in rats.

DGL extract of 75 mg, taken twice daily was used to treat functional dyspepsia and was revealed to improve symptoms in humans. The DGL dosage contained in this GI Health Blend, according to the nutrition label on Unify Health Labs, indicates 50 mg.

BioPerine ® Piper Nigrum Extract, 10 mg

Piper Nigrum Extract, also known as black pepper, may be used for medicinal purposes or as a preservative. Dietary piperine plays a role in stimulating the digestive enzymes of the pancreas, enhances the digestive capacity, and decreases GI food transit time.

However, these health benefits are only shown in animal studies. Further studies and research are required in humans to confirm effects, especially in the long-term.

BioPerine received a GRAS status (generally recognized as safe).

Berberine Hydrochloride, 3 mg

Berberine is known as an alkaloid that comes from plants. Berberine may have a role in anti-diarrhea and anti-inflammatory.

A study of 196 patients with irritable bowel syndrome received berberine hydrochloride of 400 mg twice daily for 8 weeks. The findings from the study suggest that berberine hydrochloride can reduce GI issues.

Further, berberine hydrochloride supplementation at this dosage presented with side effects that were related to digestion. Some reports included:

  • Cramping
  • Diarrhea
  • Flatulence
  • Constipation
  • Stomach pain

These symptoms disappeared after decreasing the dosage by 300 mg. Included in one scoop of the Multi-GI 5 GI Health blend is 3 mg of berberine hydrochloride, which is well under the dosage utilized in the study.

Nonetheless, if you begin to notice any of the side effects, stop taking the supplement.

Zinc (from Zinc Carnosine Complex), 1 mg

Zinc is an essential trace element and is involved in numerous life processes. Zinc can be found in meats, dairy, nuts, grains, and beans. Zinc may also play a role in strengthening the integrity of the gut.

In mice, zinc was found to impact gut microbiota and offer protection to conditions affecting digestive health. Also, the effects of zinc and their role for gut health in humans needs to be further research.

Prebiotic Blend

Fructooligosaccharide (FOS) 4 g

Oligosaccharides occur naturally and can be found in plants such as onions, chicory, garlic, asparagus, banana, artichoke, and many others.

This blend helps to feed the intestinal gut microbes and the by-product that is released into the blood helps the gastrointestinal tracts.

Low quantities of fructooligosaccharides exist in food.

Prebiotics help regulate the environment of gut microbes in humans. The gut microbes or microbiota are considered its separate organ that contains a large number of bacterial cells that will help to perform many functions.

Further, the use of prebiotics to treat and influence gut health are strain-dependent. A review of 43 studies to examine the effectiveness of prebiotics to treat irritable bowel syndrome (IBS) and constipation were inconclusive. This may be due to the limited studies available of prebiotics in humans.

Probiotic Blend

This blend of probiotic contains 5 strains of good bacteria to improve digestion, weight management, and reduce gas and bloating.

Lactobacillus gasseri (100 billion cfu/g) 9 mg

This particular probiotic helps to support immune systems and colonizes approximately 40% of your digestive tract. Also, it may help to help lower stress levels in patients suffering from irritable bowel syndrome (IBS) by improving gut microbiota in healthy adults, improve mental state, and sleep quality.

ProDura ® Bacillus coagulans (150 billion cfu/g) 7.26 mg

Bacillus coagulans is a lactic acid that produces spore-forming bacterial species. This formation protects B. coagulans as it travels through the acidic environment of the stomach to reach the intestines. Once it has reached its destination, it begins the process of germination that will aid in the digestion of carbohydrates and proteins.

B. coagulans may also contribute to increased benefits of prebiotics by encouraging the growth of more healthy gut bacteria. A study supplemented B. coagulans for 28 days in elderly subjects was found to have influenced a higher density of healthy gut bacteria.

A review of toxicology testing studies has found that Bacillus coagulans have a history of safety for human consumption.

Lactobacillus rhamnosus (350 billion cfu/g) 7.13 mg

L. rhamnosus is a commonly used strain and appears to be well documented for the prevention and treatment of infections that occur in the gastrointestinal tract. Furthermore, it may play a role in the treatment and prevention of diarrhea and prevent allergic reactions.

A meta-analysis of 12 randomized control studies suggests that Lactobacillus rhamnosus has a role in preventing antibiotic-associated diarrhea in adults who were treated with antibiotics.

A clinical trial was also able to show the ability of this probiotics role in modulating the gut microbiota composition. This eventually leads to a decrease in potentially harmful bacteria and supports the good bacteria.

Lactobacillus plantarum (400 billion cfu/g) 3 mg

These are identified as good bacteria that attack the bad bacteria.

