Hempvana Pain Relief Review: Is It Safe and Effective?

By Rocklend Davis, Ph. D.
HighYa Staff
Updated on: Jul 20, 2020

Pain management options vary as the underlying cause can significantly differ from person to person.

There are many treatment options available to manage symptoms of pain include, including heat and cold packs, herbal supplements, over the counter medications, Physical Therapy, prescription medications, or surgery.

Topical pharmaceutical products such as Hempvana pain relief cream, when applied, seek to target the local area below the skin.

The active ingredients found in these pharmaceutical products are alleged to help facilitate deeper penetration into tissues at a rapid rate.

According to Hempvana, daily application will provide you with the following benefits:

  • Relieves pain and inflammation
  • Great for arthritis and muscle soreness
  • Treats pain, not your whole body

The method regarding the topical analgesics is to reduce the need to take pain treatments orally that may contribute to gastrointestinal issues. It may be a formidable alternative to address conditions related to OA when compared to oral ingestion.

In this review, we’ll describe intended use, as well as the scientific backing of Hempvana Pain Relief Cream active ingredient.


Topical analgesics can be applied directly onto your skin at a site(s) in which you are experiencing pain.

According to the product description, Hempvana pain relief cream is intended for adult use only and can be applied up to four times daily.

The application begins by massaging a generous amount of the pain relief cream to the painful area (shoulders, elbows, wrists, knees, calves, and back) until it is thoroughly absorbed into the skin.

Is There Any Science Supporting Trolamine Salicylate 10%?

Trolamine Salicylate is used to treat minor aches and pains in the muscle and joints, such as arthritis, backaches, and sprains.

Trolamine salicylate is offered as a topical analgesic that is suspected to be a more effective and alternative means to minimize the adverse drug effects and complications of systemic analgesic use.

Salicylates specifically (provides the analgesic effect) are found in aspirins, which provide interference with inflammatory pathways.

Two studies show that a topical analgesic with salicylates compared to taken orally was associated with improved pain relief.

Based on blood samples and muscle salicylate levels, at least 82% of topically applied trolamine salicylate was absorbed during a period of 2 hours in pigs.

Since trolamine salicylate is applied directly onto the skin, the initial thought process was to increase blood flow to the area and vasodilate the blood vessels to increase the absorption of the salicylate.

However, an earlier study provides evidence of salicylate’s ability to directly affect local tissue penetration without the need to provide systemic circulation to increase clinical effectiveness.

Data from a review of studies of osteoarthritis treatment suggests that topical analgesics may only be beneficial for the first two weeks.

A study to evaluate the efficacy of decreasing pain and stiffness of muscles when applying a 10% trolamine salicylate cream was done in patients suffering from osteoarthritis in their hands.

A one-time application of the cream was found to be safe and effective for temporary relief of minor pain and stiffness affected by osteoarthritis in the hands.

Osteoarthritis (OA) affects 240 million people globally and is the standard form of arthritis. OA primarily affects the elderly and can significantly limit independence, with pain being the most predominant symptom.

OA affects joints in your body, such as your shoulder, knee, ankle, elbow, wrist, hands, and back.

Changes seen in OA joints gradually degrade and destroy cartilage, the formation of bone spurs, inflammation, degeneration of ligaments, and menisci of the knee that may lead to chronic pain, joint instability, and stiffness.

While this condition occurs more frequently in the elderly, participation in sports-related activities while experiencing traumatic injuries can lead to OA.

Is It Safe?

Topical creams are generally safe. However, the lack of research, especially long term use, means that fully identifying the safety profile for this ingredient is not possible.

The efficacy and safety of acute topical non-steroidal anti-inflammatory drugs, including salicylate, are well studied. 43 studies confirmed that topical NSAIDs were effective and safe for osteoarthritis.

Trolamine Salicylate has no listed interactions with other drugs.

Side effects: Blistering, peeling, redness, irritation at the application site, nausea/vomiting, and ringing in the ears.

Contraindications: hypersensitivity from application to skin or site of pain.

Suggested use is for the treatment of minor muscle and/or joint pain, typically applied for adults.

