Plexus Slim Review - How Well Does It Work?

By Anthony Dugarte, M.D., C.S.C.S
Updated on: May 28, 2020

What Is Plexus Slim?

Plexus Slim is a dietary supplement drink mix that allegedly supports gut health and weight loss through a blend of prebiotics and fat-burning ingredients.

While probiotics are the friendly bacteria in your gut that are vital to digestive and overall health, prebiotics are a form of fiber that act as a food source to promote their actions. According to the company, the prebiotic included in Plexus Slim is clinically-studied and responsible for many of the alleged benefits of their supplement.

By mixing Plexus Slim powder into 12–20 ounces of water 30–60 minutes before a meal, once or twice daily, the company claims that you can expect:

  • Weight Loss
  • Probiotic growth
  • A faster metabolism
  • Better glucose metabolism

In this article, we’ll help you determine if there is any merit to these claims by reviewing the available research for Plexus Slim’s blend of ingredients.

Plexus Slim Ingredients: Do They Work?

Slim’s supplement facts label:

  • Calories 5
  • Total Carbohydrate 2 g
  • Chromium 200 mcg
  • Xylooligosaccharide 1,000 mg
  • Plexus Slim Blend 531 mg – Green coffee bean extract (contains 50% chlorogenic acid less than 2% natural caffeine), Garcinia cambogia fruit extract, alpha lipoic acid, mulberry fruit extract

While XOS is alleged to handle most of the heavy lifting in this blend, we’ll briefly touch on some of the available research for Plexus Slim’s supporting ingredients.

Chromium

Chromium is naturally available in beef, fruits, broccoli, red wine, and whole wheat products. This mineral is necessary in small amounts; the RDA for men and women is 35 and 25mcg/day, respectively. You’ll get about 6-8x that amount in each serving of Plexus Slim.

While a review of 15 randomized trials did not find 10-1000mcg of chromium to benefit glucose or insulin regulation in neither diabetics nor nondiabetics, a similar dosing range offered in the form of brewer’s yeast may benefit fasting blood glucose.

Chromium supplementation in those overweight or obese is associated minor, though unlikely relevant, reductions in body weight, according to this review of 20 randomized trials.

Available support for chromium’s carbohydrate energy metabolism effects is mixed. Mild benefits may be seen in overweight, obese, or diabetic individuals. Chromium’s weight loss benefits are likely mild at best.

Plexus Slim Blend

Green coffee bean extract (GCBE) contains caffeine and is thought to help reduce appetite.

The combination of GCBE, olive oil, and caffeine reduced triglycerides in mice. A review of 3 randomized trials with GCBE doses ranging from 180-200mg daily for 4-12 weeks concluded that significant weight loss was achieved when compared to placebo.

More recently, obese women treated with 500mg of GCBE and daily exercise for 8-weeks significantly reduced their metabolic syndrome severity scores.

Garcinia cambogia extract is made from the rind of the fruit and the proposed weight loss benefits have been extensively studied.

While 2,800mg of garcinia combined with chromium significantly reduced body weight and BMI in obese individuals, 1500 mg of garcinia daily for 12-weeks did not produce significant weight loss when compared to placebo.

ALA is thought to be a powerful antioxidant and may also aid in weight loss. A review of 11 randomized trials with ALA dosing ranging from 300 to 1800mg/day.

Mulberry fruit is related to the fig. They’ve been studied less extensively when compared to the other ingredients. Rich in anthocyanins, an antioxidant found in plants, mulberry fruit extract was effective at reducing body weight in obese mice.

Plexus Slim blend offers research-tested ingredients that may offer some benefit in reducing weight. However, these studies often tested the ingredients in conjunction with other ingredients or structured exercise programs.

Thus, their effects are less likely when used alone, especially given that Plexus Slim offers much lower dosing compared to the available research.

Xylooligosaccharide

Plexus advertises that Slim’s prebiotic formula has been clinically shown to increase Lactobacillus levels by 365 times, Bifidobacterium by 290 times, and Akkermansia microbes by 250 times.

They also indicate that, in an “independent, randomized, double-blind, placebo-controlled, human clinical study, [participants] who used one pack of Slim twice a day lost an average of 5.45 pounds in 8 weeks, while the placebo group lost an average of 3.12 pounds.