The possible benefits of L. plantarum may include reducing toxins, bloody pressure, fungal activity, and symptoms of irritable bowel syndrome (IBS).

In a clinical trial, L. plantarum was able to decrease symptoms of IBS, particularly the symptoms of abdominal pain and bloating.

While there were no known side effects while taking L. plantarum, there was only one report of an adverse event by transient vertigo in one of the subjects in the trial.

Lactobacillus Casei (300 billion cfu/g) 7.13 mg

Lactobacillus Casei is reported to stimulate the production of lactic acid to help aid in healthy digestion, nutrient absorption, and regularity (gas and bloating).

In a study of 70 patients with constipation were randomized to consume 65 mL of L. casei and noted significant improvement of self-reported symptoms when compared to the control.

Is Multi-GI 5 Safe?

According to the nutrition label found on Unify Health Labs’ website, one scoop contains the 3 blends and is instructed to take twice daily.

The available blends contain ingredients that are associated with side effects that include diarrhea, cramping, flatulence, and constipation. If you do begin to experience these symptoms, stop taking the supplement, and notify your physician immediately.

The dosages of the ingredients are well under the dosages that were used in the studies. Lower dosages combined with natural ingredients provide a favorable safety profile.

It is recommended to take the dietary supplement as indicated on Unify Health Lab’s Website. Dosing of any amount should never be increased.

The Cost

Multi-GI 5 is available on Unify Health Labs website. There are multiple purchasing options and ships to you in 15-20 business days. One container of Multi-GI 5 contains 30 servings.

  • 1 bottle (1 month supply) - $69.95
  • 3 bottles - $188.85 (savings of $21.00)
  • 6 bottles - $353.70 ( savings of $66.00)

Each order is backed by a 90-day money-back guarantee with no hassle. To process your refund, email support@unifyhealthlabs.com or call 800-935-4598.

The Bottom Line

Multi-GI 5 includes 3 blends of ingredients that offer many scientifically proven benefits. As a comprehensive blend with many ingredients, this supplement may support overall gut health.

While the dosing of each ingredient is included and safe, it may be too little to achieve the proposed benefits.

We have reviewed products that seek to promote gut health with comprehensive blends and are similarly priced. You may save by avoiding the need for additional supplements, however.

Before treating symptoms on your own, speak with your doctor first.

Customer Reviews

4.1 Stars out of 175 Reviews
5 Star:42% 4 Star:40% 3 Star:5% 2 Star:4% 1 Star:7%
82% Recommend This Product
Start your review of Unify Health Labs Multi-GI 5:
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Posted on Jun 12, 2022

Healthy and full of energy

By Sherry M., Miami, FL, Verified Reviewer

After about two weeks of taking Unify Health Labs Multi-GI 5, I began to really experience a difference in my overall well-being. I felt energetic, and I experienced less bloat. My digestive system was smoother in that I was regular and went to the bathroom with ease. Finally, I found that I did not crave sugar and processed foods. Along with exercise and eating healthy, my overall health improved!

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Easy to take

Helps with regularity

Feel energetic

No “cons” were specified in this review

Helpful Review? 2 People Have Voted

Posted on Jun 10, 2022

Completely resolved all of my IBS problems

By Maria W., Nashville, TN, Verified Reviewer

I have dealt with IBS issues for years. Plagued by digestive issues, I have been taking very expensive peppermint oil capsules, which was the only thing that helped at all, and even then I would have issues.

I was a little worried at first because the advertising kept talking about helping constipation and I had the opposite issue. Well, not anymore. On top of that, I don't suffer with the gas, bloating, acid, etc., that I used to deal with on a regular basis. And I don't even take my peppermint oil, which would have been unthinkable prior to now.

I feel good. It's hard to judge whether or not it is giving me an energy boost, but I am not dragging and feel well every day. As far as losing weight, I have been taking this product daily for almost a month and I have lost several pounds, however, I have also changed my diet and have watched it very closely. Prior to this, nothing I did seemed to help with the weight loss, so while I would not promote this as a product that is going to dramatically affect your weight, I do think that it positions you so that you get better results from eating healthy and changing your diet.

I also really enjoy the lemonade flavor and actually look forward to drinking it! I enjoy it mixed in water with ice. Very refreshing on a hot summer day!

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Has provided amazing results in alleviating my IBS symptoms

Tastes great and I enjoy drinking it, also love that it has no added sugar

I believe it is contributing greatly to my digestive health

I was hoping to see faster results in the weight loss area but I will keep working on it

Helpful Review? 2 People Have Voted

Posted on Jun 5, 2022

Helpful product

By Ellen R., Kent, MN, Verified Reviewer

Multi-GI 5 has provided the best relief for my gut issues than anything I have tried in the last several years. I would give it an excellent rating if it were not for the minuscule dust particles released in the air each time I scoop it out of the jar. It causes a coughing sneezing fit regardless of how I attempt to avoid the “dust” getting into the air. Multi-GI 5 mixes easily and quickly with water and has a pleasant taste so I would like to give it an excellent rating if not for trouble breathing in the area of use.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons


Ease of preparation

Coughing fits

Helpful Review? 2 People Have Voted

Posted on Jun 4, 2022

Pleasantly surprised!

