About Nucific BIO X4

Billed as a 4-in-1 weight management probiotic, Nucific BIO X4 claims to be a “revolutionary new compound” containing 4 proven nutrients that provide digestive support, suppress appetite, and support weight loss management. This includes:

  • 39 billion colony-forming units (CFUs) of a proprietary Digestive Enzyme Blend that helps your body easily digest carbs, fats, and proteins,
  • Green tea to boost your metabolism, and
  • Caralluma Fimbriata to suppress cravings.

Despite these benefits, Nucific’s BIO X4 is claimed to cause no known side effects, contains only 100% pure ingredients, and is made without lactose, gluten, or fillers.

According to the manufacturer, you should take one capsule of BIOX4 with each meal (3 capsules daily), and as long as you exercise regular and don’t eat too many carbs or sweets, you’ll begin experiencing results within 1-2 months.

Whether you’re just starting with a weight loss regimen or have been at it for years, can Nucific BIO X4 provide the digestion support you need to break through your barriers? Consider the following:

Is BIO X4’s Ingredients Effective for Weight Loss?

According to BIO X4’s product label, the supplement contains:

  • Probiotic Blend: 4 billion CFU per capsule – Lactobacillus acidophilus, L. rhamnosus, L. plantarum, Bifidobacterium lactis, B. animalis.
  • Digestive Enzyme Blend: 88mg – Amylase (from Aspergilus Oryzae), Bromelain, Lipase (from Rhizopus Oryzae).
  • Weight Management Blend: 100mg – Green Tea Extract (50% EGCG)
  • Craving Control Blend: 166mg – Caralluma Fimbriata Extract

As we detailed in our Probiotics Buyer’s Guide, probiotics have been used for decades for the treatment of irritable bowel syndrome, allergic response, H. Pylori infection, boosting immune response, and more, and have reams of clinical data proving them to be effective.

Note: Although BIO X4’s website claims that it contains 39 billion CFUs, each capsule only contains 13 billion. In other words, by taking 3 capsules per day, you’ll cumulatively be ingesting 39 billion CFUs. This is important because some consumers shop for probiotics specifically based on the number of actual CFUs each dose provides, and Nucific’s claim might be a bit confusing.

Amylase is “an enzyme that catalyses the hydrolysis of starch into sugars,” and bromelain “is an enzyme found in pineapple juice and in the pineapple stem” that’s used for “reducing swelling (inflammation), especially of the nose and sinuses, after surgery or injury,” and more. Finally, lipase “is an enzyme that catalyzes the hydrolysis of fats (lipids).”

While there are multiple studies related to the oral administration of amylase, clinical support for many of BIO X4’s claims appears to be on the slim side. Likewise, except for treating osteoarthritis and preventing muscle soreness after exercise, there isn’t enough clinical evidence showing that bromelain can provide other benefits.

And other than treating digestive problems related to pancreatic disorders, there is insufficient clinical evidence showing that lipase can provide any other benefits. Similarly, there isn’t enough clinical evidence showing that caralluma can provide any benefits, either.

Finally, epigallocatechin gallate (EGCG), the main ingredient in green tea, is often touted as providing a wide range of benefits, although there is insufficient evidence supporting any of them.

BIO X4 Side Effects

As with most nutritional supplements, even though many of BIO X4’s ingredients may not provide the benefits claimed by the manufacturer, they should be well tolerated by most individuals.

However, the probiotics in BIO X4 may cause a temporary increase in bloating or gassiness, although this side effect should resolve itself over the course of a couple days. Caralluma might also lead to gas, constipation, or stomach pain, which should subside after a week of use.

Green tea extract generally contains at least some caffeine, depending on how it’s processed, so this might be relevant for users who are sensitive to stimulants.

Nucific’s Arbitration Agreement

Finally, it’s important to note that by placing your order for BIO X4, you’ll automatically be bound by an arbitration agreement.