The company does not provide references for this study and we did not confirm it during our literature review.

Plexus does cite one study examining the effects of XOS on the gut bacteria of healthy and diabetic subjects; those treated with 2g/day for 8-weeks had reduced harmful gut bacteria.

In another randomized trial, those that received 1.2g of XOS daily for 6-weeks had higher levels of Lactobacillus and Bifidobacterium when compared to placebo.

Those receiving 1.4 or 2.8g of XOS over 8-weeks had increased Bifidobacterium but not Lactobacillus; the effects were greater at higher doses of XOS.

Though the specific studies Plexus failed to cite were not located, XOS’s ability to boost friendly gut bacteria has been investigated. Currently, results are mixed. Its ability to increase Bifidobacterium may be more likely, particularly at doses nearly 3x than what Plexus Slim contains.

Is Plexus Slim Safe?

The company states that Plexus Slim isn't recommended for use by children under 18, and that you should consult with your physician beforehand if you’re pregnant or nursing.

Prebiotic supplementation can cause side effects like mild, temporary digestive upset, bloating, and gassiness as your bacteria levels re-balance. While this same level of clinical support doesn’t exist for prebiotics, it makes sense that you might experience similar side effects as beneficial bacteria flourish.

Chromium at 1000mcg was safe, though diarrhea, headaches, and rash have been reported. XOS and the ingredients found in the Plexus Slim Blend were safe when tested at much higher doses than what is offered in this supplement.

Though Plexus Slim doesn’t contain high levels of caffeine, you might experience related side effects like nervousness, upset stomach, and increased heart rate if you regularly consume other caffeine-containing products in addition to this supplement.

The risk for harm may be minimal, but it’s still a good idea to speak with your doctor before using Plexus Slim or similar products.

The Cost

Plexus Slim is available directly from the website.

The products come in raspberry, lemon, and watermelon flavors. A one-time purchase will run you $89.95 for 30 packets. If you subscribe, you’ll pay $84.95 for your monthly auto-shipments. Shipping is calculated at checkout.

A 60-day guarantee backs your purchase. If you’re unsatisfied with your results, call (480) 998-3490 or request a refund form online.

Plexus Slim is also available at Amazon. You won’t save with this option, however, as they price 30 packets at $105.95. Opting to purchase through Amazon also means that you’ll have 3-days to return rather than 60.

What Are the Alternatives to Plexus Slim?

Many dietary supplements claim to offer weight loss benefits through a blend of prebiotics and metabolism-boosting ingredients.

At HighYa, we previously reviewed RenewLife’s supplement line. While their products contain a similar blend of probiotics, they include additional ingredients for targeted purposes.

For example, their Healthy Weight Probiotic is intended to boost metabolism, support weight loss, and promote digestive health with the addition of coffee bean extract and xylooligosaccharides.

For $34, you’ll get roughly half the xylooligosaccharides, 10 different probiotic strains, and coffee bean extract. Though the benefits of this prebiotic were demonstrated at much higher doses, this product offers other proven ingredients at about ⅓ of the Plexus Slim Price.

You can also find 60 chewable tablets (2-month supply) of life Extension’s Florassist supplement for $13-$25. When taken as directed, you’ll get 1,000mg xylooligosaccharides for a fraction of the price of Plexus Slim.

Even if you double the dose of Florassist and add a fat-burning supplement, you are likely to save when compared to Plexus Slim Pricing.

Pros and Cons

Pros
  • There is some evidence for the proposed actions of the supplement
  • The risk for harm is low
  • You have 60-days to determine if Plexus Slim works for you
Cons
  • XOS dose may be too small to achieve the desired results
  • Very pricey when compared to other XOS-containing supplements

The Bottom Line

There is some support that Plexus Slim’s blend of ingredients can support healthy digestion and aid weight loss. However, most of the available research demonstrated the efficacy of XOS at much higher doses.

Given the amount included within Plexus Slim, this supplement may not be worth the price.

Despite a low risk for harm, as well as the ability to find more cost-effective supplements that offer XOS, you should still speak with your doctor before trying a new supplement. Your symptoms may be caused by an underlying condition that requires medical attention.

Using a dietary supplement like Plexus Slim may not appropriately address the source of your symptoms, allowing them to persist or even worsen.