By Kimberly S M., Inglewood, CA, Verified Reviewer

I was surprised at how well Multi-GI 5 works for me. I mix it with my tea throughout the day and I’m satiated and feel good. I’ve lost pounds without thinking about it and I feel more energized!

Length of Use: 6–12 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons



Feel good

The powder is overwhelming when I open the jar

Helpful Review? 2 People Have Voted

Posted on May 30, 2022

I have only been taking for a week and I have noticed a change

By Kathy K., Australia, Verified Reviewer

The taste isn’t too bad, though I have a bit of a funny sensation in my mouth. I have to hold my breath when I open it to grab the spoon to put it into the water as it makes me cough. I have noticed that I don’t feel so hungry and bloated, so that’s a good thing. I have only been taking it for a week so time will tell.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Nice tasting

It makes me cough when scooping it up

Helpful Review? 2 People Have Voted

Posted on May 29, 2022

Love this stuff

By Nicole J., Chewelah, WA, Verified Reviewer

I would take two acid reflux pills a day and a few Tums a night and still have stomach problems. I started taking this drink every morning and I have not taken any pills since starting to drink this. If I eat something spicy I might still have to eat a Tums but never have to take pills again. This stuff is amazing and I will keep using it.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Helps with my acid reflux so much

No “cons” were specified in this review

Helpful Review? 2 People Have Voted

Posted on May 28, 2022

Enjoying the results I’m getting.

By Sally B., San Diego, CA, Verified Reviewer

I have been using this for almost a month now. I think this product has been making me more regular, I haven’t been burping nearly as much as I was previous to taking it. I can’t say that about the lower gas build-up yet though. I used to have to run to the bathroom often, and sometimes not making it in time, but this has stopped that issue for me. I just ordered a few more canisters. I like the taste, although it is a little sweet, I just add a squeeze of lemon to help with that. I had to buy a blender bottle to mix the powder up because it would clump together and wouldn’t dissolve. I do have a hard time breathing when I open the canister, the powder gets inhaled and I can’t breathe.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Results with movements

Easy to follow through

Upper gas

Powder makes it hard to breathe

Lower gas

Helpful Review? 2 People Have Voted

Posted on May 27, 2022

Not sure yet

By H S., United Kingdom, Verified Reviewer

Been on this for three weeks. Take it every day with a whey drink as the taste is horrible but disappears in my drink. It’s too early to tell if it’s made a difference so going to buy a second tub and see after two months.

Length of Use: Less than 3 months

Bottom Line: No, I would not recommend this to a friend

Pros and Cons

Bowel movements are regular



Helpful Review? 2 People Have Voted

Posted on May 27, 2022

After only 3 weeks, I feel great!

By Kim S., Newark, OH, Verified Reviewer

It's hard to describe how good I feel after only three weeks of taking the Multi-GI 5. More energy, no bloating, regulated and much-improved bowel function, and best of all, love the taste! I was skeptical because most things I've tried taste like medicine or leave a bad aftertaste. Glad I came across this in my Facebook feed!

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

More energy

No bloating - stomach issues almost non-existent

Great flavor

Price - but I appreciate that I've been offered discounts so it's more affordable, otherwise I don't think I would have tried it

Helpful Review? 3 People Have Voted

Posted on May 27, 2022

Seeing differences already!

By Sandy D., Newcastle, Australia, Verified Reviewer

My husband hasn’t been getting reflux and I’ve been regular for the first time in years.

It does what it says it will. Haven’t been on it long but already feeling a difference.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

Stomach settled

Appetite reduction


Powder up the nose when opening container

Very sweet

Big container with not much in it

Helpful Review? 2 People Have Voted

Posted on May 25, 2022

New user

By Janet S., Ontario, Canada, Verified Reviewer

I recently started using this product, so I haven't noticed a significant change in any way as yet. I have noticed that I have a bit more energy instead of suffering an afternoon slump. Still waiting to see if there are other beneficial effects.

Length of Use: Less than 3 months

Bottom Line: Yes, I would recommend this to a friend

Pros and Cons

I feel like I do have more energy

The powder is so fine that it easily gets into the air and I choke on it, I have to hold my breath while scooping it into the water

The taste is very strong, it took a while to get used to it

Helpful Review? 2 People Have Voted
Showing 1-11 of 175

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