Although this is a fairly common practice among companies who sell most of their products online, if you experienced any damages from using BIO X4, this means that your legal recourse against Nucific would be extremely limited, including becoming part of a trial by jury or joining a class action lawsuit.

What’s the Customer Buzz about Nucific BIO X4?

BIO X4 was a very new product at the time of our research (Nucific’s URL was registered in April 2015 and the company’s trademark was filed in June of 2015), so there weren’t any online reviews available.

Since Nucific is such a new company, they also weren’t listed with the Better Business Bureau.

Nucific BIO X4 Pricing & Refund Policy

The BIO X4 supplement is priced as follows:

  • 1 Bottle (30-day supply): $49
  • 3 Bottles: $129
  • 6 Bottles: $240

According to the product’s website, all orders over $50 come with free shipping.

All Nucific products come with a 90-day refund policy. Although no further details were provided, you’ll need to contact Nucific’s customer service department at 888-679-5520 or support@nucific.com in order to request a refund.

Can Nucific BIO X4 Support Digestion & Weight Management?

While BIO X4’s probiotics will likely provide some level of digestion support (e.g. reducing some types of inflammation, boosting immune response, etc.), unless your intestinal flora is severely out of whack, any benefits you’ll achieve will likely be minor. On top of this, all of the supplement’s other ingredients have insufficient evidence to back up Nucific’s claims.

Considering this, it’s our opinion that BIO X4’s price isn’t in line with any benefits you can realistically expect to achieve from using the supplement.

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804 Consumer Reviews for Nucific BIO X4

Average Consumer Rating: 4.4
Rating Snapshot:
5 star: 532 4 star: 185 3 star: 21 2 star: 22 1 star:  44
Bottom Line: 91% would recommend it to a friend
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  • Good so far

    I am losing a little bit, but I am not discouraged yet. My husband is also trying it. We will keep going and hopefully lose what I need to. Thanks so much for a product that seems to be working. I just ordered some more.

    Bottom Line: Yes, I would recommend this to a friend

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  • A godsend!

    • Maumee, OH,
    • Nov 20, 2017
    • Verified Reviewer

    I have been taking BIO X4 since the middle of September and have lost 24 pounds! I have belonged to health clubs for over 30 years and go swimming 3 or 4 times a week, and I could never figure why I never lost weight. This product has been a godsend to me!

    Bottom Line: Yes, I would recommend this to a friend

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  • Thank you BIO X4!

    • Folsom, CA,
    • Nov 20, 2017
    • Verified Reviewer

    I have experienced bloating and digestion issues for years. I thought it was allergies, but I could never identify the source. I’ve been taking BIO X4 for 3 months now. My issues are completely gone. I haven’t lost weight, but I have noticed I am not as hungry all the time. Now that I’m feeling better I am looking forward to adding more exercise to my routine.

    Overall a great product. Adding to a reasonable diet and exercise is exactly the routine I need to control my weight and digestive functions.

    Bottom Line: Yes, I would recommend this to a friend

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  • Using Nucific BIO X4

    • Kannapolis, NC,
    • Nov 20, 2017
    • Verified Reviewer

    I've been using Nucific BIO X4 for about 5 weeks. I believe it is a good product but on my last doctor checkup, my thyroid readings for my test were not good so I'm trying to get my medication adjusted. I had to suspend using BIO X4 for now and will begin again after getting thyroid reading more in line.

    Bottom Line: Yes, I would recommend this to a friend

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  • Wonderful find

    After experiencing some overactive probiotic products recommended by doctors, I tried Nucific’s BIO X4 and am very happy with this product. It satisfies the probiotic digestive help without any irritable issues. Highly recommend. I️ already have!

    Bottom Line: Yes, I would recommend this to a friend

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  • Educate and execute

    • Honolulu, HI,
    • Nov 18, 2017
    • Verified Reviewer

    I love to eat good food! Tastes good, looks good and makes me feel good when finished. Food is one of those simple pleasures that can make me lose inhibitions and lead to serious overindulgence. The food gives me comfort to the extent I seek its escape when life gets rough. Food also gives joy to the extent I use it to celebrate as well. No wonder I can't control my weight and I needed help.