Customer Reviews

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  • Doubled my weight loss.

    • By Jenny Bryant,
    • Dallas, TX,
    • Jun 28, 2015
    Overall Experience:

    I have been on my weight loss journey since November and started taking Plexus Slim over a month ago. I had been steadily losing 1lb per week with diet and exercise since November. Since starting Plexus, I have been loosing 2-3 lbs per week and have had so much energy that some days I am doubling up on my workouts. Even my trainer has started taking it. I would try it, you can even buy a 3 day or 7 day trial pack. Help yourself with your weight loss, as well as your energy, blood pressure, blood sugar levels, cholesterol levels and more.

    Bottom Line: Yes, I would recommend this to a friend


  • Works Great

    • By Susie Q,
    • California,
    • Jun 28, 2015
    Overall Experience:

    I have been taking Plexus Slim plus Accelerator for 5 weeks and have lost just shy of 13 pounds. I am happy. I haven't struggled or gone on some wild exercise frenzy that I wont continue. I eat breakfast and within 45 minutes mix the pink into 24 ounces of water and take the accelerator. It has been that easy and I actually enjoy drinking plain old water all day long.

    Bottom Line: Yes, I would recommend this to a friend


  • Rescued by Plexus.

    • By Staci,
    • San Diego, CA,
    • Aug 9, 2015
    Overall Experience:

    I started using Plexus products 15 months ago. I was SUPER skeptical, in fact, I took the ingredients lists to my OBGYN before I tried the products. He did a thorough search for me on not just the ingredients but the company as well. He was impressed with the quality of the ingredients, and said right off the bat, that 3 of the ingredients in the Slim were known to have successful results for weight loss. He gave me the thumbs up, so I ordered. The reason I was interested in trying it, was because I was always fatigued, I had just finished weaning my 4th son from nursing and I was gaining weight, was extremely moody with my kids, and overall felt horrible. I had tried "other" health programs (not products) but they weren't my thing. I knew what it took to get healthy, I just needed something to make it a little easier during that transition , to help me not feel deprived and tempted by my sweet tooth.

    In my experience (I started using the products on Dec. 5th-yes, I was glutton for punishment trying to lose weight through the holidays!), I noticed my fatigue had disappeared after 3-4 days of using the products. On Christmas day, I realized I had NO desire for dessert and felt full after only eating 1/3 of what was on my plate. By New Year's day, I had lost 5 pounds. I was no longer feeling the battle between me and sweets, but more importantly, I was desiring healthier foods. I was having less mood swings, I was much happier, energized and was sleeping better. After 6 months, I had dropped 4 pant sizes, I have backed off of some of the products, and I'm still down 19 pounds, and with the help of Plexus, it has been a great tool to help with the transition into a healthier lifestyle! My husband has now lost 30 lbs, my mom is off of her cholesterol meds, and my aunt is off her Thyroid Meds (according to her DR, thanks to Plexus)!

    The customer service on the phone can be a little inconsistent, but I grant them a little grace because I know they are growing tremendously fast due to their success; however, I have never had any issues with refunds as long as it is requested within the 60 days (so, if you call them on day 58 and tell them you want your money back, you are good to go. If you call on day 61, it's a missed opportunity). I've never had to mail anything back. They ask if the package has been opened, and if it was, you keep it, if it is still sealed, then it would need to be returned and the credit will occur upon receipt.

    My 11-year old son has actually thanked me for "doing Plexus," because he says it gave him his mom back. Thank you Plexus for rescuing me.

    Bottom Line: Yes, I would recommend this to a friend


  • Learn to read

    • By Adam,
    • Tennessee,
    • Jul 22, 2015
    Overall Experience:

    I have used this product for six months, no problem and I have had some weight loss.

    This product works for some and not for others, everyone is different.

    For those people who complain about return policies and charges on their credit cards, you might want to learn to read.

    The agreement/contract you sign whether as a preferred customer or ambassador (distributor) specifically states what will happen and how.

    If you can't bother to read what you are signing or agreeing to when you click on a the submit button then you have no one to blame but yourself. Learn to take responsibility for your own actions.