If you are experiencing levels of increased pain that is not normal and new, you should notify a medical professional.

Available Alternatives

Topical pain relief creams are widely available from vendors that sell health and wellness products.

Product comparison will lead to finding a varying degree of pricing and formulation of ingredients.

Australian Dream Cream and Penetrex for Pain Relief are products that we have previously reviewed.

Both supplements contain similar ingredients that help to provide relief for joint, muscle, and back pain.

Australian Dream offers a 2 oz jar for ranging from $15-$18 (one 4 oz jar of Hempvana costs $19.99 including free shipping) and a pretty favorable safety profile.

One large 4 oz jar of Penetrex will cost you $34.95.

The Cost

Hempvana pain relief cream is available through many retailers, but purchasing a second 4 oz jar through their website can provide savings.

According to Hempvana’s website:

  • One 4 oz jar: $19.99 with free shipping
  • Two 4 oz jars: $29.98 with free shipping

A 30-Day Guarantee backs Hempvana Pain Relief Cream. To claim a full refund or replacement, you must send the item back. You will be expected to have to pay for your shipping and handling, however.

Pros and Cons

  • Active ingredient dosage formulated to offer deeper penetration to tissues
  • Easy to use and affordable
  • Studies are lacking showing long-term effectiveness of a topical application
  • Relief of pain is short term

The Bottom Line

Topical creams are generally safe but more long-term studies are required. Survey results indicate that more guidance is needed to effectively prescribe topical agents to manage pain in the long term, however.

While topical analgesics may provide good levels of pain relief, it may only be limited to acute conditions of sprains, strains, and overuse injuries.

Further, topical treatments may lead to better compliance of pain when compared to oral ingestion of NSAIDs.

Hempvana Pain Relief cream is a more affordable and reasonably priced option when compared to other topical analgesic creams used for the treatment of localized pain.

Always identify the source of your symptoms before use, and the inclusion of your physician can help determine the underlying cause and provide you the best possible care.

Customer Reviews

Start your review of Hempvana Pain Relief Cream:
  • 26 Customer Reviews
  • 46% Recommend This Product
2.8 out of 5
5 star: 34% 4 star: 11% 3 star: 3% 2 star: 3% 1 star: 46%

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  • Good product!

    • By Sandra F.,
    • Asheville, NC,
    • Aug 19, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I have had scoliosis 6" rod back surgery since 16 years old and now at 57 years old have been told on disability that I needed for the past 8 years I will have to get 2 major surgeries to redo my surgery. I’ve been avoiding this so I tried Hempvana cream and WOW!

    I won’t use any other creams to dull my pain on the skin with sciatica and osteoarthritis added with osteoporosis and other complications, so I know it works!

    Pros and Cons:

    • Cream
    • No odors
    • No pain
    • Feels cooler
    • Comfortable
    • No roll on
    • No rollers

    Bottom Line: Yes, I would recommend this to a friend

  • The best relief cream!

    • By William C.,
    • Hubbard, OH,
    • Aug 11, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    Hello, I just had to write this review to say I have had many surgeries on my hands and on my back. I'm in pain everyday and have tried everything, but for me, this product is the best I have found. And I'm on my third jar and am going to order more. I really love this product. And I'm not getting paid to say this. It really works for me at a good price that helps me since I'm on a fixed income. Thank you, Hempvana, keep on!

    Pros and Cons:

    • It really work for me
    • It's a great price
    • Not greasy and smells nice, not menthol
    • No “cons” were specified in this review

    Bottom Line: Yes, I would recommend this to a friend

  • This stuff is junk. Does not work. Smells good and that's it. Does not relieve pain.

    • By Marty S.,
    • Chambersburg, PA,
    • Aug 10, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    Horrible. Does not work. Horrible, horrible, horrible. A total waste of $20. Bio freeze worked better than this product. I do not recommend buying this product.

    Pros and Cons:

    • Smell
    • Does not work

    Bottom Line: No, I would not recommend this to a friend

  • Not happy - does not work

    • By Charlie T.,
    • Hesperia, MI,
    • Jul 26, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I purchased your Hempvana Cream to relieve the pain in my knee and shoulder. I have been using it like it says and I am not happy. It does not work. With the price being just about $20 you would think it would help a little bit but, I knew I should have not wasted my money. Do you offer a money-back guarantee?