    I started with "fad" quick weight loss diets. As I was doing my research, I came across BIO X4. A light bulb went off in my head. My digestion is all messed up. The food I was eating was the problem. So I started researching food and their nutritional value and how our bodies processes what we eat. I believed I could make dietary changes I would enjoy and help my digestion do its job with the hopes it would lead to being healthier. I thought about all the years of crap I've put in my body and how much time it would take to reverse those effects and decided to let BIO X4 help.

    This is what I loved about this product. The suggestions like taking the pill with water and waiting five minutes to eat. The pill is to be taken three times a day so I have to eat three meals a day, and I'm drinking at least six glasses of water a day, and I'm eating three meals instead of grazing through time.

    Another good suggestion is to eat protein with breakfast, in fact, I've done my research, and healthy proteins are an important part of good digestion. I now include protein with every meal.

    I've also eliminated all HFC products from my diet, and I read labels before I buy. I don't want to live in a world without sugar, but I have learned that less is more.

    Today is my last day on the pills. I did miss a few here and there. I also had two binge days but pretty much kept my food calories around 1200 a day. I also am walking at least three times a week for about 45 minutes. I've added yogurt, the right kind, and fermented vegetables, like Kim Chee and sauerkraut to my diet. I found a matcha green tea to drink daily as well.

    My energy was up after the first week on BIO X4, and my tummy was down. I have lost 7 pounds, but more importantly, I feel great.

    I really don't like the idea of taking pills, not even vitamins to be healthy. I prefer to do it the old-fashioned way. Thank you BIO X4 for giving me the education I needed to execute a healthier eating lifestyle.

    Bottom Line: Yes, I would recommend this to a friend

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  • 1 out 1 people found this review helpful

    Pretty good

    I liked it ok. It seems to help with cravings, and I would like to order more, but it is too expensive and I do not want a shipping charge.

    Bottom Line: Yes, I would recommend this to a friend

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  • Very happy camper

    • San Diego, CA,
    • Nov 18, 2017
    • Verified Reviewer

    I was very happy with my results, and I have noticed that I am no longer bloated. I have started having regular bathroom cycles and started to lose weight. I have changed my diet, but I do believe that this product has had a positive impact on diet.

    Bottom Line: Yes, I would recommend this to a friend

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  • Excellent

    Nucific has the perfect amount of probiotics that I need to maintain a healthy and active lifestyle without issues. I definitely would recommend Nucific to anyone and to my friends and family!

    Bottom Line: Yes, I would recommend this to a friend

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  • Will continue to take

    • St. Louis, MO,
    • Nov 17, 2017
    • Verified Reviewer

    I have been taking Nucific BIO X4 for a little over a month. It has really made a difference on how my system works (much better now), and I have noticed a little more energy. I've also noticed that my stomach has really gotten smaller. I don't know if I've lost weight because I didn't weigh myself before I started, but I think I have certainly lost inches! I will continue to take BIO X4 and see how it goes.

    Bottom Line: Yes, I would recommend this to a friend

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  • Helped me break the body/weight stalemate

    I have been taking BIO X4 for about 6 months or so and finally broke the stalemate of not being able to get below 150 lbs. I started out a year and a half ago at 186.5 lbs and wanted my goal weight to be 140 lbs. I thought I was asking or hoping for too much; however, I made it to 150-152 and couldn't get below that. I was so frustrated with that! I got discouraged when I couldn't see any progress.

    THEN, I saw an advertisement on Facebook for BIO X4 and read all the information after I clicked on the link! I was pleasantly surprised and thought, "What have I got to lose?!"

    Well, I have finally gotten down to 144 - 146 on a regular basis. I am still hoping for a firmer determination and working on a better frame of mind that I will reach my weight goal of 140. Thanks Dr. Amy to you and your research team who have helped me so much!

    Try it, and you will be pleasantly surprised!

    Bottom Line: Yes, I would recommend this to a friend

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