    Bottom Line: Yes, I would recommend this to a friend


  • Seriously delivers more than hoped for

    • By Angela Dhaut,
    • Harrisonburg,
    • Jan 13, 2016
    Overall Experience:

    I really didn't think this was going to work. It sounded too good to be true, and it was just the hundreds of convincing testimonials - some even from friends, that led me to be willing to see for myself. First the simple stuff: It actually DOES taste great. Much like a liquid cherry tootsie roll. It's diabetic friendly; so the sweet comes from Lohan fruit (monk fruit) and Stevia only. It is pink because of beet root extract. Totally natural, and from my own diligent research - full of safe, good stuff. Nonetheless I didn't think it would DO anything. Well, here is what I found. Over the course of days and weeks of using it daily a LOT of great things happened. I stopped wanting to finish full meals, much less get seconds, but I still enjoyed my food. I stopped snacking - just because I never felt drawn to do so. Crazy, for me, to experience that kind of liberating thing. I also just felt more balanced mood wise and started waking up more restful. After a month I lost 8 lbs and was really excited because it was seemingly because of two things. 1. I simply had total control over cravings like never before and was eating less altogether & actually craving good foods 2. The product somehow triggers the body to release stored fat. Overall extremely pleased and just wanted people to know.

    Bottom Line: Yes, I would recommend this to a friend


  • New formula, not the same

    • By Cameron B.,
    • Connecticut,
    • Dec 21, 2018
    • Verified Reviewer
    Overall Experience:

    I tried the pink drink two years ago and loved it. It suppressed my appetite and I lost weight without exercise. They changed the flavor of the pink drink and I have purchased it twice and noticed nothing. It's not the same. It doesn't taste as good as the old drink and didn't do anything as far as suppressing my appetite. I am looking for something else now to jump start my weight loss.

    Bottom Line: No, I would not recommend this to a friend


  • Trial results

    Overall Experience:

    I am near the end of a 30-day trial with Plexus Slim. When I agreed to join this trial, I told them that I would not change my diet or activity during the trial period. When I test something, I want to make sure that any improvements are most likely the result of the item I'm testing. The bag says to "eat healthy and exercise." That alone would cause a person to lose weight.

    I have not seen any difference in weight or energy level. I get the same energy boost from the ProbioSlim I buy at GNC for far less cost. Any problems I had, such as a dull headache were labeled as detox. I missed one day and paid for it when I took Plexus Slim the next day. Anything I ate passed quickly through my system.

    Regarding the price, one bag of 30 Plexus Slim is about $100 including shipping. After a while, it is recommended that you increase to two pink drinks a day, which doubles your price. Then, of course, there are other products that will take care of all kinds of things. It's an MLM, so everything is overpriced.

    I was encouraged to become an ambassador and sell Plexus to three friends. I was told that they would end up paying for my Plexus because of the commission. I don't want to do that to anyone.

    I'm going back to my GNC ProbioSlim!

    Bottom Line: No, I would not recommend this to a friend


  • Didn't work

    • By Michelle L.,
    • Tennessee,
    • May 8, 2019
    • Verified Reviewer
    Overall Experience:

    I tried the pink drink and a few of the other items for at least 3 months, I never felt any difference. I ended up canceling my monthly orders and getting rid of what I had left. This was a couple of years ago.

    Bottom Line: No, I would not recommend this to a friend


  • Product and business

    • By Anonymous ,
    • Aug 5, 2014
    Overall Experience:

    I tried Plexus for six months and never lost anything but money. I signed up to sell it and found the company did not honor compensation plan either! What a joke! Stay away from this one!

    Bottom Line: No, I would not recommend this to a friend


  • It didn't work for me.

    • By Lester Bauman,
    • Alberta,
    • Feb 10, 2016
    Overall Experience:

    I was having digestive problems, etc. and someone gave me a month's supply of Plexus BioCleanse and also their ProBiotic. It set up a very severe reaction within me - it was like dynamite going off within me and practically blew my guts out. It may be that the product actually works, but it should be used with extreme caution, starting off in much smaller doses than recommended. It turns out that I have Crohn's disease, which is probably why I had the extreme reaction. But there is no place to go to for help except self educated lay "doctors". I still think a probiotic is a good idea, but I'm pretty cynical about "cleanses", especially cleanses that you are supposed to keep on taking forever.

    Bottom Line: No, I would not recommend this to a friend


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