    Please let me know what to do with this product that you BRAG up on TV but did not do the job.

    Pros and Cons:

    • No “pros” were specified in this review
    • Your company does not answer a customer's email
    • Does not work

    Bottom Line: No, I would not recommend this to a friend


    • By Beatriz M.,
    • El Paso, TX,
    • Jul 20, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    I ordered this product online on June 12th and also upgraded it to Hempvana Gold. Since then, I never received my order nor a shipping notification from them. After trying to contact them by email, I got no response from them and so I ordered it from Walgreens, which shipped it two days later!

    Pros and Cons:

    • I tried the product for my arthritis and it helped ease the pain
    • I'm disappointed that my original order was never received from the website and I obtained it from Walgreens instead

    Bottom Line: No, I would not recommend this to a friend

  • I bought two jars of this for my sciatic nerve

    • By Daniel I.,
    • Florida,
    • Jun 23, 2020
    • Verified Reviewer
    • Length of Use: Less than 3 months
    Overall Experience:

    This did not work on my sciatic nerve nor on my shoulder muscle. I guess that works for some people depending on how severe the pain is. Because everybody's pain is different than the other. I know we have to get the best relief so you need more marijuana and you just haven't got it inside.

    Pros and Cons:

    • No “pros” were specified in this review
    • Does not work as claimed

    Bottom Line: No, I would not recommend this to a friend

  • Miracle!

    • By Ruby R.,
    • Texas,
    • May 14, 2020
    • Verified Reviewer
    Overall Experience:

    I have degenerative joint disease, I have tried so many different things, including major pain killers from pain management doctors. Nothing, and I mean absolutely nothing, has ever worked for me...until now. This is a true miracle for me. It relieved my pain instantly. Being that I have tried everything under the sun I never would have bought it on my own but I tried my mom's and I couldn't believe how quickly and well it worked. I was definitely not expecting that! I am so happy to be pain-free again! I have to apply it 2 or 3 times a day but that's ok, this has given results that even oxycodone and oxycontin couldn't. I will be stocking up!

    Bottom Line: Yes, I would recommend this to a friend

  • No response

    • By Ed D.,
    • Illinois,
    • May 14, 2020
    • Verified Reviewer
    Overall Experience:

    Ordered 3 weeks ago and they haven't shipped. Can't get any response from telephone calls or numerous e-mails. I'm beginning to think it's a scam. Can't get them to refund either as no response.

    Bottom Line: No, I would not recommend this to a friend

  • Company does not respond

    • By Larry B.,
    • Oklahoma,
    • Apr 24, 2020
    • Verified Reviewer
    Overall Experience:

    I ordered 3 jars online on March the 30th. As of today, April 22nd, I have received nothing. I have emailed several times and no response. I called and after several runaround numbers I got a male who couldn't speak real good and after a time of fumbling finally said he found the order and said it would be shipped in two weeks. Well, guess what has not arrived? Sorry company, sorry support, and I don't know about the cream because I DON'T HAVE IT TO TRY!

    Bottom Line: No, I would not recommend this to a friend

  • Hype

    • By Ronny W.,
    • Georgia,
    • Apr 22, 2020
    • Verified Reviewer
    Overall Experience:

    I found the massage when applying this cream was probably the beneficial part of the claimed relief...as the adage goes, "if you keep telling the story, it soon becomes believable." A good lubricant hand cream does as good as this 20 buck massage oil.

    Bottom Line: No, I would not recommend this to a friend

  • Hempvana Cream

    • By Teresa D.,
    • Missouri,
    • Apr 16, 2020
    • Verified Reviewer
    Overall Experience:

    I was so looking forward to using this cream to relieve the pain in my hip so I could possibly walk without my cane. I was so disappointed! No relief what-so-ever! I was duped! I suppose I should've known...

    Bottom Line: No, I would not recommend this to a friend

Showing 1-11 of 26

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